Peculiarities of ethanol sclerotherapy of ovarian endometriomas in women of active reproductive age (literature review)

Yu. Yu. Lepetenko
In: Reports of Vinnytsia National Medical University · 2025 · vol. 29(1) , pp. 164–167 · doi:10.31393/reports-vnmedical-2025-29(1)-29 · W4409197159
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This literature review identifies ethanol sclerotherapy as a safe, minimally invasive treatment for ovarian endometriomas that preserves ovarian reserve in women of reproductive age.

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This 2014–2024 literature review analyzed foreign studies from PubMed, Scopus, Web of Science, and the Cochrane Library to assess modern treatment approaches for ovarian endometriomas in women of active reproductive age, with particular attention to ethanol sclerotherapy. The review reports that sclerotherapy is viewed as a safe, minimally invasive option for endometrioid ovarian cysts that can be effective in reproductive-age patients and has little effect on ovarian reserve, supporting the idea that using it as a primary method could better preserve follicular reserve. A limitation explicitly noted is that the conclusion is based on trends across heterogeneous literature rather than a single unified study design. This paper is centrally about endometriosis — specifically, it reviews ethanol sclerotherapy for ovarian endometriomas in women of reproductive age.

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Abstract

Annotation. In order to determine modern methods of treatment of ovarian endometriomas and further develop a differentiated approach to the treatment of patients of active reproductive age with ovarian endometriomas we analyzed foreign literature from 2014-2024 using the scientometric databases PubMed, Scopus, Web of Science and the Cochrane Library. A review of the literature has identified a number of trends: sclerotherapy is currently considered a safe, minimally invasive treatment for endometrioid ovarian cysts, which is particularly effective in women of reproductive age, as the procedure has little effect on ovarian reserve. The introduction of sclerotherapy as the only method of treatment (the “gold standard”) for ovarian endometrioid cysts will maximize the preservation of the follicular reserve in patients of active reproductive age, which will significantly increase their chances of getting pregnant in the future.
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Peculiarities of ethanol sclerotherapy of ovarian endometriomas in women of active reproductive age (literature review) DOI: https://doi.org/10.31393/reports-vnmedical-2025-29(1)-29Keywords: reproduction, ovarian reserve, endometrioid cysts, sclerotherapy of ovarian endometriomas.Abstract Annotation. In order to determine modern methods of treatment of ovarian endometriomas and further develop a differentiated approach to the treatment of patients of active reproductive age with ovarian endometriomas we analyzed foreign literature from 2014-2024 using the scientometric databases PubMed, Scopus, Web of Science and the Cochrane Library. A review of the literature has identified a number of trends: sclerotherapy is currently considered a safe, minimally invasive treatment for endometrioid ovarian cysts, which is particularly effective in women of reproductive age, as the procedure has little effect on ovarian reserve. The introduction of sclerotherapy as the only method of treatment (the “gold standard”) for ovarian endometrioid cysts will maximize the preservation of the follicular reserve in patients of active reproductive age, which will significantly increase their chances of getting pregnant in the future. Downloads References Aflatoonian, A., & Tabibnejad, N. (2020). Aspiration versus Retention Ultrasound-Guided Ethanol Sclerotherapy for Treating Endometrioma: A Retrospective Cross-Sectional Study. IJRM, (18), 935. https://doi.org/10.18502/ijrm.v13i11.7960 Agarwal, S. K., Chapron, C., Giudice, L. C., Laufer, M. R., Leyland, N., Missmer, S. A., … & Taylor, H. S. (2019). Clinical Diagnosis of Endometriosis: A Call to Action. American Journal of Obstetrics and Gynecology, 220(354), e1-354.e12. DOI: 10.1016/j.ajog.2018.12.039 Alborzi, S., Askary, E., Keramati, P., Moradi Alamdarloo, S., Poordast, T., Ashraf, M. A., … & Zahiri Sorouri, Z. (2021). 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