Cervical dilatation by Lamicel--studies on the mechanism of action

K. H. Nicolaides, C C Welch, Christopher Welch, E. N. Koullapis, G M Filshie
British journal of obstetrics and gynaecology · 1983 · vol. 90(11) , pp. 1060–1064 · doi:10.1111/j.1471-0528.1983.tb06445.x · PMID:6688953 · W2080389173
Non-randomised trial OA: closed CC0
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Lamicel induced transient uterine activity without altering hormone levels or cervical tissue structure, indicating its mechanism of action for cervical dilatation is not mediated by prostaglandins or hormonal changes.

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Abstract

Lamicel is a synthetic hydrophilic polymer tent which produces cervical softening and dilatation when inserted into the endocervical canal. To investigate the mechanism of action of Lamicel, the intrauterine pressure and levels of 6-keto-prostaglandin F1 alpha, 13-14-dihydro-15-keto-prostaglandin F2 alpha, oestradiol and progesterone in plasma and amniotic fluid were measured in patients undergoing second trimester abortion. There was no significant change in any of the measured hormones during a 2-h treatment with Lamicel, but uterine activity increased significantly for 10 min after insertion, then settled spontaneously to below pre-treatment levels. Peripheral plasma levels of magnesium sulphate measured in patients undergoing first trimester abortion were not significantly raised after insertion of Lamicel. Light microscopic examination of cervical specimens, obtained at hysterectomy from patients pre-treated with Lamicel for 24 h, revealed minimum increase in vascularity, mast cell population and ground substance mucopolysaccharides.

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MeSH descriptors

Biocompatible Materials Cervix Uteri Dinoprost Dinoprost Magnesium Sulfate Polyvinyl Alcohol 6-Ketoprostaglandin F1 alpha 6-Ketoprostaglandin F1 alpha Abortion, Induced Abortion, Induced Adolescent Adult Amniotic Fluid Amniotic Fluid Biocompatible Materials Cervix Uteri Cervix Uteri Estradiol Estradiol Female

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