Comparisons of P2X3 protein levels among different endometrial tissues.

Shaojie Ding (4430266), Libo Zhu (307219), Yonghong Tian (1577806), Tianhong Zhu (4430263), Xiufeng Huang (307222), Xinmei Zhang (307224)
2017 · doi:10.1371/journal.pone.0184647.g003 · W6923426038
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This study investigated P2X3 protein expression levels across ectopic, eutopic, and control endometrial tissues using Western blot analysis. The results demonstrated that P2X3 levels were significantly elevated in both eutopic and ectopic endometrium of women with endometriosis compared to controls from women without the condition. Additionally, patients reporting pain exhibited higher P2X3 expression in both tissue types than those without pain, and a positive correlation was observed between paired ectopic and eutopic samples within individual patients. This paper is centrally about endometriosis — specifically examining the role of P2X3 receptors in endometriosis-associated pain mechanisms.

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Abstract

A. Western blot showed a specific band (55 kDa) for P2X3 in ectopic, eutopic and control endometrium. B. The levels of P2X3 protein expression in the eutopic and ectopic endometrium of women with endometriosis were both significantly higher as compared with control endometrium from women without endometriosis. C. Both in ectopic and eutopic endometrium, the levels of P2X3 protein expression significantly increased from endometriosis patients with pain than those without pain. D. There was a positive correlation between P2X3 expression levels in ectopic or eutopic endometrium which were isolated from the same patient. As an endogenous control protein, GAPDH protein expression levels showed similar among ectopic, eutopic or control endometrium. (Ec), Ectopic endometrium; (Eu), Eutopic endometrium; (Con), Control endometrium. (*P<0.05. **P<0.01.)
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P2X3 receptor involvement in endometriosis pain via ERK signaling pathway Fig 3 Comparisons of P2X3 protein levels among different endometrial tissues. A. Western blot showed a specific band (55 kDa) for P2X3 in ectopic, eutopic and control endometrium. B. The levels of P2X3 protein expression in the eutopic and ectopic endometrium of women with endometriosis were both significantly higher as compared with control endometrium from women without endometriosis. C. Both in ectopic and eutopic endometrium, the levels of P2X3 protein expression significantly increased from endometriosis patients with pain than those without pain. D. There was a positive correlation between P2X3 expression levels in ectopic or eutopic endometrium which were isolated from the same patient. As an endogenous control protein, GAPDH protein expression levels showed similar among ectopic, eutopic or control endometrium. (Ec), Ectopic endometrium; (Eu), Eutopic endometrium; (Con), Control endometrium. (*P<0.05. **P<0.01.)

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endometriosis

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