Primary squamous cell carcinoma of endometrium-a rare presentation

Kafil Akhtar, Binjul Juneja, Ghazala Mehdi, Seema Rashid
In: Obstetrics & Gynecology International Journal · 2018 · vol. 9(6) · doi:10.15406/ogij.2018.09.00393 · W2796954329
article OA: bronze CC0
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Abstract

Primary endometrial squamous cell carcinoma is an extremely rare tumor with unclear pathogenesis. We report a case of 55-year-old postmenopausal woman who presented with abdominal distention and blood-stained vaginal discharge for 9 months. Clinically, chronic pyometra was considered. Total abdominal hysterectomy with a bilateral salpingo-oophorectomy was performed and histopathological examination revealed a diagnosis of primary endometrial invasive squamous cell carcinoma with associated complete squamous cell metaplasia of glandular endometrium and coexisting multifocal squamous cell dysplasia, without involvement of the uterine cervix. The tumoral cells showed to be p16 negative and strongly p53 positive.

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