Osteometabolic profile: a possible tool in decision making for implant rehabilitation in patients under antiresorptive drugs

This comparative study included 146 patients that are under risk of developing MRONJ and needed oral rehabilitation with implant-supported prosthesis. All the included patients had metabolic profile assessments and were divided into two groups: G1-normal osteometabolic profile (92 patients), G2- altered osteometabolic profile (54 patients). All patients in G1, regardless of gender and type of prosthetic rehabilitation, showed a regular osseointegration process without any complications. However, 42 patients in G2 (77%) were diagnosed with MRONJ within six months afterimplant insertions, which did not compromise implant osseointegration and prosthetic rehabilitation. In other 12 patients (23%) in adjunct to ONJ development, implants did not osseointegrate. All patients with ONJ were successfully treated according to the SISBO pharmacological protocol.According to the results of this study, osteometabolic profile assessment can be considered a useful tool in terms of decreasing the risk of developing ONJ in patients.