Does Adjuvant Long-Acting Gestagen Therapy Improve the Outcome of Hysteroscopic Endometrial Resection in Women of Low-Resource Settings With Heavy Menstrual Bleeding?

Tarek Shokeir, Mouhamed Eid, El‐Said Abdel‐Hady
In: Journal of Minimally Invasive Gynecology · 2013 · vol. 20(2) , pp. 222–226 · doi:10.1016/j.jmig.2012.11.006 · W2057223916
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This study investigated whether adjuvant long-acting gestagen therapy improves outcomes for hysteroscopic endometrial resection in women with heavy menstrual bleeding in low-resource settings.

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Abstract

ObjectiveTo test for the hypothesis of the beneficial effect of long-acting gestagens as an adjuvant postoperative therapy on the outcome of hysteroscopic transcervical endometrial resection (TCRE) in women of low-resource settings and suffering from ovulatory heavy menstrual bleeding (menorrhagia).DesignRandomized controlled trial (Canadian Task Force classification I).SettingLow-resource tertiary care university hospital.PatientsSeventy-one premenopausal women with established ovulatory menorrhagia.InterventionAfter randomization, 37 patients were treated with TCRE plus gestagen and 34 patients with TCRE alone.Measurements and main resultsVariations in menstrual patterns and bleeding scores, as well as amenorrhea and repeat surgery rates with treatment, were determined 1 year after resection. In those who continued to menstruate at 6 months, treatment with TCRE plus gestagen was associated with a significant reduction in the number of days bleeding from 7.2 to 3.4 (p ≤ .0001), increased cycle length from 24 to 30 (p = .02), a 60% reduction in dysmenorrhea score from 62 to 25 (p ≤ .0001), and a 60% reduction in premenstrual syndrome score from 55 to 22 (p = .04). Amenorrhea rates at 12 months in the TCRE plus gestagen and TCRE alone groups were 40% versus 26% (p = .02), with combined amenorrhea and hypomenorrhea rates of 75% versus 64% (p = .02), respectively. At 12 months, repeat surgery rates were higher in the TCRE alone group (21% vs 3%, p < .05).ConclusionIn a low-resource setting, the adjuvant postoperative long-acting gestagen therapy has proven to be superior in inducing amenorrhea after hysteroscopic TCRE.

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