Abstract
Ovarian tumours constitute the second most common tumour of the female genital tract after cervical cancers. The study describes the histological subtypes of ovarian neoplasms along with other parameters like age, laterality and consistency of lesion in a tertiary care centre in Uttarakhand. The retrospective data of ovarian tumours sent to the Department of Pathology was collected over a period of 4.5 years. They were classified into benign, borderline and malignant categories in the respective histological subtypes (surface epithelial, germ cell, sex cord stromal and metastatic) based on the latest WHO classification. The consistency of tumour, laterality and age of the patient were also evaluated. Of the 130 cases studied, 73 (56%) were benign, 13 (10%) were borderline and 44 (34%) were malignant. The majority of cases (73.1%) were surface epithelial tumours, followed by germ cell tumours (20.8%), sex cord stromal tumours (4.6%) cases and metastatic tumours (1.6%). Most cases (80.8%) showed unilateral involvement while 19.2% cases had bilateral involvement. The majority of cases in the present study were benign. Serous cystadenoma was the most common benign tumour with its malignant counterpart being the most common tumour in the malignant category.
Similar content being viewed by others
Data Availability
No additional data is available.
References
Forae GD, Aligbe JU (2014) A histopathological overview of ovarian lesions in Benin City, Nigeria: how common are the functional cysts? Int J Med Public Health 4:265–268
Sankaranarayanan R, Ferlay J (2006) Worldwide burden of gynaecological cancer: the size of the problem. Best Pract Res Clin Obstet Gynaecol 20:207–225
Murthy NS, Shalini S, Suman G, Pruthvish S, Mathew A (2009) Changing trends in incidence of ovarian cancer – the Indian scenario. Asian Pac J Cancer Prev 10:1025–1030
Bag A, Rawat S, Pant NK, Jyala NS, Singh A, Pandey KC (2012) Cancer patterns in Nainital and adjoining districts of Uttarakhand: a one year survey. J Nat Sci Biol Med 3:186–188
Gaur DS, Kishore S, Harsh M, Kusum A, Bansal R (2006) Pattern of cancers amongst patients attending Himalayan Institute of Medical Sciences Dehradun. Indian J Pathol Microbiol 49:193–198
Mathew G, Sohrabi C, Franchi T, Nicola M, Kerwan A, Agha R; PROCESS Group. Preferred Reporting of Case Series in Surgery (PROCESS) 2023 guidelines. Int J Surg. 2023;109:3760-9
Hasan Y, Rizvi G, Pandey HR (2014) Histological pattern of ovarian tumours in a tertiary care hospital in Kumaon Region of Uttarakhand: a five year retro-prospective study. J Evol Med Dent Sci 3:2536–2542
Agarwal A, Joshi U, Thapliyal NC, Pant P (2018) Morphological spectrum of ovarian tumours in Kumaon Region of Uttarakhand – an institutional based study. JMSCR 6:424–428
Hatwal D, Choudhari S, Batra N, Bhatt P, Bhatt S (2016) Clinico-histopathological analysis of neoplastic and non-neoplastic lesion of ovary in Garhwal region of Uttarakhand: a 4 year study at tertiary level hospital. Indian J Pathol Oncol 3:133–140
Patel AS, Patel JM, Shah KJ (2018) Ovarian tumours - incidence and histopathological spectrum in tertiary care center. Valsad IAIM 5:84–93
Agarwal D, Kaur S, Agarwal R, Gathwal M (2018) Histopathological analysis of neoplastic lesions of the ovary: a 5-year retrospective study at tertiary health care centre. Intl J Contemp Med Res 5:E14–E17
Gupta N, Yadav M, Gupta V, Chaudhary D, Patne SCU (2019) Distribution of various histopathological types of ovarian tumours: a study of 212 cases from a tertiary care center of Eastern Uttar Pradesh. J Lab Physicians 11:75–81
Sawant A, Mahajan S (2017) Histopathological study of ovarian lesions at a tertiary health care institute. MVP J Med Sci 4:26–29
Mandal TK, Chakraborty B (2018) A retrospective analysis of ovarian tumours in a peripheral tertiary hospital in West Bengal. IOSR J Dental Med Sci 17:13–18
Hota R, Panda KM, Bhuyan T (2018) Clinical and histopathological correlation of ovarian tumour. IOSR J Dental Med Sci 17:66–71
Chanu SM, Dey B, Raphael V, Panda S, Khoglah Y (2017) Clinico-pathological profile of ovarian cysts in a tertiary care hospital. Int J Reprod Contracept Obstet Gynecol 6:4642–4645
Pradhan S, Chalise S, Pradhan B, Maharjan S (2017) A study of ovarian tumours at Kathmandu medical college teaching hospital. J Pathol Nepal 7:1188–1191
Mankar DV, Jain GK (2015) Histopathological profile of ovarian tumours: a twelve year institutional experience. Muller J Med Sci Res 6:107–111
Saha M, Banerjee A, Datta A (2018) Histological patterns of ovarian neoplasms – a five year experience in NorthEast India. Int J Med and Dent Sci 7:1576–1581
Author information
Authors and Affiliations
Contributions
Sana Ahuja: data acquisition, manuscript preparation; Michael Leonard Anthony: data acquisition; Arvind Kumar: manuscript editing; Prashant Durgapal: conceptualization and editing; Prashant P. Joshi: manuscript preparation; Shalinee Rao: manuscript editing; Sanjeev Kishore: manuscript preparation; Ashok Singh: data acquisition, manuscript preparation, and manuscript editing.
Corresponding author
Ethics declarations
Ethical Approval
The study was conducted in agreement with the Declaration of Helsinki and after approval from the Institutional Ethics Committee vide approval number IEC/20/487.
Conflict of Interest
The authors declare no competing interests.
Consent for Publication
Written informed consent was obtained from the patient for publication and any accompanying images. A copy of the written consent is available for review by the editor-in-chief of this journal on request.
Parental consent (for minors): Written informed consent was obtained from the patient’s parents/legal guardian for publication and any accompanying images. A copy of the written consent is available for review by the editor-in-chief of this journal on request.
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
This paper has been prepared by the abovementioned authors and reviewed and agreed upon for submission. The requirements for authorship as stated above in this document have been met, and that each author believes that the manuscript represents honest work. This manuscript is an original work and has not been submitted elsewhere for publication.
Rights and permissions
Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
About this article
Cite this article
Ahuja, S., Anthony, M.L., Kumar, A. et al. Histomorphological Spectrum of Ovarian Tumours in a Tertiary Care Centre of North India: A Case Series. Indian J Surg Oncol 16, 182–189 (2025). https://doi.org/10.1007/s13193-024-02059-w
Received:
Accepted:
Published:
Version of record:
Issue date:
DOI: https://doi.org/10.1007/s13193-024-02059-w