Is the spontaneous motility of isolated rat uterus controlled by prostaglandin E?
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This study investigated whether spontaneous uterine motility in isolated rat uteri is regulated by prostaglandin E.
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Abstract
Variations in the spontaneous contractile activity during 6 hours following isolation of uterine horns from proestrus, metestrus and spayed rats, were explored. In estrus and metestrus preparations the contractions declined during 60 min and between 180--200 min a progressive spontaneous recovery (abolished by indomethacin) was observed up to 360 min. Uteri from proestrus and spayed animals exhibited a continuous depression without recovery during the whole experimental period. At 60 min, uterine horns from estrus animals (which showed a marked contractile decrement) released to the suspending medium significantly less prostaglandin E-like material than at 360 min, i.e. when contractions had almost completely recovered. No modification in the amount of prostaglandin F-like material was detected accompanying these spontaneous contractile variations. In the spayed group at 60 min of functioning (i.e. when the contractile impairment was significantly smaller than at a later time) the release of PGE was greater than at 360 min. These findings suggest a possible control of rat uterine contractions by PGE, rather than by PGF.
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Too few in-corpus citations on either side for a chart; here are the lists.
Cites (2)
- Inhibition of uterine motility: the possible role of the prostaglandins and aspirin-like drugs 1975
- Studies on the contractile activity of the myometrium isolated from ovariectomized rats. 1970
Cited by (4)
- The spontaneous motility and the prostaglandin E-like material generation is different in the implantation and in the non-implantation regions of the uterus isolated from rats in natural estrus. Influences of indomethacin 1981
- Melatonin blocks in vitro generation of prostaglandin by the uterus and hypothalamus 1980
- In vitro contractile responses of the uterus from ‘restricted diet’ rats to adrenoceptor agonists. Influence of cyclo-oxygenase inhibitors 1983
- Effect of corticosterone, hydrocortisone and prostaglandin fatty acid precursors on the spontaneous motility of the uterus isolated from ovariectomized rats 1982
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Cited by (4)
- In vitro contractile responses of the uterus from ‘restricted diet’ rats to adrenoceptor agonists. Influence of cyclo-oxygenase inhibitors 1983
- Effect of corticosterone, hydrocortisone and prostaglandin fatty acid precursors on the spontaneous motility of the uterus isolated from ovariectomized rats 1982
- The spontaneous motility and the prostaglandin E-like material generation is different in the implantation and in the non-implantation regions of the uterus isolated from rats in natural estrus. Influences of indomethacin 1981
- Melatonin blocks in vitro generation of prostaglandin by the uterus and hypothalamus 1980
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