The relationship between neuropsychiatric dimensions and markers of Parkinson's disease risk in the UK Biobank

The relationship between neuropsychiatric dimensions and markers of Parkinson's disease risk in the UK Biobank | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Article The relationship between neuropsychiatric dimensions and markers of Parkinson's disease risk in the UK Biobank Bahaaeddin Attaallah, Sheena Waters, Charles Marshall, Alastair Noyce This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-6686597/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Neuropsychiatric symptoms are a significant yet often overlooked aspect of Parkinson's disease (PD). Using UK Biobank data, we examined associations between neuropsychiatric dimensions and PD risk markers. Factor analysis identified four dimensions—Depression, Anxiety, Stress-Adversity, and Alcoholism/Addiction—across three groups: PD, healthy controls, cerebrovascular disease (CVD) as neurological controls. These dimensions showed distinct patterns in PD. Depression scores were significantly elevated, while Alcoholism/Addiction scores were consistently lower. Neuroimaging linked Alcoholism/Addiction to subcortical changes specific to PD, particularly quantitative susceptibility mapping in the substantia nigra, consistent with the dopaminergic system's role in goal-directed behaviour. GBA1 carrier status was linked to age-related changes in this dimension. Furthermore, PD patients with higher Alcoholism/Addiction showed greater volatility in cognitive and motor function, with worsening before diagnosis and subsequent improvement. These findings highlight the complex interplay between psychiatric symptoms, neurobiological changes, and genetic factors in PD, suggesting that specific neuropsychiatric profiles may serve as early indicators of disease risk and progression Health sciences/Neurology/Neurological disorders/Parkinson's disease Biological sciences/Psychology Biological sciences/Neuroscience/Diseases of the nervous system/Parkinson's disease Full Text Additional Declarations There is NO Competing Interest. Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-6686597","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Article","associatedPublications":[],"authors":[{"id":458932240,"identity":"34068dee-7d9b-4f5a-9ac1-dd6183a9fbbf","order_by":0,"name":"Bahaaeddin Attaallah","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAABCElEQVRIiWNgGAWjYHACxgMPGA4wGDDwgDg2IIHGA3g1sDEwHEhAaEkDaWkgScthsCBeLfzzmx8cSKi5w2DOfvbghx8V5+3Wth8G2lJjE41Li8QxNoMDCceeMVj25CVL9py5nbztTCJQy7G03AZceo4xALWwHQaSOQYSvG23k80OALUwNhzGqUX+GPuHAwn/gFrOvzH++fffuWSz8w/xazE4xmNwILENqOVGjpk0b8MBO7MbBGwxPJZTcCCx7zCP5Yw3ZtYyx5ITzG4AbUnA4xe5w8c3Pvjw7bCcOX+O8c03NXb2ZufTHz74UGOD2/tQwANjJIJVJhBQjgLsSVE8CkbBKBgFIwMAAJFmbPPTo6bwAAAAAElFTkSuQmCC","orcid":"https://orcid.org/0000-0002-7842-7974","institution":"Queen Mary University of London","correspondingAuthor":true,"prefix":"","firstName":"Bahaaeddin","middleName":"","lastName":"Attaallah","suffix":""},{"id":458932241,"identity":"89f373d9-7ed5-4047-9d41-7ff6ff97046d","order_by":1,"name":"Sheena Waters","email":"","orcid":"https://orcid.org/0000-0001-7241-2272","institution":"Queen Mary University of London","correspondingAuthor":false,"prefix":"","firstName":"Sheena","middleName":"","lastName":"Waters","suffix":""},{"id":458932242,"identity":"49737fa3-0d60-4a3e-af1c-cfef1adeb933","order_by":2,"name":"Charles Marshall","email":"","orcid":"https://orcid.org/0000-0002-8227-2354","institution":"Queen Mary University of London","correspondingAuthor":false,"prefix":"","firstName":"Charles","middleName":"","lastName":"Marshall","suffix":""},{"id":458932243,"identity":"fbc4a64b-09b4-42c6-835c-bcc2f44aa121","order_by":3,"name":"Alastair Noyce","email":"","orcid":"","institution":"Queen Mary University of London","correspondingAuthor":false,"prefix":"","firstName":"Alastair","middleName":"","lastName":"Noyce","suffix":""}],"badges":[],"createdAt":"2025-05-17 11:10:09","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-6686597/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-6686597/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":84324087,"identity":"e57ff9e7-f21e-49d4-a6ff-d41a67b9d65f","added_by":"auto","created_at":"2025-06-10 14:50:54","extension":"pdf","order_by":1,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":1004312,"visible":true,"origin":"","legend":"Article File","description":"","filename":"output.pdf","url":"https://assets-eu.researchsquare.com/files/rs-6686597/v1_covered_8b1e5ee2-70f6-416b-930b-ace33049b82c.pdf"}],"financialInterests":"There is \u003cb\u003eNO\u003c/b\u003e Competing Interest.","formattedTitle":"The relationship between neuropsychiatric dimensions and markers of Parkinson's disease risk in the UK Biobank","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":true,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"","lastPublishedDoi":"10.21203/rs.3.rs-6686597/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-6686597/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"Neuropsychiatric symptoms are a significant yet often overlooked aspect of Parkinson's disease (PD). 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