Risk Factors of Enterostomy in Neonates With Hirschsprung Disease

Purpose: To explore the risk factors of enterostomy in neonates with Hirschsprung disease (HD) to provide reference for clinicians to make treatment decisions. Methods The medical records of 284 patients who were diagnosed with HD during the neonatal period were retrospectively analyzed. The patients were retrospectively divided into 2 groups according to whether or not they had an enterostomy before radical surgery. Univariate and multivariable logistic regression analysis were performed to identify risk factors of enterostomy. Results The incidence of enterostomy was 18.5% (34/284) in neonates with HD. Univariate and multivariate logistic regression analysis showed that serum albumin < 25.4 g/L, radiographic results as subphrenic free air and level of aganglionosis with long-segment or total colonic aganglionosis (TCA) were independent risk factors of enterostomy in neonates, with OR of 42.045 (6.131, 288.319), 285.558 (26.651, 3059.694) and 15.573 (4.319, 56.157), respectively. Conclusions The low serum albumin level, bowel perforation and level of aganglionosis with long-segment or TCA could influence the occurrence of enterostomy in neonates with HD.