Structural Genomic Rearrangements in Common Cancer Types

The Cancer genome can be used to understand the mechanisms of carcinogenesis and to develop possible therapeutic interventions. Somatic mutations cannot be inherited by next-generation while mutations in germ line cells will be transmitted to the next progeny. One of the important cancer genome databases is Cancer Genome Atlas (TCGA) created by using modern sequencing technology to identify the somatic variations in the cancer genome. We used COSMIC (Catalogue of Somatic Mutations in Cancer) to analyze the relationship between different mutation types with different types of cancer. Chromosome17 showed the highest rearrangement density, and most cancers in humans occur due to intra-chromosomal structural changes with non-inverted orientation. Inter-chromosomal deletion mutations were seen in all the primary sites except the urinary tract.