Irreversible bicyclic inhibitors of tyrosine kinases
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Abstract
PCT No. PCT/US98/15592 Sec. 371 Date Mar. 25, 1999 Sec. 102(e) Date Mar. 25, 1999 PCT Filed Jul. 29, 1998 PCT Pub. No. WO99/06396 PCT Pub. Date Feb. 11, 1999The invention provides compounds of Formula I that are irreversible inhibitors of tyrosine kinases. Also provided is a method of treating cancer, restenosis, atherosclerosis, endometriosis, and psoriasis and a pharmaceutical composition that comprises a compound that is an irreversible inhibitor of tyrosine kinases.
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