Characterizing EEG Spectro-Temporal Variability Signatures in Alzheimer’s and Parkinson’s Disease

Abstract We present an EEG-based approach to characterize disease-related spectro-temporal signatures in Alzheimer’s disease (AD) and Parkinson’s disease (PD). To this end, key spectral features were first identified using explainable machine learning, and their temporal dynamics were then examined to characterize variability patterns and statistical properties. EEG recordings were segmented into non-overlapping 4-s epochs, from which spectral features based on relative band power and spectral entropy were extracted. Random Forest classifiers were trained to discriminate individual subjects with AD and PD from healthy controls (HC) using a Leave-One-Subject-Out Cross-Validation (LOSOCV) strategy. The most discriminative spectral features and the directionality of their contributions were identified through a SHAP-based explainable analysis. Subsequently, the temporal dynamics of the key features were analyzed to characterize disease fingerprints in terms of variability at both inter-subject and intra-subject levels and their distributional profiles. Our results confirmed spectral slowing in both disorders and revealed disorder-specific differences in the dominant spectral markers: the theta/alpha ratio was the most influential feature for AD, whereas mean relative theta power was the primary feature for PD discrimination. We show that increased variability in key spectral features is a distinguishing signature of AD and PD, with disease groups exhibiting greater inter-subject heterogeneity and higher intra-subject temporal variability than HC. Moreover, the key features showed heavy-tailed behavior, for which a lognormal model provided a plausible fit across groups. We conclude that this EEG-based characterization provides a meaningful avenue for tracking deviations from healthy neural activity. Competing Interest Statement The authors have declared no competing interest. Footnotes This work was supported in part by Agencia Nacional de Investigación y Desarrollo (ANID): Grants FONDECYT POSTDOCTORADO 3260279 (YPC), BASAL CIA250006 (AW, WED, YPC), FONDECYT REGULAR 1231132 (AW), FONDECYT REGULAR 1241695 (WED, AW), FONDE-CYT REGULAR 1260530 (PP), FONDECYT EXPLORACION 13240064 (WED, AW). (e-mail: yunier.prieur{at}gmail.com), (e-mail: pavel.prado{at}uss.cl), (e-mail: wael.el-deredy{at}uv.cl)