Glycoluril-Based Metal-Organic Frameworks

Glycoluril-Based Metal-Organic Frameworks | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Glycoluril-Based Metal-Organic Frameworks Na'il Saleh, Shaikha Alneyadi This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-6883001/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract The glycoluril building blocks have only been connected via their NH sides in all the previously reported structures in porous material science, supramolecular chemistry, and many other fields. Here, we present the design and synthesis of a new glycoluril-based metal-organic framework (MOF) through the substitution of dibenzoic moieties in the methine positions of the glycoluril motif. Urea reacts with 4,4'-dioxo-[1,1'-biphenyl]-3,3'-dicarboxylic acid (the 1,2-diketone derivative) to form 4,4'-(2,5-dioxotetrahydroimidazo[4,5-d]imidazole-3a,6a(1H,4H)-diyl)dibenzoic acid (the glycoluril derivative). The reaction proceeds via cyclocondensation, yielding a rigid linker with four free NH groups, two terminal carboxylic acids, and a curved backbone suitable for MOF coordination and molecular recognition. The synthesis of NS-MOF (Zn or Zr) was successfully achieved using a solvothermal method involving the reaction of a glycoluril-based linker with zinc nitrate hexahydrate in dimethylformamide (DMF). The properties of the new MOF structures are discussed for potential applications from gas storage and separation to catalysis and biomedical delivery systems. Organic Chemistry Glycoluril Methine hydrogen atoms Urea Metal-organic framework Full Text Additional Declarations The authors declare no competing interests. Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-6883001","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":470561482,"identity":"ce1b3188-b137-4bf1-8723-3f1c5e7a17a9","order_by":0,"name":"Na'il Saleh","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAAz0lEQVRIie3OMQrCMBiG4U8EXYKu/1SvEClUXTxLQkGXdnfo0Ek3d2/RIwQC7VJwzSDYUuhqJ3ESHZ1M3RzybIHvTQI4zr+qoLwfEwHl/57ItPd6gXHdid1lmxU6JyRrTA+WepUyn0TZxlm52RDyEFSq7wlXDCT3Os5UFBBG77kRtmTcPORTb/n5dic8FWbXypYgIJlqwU00osFegZvvBbhmwVLken4yrb+Ux5DNS9vHikNjukTPJuewNt197XmFsjwz/Dy872eWveM4jtPHC8lLRySgkBnZAAAAAElFTkSuQmCC","orcid":"https://orcid.org/0000-0003-3282-1156","institution":"United Arab Emirates University","correspondingAuthor":true,"prefix":"","firstName":"Na'il","middleName":"","lastName":"Saleh","suffix":""},{"id":470561483,"identity":"8be96644-e7bf-4228-a481-6c3f06375ea1","order_by":1,"name":"Shaikha Alneyadi","email":"data:image/png;base64,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","orcid":"https://orcid.org/0000-0003-1796-9478","institution":"United Arab Emirates University","correspondingAuthor":true,"prefix":"","firstName":"Shaikha","middleName":"","lastName":"Alneyadi","suffix":""}],"badges":[],"createdAt":"2025-06-12 20:10:39","currentVersionCode":1,"declarations":{"humanSubjects":false,"vertebrateSubjects":false,"conflictsOfInterestStatement":false,"humanSubjectEthicalGuidelines":false,"humanSubjectConsent":false,"humanSubjectClinicalTrial":false,"humanSubjectCaseReport":false,"vertebrateSubjectEthicalGuidelines":false},"doi":"10.21203/rs.3.rs-6883001/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-6883001/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":84658101,"identity":"5da4bc87-5766-45a0-bbc2-da727f5dd60d","added_by":"auto","created_at":"2025-06-16 03:19:09","extension":"pdf","order_by":1,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":546463,"visible":true,"origin":"","legend":"","description":"","filename":"Manuscript12062025.pdf","url":"https://assets-eu.researchsquare.com/files/rs-6883001/v1_covered_c6fbc723-0af9-434d-a715-4c7212c6c594.pdf"}],"financialInterests":"The authors declare no competing interests.","formattedTitle":"\u003cp\u003eGlycoluril-Based Metal-Organic Frameworks\u003c/p\u003e","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":true,"hideJournal":true,"highlight":"","institution":"United Arab Emirates University","isAcceptedByJournal":false,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"Glycoluril, Methine hydrogen atoms, Urea, Metal-organic framework ","lastPublishedDoi":"10.21203/rs.3.rs-6883001/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-6883001/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003eThe glycoluril building blocks have only been connected via their NH sides in all the previously reported structures in porous material science, supramolecular chemistry, and many other fields. 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