2-SUBSTITUTED-D-HOMOOXASTEROID DERIVATIVES
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Abstract
Oxasteroid derivatives represented by general formula (a) which have excellent effects of inhibiting the polymerization of tubulin, inhibiting neovascularization and/or stabilizing p53 protein Zn formula (a) one of A and B represents C=O or CH2 while the other represents O; and R represents lower alkoxy. These compounds are useful in preventing or treating malignant tumor, endometriosis, chronic rheumatoid arthritis, diabetic retinopathy, ischemic heart diseases, arteriosclerosis, intractable skin ulcer, psoriasis, Kaposi's sarcoma, leproma, etc.
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- europepmc
- last seen: 2026-07-11T06:07:31.639957+00:00