Causal relationship between hip or knee arthritis and the risk of depression: a Mendelian randomisation analysis

INTRODUCTION: Observational studies have reported associations between OA and the occurrence of depression/depressive symptoms, but the causal relationship between OA and depression/depressive symptoms remains unclear. Our aim was to assess the causal effect of OA on depression, depressive symptoms using two-sample Mendelian randomisation (MR). METHODS: Two-sample MR was used to investigate the causal effect of OA on depression and depressive symptoms. All data were obtained from a public shared database. Traditional methods are Simple mode, Inverse variance weighted, Weighted median, Mendelian Randomization (MR-Egger), Weighted mode to assess the causal effect of OA on depression. The Pleiotrophy RESidual Sum and Outlier (MR PRESSO) and MR - Egger were used for sensitivity studies. Outlier test was used to determine the effect of outliers. Heterogeneity was calculated using Cochrane's Q statistic and inverse variance-weighted (IVW) in MR - Egger regression, with P < 0.05 indicating the presence of large heterogeneity. RESULTS: Based on the results of IVW and Weighted median, we found a causal relationship between OA and depression,depressive symptoms, and OA increased the (IVW: OR = 1.04, P =0.004) and depressive symptom (IVW: OR = 1.10, P = 0.001) Incidence. There was no horizontal pleiotropy or heterogeneity in the analyses, except for heterogeneity in the analyses of OA and depressive symptoms. CONCLUSION: We explored the causal relationship between OA and depression and depressive symptoms by two-sample MR analysis and found that OA increased the incidence of depression and depressive symptoms.