Efficacy of Local Oxygen Therapy Combined with Human Albumin for Stage 2 Pressure Ulcers: A Case Report

Efficacy of Local Oxygen Therapy Combined with Human Albumin for Stage 2 Pressure Ulcers: A Case Report | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL Public Health Challenges This is a preprint and has not been peer reviewed. Data may be preliminary. 24 April 2025 V1 Latest version Share on Efficacy of Local Oxygen Therapy Combined with Human Albumin for Stage 2 Pressure Ulcers: A Case Report Author : Author：Fengrong Tang 0000-0002-7820-7146 [email protected] Authors Info & Affiliations https://doi.org/10.22541/au.174548032.25509816/v1 Published Biomedical Journal of Scientific & Technical Research Version of record Peer review timeline 242 views 194 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract This study summarizes the nursing management of a patient with cerebral infarction and sacrococcygeal stage 2 pressure ulcer, focusing on the effectiveness of local oxygen therapy combined with human albumin. Patients are evaluated for the risk of pressure ulcers and nutritional deficiencies upon admission.We applied topical oxygen therapy combined with human albumin for dressing changes, during which the healing of pressure ulcers is assessed promptly.The pressure ulcer completely healed within one week, The new method of pressure ulcer care, which combines local oxygen therapy with human blood albumin, has been shown to shorten wound healing time, enhance nursing effectiveness, and provide a more efficient and feasible nursing technology for the clinical promotion of pressure ulcer management. Efficacy of Local Oxygen Therapy Combined with Human Albumin for Stage 2 Pressure Ulcers: A Case Report Abstract This study summarizes the nursing management of a patient with cerebral infarction and sacrococcygeal stage 2 pressure ulcer, focusing on the effectiveness of local oxygen therapy combined with human albumin. Patients are evaluated for the risk of pressure ulcers and nutritional deficiencies upon admission.We applied topical oxygen therapy combined with human albumin for dressing changes, during which the healing of pressure ulcers is assessed promptly.The pressure ulcer completely healed within one week, The new method of pressure ulcer care, which combines local oxygen therapy with human blood albumin, has been shown to shorten wound healing time, enhance nursing effectiveness, and provide a more efficient and feasible nursing technology for the clinical promotion of pressure ulcer management. Keywords local oxygen therapy; human albumin; pressure ulcers; Case reports;Nursing Introduction A pressure ulcer is a condition resulting from prolonged tissue compression, leading to ischemia, hypoxia, and malnutrition, which ultimately causes tissue ulceration and necrosis.Elderly bedridden patients with cerebral infarction are at a heightened risk of developing pressure ulcers, which can be challenging to heal once they occur. These ulcers are a prevalent condition that significantly impacts the quality of life for elderly patients and poses a serious threat to the lives of those with cerebral infarction [1-2] . Research indicates that the annual cost of treating pressure ulcers is estimated to be between $11 billion and $17.2 billion in the United States, £1.4 billion to £2.1 billion in the United Kingdom, and approximately 296.05 million Australian dollars in Australia [3-5] . Numerous treatment methods for pressure ulcers are available both domestically and internationally, including physical, biological, and integrated traditional Chinese and Western medicine approaches; however, their efficacy varies.Local oxygen therapy creates a hyper-oxygenated environment that enhances wound healing by promoting tissue oxygenation and reducing bacterial proliferation [6] . Human albumin is a blood product that contains a variety of proteins essential for the human body. It can be applied topically to ulcer surfaces to promote the growth of granulation tissue, enhance the osmotic pressure of local tissues, reduce local edema, minimize exudation from the ulcer surface, and protect the ulcer itself [7-8] . On July 10, 2024, our department admitted a patient with cerebral infarction and a stage 2 sacrococcygeal pressure ulcer. We effectively combined the aforementioned methods, utilizing a novel approach of local oxygen therapy along with human blood albumin for the treatment of pressure ulcer wounds. This strategy significantly shortened the wound healing time and improved patient care outcomes, providing a more effective and feasible nursing technology for the clinical promotion of pressure ulcer healing. Case Presentation The patient, an 88-year-old male with a height of 175 cm, a weight of 83 kg, and a BMI of 27.1 kg/m², has a history of hypertension, atrial fibrillation, and cerebral artery stenosis. He was admitted to the hospital on July 10, 2024, due to ”speech inability with right limb weakness for more than 3 hours.” Upon admission, the patient was conscious. Physical examination revealed non-fluent speech and partial comprehension difficulties. Muscle strength in the right limb was rated at V+, with slightly reduced sensation and positive pathological signs. The NIHSS score was 2. Vital signs upon admission were as follows: T: 36.5°C, P: 69 bpm, R: 20 breaths/min, BP: 188/86 mmHg. Test results indicated: glucose: 6.1 mmol/L; carbon dioxide: 22 mmol/L; lipase: 99.6 U/L; total protein: 58 g/L; albumin: 31 g/L; globulin: 27 g/L; platelet count: 99 × 10⁹/L; white blood cell count: 4.31 × 10⁹/L; percentage of neutrophils: 52.5%. The patient has no history of smoking or alcohol consumption. A stage 2 pressure ulcer measuring 3 × 2.5 cm was noted in the sacrococcygeal region. After admission, the patient received treatment including anti-infection measures, anti-thrombosis therapy, lipid regulation, stabilization of vital signs, improvement of circulation, gastric protection, and nutritional support. Blood pressure was monitored and controlled. Local oxygen therapy was applied to the pressure ulcer in conjunction with human albumin dressing changes. The patient’s pressure ulcer was completely healed after 7 days of dressing changes ( Figure1 ), and no new pressure ulcers developed. There were no signs of infection at the wound site. The wound dressing change and care methods were as follows: First, the wound was dressed according to surgical aseptic principles. The wound was flushed with normal saline, and necrotic tissue around the pressure ulcer, along with devitalized skin, was excised using sterile scissors. The surrounding skin was disinfected with 0.5% iodophor, and the wound was wiped with a 0.9% sodium chloride cotton ball to remove secretions. Subsequently, the wound was irrigated with 20 mL of 0.9% sodium chloride using a vortex flushing technique. Second, local oxygen therapy was applied to the wound. This commonly used technique in clinical practice promotes the formation of a protective crust on the wound surface, enhances oxygen content in the tissue, inhibits bacterial reproduction, and accelerates wound healing. After each dressing change and protein application, an oxidized nebulized catheter was connected to the wound to deliver oxygen. The oxygen flow rate was adjusted to 5 L/min to 8 L/min, administered 1 or 2 times a day for 10 to 15 minutes each session. Lastly, human blood albumin was applied to the wound following local oxygen therapy. A cotton swab was used to evenly distribute the human blood albumin solution over the wound (if the solution was insufficient, it could be diluted with saline). Oxygen was then blown onto the wound for approximately 5 minutes until the albumin formed a transparent film, after which Mepilex was applied. At admission, the assessment was based on weight, age, body mass index, upper arm muscle circumference, triceps skinfold thickness, protein levels, immune status, nitrogen balance, and other relevant factors. The patient’s serum albumin level was 31 g/L (normal range: 35 g/L or higher), and the total score on the NRS 2002 [10] was 5, indicating nutritional risk ( Table 1 ). The Pressure Ulcer Scale for Healing,PUSH [11] is designed to monitor and document the progress of wound healing ( Table2 ). The patients’ scores were recorded as follows: 10 points before treatment, 9 points one day after treatment, 6 points three days after treatment, 3 points five days after treatment, and 1 point seven days after treatment. The Numerical Rating Scale, NRS [12] is a single-dimensional pain scale used to assess both acute and chronic pain, including postoperative pain, cancer pain, and arthritis pain ( Table 3 ). The scores recorded were: 6 points before treatment, 6 points one day after treatment, 3 points three days after treatment, 1 point five days after treatment, and 0 points seven days after treatment. Observation of the Condition Careful observation of the patient’s condition is essential, with timely and accurate documentation of any changes. The wound is assessed at each dressing change, and nurses on each shift must attentively monitor both the patient’s overall condition and the state of the wound, ensuring effective bedside handovers. Basic Care Maintain continuous inflation of the air cushion bed and assist the patient in repositioning every two hours. It is advisable for the patient to adopt a left or right lateral decubitus position, with a tilt of 30º to 45º when lying on their side. A turning pillow should be placed against the patient’s back to prevent pressure sores on the sacrococcygeal area. Care should be taken to position the patient’s limbs correctly to mitigate poor habits and prevent complications such as foot valgus [13] , drooping, and shoulder subluxation. This approach will enhance the treatment outcome and quality of life for patients with cerebral infarction. Ensure that bed linens are clean, flat, wrinkle-free, and free of debris to minimize friction, and utilize lift sheets to assist the patient in moving around the bed. Nutritional Support Patients with cerebral infarction often experience prolonged recovery due to decreased mobility, neurological function, and sensory perception, leading to reduced tissue metabolism and extended healing times [14] . Therefore, enhancing nutritional intake and immune support, actively treating underlying conditions, and managing infections are critical for effective pressure ulcer treatment [15] . The patient was provided with a nasogastric tube three days post-admission and received daily enteral nutrition, consisting of a mixed suspension (full force) and enteral nutrition powder. By implementing early screening and assessment for nutritional risks, healthcare providers can monitor the patient’s nutritional status and address malnutrition promptly. A multidisciplinary team conducts a comprehensive evaluation of the patient and formulates a nutritional support plan aimed at improving the patient’s nutritional status. [1]¿p#1 Psychological Care Given the extensive nature of pressure ulcers and the associated pain, analgesics should be administered as necessary to alleviate discomfort. Providing psychological support is crucial; it is important to encourage patient engagement, communicate with family members, and keep them informed after each dressing change to alleviate anxiety regarding the wound. Educating patients and their families about the related conditions, pressure ulcer prevention, and care methods is essential. Frequent encouragement helps build the patient’s confidence in overcoming their condition. During hospitalization, the patient exhibited emotional stability and actively cooperated with medical staff, leading to prompt control of the disease . [1]¿p#1 Discussion Elderly patients with long-term bed rest have the highest incidence of pressure injuries. A multicenter study found that the incidence of pressure ulcers among hospitalized elderly adults ranged from 10% to 25% [16] . The healing of pressure injuries involves various tissue regeneration processes, including granulation tissue hyperplasia and scar formation, which are complex and orderly biological processes [17] . Traditional treatment methods include protecting local wounds, changing dressings, combating infections, and enhancing nutritional support. According to biological principles of healing, identifying new methods to promote the healing of pressure ulcers holds significant clinical and social value.This case study involves a single patient, resulting in a relatively small sample size; thus, the study results may vary. Additionally, there are no relevant studies addressing the contraindications and side effects of topical human albumin, but we will explore and monitor these aspects in subsequent studies. Ye et al. [18] analyzed the clinical effects of human albumin in treating pressure ulcers, revealing that patients in the observation group exhibited higher efficacy compared to the control group after using human albumin. The healing time for the observation group was (14.07 ± 2.09) days, significantly shorter than the control group’s healing time of (20.03 ± 2.11) days, with a statistically significant difference (P < 0.05). Compared to the control group, which used conventional pressure ulcer powder gauze to cover the wound surface, human albumin demonstrated a significant effect in treating pressure ulcers and was straightforward in clinical application. It can accelerate the healing of the sore surface, alleviate patient pain, and reduce the financial burden on patients. Cheng et al. [19] found that the nursing effect of moxibustion combined with oxygen therapy and hydrocolloid dressing on stage II and III pressure ulcers resulted in a shorter wound healing time in the observation group (6.43 ± 1.52 days) compared to the control group (10.25 ± 2.23 days), with a statistically significant difference (P < 0.05). This study accelerates wound healing compared to conventional wound care methods combined with external hydrocolloid dressing applications. We applied topical oxygen therapy combined with human albumin during dressing changes. Local oxygen therapy can improve wound hypoxia, promote faster granulation tissue growth, increase capillary oxygen content, and facilitate wound drying and scab formation, thereby accelerating epithelialization and achieving healing [20] . Human albumin is a biological agent [21] with high nutritional and immune effects, capable of maintaining plasma colloid osmotic pressure and regulating the dynamic balance between tissues and blood vessels. As a highly permeable colloid, it can form a protective film when applied to the wound surface, keeping it clean and preventing direct bacterial contamination. Due to the high cost of albumin, a small amount of the stock solution can be retained in the bottle after intravenous administration, allowing for its collection and subsequent use in treating pressure ulcers. This approach not only minimizes waste but also provides an effective treatment option for pressure ulcers that deserves clinical promotion and application. [1]¿p#1 References 1. 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[21] Zhang J X.Human blood albumin to joint the moist burn cream and oxygen therapy in the treatment of pressure ulcers in clinical research[J]. Journal of North Pharmacy,2016,13(10):133-134. Supplementary Material File (figure1.docx) Download 443.45 KB File (table 1.docx) Download 12.68 KB File (table 2.docx) Download 14.19 KB File (table 3.docx) Download 67.55 KB Information & Authors Information Version history V1 Version 1 24 April 2025 Peer review timeline Published Biomedical Journal of Scientific & Technical Research Version of Record 9 May 2025 Published Copyright This work is licensed under a Non Exclusive No Reuse License. Collection Public Health Challenges Keywords a case report nursing pressure ulcers Authors Affiliations Author：Fengrong Tang 0000-0002-7820-7146 [email protected] Fudan University Zhongshan Hospital Xiamen Branch View all articles by this author Metrics & Citations Metrics Article Usage 242 views 194 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Author：Fengrong Tang. Efficacy of Local Oxygen Therapy Combined with Human Albumin for Stage 2 Pressure Ulcers: A Case Report. Authorea . 24 April 2025. DOI: https://doi.org/10.22541/au.174548032.25509816/v1 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download. For more information or tips please see 'Downloading to a citation manager' in the Help menu . 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