Behavioral assessment for anxiety at 60 days after sham or endometriosis surgery.

Annelyn Torres-Reverón (5650028), Leslie L. Rivera-Lopez (5963024), Idhaliz Flores (5650034), Caroline B. Appleyard (5650037)
2018 · doi:10.1371/journal.pone.0197698.g005 · W6960948124
Lab / animal OA: green CC0
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This study evaluated anxiety-like behaviors in rats at 60 days following sham or endometriosis surgery, with some animals receiving the corticotropin releasing hormone receptor 1 antagonist antalarmin. Behavioral testing via open field and elevated zero maze assays revealed that while antalarmin treatment decreased locomotor activity compared to sham controls, it did not significantly alter the time spent in the center of the open field. Rats with induced endometriosis exhibited a significant decrease in overall locomotion regardless of drug treatment and showed a trend toward spending less time in the open segments of the elevated zero maze compared to sham-operated animals. This paper is centrally about endometriosis — specifically investigating the behavioral consequences of the disease model and the effects of CRHR1 antagonism on associated anxiety metrics.

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Abstract

Rats that received sham surgery did not receive any treatment (n = 10). Rats in the endometriosis groups received antalarmin (n = 20) or vehicle treatment (n = 20) during one week after surgery until 53 days before behavioral testing. (A and B) All animals were tested in the open field or (C and D) the elevated zero maze. (A) In comparison to sham, we observed a significant decrease in locomotor activity of the group that received antalarmin. (B) However, time spent in the center of the open field was not different between groups. (C) In the elevated zero maze, a significant decrease in locomotion was observed for rats that had endometriosis as compared to sham, regardless of the drug treatment. (D) Rats with endometriosis, regardless of drug treatment, showed a trend towards spending less time in the open segment of the zero maze as compared to sham group. * represents p< 0.05 compared to sham.
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Antagonizing the corticotropin releasing hormone receptor 1 with antalarmin reduces the progression of endometriosis Fig 5 Behavioral assessment for anxiety at 60 days after sham or endometriosis surgery. Rats that received sham surgery did not receive any treatment (n = 10). Rats in the endometriosis groups received antalarmin (n = 20) or vehicle treatment (n = 20) during one week after surgery until 53 days before behavioral testing. (A and B) All animals were tested in the open field or (C and D) the elevated zero maze. (A) In comparison to sham, we observed a significant decrease in locomotor activity of the group that received antalarmin. (B) However, time spent in the center of the open field was not different between groups. (C) In the elevated zero maze, a significant decrease in locomotion was observed for rats that had endometriosis as compared to sham, regardless of the drug treatment. (D) Rats with endometriosis, regardless of drug treatment, showed a trend towards spending less time in the open segment of the zero maze as compared to sham group. * represents p< 0.05 compared to sham.

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endometriosis

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