Medium chain triglycerides induce metabolic shifts in dogs with idiopathic epilepsy: a multi-omics approach

Medium chain triglycerides induce metabolic shifts in dogs with idiopathic epilepsy: a multi-omics approach | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Medium chain triglycerides induce metabolic shifts in dogs with idiopathic epilepsy: a multi-omics approach Fien Verdoodt, Lieselot Y. Hemeryck, Evy Goosssens, Jenifer Molina, and 5 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-8078706/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Background Medium chain triglycerides (MCT) are a class of dietary lipids with proposed beneficial health effects in animals and humans alike. Their mechanism of action in specific applications, like epilepsy, remains however unclear. Therefore, the aim of this study was to identify alterations in the fecal and plasma metabolome and fecal microbiome in dogs with idiopathic epilepsy (IE) following an MCT diet. Nutrition & Dietetics Small Animal Medicine Medium chain triglycerides multi-omics gut-brain axis metabolome microbiome Full Text Additional Declarations The authors declare potential competing interests as follows: F. Verdoodt worked on a doctoral research project, including the current study, regarding the role of the gastrointestinal microbiome and nutrition in canine IE, which is financially supported by Nestlé Purina Petcare Europe. J. Molina is employed by Nestlé Purina Petcare Europe. C. Petzinger Germain is employed by Nestlé Purina Research. M. Hesta is a member of the Advisory Board of Nestlé Purina Petcare, and has been paid for several consulting services by a variety of pet food companies. The other authors have no financial or personal relationships with other people or organizations that could inappropriately influence or bias the content of the paper. Supplementary Files 2025SupplementaryVerdoodt.xlsx Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. 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Verdoodt worked on a doctoral research project, including the current study, regarding the role of the gastrointestinal microbiome and nutrition in canine IE, which is financially supported by Nestlé Purina Petcare Europe.\nJ. Molina is employed by Nestlé Purina Petcare Europe.\nC. Petzinger Germain is employed by Nestlé Purina Research.\nM. 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