pregnancy outcome and follow-up of offspring of donor oocytes recipient from PCOS patients

Background: The use of donated oocytes (DO) for in vitro fertilization(IVF) treatment in patients with infertility is generally recognized, and women with polycystic ovarian syndrome (PCOS) are able to participate in oocyte donation programs as donor patients. However, the pregnancy outcomes and follow-up of offspring of PCOS receptor is unclear. Objective Comparing the pregnancy outcomes and follow-up of offspring in PCOS and non-PCOS receptor. Design : Retrospective cohort study. Methods A total of 62 patients who had undergoing oocyte reception program were separated into two groups: Group I, PCOS oocyte receptor (𝑛=30); Group II, non-PCOS receptors (𝑛=32). Medical records were reviewed and rates of fertilization, cleavage, high quality embryos and blastocysts were compared between PCOS and non-PCOS receptors. Rates of implantation, pregnancy, ectopic pregnancy, early abortion, multiple pregnancy, and offspring outcome were calculated in first single vitrified-warmed blastocyst transfer (SVBT) were analyzed between PCOS and non-PCOS receptors. Results The average recipient age from PCOS and non-PCOS patients were 36.3 ± 2.6 and 36.2 ± 2.8, respectively. Rates of fertilization, cleavage, high quality embryos and blastocysts were not significantly different. Rates of implantation, pregnancy, ectopic pregnancy, early abortion, and multiple pregnancy were not significantly different in SVBT between PCOS and non-PCOS receptors. The incidences for complications such as PIH, or gestational diabetes between PCOS and non-PCOS receptors were similar (11.8% vs.11.1%, 5.9% vs.5.5%; P > 0.05). Preterm birth were similar (11.8% vs.16.7%, P > 0.05). Donor oocytes were more likely to deliver by caesarean section (80.0% vs. 86.7%: P > 0.05). And the mean gestational age, as well as the birth weight, and height were comparable for both groups in full-term delivery. Conclusions There was no difference in the pregnancy outcomes and follow-up of offspring between PCOS and non-PCOS receptor.