Clinical analysis of pain after transvaginal mesh surgery in patients with pelvic organ prolapse

Clinical analysis of pain after transvaginal mesh surgery in patients with pelvic organ prolapse | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Help Center Sign In Submit a Preprint Cite Share Download PDF Research article Clinical analysis of pain after transvaginal mesh surgery in patients with pelvic organ prolapse Chang Shi, Ying Zhao, Qing Hu, Runqi Gong, Yitong Yin, Zhijun Xia This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-38744/v2 This work is licensed under a CC BY 4.0 License Status: Published Journal Publication published 30 Jan, 2021 Read the published version in BMC Women's Health → Version 2 posted 7 You are reading this latest preprint version Show more versions Abstract Background: The purpose of this study was to investigate the relevant factors of pain after transvaginal mesh (TVM) surgery for the treatment of pelvic organ prolapse and to analyse the management and relief of the pain. Methods: A multicentre retrospective study of a clinical database of patients who underwent TVM surgery was conducted, and pain related aspects were analysed. Results: A total of 1855 patients were included in the study. We divided the patients into two groups: pain-free (1805 patients) and pain (50 patients) group. The incidence of pain after TVM surgery was 2.70%, with a median occurrence time of 7.5 months. Pain mainly involved the vagina, perineum, buttocks, groin, inner thighs, and lower abdomen. Excessive intraoperative blood loss (OR=1.284, 95%CI 0.868-2.401) and postoperative anatomic failure (OR=1.577, 95%CI 0.952-3.104) were analysed as risk factors with statistical significance. Mesh exposure rate in the pain group was 38%, showing a significant difference between the groups (P<0.01). Forty patients underwent non-surgical treatment, with a relief rate of 40.0%, 33 patients received surgical treatment, 15 underwent partial mesh removal, and 18 underwent complete mesh removal, with a relief rate of 84.8%. The total relief rate was 88% within all 50 patients suffering from pain. Conclusions: Excessive intraoperative bleeding and unsatisfactory postoperative anatomic outcomes can increase the risk of postoperative pain; mesh exposure is also associated with the pain. Most patients can get pain relief with proper management, more than half of whom may need mesh removal with differing approach. Internal Medicine Preventive Medicine Transvaginal mesh surgery Mesh complications Postoperative pain Pelvic organ prolapse Figures Figure 1 Background Pelvic organ prolapse (POP) is a common pelvic floor disorder among women, with population-based epidemiologic studies reporting the prevalence range from 2.9% to 34.3% in general population [1-4]. Women have an 11-12.6% lifetime risk of surgery for POP by the age of 80 [5,6]. Traditional surgical procedures using weak native tissues have a high risk of failure, with almost 30% of the patients requiring reoperation [7]. Transvaginal mesh (TVM) surgery, as a minimally invasive surgery, seems to provide better anatomic outcomes and appears to be an attractive option to treat POP [8,9]. Although these devices have improved outcomes, the safety of synthetic mesh has been questioned owing to the surgical complications, prompting the US Food and Drug Administration to issue warnings about adverse events associated with the mesh [10]. Complications following TVM surgery include exposure, pain, sexual dysfunction, recurrent POP, and urogenital and rectovaginal fistulas [11]. Previous studies have reported a 1-3% incidence of pain after the pelvic floor repair procedures with mesh kits [8,12]. As one of the main complaints and complications, pain adversely affects a patient’s quality of life to a great extent [13,14]. The risk factors and development mechanisms of the pain have not been fully understood; relevant factors reported include patient’s overall health and oestrogen status, mesh materials, surgeon’s experience, infection, and pelvic floor muscle spasms [15-17]. The primary objective of this clinical analysis, therefore, was to identify patient and surgical factors associated with the development of pain after the TVM surgery. The secondary aim was to conduct a clinical analysis of the management and relief of the pain. Methods In this multicentre retrospective study, patients who underwent TVM surgery for POP without hysterectomy were identified from the Pelvic Floor Medical Alliance of Northeast China and Inner Mongolia between January 2013 and October 2018 . Patients were excluded if they had a history of chronic pain caused by endometriosis, vulvodynia, vaginismus, interstitial cystitis, or lower back conditions, since they have a higher risk of persistent postoperative pain and may not be ideal candidates for the synthetic material placement [18]. Operations were carried out by experienced urogynaecology surgeons. Relevant demographic characteristics and surgical data were extracted from patient electronic medical records. POP stage examinations were performed before and at 3 months follow-up after the surgery with the patient in a lithotomy position, according to the International Urogynecological Association (IUGA)/International Continence Society (ICS) Pelvic Organ Prolapse Quantification (POP-Q) system [19]. Objective anatomic failure was defined if any point was at stage II or beyond, according to the POP-Q, which was in accordance with previous reports [20, 21]. Patients were recommended to be followed-up at 3 months postoperatively and every 3-6 months subsequently. Follow-up included evaluating anatomic outcomes, screening for mesh exposure or erosion by physical examination, and inquiring about complications such as pain, vaginal discharge, vaginal bleeding, and sexual dysfunction. The IUGA/ICS joint terminology and classification was used to assess the postoperative complications [22]. Patients who met the criteria for category 1B-3B ( provoked pain, pain during sexual intercourse, pain during physical activities, and spontaneous pain) were classified into a pain group, and the patients who did not meet the aforementioned criteria were classified into a pain-free group. For the pain group, detailed descriptions from the patients’ medical records were collected, including pain occurrence time, type, location, degree, and remission . Pain caused by an intraoperative puncture injury and surgical incision is usually relieved in a short term after surgery without intervention, and was therefore not considered a complication. The primary treatment of choice was non-surgical, including topical oestrogen, antibiotics, 1:5000 potassium permanganate sitz bath, biofeedback therapy, or a combination of the above. Patients in whom the conservative treatment was ineffective or who had the indications for mesh removal underwent surgery. Partial mesh removal was performed in cases of limited mesh exposure with no other bothersome symptoms and when mesh contracture was found. After irrigating with saline solution, we made an incision in the exposure or contracture site, removed the involved part of the mesh, and trimmed the edges of the vaginal epithelium. When the exposures were larger, presenting with severe symptoms, or mesh arms pierced the obturator space or ischiorectal fossa, the mesh was removed as much as possible. Complete mesh removal was performed by making an incision in the vaginal epithelium, dissecting the mesh from the overlying epithelium and underlying connective tissue, and closing the vagina with an absorbable suture. After the mesh and its arms were completely removed, a concomitant prolapse repair would be performed if needed. In cases of anatomic failure with obvious pain, we partially removed the mesh and reconnected the remaining part or performed complete mesh removal and reconstructed the normal anatomic structure with other repair procedures. Sample size calculation The sample size calculation was conducted by Power Analysis and Sample Size Software version 15.0 for Windows. According to statistics, 2260 patients underwent TVM surgery in a specified period. Considering problems such as incomplete data and loss of follow-up, the actual number of patients included in the study was about 80% of 2260 patients (1,808). According to earlier studies, the incidence of pain is about 2% (1-3%) [8,12]. When the sample proportion is 0.02, a sample size of 1808 produces a two-sided 95% confidence interval (1-Alpha) with a width equal to 0.014. Statistical analysis SPSS version 25.0 (IBM Statistics for Windows) was used for data analyses. Continuous variables are presented as the mean and standard deviation or median and ranges; categorical variables are summarised using number count and percentage. Independent samples t-test was used to compare continuous variables, chi-square or Fisher’s exact test was used to compare categorical variables, and Mann-Whitney U test was used to compare rank variables between the groups. For variables with statistical differences, logistic regression was used to determine the contributions of the indicators to increase the risk of pain. A P value <0.05 was considered statistically significant. Results A total of 2260 patients underwent TVM surgery for POP between January 2013 and October 2018. After the exclusion of 285 patients lost to follow-up, 97 with incomplete data, and 23 with baseline self-reported chronic pain, 1855 patients were included in this study. The median follow-up length with interquartile range was 24 (11, 31) months. Fifty (2.7%) patients reported postoperative pain and were classified into the pain group, and the other 1805 patients were classified into the pain-free group. A description of baseline demographic characteristics and surgical data of both groups are shown in Table 1. All patients had menopause. The mean age was 64.97±8.98 years, and patients in the pain group were older than those in the pain-free group (67.00±4.85 vs 64.91±9.07 years, P =0.005). Differences in body mass index, parity, previous hysterectomy, previous POP surgery (without mesh implantation), and comorbidities including hypertension and diabetes mellitus were proportionally minor between the groups. Concomitant mid-urethral slings (MUS) for the treatment of stress urinary incontinence (SUI) were implanted in 244 (13.2%) patients, and no differences were noted between the two groups in concomitant MUS or surgical procedure. Moreover, patients in the pain group were likely to lose more blood during the operation (89.50±17.85 vs 83.12±11.05 ml, P =0.015). The POP-Q stage and values (Aa, Ba, Ap, Bp, C, D, and Tvl) of both groups before and at 3 months after the surgery are presented in Table 2 and Table 3. All patients had symptoms with grades III-IV POP preoperatively, with sufficient indications for prolapse surgery deemed by their surgeons. We found no difference in preoperative POP-Q evaluation between the two groups; whereas the differences of POP-Q stage ( P =0.038) and values of Aa, Ba, C ( P =0.019, P =0.029, P =0.016, respectively) at 3 months postoperatively were significant. Thirty patients in the pain-free group and four patients in the pain group experienced anatomic failure with the stage II. Logistic analysis was performed on the contribution of each indicator to the risk of pain, including age, POP-Q values, and intraoperative blood loss. The combined effects of Aa, Ba, and C points were adopted for the assessment. The results showed that patients with greater blood loss (OR=1.28, 95% CI 0.87-2.40, P =0.026) and lager POP-Q values (OR=1.58, 95% CI 0.95-3.10, P =0.011) had a higher risk of suffering from pain, while age was not statistically significant ( P =0.146). The period between mesh implantation and pain occurrence ranged from 1 to 31 months, with a median of 7.5 months. The pain was localised in the vagina, perineum, buttocks, groin, lower abdomen, or multiple sites (Fig. 1). Most of the patients had spontaneous pain (88%); pain in the buttocks, groin, and inner thigh was sometimes aggravated while sitting or by certain movements such as walking, urination, and defecation. Points of tenderness or cord-like changes could sometimes be found at the physical examination in patients with vaginal pain. Mesh exposure was found in 19 patients, 13 of whom experienced vaginal discharge or developed local inflammation. The exposure rate in the pain group was 38% (19/50) and the pain-free group was 4.4% (79/1805), with a significant difference between the groups (OR=13.39, 95% CI 7.25-24.74, P <0.01). The management measures and pain remission are summarised in Table 4 and Fig. 1. A majority of patients (80%) had received conservative treatment, including topical oestrogen, antibiotics, and physiotherapy; 33 patients, in whom the non-surgical management was unsuccessful or who had indications, received surgical intervention, including partial mesh removal for 15 patients and complete mesh removal for 18 patients. A total of 44 (88%) patients reported pain relief after the management, 16 by conservative treatment and 28 by surgical intervention. Discussion In this retrospective study, we investigated the relevant factors of pain after TVM surgery for the treatment of POP, and analysed the management and relief of pain based on our clinical experience. The incidence of pain in our study was 2.7%. Excessive intraoperative blood loss and large postoperative POP-Q values were considered as risk factors. The vagina was the most common site of pain, followed by the perineum, buttock, and groin; few patients had lower abdomen or generalised pain. In some patients, pain could be relieved by conservative therapy. Mesh removal was an effective treatment with the relief rate of 84.8%, and mesh exposure was the most common reason for the removal. The process by which pain develops after TVM surgery is probably multifactorial, and the manifestations of pain are varied. The relationship between excessive intraoperative blood loss and postoperative pain has not been determined. A previous study shows that excessive intraoperative blood loss can increase the risk of mesh exposure 7.3-fold [23] and may lead to postoperative inflammatory reaction, which may be related to the development of pain. One out five patients with mesh exposure in our study reported pain, compared with 0-54% in the previous studies [13,18,20,24]. The exposure itself may not have been the cause of pain, while the resulting inflammatory reaction might have been relevant. It has been proposed that chronic inflammatory response caused by the exposed mesh can lead to vaginal pain [25]. Unsatisfactory postoperative anatomic outcomes may also increase the risk of pain, which may be related to the insufficient tension of the mesh. Patients with this condition may experience abdominal and perineal distension accompanied by the pain, which can also occur occasionally in untreated POP patients. In addition, although MUS is also a transvaginal implant, the concomitant MUS implantation for SUI was thought to be unrelated to the pain, in accord with previous findings [26]. Pain can sometimes resolve on its own or improve with physiotherapy, oestrogen cream, or antibiotic treatment [13,27]. Since pain usually includes hypertonia of the pelvic floor muscles, pelvic floor physiotherapy has showed a good curative effect [28]. For the mesh exposure, more aggressive management might be required when the pain appears, rather than conservative treatment such as topical oestrogen and closure of the vaginal epithelium [27]. Partial or total mesh removal is a better option for patients who have not responded to the conservative treatment, and the rate of pain relief after the mesh removal ranges from 50% to 84% in prior studies [18]. Pain can also result from mesh arms piercing the obturator space or ischiorectal fossa [29,30], which can be markedly improved after the mesh is removed. Thus, during the process of puncture for mesh implantation, we would like to emphasise that the implants must be placed in the interstitial space rather than in the tissue. In some cases, pain can be explained by bunching, folding, or contracture of the mesh [29,31]. Mesh contracture may result in a concomitant contracture of the underlying pelvic floor musculature and excessive tension on the mesh arms, causing increased pelvic floor muscle tone and tenderness [17,30]. Pain in these cases usually is unresponsive to conservative measures, but can be relieved following mesh removal. In addition, some patients had persistent pain from the moment the mesh was implanted, while no abnormality was found at the examination. In a previous study, the removal of all vaginally accessible meshes was performed in such cases [18]. Both conservative and surgical approaches in our study were used, while the improvement was unsatisfactory. The mechanism of such pain has not been clearly identified. Nevertheless, new complications may be associated with the removal of the mesh, including recurrent POP, and a concomitant prolapse repair should be performed if needed. In this study, a small number of patients had undergone previous hysterectomy. Although several approaches including TVM for the management of POP have been reported, the best strategy for post-hysterectomy vaginal vault prolapse (VVP) remains controversial. Studies have suggested that laparoscopic sacrocolpopexy and sacrospinous fixation in the treatment of primary VVP and transvaginal bilateral sacrospinous fixation in the treatment of recurrent VVP appears to be effective and safe for the improvement of quality of life and sexual function [32]. As noted in a systematic review, TVM surgery had the highest reoperation rates (including complications and recurrence) in the treatment of VVP [33]. Therefore, we should be more careful in evaluating and selecting the appropriate approach before the TVM is intended for the reconstruction of VVP. Health-related quality of life (HR-QoL) is widely recognised as an important outcome measure following urogynaecological surgery [34]. Taking into account the significant impact of POP on physical and mental health [35], in addition to the surgical effect, that is, anatomical reduction, surgeons should focus on the assessment of postoperative function recovery and improvement of quality of life of the patients. Therefore, multidisciplinary approach in the treatment of women with POP is very important. Although studies have shown that general HR-QoL improved significantly (mainly shown as improvement of sexual activity, mobility, excretion, depression, etc.) after apical POP reconstructive surgery [36], the use of TVM can still lead to some serious complications, such as pain, sexual dysfunction, and mesh exposure [11]. Therefore, the application of TVM should have strict indications, and is usually recommended for patients ≥50 years old or with low sexual activity, severe pelvic floor structural damage, or recurrence [21,35]. Surgeons should weigh the risks and benefits on an individual level based on the patient characteristics when opting for mesh kits for surgical repair, to achieve better treatment outcomes in patients with POP. This study had the following limitations: Firstly, pain was not directly measured with validated instruments, and the metric used for pain relief was based on subjective phrases in medical records at times. Secondly, since the mesh we used was mainly Prolift™, the factors of mesh itself (size, shape and material) are not included in the study. Then, since the pain may occur years after surgery, longer-term follow-up might be required. Finally, the cases in this study came from specific regions, and it is unclear whether the conclusions can apply to patients in other parts of the world. This study had several limitations. First, pain was not directly measured with validated instruments, and the metric used for analysis of pain relief was based on subjective phrases in medical records at times. Second, since the pain may occur years after the surgery, longer-term follow-up might be required. Third, the cases in this study were collected from specific geographical regions, and it is unclear whether the conclusions can apply to patients in other parts of the world. Despite these limitations, the evidence of our study is strengthened by the relatively large number of patients and detailed data available from surgical and medical records. Moreover, this study investigated the relevant factors of postoperative pain, one of the inconvenient complications after the TVM surgery, the observations of which are relatively new to the available literature. The clinical practice shown in this study may provide important information about the strategy of the pain management following TVM surgery. In the future, we will carry out more in-depth studies on the mesh complications to provide more important reference for the postoperative management of TVM. Conclusions The aetiology and development of pain after TVM surgery involves a variety of factors. Excessive intraoperative bleeding and failure with postoperative anatomic outcomes can increase the risk of pain, and patients with mesh exposure are more likely to develop this symptom. Patients can obtain pain relief with non-surgical or surgical management, more than half of whom need mesh removal with differing approach. More factors related to the postoperative pain remain to be explored. Through continuous research and improvement, we hope that TVM surgery can have better effects and safety. Declarations Acknowledgements Not applicable. Authors' contributions CS: study design, data analysis, manuscript writing; YZ: data collection and analysis; QH: project development, data collection; RG, YY: critical revision of the manuscript; ZX: Study design, project development, manuscript writing. All authors reviewed and approved the final version. Funding This work was supported by Shenyang Science and Technology Plan Project (18-014-4-29). The funder gave us financial help to conduct the research but was not involved in study design, data collection, analysis, interpretation or in the writing of the report. The study’s content is solely the responsibility of the authors. Availability of data and materials The datasets generated and/or analyzed during the current study are not publicly available due to ethical issues and potential for organizational privacy to be compromised, but are available from the corresponding author upon reasonable request. Ethics approval and consent to participate The study was approved by the Ethics Committee of Shengjing Hospital of China Medical University (No. 2019PS482K). As the study was based on data routinely collected from electronic medical records, no additional testing/inspections were needed for patients who involved in the research, the Ethics Committee approved the waiver of informed consent. Consent to publish Not Applicable. Competing interests The authors declare that they have no competing interests. Abbreviations POP: Pelvic organ prolapse; TVM: Transvaginal mesh; POP-Q: Pelvic organ prolapse quantification; SUI: Stress urinary incontinence; MUS: Mid-urethral slings; VVP: Vaginal vault prolapse; HR-QoL: Health-related quality of life. References Hendrix SL, Clark A, Nygaard I, Aragaki A, Barnabei V, McTiernan A. Pelvic organ prolapse in the Women's Health Initiative: gravity and gravidity. Am J Obstet Gynecol. 2002;186(6):1160-6. Handa VL, Garrett E, Hendrix S, Gold E, Robbins J. 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Lagana AS, La Rosa VL, Rapisarda AMC, Vitale SG. Pelvic organ prolapse: the impact on quality of life and psychological well-being. J Psychosom Obst Gyn. 2018;39(2):164-6. Altman D, Geale K, Falconer C, Morcos E. A generic health-related quality of life instrument for assessing pelvic organ prolapse surgery: correlation with condition-specific outcome measures. Int Urogynecol J. 2018;29(8):1093-9. Tables Table 1 Patients Characteristics and Surgical data Characteristics Total Pain Pain-free Mean difference/OR 95% CI t/x 2 value P value n=(1855) (n=50) (n=1805) Age, y 64.97±8.98 67.00±4.85 64.91±9.07 2.09 0.65 to 3.53 2.91 0.005* BMI, kg/m2 23.66±1.79 23.98±1.16 23.65±1.80 0.33 -0.01 to 0.67 1.96 0.055 Parity, n 2.27±0.90 2.42±0.73 2.27±0.90 0.15 -0.10 to 0.40 1.18 0.238 Hypertension 1150 (61.99) 32 (64.00) 1118 (61.94) 1.09 0.61 to 1.96 0.09 0.767 Diabetes mellitus 274 (14.77) 8 (16.00) 266 (14.74) 1.10 0.51 to 2.37 0.06 0.804 Previous hysterectomy 51 (2.75) 2 (4.00) 49 (2.71) 1.49 0.35 to 6.32 0.30 0.646 Previous POP surgery 376 (20.27) 9 (18.00) 367 (20.33) 0.86 0.41 to 1.79 0.16 0.686 Surgical procedure Total 1641 (88.46) 46 (92.00) 1595 (88.36) 1.51 0.54 to 4.25 0.66 0.935 Anterior 63 (3.40) 1 (2.00) 62 (3.43) 0.57 0.08 to 4.22 Posterior 151 (8.14) 3 (6.00) 148 (8.20) 0.72 0.22 to 2.32 Concomitant MUS surgery 244 (13.15) 7 (14.00) 237 (13.13 ） 1.08 0.48 to 2.42 0.03 0.858 Operation time, min 78.73±11.41 81.50±12.76 78.65±11.37 2.85 -0.36 to 6.06 1.74 0.082 Estimated blood lose, ml 83.28±11.33 89.50±17.85 83.12±11.05 5.38 1.28 to 11.48 2.51 0.015* Values are presented as mean±SD, median (range), and n (percentage) BMI body mass index, MUS mid-urethral slings *P < 0.05 Table 2 POP-Q stage in both groups before and after surgery Pre-operative Post-operative (3 months) POP-Q stage Pain Pain-free OR 95% CI x 2 value P value POP-Q stage Pain Pain-free OR 95% CI Z value P value n=50 (n=1805) (n=50) (n=1805) Stage 0-II 0 0 - - - - Stage 0 17(34.00) 825(45.70) - - -2.07 0.038* Stage III 31(62.00) 1168(64.71) - - 0.16 0.693 Stage I 29(58.00) 950(52.63) 1.48 0.81 to 2.72 Stage IV 19(38.00) 637(35.29) 1.12 0.63 to 2.01 Stage II 4(8.00) 30(1.67) 6.47 20.05 to 20.41 Values are presented as n (percentage) *P < 0.05 Table 3 POP-Q values in both groups before and after surgery Pre-operaitve Post-operative (3 months) Pain Pain-free Mean difference 95% CI t value P value Pain Pain-free Mean difference 95% CI t value P value (n=50) (n=1805) (n=50) (n=1805) Aa 2.08±0.60 2.06±0.92 0.02 -0.16 to 0.19 0.22 0.829 -2.41±0.81 -2.69±0.47 0.28 0.05 to 0.51 2.43 0.019* Ba 3.66±1.15 3.56±0.76 0.10 -0.23 to 0.43 0.60 0.554 -2.24±1.16 -2.61±0.46 0.37 0.04 to 0.70 2.25 0.029* C 1.90±1.39 1.95±1.50 -0.05 -0.47 to 0.37 -0.23 0.817 -4.83±1.30 -5.29±0.67 0.46 0.09 to 0.83 2.49 0.016* Tvl 6.58±0.57 6.45±0.57 0.13 -0.03 to 0.29 0.23 0.228 6.62±0.56 6.70±0.54 -0.08 -0.23 to 0.07 -1.04 0.300 Ap 1.46±0.97 1.68±0.95 -0.22 -0.49 to 0.05 -1.62 0.668 -2.73±0.37 -2.69±0.35 -0.04 -0.13 to 0.06 -0.75 0.456 Bp 2.26±1.37 2.34±1.01 -0.08 -0.48 to 0.31 -0.43 0.822 -2.62±0.40 -2.60±0.31 -0.02 -0.13 to 0.10 -0.33 0.745 D 1.63±1.72 1.57±1.27 0.06 -0.45 to 0.56 0.23 0.108 -6.00±1.37 -6.36±0.49 0.36 -0.04 to 0.76 1.83 0.074 Valuse are presented as mean±SD *P < 0.05 Table 4 Managements for patients in pain group Precedure Total Relief Conservative treatment 40 16 Topical estrogen 32 - Antibiotics 11 - Physical therapy 35 - Surgical intervention 33 28 Partial mesh removal 15 12 Mesh exposure 6 5 Mesh contracture/folding 6 6 Mesh arms piercing obturator space/ischiorectal fossa 1 0 Anatomy failure 2 1 Complete mesh removal 18 16 Mesh exposure 7 7 Mesh arms piercing obturator space/ischiorectal fossa 8 7 Anatomy failure 2 2 No abnormality on examination 1 0 Cite Share Download PDF Status: Published Journal Publication published 30 Jan, 2021 Read the published version in BMC Women's Health → Version 2 posted Editorial decision: Minor revision 17 Jan, 2021 Reviewer # 1 agreed at journal 14 Jan, 2021 Review # 1 received at journal 14 Jan, 2021 Reviewers invited by journal 11 Jan, 2021 Editor assigned by journal 20 Oct, 2020 Submission checks completed at journal 19 Oct, 2020 Editor invited by journal 19 Oct, 2020 You are reading this latest preprint version Show more versions Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. 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Also discoverable on Platform About Our Team In Review Editorial Policies Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-38744","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Research article","associatedPublications":[],"authors":[{"id":3696589,"identity":"c66309dd-5237-4b2f-8e67-52ea08e55b03","order_by":0,"name":"Chang Shi","email":"","orcid":"","institution":"Shengjing Hospital of China Medical University","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Chang","middleName":"","lastName":"Shi","suffix":""},{"id":3696590,"identity":"926dbb75-fb48-40d9-9085-c8f0ce8c524b","order_by":1,"name":"Ying Zhao","email":"","orcid":"","institution":"Shengjing Hospital of China Medical University","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Ying","middleName":"","lastName":"Zhao","suffix":""},{"id":3696591,"identity":"20b7053d-1526-444a-9f33-eff23fdfadba","order_by":2,"name":"Qing Hu","email":"","orcid":"","institution":"Shengjing Hospital of China Medical University","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Qing","middleName":"","lastName":"Hu","suffix":""},{"id":3696592,"identity":"176a6734-7a45-405b-9788-5205b490b42c","order_by":3,"name":"Runqi Gong","email":"","orcid":"","institution":"Shengjing Hospital of China Medical University","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Runqi","middleName":"","lastName":"Gong","suffix":""},{"id":3696593,"identity":"d6b5b8bf-b43c-46e1-af19-1b3f2053de72","order_by":4,"name":"Yitong Yin","email":"","orcid":"","institution":"Shengjing Hospital of China Medical University","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Yitong","middleName":"","lastName":"Yin","suffix":""},{"id":3696594,"identity":"db616166-870e-4498-8f85-3d45fa5779aa","order_by":5,"name":"Zhijun Xia","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAAxElEQVRIie2QsQrCMBCGrxzUJZo1WcRHOCmIQ2kfxCUidHNydSh0cPRhCs6FgB37CgVfIOAqYuILJN0E88Ft/8fd/QCRyC+CdoQdjqjHKQqBvKQVTdlFQANbibBsjw+zhVfRambFc77zKrJJiexhh5uedyPcq2PtUzgCKads9EJRUmu/kuLMdE7JGkYiSOHI1rVVCsJQRTbsZEvOlNC2ZBXyCw19+xSwLPlV69Gcc7/iQPmG/TepQuKOxACUoeFIJBL5Qz5fyDRBHPsMCAAAAABJRU5ErkJggg==","orcid":"https://orcid.org/0000-0003-4628-569X","institution":"Shengjing Hospital of China Medical University","correspondingAuthor":true,"submittingAuthor":false,"prefix":"","firstName":"Zhijun","middleName":"","lastName":"Xia","suffix":""}],"badges":[],"createdAt":"2020-06-29 09:07:47","currentVersionCode":2,"declarations":"","doi":"10.21203/rs.3.rs-38744/v2","doiUrl":"https://doi.org/10.21203/rs.3.rs-38744/v2","draftVersion":[],"editorialEvents":[{"content":"https://doi.org/10.1186/s12905-021-01192-w","type":"published","date":"2021-01-30T15:00:39+00:00"}],"editorialNote":"","failedWorkflow":false,"files":[{"id":3202719,"identity":"79c865ab-f88e-43c6-b1c1-4503bdfcf945","added_by":"auto","created_at":"2020-10-26 18:11:21","extension":"jpg","order_by":1,"title":"Figure 1","display":"","copyAsset":false,"role":"figure","size":60911,"visible":true,"origin":"","legend":"Sites of the pain and relief after treatment","description":"","filename":"Fig1.jpg","url":"https://assets-eu.researchsquare.com/files/rs-38744/v2/2f7abda1a367616ea5362676.jpg"},{"id":13605925,"identity":"2b519a52-f345-4d67-a682-0a952ee316a1","added_by":"auto","created_at":"2021-09-17 06:05:37","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":271327,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-38744/v2/0408fa89-65f7-4abb-b945-1d1743e4a756.pdf"}],"financialInterests":"","formattedTitle":"Clinical analysis of pain after transvaginal mesh surgery in patients with pelvic organ prolapse","fulltext":[{"header":"Background","content":"\u003cp\u003ePelvic organ prolapse (POP) is a common pelvic floor disorder among women, with population-based epidemiologic studies reporting the prevalence range from 2.9% to 34.3% in general population [1-4]. Women have an 11-12.6% lifetime risk of surgery for POP by the age of 80 [5,6]. Traditional surgical procedures using weak native tissues have a high risk of failure, with almost 30% of the patients requiring reoperation [7]. Transvaginal mesh (TVM) surgery, as a minimally invasive surgery, seems to provide better anatomic outcomes and appears to be an attractive option to treat POP [8,9].\u003c/p\u003e\n\u003cp\u003eAlthough these devices have improved outcomes, the safety of synthetic mesh has been questioned owing to the surgical complications, prompting the US Food and Drug Administration to issue warnings about adverse events associated with the mesh [10]. Complications following TVM surgery include exposure, pain, sexual dysfunction, recurrent POP, and urogenital and rectovaginal fistulas [11]. Previous studies have reported a 1-3% incidence of pain after the pelvic floor repair procedures with mesh kits [8,12]. As one of the main complaints and complications, pain adversely affects a patient\u0026rsquo;s quality of life to a great extent [13,14]. The risk factors and development mechanisms of the pain have not been fully understood; relevant factors reported include patient\u0026rsquo;s overall health and oestrogen status, mesh materials, surgeon\u0026rsquo;s experience, infection, and pelvic floor muscle spasms [15-17].\u003c/p\u003e\n\u003cp\u003eThe primary objective of this clinical analysis, therefore, was to identify patient and surgical factors associated with the development of pain after the TVM surgery. The secondary aim was to conduct a clinical analysis of the management and relief of the pain.\u003c/p\u003e"},{"header":"Methods","content":"\u003cp\u003eIn this multicentre retrospective study, patients who underwent TVM surgery for POP without hysterectomy were identified from the Pelvic Floor Medical Alliance of Northeast China and Inner Mongolia between January 2013 and October 2018\u003cem\u003e. Patients were excluded if they had a history of chronic pain caused by endometriosis, vulvodynia, vaginismus, interstitial cystitis, or lower back conditions, since they have a higher risk of persistent postoperative pain and may not be ideal candidates for the synthetic material placement [18]. \u003c/em\u003e\u003c/p\u003e\n\u003cp\u003eOperations were carried out by experienced urogynaecology surgeons. Relevant demographic characteristics and \u003cem\u003esurgical data\u003c/em\u003e were extracted from patient electronic medical records. POP stage examinations were performed before and at 3 months follow-up after the surgery with the patient in a lithotomy position, according to the \u003cem\u003eInternational Urogynecological Association (IUGA)/International Continence Society (ICS)\u003c/em\u003e Pelvic Organ Prolapse Quantification (POP-Q) system [19].\u003cem\u003e Objective anatomic failure was defined if any point was at stage II or beyond, according to the POP-Q, which was in accordance with previous reports [20, 21].\u003c/em\u003e\u003c/p\u003e\n\u003cp\u003e\u003cem\u003ePatients were recommended to be followed-up at 3 months postoperatively and every 3-6 months subsequently. Follow-up included\u003c/em\u003e\u003cem\u003eevaluating anatomic outcomes, screening for mesh exposure or erosion by physical examination, and inquiring about complications\u003c/em\u003e\u003cem\u003esuch as pain, vaginal discharge, vaginal bleeding, and sexual dysfunction. The IUGA/ICS joint terminology and classification was used to assess the postoperative complications [22]. Patients who met the criteria for category 1B-3B\u003c/em\u003e (\u003cem\u003eprovoked pain, pain during sexual intercourse, pain during physical activities, and spontaneous pain) were classified into a pain group, \u003c/em\u003eand the patients who did not meet the aforementioned criteria were classified into a pain-free group. For the pain group,\u003cem\u003e detailed descriptions from the patients\u0026rsquo; medical records were collected, including pain occurrence time, type, location, degree, and remission\u003c/em\u003e. \u003cem\u003ePain caused by an intraoperative puncture injury and surgical incision is usually relieved in a short term after surgery without intervention, and was therefore not considered a complication.\u003c/em\u003e\u003c/p\u003e\n\u003cp\u003eThe primary treatment of choice was non-surgical, including topical oestrogen, antibiotics, 1:5000 potassium permanganate sitz bath, biofeedback therapy, or a combination of the above. Patients in whom the conservative treatment was ineffective or who had the indications for mesh removal underwent surgery.\u003cem\u003e Partial mesh removal was performed in cases of limited mesh exposure with no other bothersome symptoms and when mesh contracture was found. After irrigating with saline solution, we made an incision in the exposure or contracture site, removed the involved part of the mesh, and trimmed the edges of the vaginal epithelium. When the exposures were larger, presenting with severe symptoms, or mesh arms pierced the obturator space or ischiorectal fossa, the mesh was removed as much as possible. Complete mesh removal was performed by making an incision in the vaginal epithelium, dissecting the mesh from the overlying epithelium and underlying connective tissue, and closing the vagina with an absorbable suture. After\u003c/em\u003e the mesh and its arms were completely removed, \u003cem\u003ea concomitant prolapse repair would be performed if needed. In cases of anatomic failure with obvious pain, we partially removed the mesh and reconnected the remaining part or performed complete mesh removal and reconstructed the normal anatomic structure with other repair procedures.\u003c/em\u003e\u003c/p\u003e\n\u003cp\u003e\u003cem\u003eSample size calculation\u003c/em\u003e\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;The sample size calculation was conducted by Power Analysis and Sample Size Software version 15.0 for Windows. According to statistics, 2260 patients underwent TVM surgery in a specified period. Considering problems such as incomplete data and loss of follow-up, the actual number of patients included in the study was about 80% of 2260 patients (1,808). According to earlier studies, the incidence of pain is about 2% (1-3%) [8,12]. When the sample proportion is 0.02, a sample size of 1808 produces a two-sided 95% confidence interval (1-Alpha) with a width equal to 0.014.\u003c/p\u003e\n\u003cp\u003e\u003cem\u003eStatistical analysis\u003c/em\u003e\u003c/p\u003e\n\u003cp\u003eSPSS version 25.0 (IBM Statistics for Windows) was used for data analyses. Continuous variables are presented as the mean and standard deviation or median and ranges; categorical variables are summarised using number count and percentage. Independent samples t-test was used to compare continuous variables, chi-square or Fisher\u0026rsquo;s exact test was used to compare categorical variables, and Mann-Whitney U test was used to compare rank variables between the groups. For variables with statistical differences, logistic regression was used to determine the contributions of the indicators to increase the risk of pain. A \u003cem\u003eP\u003c/em\u003e value \u0026lt;0.05 was considered statistically significant.\u003c/p\u003e"},{"header":"Results","content":"\u003cp\u003eA total of 2260 patients underwent TVM surgery for POP between January 2013 and October 2018. After the exclusion of 285 patients lost to follow-up, 97 with incomplete data, and 23 with baseline self-reported chronic pain, 1855 patients were included in this study. The median follow-up length with interquartile range was 24 (11, 31) months. Fifty (2.7%) patients reported postoperative pain and were classified into the pain group, and the other 1805 patients were classified into the pain-free group.\u003c/p\u003e\n\u003cp\u003eA description of baseline demographic characteristics and surgical data of both groups are shown in Table 1. All patients had menopause. The mean age was 64.97\u0026plusmn;8.98 years, and patients in the pain group were older than those in the pain-free group (67.00\u0026plusmn;4.85 vs 64.91\u0026plusmn;9.07 years, \u003cem\u003eP\u003c/em\u003e=0.005). Differences in body mass index, parity, previous hysterectomy, previous POP surgery (without mesh implantation), and comorbidities including hypertension and diabetes mellitus were proportionally minor between the groups. Concomitant mid-urethral slings (MUS) for the treatment of stress urinary incontinence (SUI) were implanted in 244 (13.2%) patients, and no differences were noted between the two groups in concomitant MUS or surgical procedure. Moreover, patients in the pain group were likely to lose more blood during the operation (89.50\u0026plusmn;17.85 vs 83.12\u0026plusmn;11.05 ml, \u003cem\u003eP\u003c/em\u003e=0.015).\u003c/p\u003e\n\u003cp\u003eThe POP-Q stage and values (Aa, Ba, Ap, Bp, C, D, and Tvl) of both groups before and at 3 months after the surgery are presented in Table 2 and Table 3. All patients had symptoms with grades III-IV POP preoperatively, with sufficient indications for prolapse surgery deemed by their surgeons. We found no difference in preoperative POP-Q evaluation between the two groups; whereas the differences of POP-Q stage (\u003cem\u003eP\u003c/em\u003e=0.038) and values of Aa, Ba, C (\u003cem\u003eP\u003c/em\u003e=0.019, \u003cem\u003eP\u003c/em\u003e=0.029, \u003cem\u003eP\u003c/em\u003e=0.016, respectively) at 3 months postoperatively were significant. Thirty patients in the pain-free group and four patients in the pain group experienced anatomic failure with the stage II.\u003c/p\u003e\n\u003cp\u003eLogistic analysis was performed on the contribution of each indicator to the risk of pain, including age, POP-Q values, and intraoperative blood loss. The combined effects of Aa, Ba, and C points were adopted for the assessment. The results showed that patients with greater blood loss (OR=1.28, 95% CI 0.87-2.40,\u003cem\u003e P\u003c/em\u003e=0.026) and lager POP-Q values (OR=1.58, 95% CI 0.95-3.10, \u003cem\u003eP\u003c/em\u003e=0.011) had a higher risk of suffering from pain, while age was not statistically significant (\u003cem\u003eP\u003c/em\u003e=0.146).\u003c/p\u003e\n\u003cp\u003eThe period between mesh implantation and pain occurrence ranged from 1 to 31 months, with a median of 7.5 months. The pain was localised in the vagina, perineum, buttocks, groin, lower abdomen, or multiple sites (Fig. 1). Most of the patients had spontaneous pain (88%); pain in the buttocks, groin, and inner thigh was sometimes aggravated while sitting or by certain movements such as walking, urination, and defecation. Points of tenderness or cord-like changes could sometimes be found at the physical examination in patients with vaginal pain. Mesh exposure was found in 19 patients, 13 of whom experienced vaginal discharge or developed local inflammation. The exposure rate in the pain group was 38% (19/50) and the pain-free group was 4.4% (79/1805), with a significant difference between the groups (OR=13.39, 95% CI 7.25-24.74, \u003cem\u003eP\u003c/em\u003e\u0026lt;0.01).\u003c/p\u003e\n\u003cp\u003eThe management measures and pain remission are summarised in Table 4 and Fig. 1. A majority of patients (80%) had received conservative treatment, including topical oestrogen, antibiotics, and physiotherapy; 33 patients, in whom the non-surgical management was unsuccessful or who had indications, received surgical intervention, including partial mesh removal for 15 patients and complete mesh removal for 18 patients. A total of 44 (88%) patients reported pain relief after the management, 16 by conservative treatment and 28 by surgical intervention.\u003c/p\u003e"},{"header":"Discussion","content":"\u003cp\u003eIn this retrospective study, we investigated the relevant factors of pain after TVM surgery for the treatment of POP, and analysed the management and relief of pain based on our clinical experience. The incidence of pain in our study was 2.7%. Excessive intraoperative blood loss and large postoperative POP-Q values were considered as risk factors. The vagina was the most common site of pain, followed by the perineum, buttock, and groin; few patients had lower abdomen or generalised pain. In some patients, pain could be relieved by conservative therapy. Mesh removal was an effective treatment with the relief rate of 84.8%, and mesh exposure was the most common reason for the removal.\u003c/p\u003e\n\u003cp\u003eThe process by which pain develops after TVM surgery is probably multifactorial, and the manifestations of pain are varied. The relationship between excessive intraoperative blood loss and postoperative pain has not been determined. A previous study shows that excessive intraoperative blood loss can increase the risk of mesh exposure 7.3-fold [23] and may lead to postoperative inflammatory reaction, which may be related to the development of pain. One out five patients with mesh exposure in our study reported pain, compared with 0-54% in the previous studies [13,18,20,24]. The exposure itself may not have been the cause of pain, while the resulting inflammatory reaction might have been relevant. It has been proposed that chronic inflammatory response caused by the exposed mesh can lead to vaginal pain [25]. Unsatisfactory postoperative anatomic outcomes may also increase the risk of pain, which may be related to the insufficient tension of the mesh. Patients with this condition may experience abdominal and perineal distension accompanied by the pain, which can also occur occasionally in untreated POP patients. In addition, although MUS is also a transvaginal implant, the concomitant MUS implantation for SUI was thought to be unrelated to the pain, in accord with previous findings [26].\u003c/p\u003e\n\u003cp\u003ePain can sometimes resolve on its own or improve with physiotherapy, oestrogen cream, or antibiotic treatment [13,27]. Since pain usually includes hypertonia of the pelvic floor muscles, pelvic floor physiotherapy has showed a good curative effect [28]. For the mesh exposure, more aggressive management might be required when the pain appears, rather than conservative treatment such as topical oestrogen and closure of the vaginal epithelium [27]. Partial or total mesh removal is a better option for patients who have not responded to the conservative treatment, and the rate of pain relief after the mesh removal ranges from 50% to 84% in prior studies [18].\u003c/p\u003e\n\u003cp\u003ePain can also result from mesh arms piercing the obturator space or ischiorectal fossa [29,30], which can be markedly improved after the mesh is removed. Thus, during the process of puncture for mesh implantation, we would like to emphasise that the implants must be placed in the interstitial space rather than in the tissue. In some cases, pain can be explained by bunching, folding, or contracture of the mesh [29,31]. Mesh contracture may result in a concomitant contracture of the underlying pelvic floor musculature and excessive tension on the mesh arms, causing increased pelvic floor muscle tone and tenderness [17,30]. Pain in these cases usually is unresponsive to conservative measures, but can be relieved following mesh removal. In addition, some patients had persistent pain from the moment the mesh was implanted, while no abnormality was found at the examination. In a previous study, the removal of all vaginally accessible meshes was performed in such cases [18]. Both conservative and surgical approaches in our study were used, while the improvement was unsatisfactory. The mechanism of such pain has not been clearly identified. Nevertheless, new complications may be associated with the removal of the mesh, including recurrent POP, and a concomitant prolapse repair should be performed if needed.\u003c/p\u003e\n\u003cp\u003eIn this study, a small number of patients had undergone previous hysterectomy. Although several approaches including TVM for the management of POP have been reported, the best strategy for post-hysterectomy vaginal vault prolapse (VVP) remains controversial. Studies have suggested that laparoscopic sacrocolpopexy and sacrospinous fixation in the treatment of primary VVP and transvaginal bilateral sacrospinous fixation in the treatment of recurrent VVP appears to be effective and safe for the improvement of quality of life and sexual function [32]. As noted in a systematic review, TVM surgery had the highest reoperation rates (including complications and recurrence) in the treatment of VVP [33]. Therefore, we should be more careful in evaluating and selecting the appropriate approach before the TVM is intended for the reconstruction of VVP.\u003c/p\u003e\n\u003cp\u003eHealth-related quality of life (HR-QoL) is widely recognised as an important outcome measure following urogynaecological surgery [34]. Taking into account the significant impact of POP on physical and mental health [35], in addition to the surgical effect, that is, anatomical reduction, surgeons should focus on the assessment of postoperative function recovery and improvement of quality of life of the patients. Therefore, multidisciplinary approach in the treatment of women with POP is very important. Although studies have shown that general HR-QoL improved significantly (mainly shown as improvement of sexual activity, mobility, excretion, depression, etc.) after apical POP reconstructive surgery [36], the use of TVM can still lead to some serious complications, such as pain, sexual dysfunction, and mesh exposure [11]. Therefore, the application of TVM should have strict indications, and is usually recommended for patients \u0026ge;50 years old or with low sexual activity, severe pelvic floor structural damage, or recurrence [21,35]. Surgeons should weigh the risks and benefits on an individual level based on the patient characteristics when opting for mesh kits for surgical repair, to achieve better treatment outcomes in patients with POP.\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;This study had the following limitations: Firstly, pain was not directly measured with validated instruments, and the metric used for pain relief was based on subjective phrases in medical records at times. Secondly, since the mesh we used was mainly Prolift\u0026trade;, the factors of mesh itself (size, shape and material) are not included in the study. Then, since the pain may occur years after surgery, longer-term follow-up might be required. Finally, the cases in this study came from specific regions, and it is unclear whether the conclusions can apply to patients in other parts of the world. This study had several limitations. First, pain was not directly measured with validated instruments, and the metric used for analysis of pain relief was based on subjective phrases in medical records at times. Second, since the pain may occur years after the surgery, longer-term follow-up might be required. Third, the cases in this study were collected from specific geographical regions, and it is unclear whether the conclusions can apply to patients in other parts of the world.\u003c/p\u003e\n\u003cp\u003eDespite these limitations, the evidence of our study is strengthened by the relatively large number of patients and detailed data available from surgical and medical records. Moreover, this study investigated the relevant factors of postoperative pain, one of the inconvenient complications after the TVM surgery, the observations of which are relatively new to the available literature. The clinical practice shown in this study may provide important information about the strategy of the pain management following TVM surgery. In the future, we will carry out more in-depth studies on the mesh complications to provide more important reference for the postoperative management of TVM.\u003c/p\u003e"},{"header":"Conclusions","content":"\u003cp\u003eThe aetiology and development of pain after TVM surgery involves a variety of factors. Excessive intraoperative bleeding and failure with postoperative anatomic outcomes can increase the risk of pain, and patients with mesh exposure are more likely to develop this symptom. Patients can obtain pain relief with non-surgical or surgical management, more than half of whom need mesh removal with differing approach. More factors related to the postoperative pain remain to be explored. Through continuous research and improvement, we hope that TVM surgery can have better effects and safety.\u003c/p\u003e"},{"header":"Declarations","content":"\u003cp\u003e\u003cstrong\u003eAcknowledgements\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eNot applicable.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAuthors' contributions\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eCS: study design, data analysis, manuscript writing; YZ: data collection and analysis; QH: project development, data collection; RG, YY: critical revision of the manuscript; ZX: Study design, project development, manuscript writing. All authors reviewed and approved the final version.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eFunding\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThis work was supported by Shenyang Science and Technology Plan Project (18-014-4-29). The funder gave us financial help to conduct the research but was not involved in study design, data collection, analysis, interpretation or in the writing of the report. The study\u0026rsquo;s content is solely the responsibility of the authors.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAvailability of data and materials\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe datasets generated and/or analyzed during the current study are not publicly available due to ethical issues and potential for organizational privacy to be compromised, but are available from the corresponding author upon reasonable request.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eEthics approval and consent to participate\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe study was approved by the Ethics Committee of Shengjing Hospital of China Medical University (No. 2019PS482K). As the study was based on data routinely collected from electronic medical records, no additional testing/inspections were needed for patients who involved in the research, the Ethics Committee approved the waiver of informed consent.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConsent to publish\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eNot Applicable.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eCompeting interests\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe authors declare that they have no competing interests.\u003c/p\u003e"},{"header":"Abbreviations","content":"\u003cp\u003ePOP: Pelvic organ prolapse; TVM: Transvaginal mesh; POP-Q: Pelvic organ prolapse quantification; SUI: Stress urinary incontinence; MUS: Mid-urethral slings; VVP: Vaginal vault prolapse; HR-QoL: Health-related quality of life.\u003c/p\u003e"},{"header":"References","content":"\u003col\u003e\n\u003cli\u003eHendrix SL, Clark A, Nygaard I, Aragaki A, Barnabei V, McTiernan A. 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Am J Obstet Gynecol. 2010;203(3):235.e1.\u003c/li\u003e\n\u003cli\u003eKinjo M, Yoshimura Y, Kitagawa Y, Okegawa T, Nutahara K. Sexual activity and quality of life in Japanese pelvic organ prolapse patients after transvaginal mesh surgery. J Obstet Gynaecol Re. 2018;44(7):1302-7.\u003c/li\u003e\n\u003cli\u003eHaylen BT, Freeman RM, Swift SE, et al. An International Urogynecological Association (IUGA)/International Continence Society (ICS) joint terminology and classification of the complications related directly to the insertion of prostheses (meshes,implants,tapes) and grafts in female pelvic floor surgery. Neurourol Urodynam. 2011;30(1):2-12.\u003c/li\u003e\n\u003cli\u003eGold KP, Ward RM, Zimmerman CW, et al. Factors associated with exposure of transvaginally placed polypropylene mesh for pelvic organ prolapse. Int Urogynecol J. 2012;23(10):1461-6.\u003c/li\u003e\n\u003cli\u003eGlazener CM, Breeman S, Elders A, et al. Mesh, graft, or standard repair for women having primary transvaginal anterior or posterior compartment prolapse surgery: two parallel-group, multicentre, randomised, controlled trials (PROSPECT). Lancet. 2017;389(10067):381-92.\u003c/li\u003e\n\u003cli\u003eCundiff GW, Quinlan DJ, van Rensburg JA, Slack M. Foundation for an evidence-informed algorithm for treating pelvic floor mesh complications: a review. BJOG. 2018;125(8):1026-37.\u003c/li\u003e\n\u003cli\u003eLee D, Dillon B, Lemack G, Gomelsky A, Zimmern P. Transvaginal mesh kits-how \"serious\" are the complications and are they reversible? Urology. 2013;81(1):43-8.\u003c/li\u003e\n\u003cli\u003eJeffrey ST, Nieuwoudt A. Beyond the complications: medium-term anatomical, sexual and functional outcomes following removal of trocar-guided transvaginal mesh. A retrospective cohort study. Int Urogynecol J. 2012;23(10):1391-6.\u003c/li\u003e\n\u003cli\u003eRosenbaum TY, Owens A. The role of pelvic floor physical therapy in the treatment of pelvic and genital pain-related sexual dysfunction (CME). J Sex Med. 2008;5(3):513-23.\u003c/li\u003e\n\u003cli\u003eMarcus-Braun N, Bourret A, von Theobald P. Persistent pelvic pain following transvaginal mesh surgery: a cause for mesh removal. Eur J Obstet Gynecol Reprod Biol. 2012;162(2):224-8.\u003c/li\u003e\n\u003cli\u003eFeiner B, Maher C.Vaginal mesh contraction: definition, clinical presentation, and management. Obstet Gynecol. 2010;115(2):325-30.\u003c/li\u003e\n\u003cli\u003eGyang AN, Feranec JB, Patel RC, Lamvu GM. Managing chronic pelvic pain following reconstructive pelvic surgery with transvaginal mesh. Int Urogynecol J. 2014;25(3):313-8.\u003c/li\u003e\n\u003cli\u003eVitale SG, Lagana AS, Noventa M, et al. Transvaginal bilateral sacrospinous fixation after second recurrence of vaginal vault prolapse: efficacy and impact on quality of life and sexuality. Biomed Res Int. 2018;2018:1-6.\u003c/li\u003e\n\u003cli\u003eCoolen ALWM, Bui BN, Dietz V, et al. The treatment of post-hysterectomy vaginal vault prolapse: a systematic review and meta-analysis. Int Urogynecol J. 2018;28(12):1767-83.\u003c/li\u003e\n\u003cli\u003eBarber MD, Maher C. Apical prolapse. Int Urogynecol J. 2013;24(11):1815-33.\u003c/li\u003e\n\u003cli\u003eLagana AS, La Rosa VL, Rapisarda AMC, Vitale SG. Pelvic organ prolapse: the impact on quality of life and psychological well-being. J Psychosom Obst Gyn. 2018;39(2):164-6.\u003c/li\u003e\n\u003cli\u003eAltman D, Geale K, Falconer C, Morcos E. A generic health-related quality of life instrument for assessing pelvic organ prolapse surgery: correlation with condition-specific outcome measures. Int Urogynecol J. 2018;29(8):1093-9.\u003c/li\u003e\n\u003c/ol\u003e"},{"header":"Tables","content":"\u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif; color: rgb(0, 0, 0); background-color: rgb(255, 255, 255);'\u003eTable 1 Patients Characteristics and Surgical data\u003c/span\u003e\u003c/p\u003e\n\u003ctable style=\"width: 6.0e+2pt;border: none;margin-left:4.65pt;border-collapse:collapse;\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"2\" rowspan=\"2\" style=\"width:128.35pt;border-top: solid windowtext 1.0pt;border-left:none;border-bottom:solid black 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:16.75pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003eCharacteristics\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:77.95pt;border:none;border-top:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:16.75pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003eTotal\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:70.9pt;border:none;border-top:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:16.75pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003ePain\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:70.85pt;border:none;border-top:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:16.75pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003ePain-free\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width: 70.9pt;border-top: 1pt solid windowtext;border-left: none;border-bottom: 1pt solid black;border-right: none;background: yellow;padding: 0in 5.4pt;height: 16.75pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003eMean difference/OR\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width:70.85pt;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid black 1.0pt;border-right:none;background:yellow;padding:0in 5.4pt 0in 5.4pt;height:16.75pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e95% CI\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width:56.7pt;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid black 1.0pt;border-right:none;background:yellow;padding:0in 5.4pt 0in 5.4pt;height:16.75pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cem\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003et/x\u003csup\u003e2\u003c/sup\u003e\u003c/span\u003e\u003c/em\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e\u0026nbsp;value\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width:49.6pt;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid black 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:16.75pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cem\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003eP\u003c/span\u003e\u003c/em\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e\u0026nbsp;value\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:77.95pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003en=(1855)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:70.9pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e(n=50)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:70.85pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e(n=1805)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"2\" style=\"width:128.35pt;border:none;padding:0in 5.4pt 0in 5.4pt;height:14.6pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003eAge, y\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:77.95pt;padding:0in 5.4pt 0in 5.4pt;height:14.6pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e64.97\u0026plusmn;8.98\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:70.9pt;padding:0in 5.4pt 0in 5.4pt;height:14.6pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e67.00\u0026plusmn;4.85\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:70.85pt;padding:0in 5.4pt 0in 5.4pt;height:14.6pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e64.91\u0026plusmn;9.07\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:70.9pt;background:yellow;padding:0in 5.4pt 0in 5.4pt;height:14.6pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e2.09\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:70.85pt;background:yellow;padding:0in 5.4pt 0in 5.4pt;height:14.6pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e0.65 to 3.53\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.7pt;background:yellow;padding:0in 5.4pt 0in 5.4pt;height:14.6pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e2.91\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.6pt;padding:0in 5.4pt 0in 5.4pt;height:14.6pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e0.005*\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"2\" style=\"width:128.35pt;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003eBMI, kg/m2\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:77.95pt;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e23.66\u0026plusmn;1.79\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:70.9pt;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e23.98\u0026plusmn;1.16\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:70.85pt;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e23.65\u0026plusmn;1.80\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:70.9pt;background:yellow;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e0.33\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:70.85pt;background:yellow;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e-0.01 to 0.67\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.7pt;background:yellow;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e1.96\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.6pt;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e0.055\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"2\" style=\"width:128.35pt;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003eParity, n\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:77.95pt;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e2.27\u0026plusmn;0.90\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:70.9pt;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e2.42\u0026plusmn;0.73\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:70.85pt;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e2.27\u0026plusmn;0.90\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:70.9pt;background:yellow;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e0.15\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:70.85pt;background:yellow;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e-0.10 to 0.40\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.7pt;background:yellow;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e1.18\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.6pt;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e0.238\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"2\" style=\"width:128.35pt;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003eHypertension\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:77.95pt;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e1150 (61.99)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:70.9pt;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e32 (64.00)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:70.85pt;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e1118 (61.94)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:70.9pt;background:yellow;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e1.09\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:70.85pt;background:yellow;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e0.61 to 1.96\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.7pt;background:yellow;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e0.09\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.6pt;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e0.767\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"2\" style=\"width:128.35pt;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003eDiabetes mellitus\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:77.95pt;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e274 (14.77)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:70.9pt;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e8 (16.00)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:70.85pt;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e266 (14.74)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:70.9pt;background:yellow;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e1.10\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:70.85pt;background:yellow;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e0.51 to 2.37\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.7pt;background:yellow;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e0.06\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.6pt;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e0.804\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"2\" style=\"width:128.35pt;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003ePrevious hysterectomy\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:77.95pt;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e51 (2.75)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:70.9pt;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e2 (4.00)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:70.85pt;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e49 (2.71)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:70.9pt;background:yellow;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e1.49\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:70.85pt;background:yellow;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e0.35 to 6.32\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.7pt;background:yellow;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e0.30\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.6pt;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e0.646\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"2\" style=\"width:128.35pt;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003ePrevious POP surgery\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:77.95pt;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e376 (20.27)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:70.9pt;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e9 (18.00)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:70.85pt;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e367 (20.33)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:70.9pt;background:yellow;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e0.86\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:70.85pt;background:yellow;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e0.41 to 1.79\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.7pt;background:yellow;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e0.16\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.6pt;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e0.686\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"3\" style=\"width:64.55pt;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003eSurgical procedure\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.8pt;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003eTotal\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:77.95pt;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e1641 (88.46)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:70.9pt;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e46 (92.00)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:70.85pt;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e1595 (88.36)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:70.9pt;background:yellow;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e1.51\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:70.85pt;background:yellow;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e0.54 to 4.25\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"3\" style=\"width:56.7pt;background:yellow;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e0.66\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"3\" style=\"width:49.6pt;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e0.935\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:63.8pt;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003eAnterior\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:77.95pt;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e63 (3.40)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:70.9pt;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e1 (2.00)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:70.85pt;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e62 (3.43)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:70.9pt;background:yellow;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e0.57\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:70.85pt;background:yellow;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e0.08 to 4.22\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:63.8pt;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003ePosterior\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:77.95pt;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e151 (8.14)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:70.9pt;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e3 (6.00)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:70.85pt;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e148 (8.20)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:70.9pt;background:yellow;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e0.72\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:70.85pt;background:yellow;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e0.22 to 2.32\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"2\" style=\"width:128.35pt;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003eConcomitant MUS surgery\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:77.95pt;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e244 (13.15)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:70.9pt;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e7 (14.00)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:70.85pt;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e237 (13.13\u003c/span\u003e\u003cspan style=\"font-size: 13px; font-family: SimSun;\"\u003e）\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:70.9pt;background:yellow;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e1.08\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:70.85pt;background:yellow;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e0.48 to 2.42\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.7pt;background:yellow;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e0.03\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.6pt;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e0.858\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"2\" style=\"width:128.35pt;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003eOperation time, min\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:77.95pt;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e78.73\u0026plusmn;11.41\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:70.9pt;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e81.50\u0026plusmn;12.76\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:70.85pt;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e78.65\u0026plusmn;11.37\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:70.9pt;background:yellow;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e2.85\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:70.85pt;background:yellow;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e-0.36 to 6.06\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.7pt;background:yellow;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e1.74\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.6pt;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e0.082\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"2\" style=\"width:128.35pt;border:none;border-bottom: solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003eEstimated blood lose, ml\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:77.95pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e83.28\u0026plusmn;11.33\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:70.9pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e89.50\u0026plusmn;17.85\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:70.85pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e83.12\u0026plusmn;11.05\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:70.9pt;border:none;border-bottom:solid windowtext 1.0pt;background:yellow;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e5.38\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:70.85pt;border:none;border-bottom:solid windowtext 1.0pt;background:yellow;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e1.28 to 11.48\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.7pt;border:none;border-bottom:solid windowtext 1.0pt;background:yellow;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e2.51\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.6pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e0.015*\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003eValues are presented as mean\u0026plusmn;SD, median (range), and n (percentage)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003eBMI body mass index, MUS mid-urethral slings\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e*P \u0026lt; 0.05\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003eTable 2 POP-Q stage in both groups before and after surgery\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003ctable style=\"border: none;width:740.05pt;margin-left:4.65pt;border-collapse:collapse;\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"7\" style=\"width: 362.25pt;border-top: 1pt solid windowtext;border-left: none;border-bottom: 1pt solid windowtext;border-right: none;padding: 0in 5.4pt;height: 15.9pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003ePre-operative\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.15pt;border-right: none;border-bottom: none;border-left: none;border-image: initial;border-top: 1pt solid windowtext;padding: 0in 5.4pt;height: 15.9pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px; font-family: SimSun;\"\u003e \u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"7\" style=\"width: 363.65pt;border-top: 1pt solid windowtext;border-left: none;border-bottom: 1pt solid windowtext;border-right: none;padding: 0in 5.4pt;height: 15.9pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003ePost-operative (3 months)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"width:57.4pt;border:none;border-bottom: solid black 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:15.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003ePOP-Q stage\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50pt;padding: 0in 5.4pt;height: 15.45pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003ePain\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.45pt;padding: 0in 5.4pt;height: 15.45pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003ePain-free\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width:35.45pt;border:none;border-bottom: solid black 1.0pt;background:yellow;padding:0in 5.4pt 0in 5.4pt;height:15.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003eOR\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width:63.8pt;border:none;border-bottom: solid black 1.0pt;background:yellow;padding:0in 5.4pt 0in 5.4pt;height:15.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e95% CI\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width:49.6pt;border:none;border-bottom: solid black 1.0pt;background:yellow;padding:0in 5.4pt 0in 5.4pt;height:15.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cem\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003ex\u003csup\u003e2\u003c/sup\u003e\u003c/span\u003e\u003c/em\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e\u0026nbsp;value\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width:42.55pt;border:none;border-bottom: solid black 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:15.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cem\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003eP\u003c/span\u003e\u003c/em\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e\u0026nbsp;value\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.15pt;padding: 0in 5.4pt;height: 15.45pt;vertical-align: bottom;\"\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width:54.35pt;border:none;border-bottom: solid black 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:15.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003ePOP-Q stage\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 59.5pt;padding: 0in 5.4pt;height: 15.45pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003ePain\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 59.9pt;padding: 0in 5.4pt;height: 15.45pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003ePain-free\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width:35.2pt;border:none;border-bottom: solid black 1.0pt;background:yellow;padding:0in 5.4pt 0in 5.4pt;height:15.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003eOR\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width:70.25pt;border:none;border-bottom: solid black 1.0pt;background:yellow;padding:0in 5.4pt 0in 5.4pt;height:15.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e95% CI\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width:42.2pt;border:none;border-bottom: solid black 1.0pt;background:yellow;padding:0in 5.4pt 0in 5.4pt;height:15.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cem\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003eZ\u003c/span\u003e\u003c/em\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e\u0026nbsp;value\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width:42.25pt;border:none;border-bottom: solid black 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:15.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cem\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003eP\u003c/span\u003e\u003c/em\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e\u0026nbsp;value\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 50pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 5.4pt;height: 15.9pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003en=50\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.45pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 5.4pt;height: 15.9pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e(n=1805)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.15pt;padding: 0in 5.4pt;height: 15.9pt;vertical-align: bottom;\"\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003ctd style=\"width: 59.5pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 5.4pt;height: 15.9pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e(n=50)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 59.9pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 5.4pt;height: 15.9pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e(n=1805)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 57.4pt;padding: 0in 5.4pt;height: 15.45pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003eStage 0-II\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50pt;padding: 0in 5.4pt;height: 15.45pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e0\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.45pt;padding: 0in 5.4pt;height: 15.45pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e0\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;background: yellow;padding: 0in 5.4pt;height: 15.45pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e-\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;background: yellow;padding: 0in 5.4pt;height: 15.45pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e-\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;background: yellow;padding: 0in 5.4pt;height: 15.45pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e-\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;padding: 0in 5.4pt;height: 15.45pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e-\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.15pt;padding: 0in 5.4pt;height: 15.45pt;vertical-align: bottom;\"\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003ctd style=\"width: 54.35pt;padding: 0in 5.4pt;height: 15.45pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003eStage 0\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 59.5pt;padding: 0in 5.4pt;height: 15.45pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e17(34.00)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 59.9pt;padding: 0in 5.4pt;height: 15.45pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e825(45.70)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.2pt;background: yellow;padding: 0in 5.4pt;height: 15.45pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e-\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.25pt;background: yellow;padding: 0in 5.4pt;height: 15.45pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e-\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"3\" style=\"width:42.2pt;border:none;border-bottom: solid black 1.0pt;background:yellow;padding:0in 5.4pt 0in 5.4pt;height:15.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e-2.07\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"3\" style=\"width:42.25pt;border:none;border-bottom: solid black 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:15.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e0.038*\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 57.4pt;padding: 0in 5.4pt;height: 15.45pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003eStage III\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50pt;padding: 0in 5.4pt;height: 15.45pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e31(62.00)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.45pt;padding: 0in 5.4pt;height: 15.45pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e1168(64.71)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;background: yellow;padding: 0in 5.4pt;height: 15.45pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e-\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;background: yellow;padding: 0in 5.4pt;height: 15.45pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e-\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width:49.6pt;border:none;border-bottom: solid black 1.0pt;background:yellow;padding:0in 5.4pt 0in 5.4pt;height:15.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e0.16\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width:42.55pt;border:none;border-bottom: solid black 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:15.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e0.693\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.15pt;padding: 0in 5.4pt;height: 15.45pt;vertical-align: bottom;\"\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003ctd style=\"width: 54.35pt;padding: 0in 5.4pt;height: 15.45pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003eStage I\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 59.5pt;padding: 0in 5.4pt;height: 15.45pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e29(58.00)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 59.9pt;padding: 0in 5.4pt;height: 15.45pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e950(52.63)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.2pt;background: yellow;padding: 0in 5.4pt;height: 15.45pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e1.48\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.25pt;background: yellow;padding: 0in 5.4pt;height: 15.45pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e0.81 to 2.72\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 57.4pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 5.4pt;height: 15.9pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003eStage IV\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 5.4pt;height: 15.9pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e19(38.00)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.45pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 5.4pt;height: 15.9pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e637(35.29)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;background: yellow;padding: 0in 5.4pt;height: 15.9pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e1.12\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;background: yellow;padding: 0in 5.4pt;height: 15.9pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e0.63 to 2.01\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.15pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 5.4pt;height: 15.9pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px; font-family: SimSun;\"\u003e \u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 54.35pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 5.4pt;height: 15.9pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003eStage II\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 59.5pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 5.4pt;height: 15.9pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e4(8.00)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 59.9pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 5.4pt;height: 15.9pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e30(1.67)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.2pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;background: yellow;padding: 0in 5.4pt;height: 15.9pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e6.47\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.25pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;background: yellow;padding: 0in 5.4pt;height: 15.9pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e20.05 to 20.41\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003eValues are presented as n (percentage)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e*P \u0026lt; 0.05\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003eTable 3 POP-Q values in both groups before and after surgery\u0026nbsp;\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003ctable style=\"width: 97%;border: none;border-collapse:collapse;\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:3.92%;border:none;border-top:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:15.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px; font-family: SimSun;\"\u003e \u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"6\" style=\"width:45.48%;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:15.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003ePre-operaitve\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:1.94%;border:none;border-top:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:15.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px; font-family: SimSun;\"\u003e \u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"6\" style=\"width:48.66%;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:15.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003ePost-operative (3 months)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:3.92%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003ctd style=\"width:8.18%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003ePain\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:8.18%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003ePain-free\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width:7.7%;border:none;border-bottom: solid black 1.0pt;background:yellow;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003eMean difference\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width:9.74%;border:none;border-bottom: solid black 1.0pt;background:yellow;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e95% CI\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width:5.82%;border:none;border-bottom: solid black 1.0pt;background:yellow;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cem\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003et\u003c/span\u003e\u003c/em\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e\u0026nbsp;value\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width:5.84%;border:none;border-bottom: solid black 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cem\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003eP\u003c/span\u003e\u003c/em\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e\u0026nbsp;value\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:1.94%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003ctd style=\"width:8.76%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003ePain\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:8.78%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003ePain-free\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width:7.78%;border:none;border-bottom: solid black 1.0pt;background:yellow;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003eMean difference\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width:9.74%;border:none;border-bottom: solid black 1.0pt;background:yellow;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e95% CI\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width:6.8%;border:none;border-bottom: solid black 1.0pt;background:yellow;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cem\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003et\u003c/span\u003e\u003c/em\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e\u0026nbsp;value\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width:6.82%;border:none;border-bottom: solid black 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cem\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003eP\u003c/span\u003e\u003c/em\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e\u0026nbsp;value\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:3.92%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:15.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px; font-family: SimSun;\"\u003e \u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:8.18%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:15.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e(n=50)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:8.18%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:15.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e(n=1805)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:1.94%;padding:0in 5.4pt 0in 5.4pt;height:15.45pt;\"\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003ctd style=\"width:8.76%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:15.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e(n=50)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:8.78%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:15.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e(n=1805)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:3.92%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003eAa\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:8.18%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e2.08\u0026plusmn;0.60\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:8.18%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e2.06\u0026plusmn;0.92\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:7.7%;background:yellow;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e0.02\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.74%;background:yellow;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e-0.16 to 0.19\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:5.82%;background:yellow;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e0.22\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:5.84%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e0.829\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:1.94%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003ctd style=\"width:8.76%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e-2.41\u0026plusmn;0.81\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:8.78%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e-2.69\u0026plusmn;0.47\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:7.78%;background:yellow;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e0.28\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.74%;background:yellow;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e0.05 to 0.51\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.8%;background:yellow;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e2.43\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.82%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e0.019*\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:3.92%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003eBa\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:8.18%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e3.66\u0026plusmn;1.15\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:8.18%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e3.56\u0026plusmn;0.76\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:7.7%;background:yellow;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e0.10\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.74%;background:yellow;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e-0.23 to 0.43\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:5.82%;background:yellow;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e0.60\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:5.84%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e0.554\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:1.94%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003ctd style=\"width:8.76%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e-2.24\u0026plusmn;1.16\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:8.78%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; 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font-family: \"Times New Roman\", serif;'\u003e2.25\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.82%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e0.029*\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:3.92%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003eC\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:8.18%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e1.90\u0026plusmn;1.39\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:8.18%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e1.95\u0026plusmn;1.50\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:7.7%;background:yellow;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e-0.05\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.74%;background:yellow;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e-0.47 to 0.37\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:5.82%;background:yellow;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e-0.23\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:5.84%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e0.817\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:1.94%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003ctd style=\"width:8.76%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e-4.83\u0026plusmn;1.30\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:8.78%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e-5.29\u0026plusmn;0.67\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:7.78%;background:yellow;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e0.46\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.74%;background:yellow;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e0.09 to 0.83\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.8%;background:yellow;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e2.49\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.82%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e0.016*\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:3.92%;padding:0in 5.4pt 0in 5.4pt;height:15.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003eTvl\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:8.18%;padding:0in 5.4pt 0in 5.4pt;height:15.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e6.58\u0026plusmn;0.57\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:8.18%;padding:0in 5.4pt 0in 5.4pt;height:15.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e6.45\u0026plusmn;0.57\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:7.7%;background:yellow;padding:0in 5.4pt 0in 5.4pt;height:15.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e0.13\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 9.74%;background: yellow;padding: 0in 5.4pt;height: 15.45pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e-0.03 to 0.29\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 5.82%;background: yellow;padding: 0in 5.4pt;height: 15.45pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e0.23\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:5.84%;padding:0in 5.4pt 0in 5.4pt;height:15.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e0.228\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:1.94%;padding:0in 5.4pt 0in 5.4pt;height:15.45pt;\"\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003ctd style=\"width:8.76%;padding:0in 5.4pt 0in 5.4pt;height:15.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e6.62\u0026plusmn;0.56\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:8.78%;padding:0in 5.4pt 0in 5.4pt;height:15.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e6.70\u0026plusmn;0.54\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:7.78%;background:yellow;padding:0in 5.4pt 0in 5.4pt;height:15.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e-0.08\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.74%;background:yellow;padding:0in 5.4pt 0in 5.4pt;height:15.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e-0.23 to 0.07\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.8%;background:yellow;padding:0in 5.4pt 0in 5.4pt;height:15.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e-1.04\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.82%;padding:0in 5.4pt 0in 5.4pt;height:15.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e0.300\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:3.92%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003eAp\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:8.18%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e1.46\u0026plusmn;0.97\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:8.18%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e1.68\u0026plusmn;0.95\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:7.7%;background:yellow;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e-0.22\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.74%;background:yellow;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e-0.49 to 0.05\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:5.82%;background:yellow;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e-1.62\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:5.84%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e0.668\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:1.94%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003ctd style=\"width:8.76%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e-2.73\u0026plusmn;0.37\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:8.78%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e-2.69\u0026plusmn;0.35\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:7.78%;background:yellow;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e-0.04\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.74%;background:yellow;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e-0.13 to 0.06\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.8%;background:yellow;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e-0.75\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.82%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e0.456\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:3.92%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003eBp\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:8.18%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e2.26\u0026plusmn;1.37\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:8.18%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e2.34\u0026plusmn;1.01\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:7.7%;background:yellow;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e-0.08\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.74%;background:yellow;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e-0.48 to 0.31\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:5.82%;background:yellow;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e-0.43\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:5.84%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e0.822\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:1.94%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003ctd style=\"width:8.76%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e-2.62\u0026plusmn;0.40\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:8.78%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e-2.60\u0026plusmn;0.31\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:7.78%;background:yellow;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e-0.02\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.74%;background:yellow;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e-0.13 to 0.10\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.8%;background:yellow;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e-0.33\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.82%;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e0.745\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:3.92%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:15.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003eD\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:8.18%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:15.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e1.63\u0026plusmn;1.72\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:8.18%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:15.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e1.57\u0026plusmn;1.27\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:7.7%;border:none;border-bottom:solid windowtext 1.0pt;background:yellow;padding:0in 5.4pt 0in 5.4pt;height:15.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e0.06\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.74%;border:none;border-bottom:solid windowtext 1.0pt;background:yellow;padding:0in 5.4pt 0in 5.4pt;height:15.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e-0.45 to 0.56\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:5.82%;border:none;border-bottom:solid windowtext 1.0pt;background:yellow;padding:0in 5.4pt 0in 5.4pt;height:15.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e0.23\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:5.84%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:15.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e0.108\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:1.94%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:15.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px; font-family: SimSun;\"\u003e \u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:8.76%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:15.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e-6.00\u0026plusmn;1.37\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:8.78%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:15.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e-6.36\u0026plusmn;0.49\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:7.78%;border:none;border-bottom:solid windowtext 1.0pt;background:yellow;padding:0in 5.4pt 0in 5.4pt;height:15.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e0.36\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.74%;border:none;border-bottom:solid windowtext 1.0pt;background:yellow;padding:0in 5.4pt 0in 5.4pt;height:15.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e-0.04 to 0.76\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.8%;border:none;border-bottom:solid windowtext 1.0pt;background:yellow;padding:0in 5.4pt 0in 5.4pt;height:15.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e1.83\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.82%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:15.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e0.074\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003eValuse are presented as mean\u0026plusmn;SD\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e*P \u0026lt; 0.05\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003eTable 4 Managements for patients in pain group\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003ctable style=\"border: none;width:100.0%;border-collapse:collapse;\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 77.96%;border-top: 1pt solid windowtext;border-left: none;border-bottom: 1pt solid windowtext;border-right: none;padding: 0in 5.4pt;height: 15.9pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003ePrecedure\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 10.64%;border-top: 1pt solid windowtext;border-left: none;border-bottom: 1pt solid windowtext;border-right: none;padding: 0in 5.4pt;height: 15.9pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003eTotal\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 11.4%;border-top: 1pt solid windowtext;border-left: none;border-bottom: 1pt solid windowtext;border-right: none;padding: 0in 5.4pt;height: 15.9pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003eRelief\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 77.96%;padding: 0in 5.4pt;height: 15.45pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003eConservative treatment\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 10.64%;padding: 0in 5.4pt;height: 15.45pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e40\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 11.4%;padding: 0in 5.4pt;height: 15.45pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e16\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 77.96%;padding: 0in 5.4pt;height: 15.45pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e\u0026nbsp; Topical estrogen\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 10.64%;padding: 0in 5.4pt;height: 15.45pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e32\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 11.4%;padding: 0in 5.4pt;height: 15.45pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e-\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 77.96%;padding: 0in 5.4pt;height: 15.45pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e\u0026nbsp; Antibiotics\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 10.64%;padding: 0in 5.4pt;height: 15.45pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e11\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 11.4%;padding: 0in 5.4pt;height: 15.45pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e-\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 77.96%;padding: 0in 5.4pt;height: 15.45pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e\u0026nbsp; Physical therapy\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 10.64%;padding: 0in 5.4pt;height: 15.45pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e35\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 11.4%;padding: 0in 5.4pt;height: 15.45pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e-\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 77.96%;padding: 0in 5.4pt;height: 15.45pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003eSurgical intervention\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 10.64%;padding: 0in 5.4pt;height: 15.45pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e33\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 11.4%;padding: 0in 5.4pt;height: 15.45pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e28\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 77.96%;padding: 0in 5.4pt;height: 15.45pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e\u0026nbsp; Partial mesh removal\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 10.64%;padding: 0in 5.4pt;height: 15.45pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e15\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 11.4%;padding: 0in 5.4pt;height: 15.45pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e12\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 77.96%;padding: 0in 5.4pt;height: 15.45pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e\u0026nbsp; \u0026nbsp; Mesh exposure\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 10.64%;padding: 0in 5.4pt;height: 15.45pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e6\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 11.4%;padding: 0in 5.4pt;height: 15.45pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e5\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 77.96%;padding: 0in 5.4pt;height: 15.45pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;Mesh contracture/folding\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 10.64%;padding: 0in 5.4pt;height: 15.45pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e6\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 11.4%;padding: 0in 5.4pt;height: 15.45pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e6\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 77.96%;padding: 0in 5.4pt;height: 15.45pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e\u0026nbsp; \u0026nbsp; Mesh arms piercing obturator space/ischiorectal fossa\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 10.64%;padding: 0in 5.4pt;height: 15.45pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e1\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 11.4%;padding: 0in 5.4pt;height: 15.45pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e0\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 77.96%;padding: 0in 5.4pt;height: 15.45pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e\u0026nbsp; \u0026nbsp; Anatomy failure\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 10.64%;padding: 0in 5.4pt;height: 15.45pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e2\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 11.4%;padding: 0in 5.4pt;height: 15.45pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e1\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 77.96%;padding: 0in 5.4pt;height: 15.45pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e\u0026nbsp; Complete mesh removal\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 10.64%;padding: 0in 5.4pt;height: 15.45pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e18\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 11.4%;padding: 0in 5.4pt;height: 15.45pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e16\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 77.96%;padding: 0in 5.4pt;height: 15.45pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif;'\u003e\u0026nbsp; \u0026nbsp; Mesh exposure\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 10.64%;padding: 0in 5.4pt;height: 15.45pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"background-color: rgb(255, 255, 255);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size: 13px; 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font-family: \"Times New Roman\", serif;'\u003e0\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size: 13px; font-family: \"Times New Roman\", serif; color: rgb(0, 0, 0); background-color: rgb(255, 255, 255);'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e"}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":true,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":false,"highlight":"","institution":"","isAcceptedByJournal":true,"isAuthorSuppliedPdf":false,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"bmc-womens-health","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"bmwh","sideBox":"Learn more about [BMC Women's Health](http://bmcwomenshealth.biomedcentral.com/)","snPcode":"","submissionUrl":"https://www.editorialmanager.com/bmwh/default.aspx","title":"BMC Women's Health","twitterHandle":"","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"em","reportingPortfolio":"BMC Series","inReviewEnabled":true,"inReviewRevisionsEnabled":true},"keywords":"Transvaginal mesh surgery, Mesh complications, Postoperative pain, Pelvic organ prolapse","lastPublishedDoi":"10.21203/rs.3.rs-38744/v2","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-38744/v2","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003e\u003cstrong\u003eBackground:\u003c/strong\u003e The purpose of this study was to investigate the relevant factors of pain after transvaginal mesh (TVM) surgery for the treatment of pelvic organ prolapse and to analyse the management and relief of the pain.\u003c/p\u003e\u003cp\u003e\u003cstrong\u003eMethods: \u003c/strong\u003eA multicentre retrospective study of a clinical database of patients who underwent TVM surgery was conducted, and pain related aspects were analysed.\u003c/p\u003e\u003cp\u003e\u003cstrong\u003eResults:\u003c/strong\u003e A total of 1855 patients were included in the study. We divided the patients into two groups: pain-free (1805 patients) and pain (50 patients) group. The incidence of pain after TVM surgery was 2.70%, with a median occurrence time of 7.5 months. Pain mainly involved the vagina, perineum, buttocks, groin, inner thighs, and lower abdomen. Excessive intraoperative blood loss (OR=1.284, 95%CI 0.868-2.401) and postoperative anatomic failure (OR=1.577, 95%CI 0.952-3.104) were analysed as risk factors with statistical significance. Mesh exposure rate in the pain group was 38%, showing a significant difference between the groups (P\u0026lt;0.01). Forty patients underwent non-surgical treatment, with a relief rate of 40.0%, 33 patients received surgical treatment, 15 underwent partial mesh removal, and 18 underwent complete mesh removal, with a relief rate of 84.8%. The total relief rate was 88% within all 50 patients suffering from pain.\u003c/p\u003e\u003cp\u003e\u003cstrong\u003eConclusions: \u003c/strong\u003eExcessive intraoperative bleeding and unsatisfactory postoperative anatomic outcomes can increase the risk of postoperative pain; mesh exposure is also associated with the pain. Most patients can get pain relief with proper management, more than half of whom may need mesh removal with differing approach.\u0026nbsp;\u003c/p\u003e","manuscriptTitle":"Clinical analysis of pain after transvaginal mesh surgery in patients with pelvic organ prolapse","msid":"","msnumber":"","nonDraftVersions":[{"code":2,"date":"2020-10-26 17:58:14","doi":"10.21203/rs.3.rs-38744/v2","editorialEvents":[{"type":"communityComments","content":0},{"type":"decision","content":"Minor revision","date":"2021-01-18T00:00:00+00:00","index":"","fulltext":""},{"type":"reviewerAgreed","content":"","date":"2021-01-15T00:00:00+00:00","index":1,"fulltext":""},{"type":"editorInvitedReview","content":"","date":"2021-01-15T00:00:00+00:00","index":1,"fulltext":"Recommendation: Accept without revision\nForm responses:\n---\n\nComments to Author:\n---\nThe Authors have adequately addressed the critical issues raised by the Reviewers and the overall quality of the Manuscript is satisfactory now. For this reason, no further changes are required.* Publons Reviewer Recognition. Springer Nature can send verification of this review directly to Publons (a subsidiary of Clarivate Analytics). If you would like to take advantage of this service, please click on the “Yes” option below. Your name, email address, title of the reviewed manuscript, name of the journal, and date of your review submission (the “Review Data”) will then be transmitted to Publons upon publication of the manuscript. If you have already registered at Publons, they will notify you of the receipt of this review and update your profile as per your settings and their policy. If you are not registered with Publons, you will receive an email from them asking you to register in order for them to be able to recognize your review on your new profile page. Publons may use the Review Data to generate derivative metadata for the benefit of Publons and you as a reviewer, carefully considering the sensitivity of such information. For example, Publons may verify your record as a reviewer by updating your profile published on its webservice if you have registered for such service or help editors to identify candidate reviewers. Please find the details of processing in Publons’ privacy policy https://publons.com/about/terms: **No**\n* Declaration of competing interests: **I declare that I have no competing interests.**\n* Reviewer Publication Consent. I agree for my report to be made available under an Open Access Creative Commons CC-BY License (http://creativecommons.org/licenses/by/4.0) if this manuscript is accepted for publication. Any comments that I do not wish to be included in the published report have been included as confidential comments to the editor, which will not be published.: **I agree to the terms of the CC-BY 4.0 license; please do not publish my name with my report. (default)**\n* Is the study design appropriate to answer the research question (including the use of appropriate controls), and are the conclusions supported by the evidence presented?: **Yes**\n* Are the methods sufficiently described to allow the study to be repeated?: **Yes**\n* Is the use of statistics and treatment of uncertainties appropriate?: **Yes**\n* Is the presentation of the work clear?: **Yes**\n* Are the images in this manuscript (including electrophoretic gels and blots) free from apparent manipulation?: **Yes**\n"},{"type":"reviewersInvited","content":"","date":"2021-01-12T00:00:00+00:00","index":"","fulltext":""},{"type":"editorAssigned","content":"","date":"2020-10-20T12:00:00+00:00","index":"","fulltext":""},{"type":"checksComplete","content":"","date":"2020-10-19T12:00:00+00:00","index":"","fulltext":""},{"type":"editorInvited","content":"","date":"2020-10-19T12:00:00+00:00","index":"","fulltext":""}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"bmc-womens-health","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"bmwh","sideBox":"Learn more about [BMC Women's Health](http://bmcwomenshealth.biomedcentral.com/)","snPcode":"","submissionUrl":"https://www.editorialmanager.com/bmwh/default.aspx","title":"BMC Women's Health","twitterHandle":"","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"em","reportingPortfolio":"BMC Series","inReviewEnabled":true,"inReviewRevisionsEnabled":true}},{"code":1,"date":"2020-07-30 14:21:54","doi":"10.21203/rs.3.rs-38744/v1","editorialEvents":[{"type":"communityComments","content":0},{"type":"decision","content":"Major revision","date":"2020-09-21T12:00:00+00:00","index":"","fulltext":""},{"type":"editorInvitedReview","content":"","date":"2020-09-18T12:00:00+00:00","index":6,"fulltext":"Recommendation: Reviewer's comments unavailable pending editorial decision\n"},{"type":"editorInvitedReview","content":"","date":"2020-09-18T12:00:00+00:00","index":3,"fulltext":"Recommendation: Reject\nForm responses:\n---\n\nComments to Author:\n---\nMy comments,\n1.Under the method\n 1.1. the operation was done by experienced urogynecologist but in the conclusion part recommended surgery should be better done by experienced surgeons. How do explain this contradictions?\n 1.2. how do you control those patients presented pain may from different origin eg. pelvic mass, urinary tract infection, others after operation\n2. Result\n 2.1. The figure color selection is not clear better to use another color.\n3. Discussion\n Almost all discussion contents are not arise from result. It contains personal opinion, scientific facts. All part of the discussion should be re-write based on the findings.\n4. conclusion\n \u003e\u003e\u003e should based on from results\n* Publons Reviewer Recognition. Springer Nature can send verification of this review directly to Publons (a subsidiary of Clarivate Analytics). If you would like to take advantage of this service, please click on the “Yes” option below. Your name, email address, title of the reviewed manuscript, name of the journal, and date of your review submission (the “Review Data”) will then be transmitted to Publons upon publication of the manuscript. If you have already registered at Publons, they will notify you of the receipt of this review and update your profile as per your settings and their policy. If you are not registered with Publons, you will receive an email from them asking you to register in order for them to be able to recognize your review on your new profile page. Publons may use the Review Data to generate derivative metadata for the benefit of Publons and you as a reviewer, carefully considering the sensitivity of such information. For example, Publons may verify your record as a reviewer by updating your profile published on its webservice if you have registered for such service or help editors to identify candidate reviewers. Please find the details of processing in Publons’ privacy policy https://publons.com/about/terms: **No**\n* Declaration of competing interests: **'I declare that I have no competing interests.**\n* Reviewer Publication Consent. I agree for my report to be made available under an Open Access Creative Commons CC-BY License (http://creativecommons.org/licenses/by/4.0) if this manuscript is accepted for publication. Any comments that I do not wish to be included in the published report have been included as confidential comments to the editor, which will not be published.: **I agree to the terms of the CC-BY 4.0 license; please do not publish my name with my report. (default)**\n* Is the study design appropriate to answer the research question (including the use of appropriate controls), and are the conclusions supported by the evidence presented?: **No**\n* Are the methods sufficiently described to allow the study to be repeated?: **No**\n* Is the use of statistics and treatment of uncertainties appropriate?: **No**\n* Is the presentation of the work clear?: **No**\n* Are the images in this manuscript (including electrophoretic gels and blots) free from apparent manipulation?: **No**\n"},{"type":"editorInvitedReview","content":"","date":"2020-09-13T12:00:00+00:00","index":2,"fulltext":"Recommendation: Accept without revision\nForm responses:\n---\n\nComments to Author:\n---\nPlease include all comments for the authors in this box rather than uploading your report as an attachment. Please only upload as attachments annotated versions of manuscripts, graphs, supporting materials or other aspects of your report which cannot be included in a text format.\n\nPlease overwrite this text when adding your comments to the authors.* Publons Reviewer Recognition. Springer Nature can send verification of this review directly to Publons (a subsidiary of Clarivate Analytics). If you would like to take advantage of this service, please click on the “Yes” option below. Your name, email address, title of the reviewed manuscript, name of the journal, and date of your review submission (the “Review Data”) will then be transmitted to Publons upon publication of the manuscript. If you have already registered at Publons, they will notify you of the receipt of this review and update your profile as per your settings and their policy. If you are not registered with Publons, you will receive an email from them asking you to register in order for them to be able to recognize your review on your new profile page. Publons may use the Review Data to generate derivative metadata for the benefit of Publons and you as a reviewer, carefully considering the sensitivity of such information. For example, Publons may verify your record as a reviewer by updating your profile published on its webservice if you have registered for such service or help editors to identify candidate reviewers. Please find the details of processing in Publons’ privacy policy https://publons.com/about/terms: **No**\n* Declaration of competing interests: **I declare that I have no competing interests'**\n* Reviewer Publication Consent. I agree for my report to be made available under an Open Access Creative Commons CC-BY License (http://creativecommons.org/licenses/by/4.0) if this manuscript is accepted for publication. Any comments that I do not wish to be included in the published report have been included as confidential comments to the editor, which will not be published.: **I agree to the terms of the CC-BY 4.0 license; please do not publish my name with my report. (default)**\n* Is the study design appropriate to answer the research question (including the use of appropriate controls), and are the conclusions supported by the evidence presented?: **Yes**\n* Are the methods sufficiently described to allow the study to be repeated?: **Yes**\n* Is the use of statistics and treatment of uncertainties appropriate?: **Yes**\n* Is the presentation of the work clear?: **Yes**\n* Are the images in this manuscript (including electrophoretic gels and blots) free from apparent manipulation?: **Yes**\n"},{"type":"reviewerAgreed","content":"","date":"2020-09-11T12:00:00+00:00","index":6,"fulltext":""},{"type":"reviewerAgreed","content":"","date":"2020-09-07T12:00:00+00:00","index":4,"fulltext":""},{"type":"reviewerAgreed","content":"","date":"2020-09-07T12:00:00+00:00","index":5,"fulltext":""},{"type":"reviewerAgreed","content":"","date":"2020-09-06T12:00:00+00:00","index":2,"fulltext":""},{"type":"reviewerAgreed","content":"","date":"2020-09-06T12:00:00+00:00","index":3,"fulltext":""},{"type":"editorInvitedReview","content":"","date":"2020-08-17T12:00:00+00:00","index":1,"fulltext":"Recommendation: Accept after minor essential revisions\nForm responses:\n---\n\nComments to Author:\n---\nI read with great interest the Manuscript titled \"Clinical analysis of pain after transvaginal mesh surgery in patients with pelvic organ prolapse\" (BMWH-D-20-00702R1), which falls within the aim of BMC Women's Health. The Authors aimed to investigate the relevant factors of pain after transvaginal mesh surgery for the treatment of pelvic organ prolapse, and to analyze the management and relief of the pain. \nIn my honest opinion, the topic is interesting enough to attract the readers' attention. Nevertheless, the authors should clarify some points and improve the discussion citing relevant and novel key articles about the topic.\n\nAuthors should consider the following recommendations:\n\n- The Manuscript should be further revised by a native English speaker in order to improve readability.\n- The Authors did not mention the sample size calculation for their study. It is essential to specify this data in order to guarantee an adequate significance of the results obtained by the Authors.\n- In the Results section, the Authors have simply reported the p values from which however it is not possible to deduce the real clinical relevance of the highlighted statistical significance. In order to better understand the results obtained, I strongly suggest reporting not only the p values but also the corresponding confidence intervals and the effect size of the comparisons.\n- What are the actual clinical implications of this study? it is important to report the results obtained by the authors in the context of clinical practice and to adequately highlight what contribution this study adds to the literature already existing on the topic and to future study perspectives.\n- Although several approaches are able for the management of POP, the best strategy in case of recurrence after vaginal vault prolapse still remains debated. I would discuss the available evidence about novel techniques, referring to: PMID: 29675427; PMID: 29038834.\n- Pelvic organ prolapse is a very common condition in female population with a severe impact on quality of life and a significant impairment of sexual function; for this reason, a multidisciplinary approach is recommended for an accurate management. I would stress this point, discussing some key articles: PMID: 29672997; PMID: 29508043; PMID: 28589780.\n* Publons Reviewer Recognition. Springer Nature can send verification of this review directly to Publons (a subsidiary of Clarivate Analytics). If you would like to take advantage of this service, please click on the “Yes” option below. Your name, email address, title of the reviewed manuscript, name of the journal, and date of your review submission (the “Review Data”) will then be transmitted to Publons upon publication of the manuscript. If you have already registered at Publons, they will notify you of the receipt of this review and update your profile as per your settings and their policy. If you are not registered with Publons, you will receive an email from them asking you to register in order for them to be able to recognize your review on your new profile page. Publons may use the Review Data to generate derivative metadata for the benefit of Publons and you as a reviewer, carefully considering the sensitivity of such information. For example, Publons may verify your record as a reviewer by updating your profile published on its webservice if you have registered for such service or help editors to identify candidate reviewers. Please find the details of processing in Publons’ privacy policy https://publons.com/about/terms: **No**\n* Declaration of competing interests: **I declare that I have no competing interests.**\n* Reviewer Publication Consent. I agree for my report to be made available under an Open Access Creative Commons CC-BY License (http://creativecommons.org/licenses/by/4.0) if this manuscript is accepted for publication. Any comments that I do not wish to be included in the published report have been included as confidential comments to the editor, which will not be published.: **I agree to the terms of the CC-BY 4.0 license; please do not publish my name with my report. (default)**\n* Is the study design appropriate to answer the research question (including the use of appropriate controls), and are the conclusions supported by the evidence presented?: **Yes**\n* Are the methods sufficiently described to allow the study to be repeated?: **Yes**\n* Is the use of statistics and treatment of uncertainties appropriate?: **Yes**\n* Is the presentation of the work clear?: **Yes**\n* Are the images in this manuscript (including electrophoretic gels and blots) free from apparent manipulation?: **Yes**\n"},{"type":"reviewerAgreed","content":"","date":"2020-08-08T12:00:00+00:00","index":1,"fulltext":""},{"type":"editorAssigned","content":"","date":"2020-08-07T12:00:00+00:00","index":"","fulltext":""},{"type":"reviewersInvited","content":"","date":"2020-08-07T12:00:00+00:00","index":"","fulltext":""},{"type":"checksComplete","content":"","date":"2020-07-28T12:00:00+00:00","index":"","fulltext":""},{"type":"editorInvited","content":"","date":"2020-07-27T12:00:00+00:00","index":"","fulltext":""}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"bmc-womens-health","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"bmwh","sideBox":"Learn more about [BMC Women's Health](http://bmcwomenshealth.biomedcentral.com/)","snPcode":"","submissionUrl":"https://www.editorialmanager.com/bmwh/default.aspx","title":"BMC Women's Health","twitterHandle":"","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"em","reportingPortfolio":"BMC Series","inReviewEnabled":true,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"a5d7e6f1-9f50-4118-8e39-69f72b582aac","owner":[],"postedDate":"October 26th, 2020","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"published-in-journal","subjectAreas":[{"id":889360,"name":"Internal Medicine"},{"id":889361,"name":"Preventive Medicine"}],"tags":[],"updatedAt":"2021-01-31T15:02:32+00:00","versionOfRecord":{"articleIdentity":"rs-38744","link":"https://doi.org/10.1186/s12905-021-01192-w","journal":{"identity":"bmc-womens-health","isVorOnly":false,"title":"BMC Women's Health"},"publishedOn":"2021-01-30 15:00:39","publishedOnDateReadable":"January 30th, 2021"},"versionCreatedAt":"2020-10-26 17:58:14","video":"","vorDoi":"10.1186/s12905-021-01192-w","vorDoiUrl":"https://doi.org/10.1186/s12905-021-01192-w","workflowStages":[]},"version":"v2","identity":"rs-38744","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-38744","identity":"rs-38744","version":["v2"]},"buildId":"GqpaHPwrfC8PjnIFayRh5","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}