Correlation Analysis of Dynamic Changes of Serum Calprotectin, Anti-Sa, sCD14-ST and Bone - Joint Injury and Systemic Inflammatory Response in Children with Acute Osteoarticular Infections

Correlation Analysis of Dynamic Changes of Serum Calprotectin, Anti-Sa, sCD14-ST and Bone - Joint Injury and Systemic Inflammatory Response in Children with Acute Osteoarticular Infections | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Correlation Analysis of Dynamic Changes of Serum Calprotectin, Anti-Sa, sCD14-ST and Bone - Joint Injury and Systemic Inflammatory Response in Children with Acute Osteoarticular Infections Song HUI, Zhou ZHANG, Tai MENG This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-7873940/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Objective: To explore the correlation of dynamic changes of serum calprotectin, anti - Sa, sCD14 - ST levels with bone - joint injury and systemic inflammatory response in children with acute osteoarticular infections. Methods: A retrospective study was conducted on 120 children who underwent bone - joint surgery in our hospital from June 2022 to June 2024. According to whether acute osteoarticular infections occurred post - operation, they were divided into infection group (n=49) and non - infection group (n=71).Differences in dynamic changes of serum calprotectin, anti - Sa, sCD14 - ST levels between the two groups were compared.Differences in bone - joint injury and systemic inflammatory response among children with different levels of calprotectin, anti - Sa, sCD14 - ST were compared.The correlation of serum calprotectin, anti - Sa, sCD14 - ST indicators with bone - joint injury and serum inflammatory indicators, risk factors for acute osteoarticular infections in children, and the clinical value of serum calprotectin, anti - Sa, sCD14 - ST in diagnosing acute osteoarticular infections in children were analyzed. Results: Preoperative serum calprotectin, anti - Sa, sCD14 - ST levels showed no significant difference between the two groups ( P >0.05).Postoperative day 3 and day 7, serum calprotectin, anti - Sa, sCD14 - ST levels were higher in the infection group than in the non - infection group, with statistical significance ( P <0.05).Lysholms knee function score and KOOS score were lower in the high calprotectin group than in the low calprotectin group, lower in the high anti - Sa group than in the low anti - Sa group, and lower in the high sCD14 - ST group than in the low sCD14 - ST group, with significant differences ( P <0.05).Serum IL - 1β, IL - 6, IL - 27, TNF - α levels were higher in the high calprotectin group than in the low calprotectin group, higher in the high anti - Sa group than in the low anti - Sa group, and higher in the high sCD14 - ST group than in the low sCD14 - ST group, with statistical significance ( P <0.05).Pearson correlation analysis showed that serum calprotectin, anti - Sa, sCD14 - ST indicators were negatively correlated with Lysholms knee function score and KOOS score ( P <0.05), and positively correlated with serum IL - 1β, IL - 6, IL - 27, TNF - α levels ( P <0.05~ P <0.01).Logistic regression analysis indicated that elevated serum calprotectin, anti - Sa, sCD14 - ST levels were risk factors for acute osteoarticular infections in children ( P <0.05).The AUC for diagnosing acute osteoarticular infections in children using serum calprotectin, anti - Sa, sCD14 - ST levels were 0.764, 0.740, 0.766, respectively, and the combined diagnostic AUC was 0.805, with significant data differences ( Z =4.646, P <0.05). Conclusion: Dynamic monitoring of serum calprotectin, anti - Sa, sCD14 - ST levels can assist clinical diagnosis of acute osteoarticular infections in children and shows certain correlation with bone - joint injury and systemic inflammatory response, serving as auxiliary indicators for infection assessment in children. Trial registration: Not applicable. Childhood acute osteoarticular infection Calprotectin Anti - Sa sCD14 - ST Bone - joint injury Systemic inflammatory response Correlation analysis Full Text Additional Declarations No competing interests reported. Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-7873940","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":552917754,"identity":"2b333b2a-7c61-487f-99cb-42125d1b752a","order_by":0,"name":"Song 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Infections","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"Childhood acute osteoarticular infection, Calprotectin, Anti - Sa, sCD14 - ST, Bone - joint injury, Systemic inflammatory response, Correlation analysis","lastPublishedDoi":"10.21203/rs.3.rs-7873940/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-7873940/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003e\u003cstrong\u003eObjective: \u003c/strong\u003eTo explore the correlation of dynamic changes of serum calprotectin, anti - Sa, sCD14 - ST levels with bone - joint injury and systemic inflammatory response in children with acute osteoarticular infections.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eMethods: \u003c/strong\u003eA retrospective study was conducted on 120 children who underwent bone - joint surgery in our hospital from June 2022 to June 2024. According to whether acute osteoarticular infections occurred post - operation, they were divided into infection group (n=49) and non - infection group (n=71).Differences in dynamic changes of serum calprotectin, anti - Sa, sCD14 - ST levels between the two groups were compared.Differences in bone - joint injury and systemic inflammatory response among children with different levels of calprotectin, anti - Sa, sCD14 - ST were compared.The correlation of serum calprotectin, anti - Sa, sCD14 - ST indicators with bone - joint injury and serum inflammatory indicators, risk factors for acute osteoarticular infections in children, and the clinical value of serum calprotectin, anti - Sa, sCD14 - ST in diagnosing acute osteoarticular infections in children were analyzed.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eResults: \u003c/strong\u003ePreoperative serum calprotectin, anti - Sa, sCD14 - ST levels showed no significant difference between the two groups (\u003cem\u003eP\u003c/em\u003e\u0026gt;0.05).Postoperative day 3 and day 7, serum calprotectin, anti - Sa, sCD14 - ST levels were higher in the infection group than in the non - infection group, with statistical significance (\u003cem\u003eP\u003c/em\u003e\u0026lt;0.05).Lysholms knee function score and KOOS score were lower in the high calprotectin group than in the low calprotectin group, lower in the high anti - Sa group than in the low anti - Sa group, and lower in the high sCD14 - ST group than in the low sCD14 - ST group, with significant differences (\u003cem\u003eP\u003c/em\u003e\u0026lt;0.05).Serum IL - 1β, IL - 6, IL - 27, TNF - α levels were higher in the high calprotectin group than in the low calprotectin group, higher in the high anti - Sa group than in the low anti - Sa group, and higher in the high sCD14 - ST group than in the low sCD14 - ST group, with statistical significance (\u003cem\u003eP\u003c/em\u003e\u0026lt;0.05).Pearson correlation analysis showed that serum calprotectin, anti - Sa, sCD14 - ST indicators were negatively correlated with Lysholms knee function score and KOOS score (\u003cem\u003eP\u003c/em\u003e\u0026lt;0.05), and positively correlated with serum IL - 1β, IL - 6, IL - 27, TNF - α levels (\u003cem\u003eP\u003c/em\u003e\u0026lt;0.05~\u003cem\u003eP\u003c/em\u003e\u0026lt;0.01).Logistic regression analysis indicated that elevated serum calprotectin, anti - Sa, sCD14 - ST levels were risk factors for acute osteoarticular infections in children (\u003cem\u003eP\u003c/em\u003e\u0026lt;0.05).The AUC for diagnosing acute osteoarticular infections in children using serum calprotectin, anti - Sa, sCD14 - ST levels were 0.764, 0.740, 0.766, respectively, and the combined diagnostic AUC was 0.805, with significant data differences (\u003cem\u003eZ\u003c/em\u003e=4.646, \u003cem\u003eP\u003c/em\u003e\u0026lt;0.05).\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConclusion: \u003c/strong\u003eDynamic monitoring of serum calprotectin, anti - Sa, sCD14 - ST levels can assist clinical diagnosis of acute osteoarticular infections in children and shows certain correlation with bone - joint injury and systemic inflammatory response, serving as auxiliary indicators for infection assessment in children.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eTrial registration:\u003c/strong\u003e \u0026nbsp;Not applicable.\u003c/p\u003e","manuscriptTitle":"Correlation Analysis of Dynamic Changes of Serum Calprotectin, Anti-Sa, sCD14-ST and Bone - Joint Injury and Systemic Inflammatory Response in Children with Acute Osteoarticular Infections","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2025-12-01 08:59:24","doi":"10.21203/rs.3.rs-7873940/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"e780499e-3958-4ff4-8192-5b856aafc890","owner":[],"postedDate":"December 1st, 2025","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[],"tags":[],"updatedAt":"2025-12-29T07:39:48+00:00","versionOfRecord":[],"versionCreatedAt":"2025-12-01 08:59:24","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-7873940","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-7873940","identity":"rs-7873940","version":["v1"]},"buildId":"8U1c8b4HqxoKbykW_rLl7","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}