Detection of Serum Osteopontin,CA125 and CA19-9 in Patients with Endometriosis and its Signficances

Objective To investigate the diagnostic value of osteopontin(OPN),serum CA125 and CA19-9 for endometriosis.Methods Serum samples of 45 patients with endometriosis and 45 cases of healthy women were collected,respectively from January 2005 to December 2008.OPN was determined using ELISA method and CA125,CA19-9 level were detected by chemiluminescence.Results Compared with the healthy women,OPN and CA125,CA19-9 of patients with endometriosis were significantly increased(P0.01).OPN and CA125,CA19-9 of patients with endometriosis in severe group(AFS stage Ⅲ and Ⅴ)was significantly higher than those of mild group(AFS stage Ⅰ and Ⅱ)(P0.01).Conclusion OPN and CA19-9 can be used as diagnostic and surveillance indicators for endometriosis.Combination of OPN,CA19-9 and CA125 detection can improve their clinical value.