Prophylaxis of relapses for the women of postmenopausal period with of high quality pathology of endometrium

The objective: decline of frequency of relapses of pathological processes of endometrium for the women of postmenopausal age on the basis of improvement and introduction of algorithm of diagnostic and treatment-and-prophylactic measures.Materials and methods. 144 patients (1 group) were inspected, which appealed for a help for period from 2015 to 2019 At the selection of patients for our research we used the followings criteria of including: age > 60 years; proof postmenopausal period; absence of complaints from the side of organs of the genesial system; suspicion on an endometrial pathological process from data of ultrasonic research of organs of small pelvis and gynaecological review. The algorithm of diagnostic and treatment-and-prophylactic measures improved by us was used for 100 women of postmenopausal age with the pathological processes of эндометрия (2 group). Age of patients of a 1 group hesitated from 60 to 87 years (middle age 68,6±5,6 years). All patients were in proof postmenopausal period and were up-diffused on two groups in obedience to the age-related classification. The terms of offensive of menopause varied from 38 to 56 years. On the average, menopause came in age 44,7±4,9. Middle duration of postmenopausal period in the moment of research was 15,9±1,1 years. Hysteroscopy with a separate diagnostic endometrectomy was conducted in a gynaecological separation in the conditions of small operating-room under general brief intravenous anaesthesia in obedience to the generally accepted recommendations. Morphological and immunohistochemical researches were conducted on standard methods.Results. The results of the conducted researches testify to high actuality of study of pathology of endometrium for the women of postmenopausal period. For effective diagnostics of relapse of pathology of endometrium for the women of postmenopausal age, except for ultrasonic research, it is necessary to use hysteroscopy with subsequent morphological research.Conclusion. With the purpose of decline of frequency of relapse and warning of malignancy it is necessary to use the differentiated going near the leadthrough of endometrial interferences (hysteroresectoscopy or ablation) and individually directed hormonal correction under control the immunohistochemical indexes of proliferation: Ki-67; bcl-2; Bax and aromatase histohematin 450.The use of the algorithm improved by us for the women of postmenopausal age with pathology of endometrium allows to reduce frequency of relapses and warn development of endometrial adenocarcinoma.