Features of infertility for women with different thyroid violations

D.Yu. Beraya
In: Perinatology and reproductology: from research to practice · 2021 · vol. 1(4) , pp. 61–65 · doi:10.52705/2788-6190-2021-4-9 · W4285324422
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⚙ AI-generated summary by claude@2026-06, 2026-06-13 ⓘ

Thyroid pathology is more prevalent in infertile women than fertile women, with specific thyroid conditions linked to different primary infertility causes and increased pregnancy loss.

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The paper studied the frequency and structure of thyroid disorders among women with infertility by screening 298 infertile patients and comparing results with 50 fertile controls. Using a generally accepted diagnostic algorithm, thyroid pathology was assessed and infertility causes were described in relation to different thyroid conditions, including autoimmune thyroiditis and other thyroid-related dysfunctions. Autoimmune thyroiditis-associated thyroid disorder was reported to be linked with a higher frequency of pregnancy failure/unmaturing of pregnancy (2–2.4 times higher than in the control group), and thyroid pathology prevalence was 48% in infertile women versus 12.5% in fertile women (3.8-fold higher). The authors also stated a limitation that clinical symptoms had low diagnostic value compared with laboratory diagnostics, with symptom sensitivity ranging from 16.1% to 27.8% despite higher specificity. Relevance to endometriosis: the paper reports that, in the infertility cohort stratified by thyroid status, “outward genital endometriosis” was a leading infertility cause in several thyroid groups (including 34.4% for autoimmune thyroiditis and 26.6% for compensated thyroprivia), though the study’s main focus is thyroid disorders as they relate to infertility.

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Abstract

The objective: study of frequency and structure of thyroid violations for women with infertility. Materials and methods. For the performance of the put goal the screening estimation of pathology of thyroid was conducted for 298 women with infertility (basic group) and at 50 fertile of women which appealed to the clinic for the selection of method of contraception (control group). The inspection of patients with infertility was conducted in accordance with the generally accepted diagnostic algorithm, including endoscopic methods, and treatment – depending on found out reasons of infertility Results. Leading place in the structure of reasons of infertility for women with autoimmune thyroiditis occupied outward genital endometriosis (34,4%), for women with found out a thyroprivia is an endocrine factor of infertility (syndrome of polycystic ovaries) – 29,8%, for patients with the compensated thyroprivia is outward genital endometriosis (26,6%), for women with a euthyroid goitre and for patients without pathology of thyroid is a pipe-peritoneal factor (33,3% and 39,8% accordingly). For patients with autoimmune thyropathy high-frequency of unmaturing of pregnancy is characteristic – at 2–2,4 time which exceeds analogical indexes in a control group. Conclusion. For patients with infertility prevalence of thyroid pathology at 3,8 time higher by comparison to fertile women (48% and 12,5% accordingly). In the structure of pathology of thyroid the transmitter of antibodies prevails to thyroperoxidase in combination with the ultrasonic signs of autoimmune thyroiditis (24% and 8,7% accordingly); subclinical thyroprivia as a result of autoimmune thyroiditis (8,6% and 2,5% accordingly); euthyroid goitre (7,8% and 2,5% accordingly). The results of questionnaire, conducted for women with infertility, showed the low diagnostic value of clinical симптоматики of thyroprivia by comparison to laboratory diagnostics in verification of this diagnosis. A sensitiveness of symptoms was low and hesitated from 16,1% to 27,8%, while specificity of symptoms was considerable and varied from 85,1% to 94,5%.
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Keywords

infertility for women, thyroid pathologyAbstract DOI: 10.52705/2788-6190-2021-4-9 УДК 618.2-055.23-053.7-083-082:614.2 The objective: study of frequency and structure of thyroid violations for women with infertility.

Materials

and methods. For the performance of the put goal the screening estimation of pathology of thyroid was conducted for 298 women with infertility (basic group) and at 50 fertile of women which appealed to the clinic for the selection of method of contraception (control group). The inspection of patients with infertility was conducted in accordance with the generally accepted diagnostic algorithm, including endoscopic methods, and treatment – depending on found out reasons of infertility Results. Leading place in the structure of reasons of infertility for women with autoimmune thyroiditis occupied outward genital endometriosis (34,4%), for women with found out a thyroprivia is an endocrine factor of infertility (syndrome of polycystic ovaries) – 29,8%, for patients with the compensated thyroprivia is outward genital endometriosis (26,6%), for women with a euthyroid goitre and for patients without pathology of thyroid is a pipe-peritoneal factor (33,3% and 39,8% accordingly). For patients with autoimmune thyropathy high-frequency of unmaturing of pregnancy is characteristic – at 2–2,4 time which exceeds analogical indexes in a control group. Conclusion. For patients with infertility prevalence of thyroid pathology at 3,8 time higher by comparison to fertile women (48% and 12,5% accordingly). In the structure of pathology of thyroid the transmitter of antibodies prevails to thyroperoxidase in combination with the ultrasonic signs of autoimmune thyroiditis (24% and 8,7% accordingly); subclinical thyroprivia as a result of autoimmune thyroiditis (8,6% and 2,5% accordingly); euthyroid goitre (7,8% and 2,5% accordingly). The results of questionnaire, conducted for women with infertility, showed the low diagnostic value of clinical симптоматики of thyroprivia by comparison to laboratory diagnostics in verification of this diagnosis. A sensitiveness of symptoms was low and hesitated from 16,1% to 27,8%, while specificity of symptoms was considerable and varied from 85,1% to 94,5%. Downloads Published How to Cite Issue Section License Copyright (c) 2021 D. Beraya This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

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endometriosisinfertility

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