Significance and change of inhibin B in infertile women with endometriosis

Objective To study the relation of inhibin B with follicular development and IVF results in patients with endometriosis during controlled ovarian hyperstimulation(COH)in the process of invitro fertilization embryo transfer(IVF ET)so as to to evaluate the reason of infertility caused by endometriosis(Ems).Methods Enzymelinked immunosorbent assay(ELISA)was used to detect levels of inhibin B of 40 women with endometriosis(the Ems Group)and 20 women undergoing IVF ET because of tubal factor leading to infertility(the Control Group).Their levels of inhibin B in early follicular phase(on day 1),medium-term follicular phase(from day 4 to 6)and late follicular phase(on day HCG).Then levels of inhibin B of the above-mentioned groups were campared with their follicular development and IVF results.Results Inhibin B levels and number of follicular development of the above-mentioned phases as well as the E2 levels peaked on the day of HCG in the Ems Group were significantly lower than those in the control group P0.01).There was no significant difference in volumes and days of gonadotropin stimulation,the fertilization and pregnancy rates between the two groups.Conclusion Decreased inhibin B level in patients with endometriosis suggests that granulosa cell function may be impaired and the oocyte quality may be affected as well,which may contribute to infertility.