Diagnosis and management of uterine fibroids: current trends and future strategies

Azaz Ahmad, Manoj Kumar, Nihar Ranjan Bhoi, Badruddeen Badruddeen, Juber Akhtar, Mohammad Irfan Khan, Mohd Ajmal, Mohammad Ahmad
In: Journal of Basic and Clinical Physiology and Pharmacology · 2023 · vol. 34(3) , pp. 291–310 · doi:10.1515/jbcpp-2022-0219 · PMID:36989026 · W4361294286
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This review discusses the diagnosis and management of uterine fibroids, highlighting their common symptoms, prevalence, and current treatment options, while calling for further gene-level research for more efficient disease treatment.

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Abstract

Uterine fibroids (UFs), leiomyomas or myomas, are a type of malignancy that affects the smooth muscle of the uterus, and it is most commonly detected in women of reproductive age. Uterine fibroids are benign monoclonal growths that emerge from uterine smooth muscle cells (myometrium) as well as fibroblasts. Uterine fibroid symptoms include abnormal menstrual bleeding leading to anaemia, tiredness, chronic vaginal discharge, and pain during periods. Other symptoms include protrusion of the abdomen, pain during intercourse, dysfunctions of bladder/bowel leading to urinary incontinence/retention, pain, and constipation. It is also associated with reproductive issues like impaired fertility, conceiving complications, and adverse obstetric outcomes. It is the leading cause of gynaecological hospitalisation in the American subcontinent and a common reason for the hysterectomy. Twenty-five percent of the reproductive women experience the symptoms of uterine fibroids, and among them, around 25% require hospitalization due to the severity of the disease. The frequency of the disease remains underestimated as many women stay asymptomatic and symptoms appear gradually; therefore, the condition remains undiagnosed. The exact frequency of uterine fibroids varies depending on the diagnosis, and the population investigated; nonetheless, the incidence of uterine fibroids in reproductive women ranges from 5.4 percent to 77 percent. The uterine fibroid treatment included painkillers, supplementation with iron, vitamin D3, birth control, hormone therapy, gonadotropin-releasing hormone (GnRH) agonists, drugs modulating the estrogen receptors, and surgical removal of the fibroids. However, more research needed at the level of gene to get a keen insight and treat the disease efficiently.

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