Dienogest

National Cancer Institute
In: Definitions · 2020 · doi:10.32388/7jmaa6 · W4233107003
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The provided text contains only a templated webpage structure and general licensing information, without any description of study design, participants, methods, outcomes, or results. As such, there is no substantive biomedical content from which to identify what the paper studied or its key findings. The only explicit caveat is that the content shown is incomplete (it references a “newer version available” and a “source” for further details). The paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index based on the title “Dienogest.”

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Abstract

An orally-active, semisynthetic, fourth generation, nonethinylated progestogen with antiproliferative, antiandrogenic, anti-inflammatory and antiangiogenic activities that is used in hormone therapy and as a female contraceptive.Upon oral administration, dienogest binds intracellular progesterone receptors which then translocate to the nucleus where the drug-receptor complex interacts with progesterone response elements, thus altering the expression of target genes.Dienogest reduces the production of estradiol, prevents ovulation and alters the cervical mucus and endometrium.In addition, dienogest appears to suppress the expression of cell cycle regulator cyclin D1.Altogether, this may prevent the growth of endometrial epithelial cells and may reduce symptoms associated with leiomyoma.
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