Human Epididymal Secretory Protein 4 of Early Diagnosis Value for Endometrial Cancer: A Systematic Review and Meta Analysis

Human Epididymal Secretory Protein 4 of Early Diagnosis Value for Endometrial Cancer: A Systematic Review and Meta Analysis | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Human Epididymal Secretory Protein 4 of Early Diagnosis Value for Endometrial Cancer: A Systematic Review and Meta Analysis Jie Yuan, Chen Xu, ChunYong Liu, ruiling Yan This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-4577128/v1 This work is licensed under a CC BY 4.0 License Status: Under Review Version 1 posted 9 You are reading this latest preprint version Abstract Objective The diagnostic value of Human Epididymal Secretory Protein 4 (HE4) for Endometrial Cancer (EC) was assessed using Evidence-based medicine (EBM) and Systematic Review (SR) methodologies. Methods Relevant literature was obtained from databases such as The Cochrane Library, PubMed, Web of Science, EMBASE, CBM, CNKI, and Wan Fang Data up to April 1st, 2024. The Quality Assessment of Diagnostic Accuracy Studies 2 (QUADAS-2) tool was utilized to evaluate the quality of the selected studies. Meta-analysis was conducted using Revman 5.3, STATA 16.1, and Meta-disc software. Results The analysis of 22 selected studies, comprising 3776 cases in the case group and 5260 cases in the control group with a total sample size of 9036 cases, revealed that HE4 exhibited a pooled sensitivity of 0.59 [95%CI (0.53, 0.64)], specificity of 0.93 [95%CI (0.88, 0.96)], positive likelihood ratio (PLR) of 6.87 [95%CI (4.57, 10.33)], negative likelihood ratio (NLR) of 0.46 [95%CI (0.39, 0.54)], diagnostic odds ratio (DOR) of 14.36 [95%CI (9.37, 21.17)], and area under the pooled receiver operating characteristic curve (AUC) of 0.78 [95%CI (0.75, 0.82)]. Conclusions HE4 demonstrates high specificity and moderate sensitivity in diagnosing EC, offering valuable assistance to clinicians either alone or in conjunction with other tumor markers. Human Epididymal Secretory Protein 4 Endometrial Cancer Diagnostic value Systematic Review Full Text Additional Declarations No competing interests reported. Supplementary Files fourfoldtablesoriginaldatas.xlsx Cite Share Download PDF Status: Under Review Version 1 posted Editorial decision: Revision requested 18 Jul, 2024 Reviews received at journal 15 Jul, 2024 Reviewers agreed at journal 12 Jul, 2024 Reviews received at journal 07 Jul, 2024 Reviewers agreed at journal 01 Jul, 2024 Reviewers invited by journal 01 Jul, 2024 Editor assigned by journal 28 Jun, 2024 Submission checks completed at journal 26 Jun, 2024 First submitted to journal 13 Jun, 2024 You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-4577128","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":327661328,"identity":"c684da76-2e22-4d2a-8aa7-43ebf13889c1","order_by":0,"name":"Jie 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4, Endometrial Cancer, Diagnostic value, Systematic Review","lastPublishedDoi":"10.21203/rs.3.rs-4577128/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-4577128/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003ch2\u003eObjective\u003c/h2\u003e \u003cp\u003e The diagnostic value of Human Epididymal Secretory Protein 4 (HE4) for Endometrial Cancer (EC) was assessed using Evidence-based medicine (EBM) and Systematic Review (SR) methodologies.\u003c/p\u003e\u003ch2\u003eMethods\u003c/h2\u003e \u003cp\u003eRelevant literature was obtained from databases such as The Cochrane Library, PubMed, Web of Science, EMBASE, CBM, CNKI, and Wan Fang Data up to April 1st, 2024. The Quality Assessment of Diagnostic Accuracy Studies 2 (QUADAS-2) tool was utilized to evaluate the quality of the selected studies. Meta-analysis was conducted using Revman 5.3, STATA 16.1, and Meta-disc software.\u003c/p\u003e\u003ch2\u003eResults\u003c/h2\u003e \u003cp\u003eThe analysis of 22 selected studies, comprising 3776 cases in the case group and 5260 cases in the control group with a total sample size of 9036 cases, revealed that HE4 exhibited a pooled sensitivity of 0.59 [95%CI (0.53, 0.64)], specificity of 0.93 [95%CI (0.88, 0.96)], positive likelihood ratio (PLR) of 6.87 [95%CI (4.57, 10.33)], negative likelihood ratio (NLR) of 0.46 [95%CI (0.39, 0.54)], diagnostic odds ratio (DOR) of 14.36 [95%CI (9.37, 21.17)], and area under the pooled receiver operating characteristic curve (AUC) of 0.78 [95%CI (0.75, 0.82)].\u003c/p\u003e\u003ch2\u003eConclusions\u003c/h2\u003e \u003cp\u003eHE4 demonstrates high specificity and moderate sensitivity in diagnosing EC, offering valuable assistance to clinicians either alone or in conjunction with other tumor markers.\u003c/p\u003e","manuscriptTitle":"Human Epididymal Secretory Protein 4 of Early Diagnosis Value for Endometrial Cancer: A Systematic Review and Meta Analysis","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2024-07-18 16:57:58","doi":"10.21203/rs.3.rs-4577128/v1","editorialEvents":[{"type":"communityComments","content":0},{"type":"decision","content":"Revision requested","date":"2024-07-18T07:45:04+00:00","index":"","fulltext":""},{"type":"editorInvitedReview","content":"","date":"2024-07-15T13:08:34+00:00","index":"hide","fulltext":""},{"type":"reviewerAgreed","content":"161297957838787907579894760625182449361","date":"2024-07-12T13:25:58+00:00","index":"hide","fulltext":""},{"type":"editorInvitedReview","content":"","date":"2024-07-07T12:40:38+00:00","index":"hide","fulltext":""},{"type":"reviewerAgreed","content":"198052934939190914190261145303227771355","date":"2024-07-02T03:54:02+00:00","index":"hide","fulltext":""},{"type":"reviewersInvited","content":"","date":"2024-07-01T12:21:07+00:00","index":"","fulltext":""},{"type":"editorAssigned","content":"","date":"2024-06-28T14:21:15+00:00","index":"","fulltext":""},{"type":"checksComplete","content":"","date":"2024-06-26T08:58:44+00:00","index":"","fulltext":""},{"type":"submitted","content":"Discover Oncology","date":"2024-06-13T15:17:01+00:00","index":"","fulltext":""}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"discover-oncology","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"dion","sideBox":"Learn more about [Discover Oncology](https://www.springer.com/12672)","snPcode":"","submissionUrl":"","title":"Discover Oncology","twitterHandle":"","acdcEnabled":true,"dfaEnabled":true,"editorialSystem":"stoa","reportingPortfolio":"Discover Series","inReviewEnabled":true,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"1bc3ad75-bdb2-432b-b3d8-8178f90468b2","owner":[],"postedDate":"July 18th, 2024","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"under-review","subjectAreas":[],"tags":[],"updatedAt":"2024-08-13T07:26:04+00:00","versionOfRecord":[],"versionCreatedAt":"2024-07-18 16:57:58","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-4577128","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-4577128","identity":"rs-4577128","version":["v1"]},"buildId":"qtupq5eGEP_6zYnWcrvyt","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}