Nickel toxicity to safflower seed germination and seedling morpho-anatomy

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The effects of 0, 0.75, 1.0, 3.0, 5.0, 10.0-, and 15.0-mM Ni on seed germination rate, protein, and pigment content of germinating seeds were investigated. Also, the toxicity of 0.75 mM Ni on plant growth, malondialdehyde (MDA) amount, and anatomy of 21-day-old safflower seedlings’ roots, stems, and leaves were determined. While Ni (especially higher than 3.0 mM) adversely affected the germination rate, radicle length, protein, and pigment content of safflower seeds, it also negatively affected the biomass production, plant length, leaf number, MDA amount, as well as some cell size/structure of roots (endodermis, phloem, trachea), stems (trachea and tracheid), and leaves (epidermis and sponge parenchyma) of safflower seedlings. Our results revealed that seedling growth was more sensitive to Ni exposure than germination. Although severe toxic effects were observed in 0.75 mM Ni treatment for plant growth parameters, seed germination only started to be highly affected at concentrations higher than 3.0 mM Ni. Carthamus tinctorius L. Crop Heavy metal Ni Stress Figures Figure 1 Figure 2 Figure 3 Figure 4 Figure 5 Figure 6 Figure 7 Figure 8 Figure 9 1. Introduction Increased human activity, rapid industrialization, and contemporary farming practices have contributed to heavy metal contamination, which is hazardous to the biota. Significant tracts of land face the risk of being contaminated with various metals due to industrial waste, the prevalent usage of pesticides and fertilizers, and the release of heavy metals from metalliferous mines. Ni is one of these heavy metals in soil that is rapidly rising to the top of the list of global environmental problems (Singh et al. 2016 ; Prasad 2005 ). Germination is the first response of defense against unfavorable environmental conditions. Ni is known to inhibit seed germination in different plant species (Moosavi et al. 2016). Especially the early stages of seed germination have been shown to be gradually affected by Ni in high concentrations. Ni prevents the uptake of water during the imbibition phase, thereby stopping the onset of seed germination. Ni harms protein synthesis, the recovery of K and Mg, and the reactivation of oxygen in seeds during germination (Ashraf et al. 2011 ). Moreover, it is reported that during the process of germination, some key glycolytic and proteolytic enzymes for initiating seed germination, such as α-amylase and protease, are negatively affected by Ni. Thus, Ni can prevent sugars from being converted from starch, which is essential to provide energy to the growing plumule and radicle (Ashraf et al. 2011 ). Ni has the ability to penetrate the seed coat, a crucial component of the first line of defense against abiotic stressors, alters numerous physiological processes involved in germination, and determines their impact on imbibition and radicle elongation (Moreira et al. 2020). Some plants have the capacity to adsorb Ni ions in their seed coats, which prevents Ni from reaching the embryo and protects the seeds while germinating. According to some studies, certain seeds can germinate in the presence of high concentrations of Ni, but seedling growth may be impaired (Moreira et al. 2020). In addition to its toxic effects on germination, Ni also causes changes in plant physiology, morphology, and anatomy. Vital plant biomolecules, such as enzymes, membranes, and proteins can be directly damaged by Ni. Furthermore, Ni can also disrupt many physiological processes, as it easily wins the competition against other essential metals, such as Mg and Fe. Because Ni reduces the photosynthetic efficiency, morphologic parameters like biomass are directly affected by its toxicity. The uptake of Ni is known to trigger anatomical changes in various plant organs. It has been shown that heavy metals can alter several cell types, such as parenchymatous tissue in the cortex, pith, sclerenchyma, and xylem vessels in the roots. Thus, root diameter shrinkage may occur (Batool et al. 2015 ). Consequently, the movement of water can be interrupted from underground to aerial parts. Ni stress also modifies stem and root anatomy. It is reported that metals have negative impacts on the size of mesophyll parenchyma, vascular bundles, epidermal cells, and the diameter of xylem vessels. In addition, stomatal deformation, and alterations of their density in the adaxial and abaxial sides of leaves have also been reported under Ni stress (Molas, 1998; Batool et al. 2015 ; Ribeiro et al. 2020 ). Ultimately, these anatomical stress responses directly affect crucial physiological processes such as transpiration, photosynthesis, and gas exchange. Safflower ( Carthamus tinctorius L.) is a plant that belongs to the Asteraceae family. With its ability to tolerate conditions such as drought, salt, and metal stress, safflower is a notable oilseed crop used in bioenergy production and phytoremediation (Al Chami et al. 2015 ; Pourghasemian et al. 2019 ; Çulha-Erdal et al. 2021; Baran and Ekmekci, 2022). According to the data of the Seed Registration and Certification Central Directorate (TTSM, 2021), there are 15 safflower cultivars registered in Türkiye, and the cultivar Olas, which stands out with its high oil content and yield, was registered in 2015 and (Arslan and Culpan, 2020 ). The anatomic responses of safflower to heavy metal stress, particularly Ni, are still poorly understood. Identification of alterations in the morpho-anatomical structure of safflower seedlings and the change in some seed germination parameters in Ni-exposed safflower seeds to widely understand this plant’s tolerance and toxicity responses to Ni was the goal of this study. 2. Material and methods 2.1. Plant material Seeds of safflower ( C. tinctorius ) cultivar Olas were procured from Trakya Agricultural Research Institute, Edirne. 2.2. Germination experiments and seedling growth Uniform safflower seeds were selected, and surfaces were sterilized with %5 sodium hypochlorite for 5 min, then washed with distilled water 10 times. After the sterilization step, safflower seeds were germinated under dark conditions at 23±2°C for 4 days. In the germination experiments, treatment series were set up using 0, 0.75, 1.0, 3.0, 5.0, 10.0, and 15.0 mM concentrations of Ni (NiCl 2 .6H 2 O) solution, while in the control series, only distilled water was used. Moreover, to ensure that the negative impacts of NiCl 2 were solely on Ni, the effect of 50 mM NaCl and KCl on germination rate was also tested. To calculate the germination rate, petri dishes were checked daily for 3 days. Radicle lengths were recorded every day. Seeds were considered germinated when a root had emerged over 5 mm. For morpho-anatomic and physiologic tests, following the method in our previous study (Baran and Ekmekçi, 2022 ), safflower seedlings were transferred to a hydroponic culture containing Hoagland’s nutrient solution after germination and were grown for 10 days in a control condition. On the 10th day of the growth, Ni stress was treated by applying Hoagland's nutrient solution containing 0.75 mM Ni for the next 7 days. All experiments were carried out in a growth cabinet (Nüve, TK-600) at 23°C, 16/8 hours light/dark photoperiod, 180–200 µmol.m − 1 s − 1 light intensity and 40–50% humidity. Experiments were terminated, and plants were harvested on the 21st day. 2.3. Determination of total protein of seeds For the determination of total protein, 0.02 mg of 72-hour-old germinating seeds were homogenized using 750 µl of 100 mM potassium phosphate buffer (pH 7.5) with 1 mM EDTA and 1% PVP-40. Homogenized samples were centrifuged with Nüve NF 800R at 14.000 rpm for 20 min at 4°C. Bradford ( 1976 )’s method was followed to determine the protein content from supernatants at 595 nm using a Soif UV/Vis 5100 Optical Instruments spectrophotometer. Bovine serum albumin was used to prepare a standard curve and protein content was calculated as g seed − 1 . 2.4. Determination of pigment content of seeds Chlorophyll a, b, and carotenoid contents in 72-hour-old cotyledons of safflower were determined according to Lichtenthaler ( 1987 ). In 1 ml 100% acetone, 0.03 g of cotyledons were grounded for extraction, and then the extracts were centrifuged at 3500 rpm for 5 min. The absorbance of the samples was recorded at 470 nm for carotenoids, 644.8 nm for chlorophyll b, and 661.6 nm for chlorophyll a. 2.5 Determination of malondialdehyde (MDA) amount of seedlings The amount of MDA, the last product of membrane damage, was determined using Esterbauer and Cheeseman (X)’s method. 0.1 g of leaf (fresh weight; FW) samples taken from plants were homogenized with 0.1% trichloroacetic acid (TCA) at 4°C. The homogenate was centrifuged at 10000 rpm for 15 minutes. Then, 0.5 ml supernatant was added to a glass tube with 1 ml TCA-TBA-HCl (15% trichloroacetic acid, 0.375% thiobarbituric acid, 0.25 N HCl) solution and 0.5 ml tris/HCl buffer (from a 0.1 M solution with 7.6 pH). The solution was heated for 45 minutes in a 97°C water bath. After this step, the solution was centrifuged at 10000 rpm for 5 minutes. Absorbance values at 532 and 600 nm wavelengths were recorded. The MDA amount in leaf tissues was calculated as g FW − 1 . 2.6. Morphologic and anatomic measurements of seedlings The fresh and dry weight (DW) of roots and shoots of safflower were determined as g and dg plant − 1 , while their lengths were determined as cm plant − 1 . For DW measurement, plant parts were oven-dried at 80°C until a constant weight was obtained. For the anatomical studies, Johansen ( 1940 ) and Ma et al. ( 1993 ) were followed in the sectioning and staining methods with modifications. 3 mm pieces were taken from the root, stem, and leaf of safflowers. The plant sections were fixed in 70% ethanol for 48 hours, after that they proceeded through a series of xylol and ethyl alcohol at 70, 90, and 96%. Then the plant parts were embedded in paraffin and sectioned by a sliding microtome at thicknesses of 10–15 µm. To remove the paraffin from the sections, the samples were placed in an oven set at 65°C. After that, the samples were exposed to the xylol and ethyl alcohol series, soaked in saffron all night long, following stained for 20 seconds using fast green. Measurements and photographs were taken with the help of a camera-equipped light microscope (Leica DM750). In this study, cortex width and length, endodermis width and length, phloem width and length, trachea diameter, and tracheid diameter in the root; epidermis width and length, cortex width and length, trachea diameter, tracheid diameter, phloem width and length, and pith diameter in the stem; epidermis width and length, spongy parenchyma width and length, palisade parenchyma width and length were observed in the leaf of safflower plants grown under control and Ni conditions. 2.7. Experimental design and data analysis This study used a completely randomized experimental design. Anatomical measurements were performed with 6 plant replicates and 5 cell repeats in each plant. Thus, a total of 30 measurements were taken for each anatomic parameter. For germination experiments, a setup with a total of 100 seeds, 25 seeds in each Petri dish, and experimental replication was performed 3 times. The other experiments in this study were performed with min 3 repeats. Statistical significances were assessed with an independent samples T-test for anatomical data and seedling parameters; One-Way ANOVA was performed for germination experiments using SPSS 20.0 software (IBM SPSS Statistics), and a P-value < 0.05 was defined as significant. 3. Results and Discussion 3.1. Effects of Ni on plant growth Toxic doses of Ni harm crop growth and production. According to our results, plant growth was inhibited after Ni application in safflower. The root and shoot fresh weight of safflower were decreased by 66 and 65%, respectively, at 0.75 mM Ni treatment compared to their controls. These decreases were found to be around 51.6 and 19.9% in dry weight measurements (Fig. 1 -a). Although some of Ni are transported to the upper part of the plant, Ni mainly accumulates in the roots of safflower (Baran and Ekmekçi, 2022 ). Therefore, the dry weight of the roots was expected to be more affected by Ni than the dry weight of the shoots, and these results are in concordance with our previous study (Baran and Ekmekçi, 2022 ). Tunçtürk et al. ( 2023 ) also had similar results in safflower plants under metal toxicity. In their study in which they applied 0-100 mg/L Cd to the safflower plant, they reported that the Cd stress decreased plant height, root length and weight, stem weight, leaf weight, and leaf number. In the present study, at the 0.75 mM Ni concentration, the shoot length of safflower decreased by 40%, while there was no significant difference in roots compared to the control (Fig. 1 -b). Naveed et al. ( 2023 )’s results show a decrease in the length of shoots and no significant change in the length of roots at the highest Ni treatment (75 mM) compared to the controls in Albizia lebbeck (L.). Since Ni affects plant growth in many ways, leaf growth also slows down. It has been shown that under Ni treatment, the length of the stomatal guard cells of the leaves increases significantly in contrast to the width (Fig. 3 ). In our study, the number of leaves reduced from 2.8 to 1.7 per plant at 0.75 mM Ni treatment (Fig. 2 ). Similar to this, Naveed et al. ( 2023 ) also reported that the number of leaves significantly reduced (67%) under Ni stress. Also, the stomatal index was determined as 20.53 and 22.82 in the control group and 0.75 mM Ni treatment, respectively. Contrary to our findings, many researchers reported that plants under Ni stress have fewer stomatal density per area (Ahmad et al. 2011; Saraiva et al. 2021 ; Naveed et al. 2023 ). 3.2. Effects of Ni on seed germination Various glycolytic and proteolytic enzymes are produced in the germinating seed. Toxic Ni concentrations interfere with enzymes and osmatic regulation, and thus, the germination rate decreases (Ashraf et al. 2011 ). These enzymes are indispensable for metabolic activities like starch hydrolysis for energy production to initiate the germination process. In the present study, the germination rate of safflower seeds was decreased with increasing Ni levels (0–50 mM). 4 days after the beginning of the experiment, the germination rate was determined as 84, 84, 75, 51, 46, 23 and 11% at 0, 0.75, 1.0, 3.0, 5.0, 10.0, and 15.0 mM Ni levels, respectively (Fig. 4 -a). It was observed that there was a strict decline in germination rates starting with the treatment of 3.0 mM Ni. In the 10.0 mM Ni treatment, this decrease was quite drastic, and there was only 11% germination at the highest concentration of 15.0 mM. Moreover, to ensure that the observed effect was not due to Cl, an experiment was also conducted with NaCl and KCl at 50.0 mM, almost 3 times higher than the highest concentration in the germination experiments. According to these results, no difference from the control group was observed, and it was revealed that this level of Cl did not affect the germination of safflower seeds (Fig. 4 -b). Similar to our results, many researchers reported that Ni concentrations reduce the germination rate in different plant species (Houshmandfar and Moraghebi, 2011 ; Thakur et al. 2016). Treatment of 0.75 mM Ni, which was toxic to plant biomass production and anatomy, did not decrease the germination rate of the safflower plant. Consequently, our findings indicate that the germination process is more tolerant to Ni toxicity in safflower plants than plant growth and development. Our results show that 0.75 and 1.0 mM of Ni had no significant toxic influence on safflower’s radicle length. Coherent with germination rates, significant toxicity on radicle growth at day 3 was recorded at 3.0 mM of Ni exposure. Ni toxicity on the radicles can also be observed as darkened tips, especially at higher than 5.0 mM Ni treatments (Table 1 ). Table 1. Effect of increasing Ni concentrations (0-15 mM) on radicle length in germinating safflowers 3.3. Effect of Ni on the total protein amount of seeds According to our results, 0.75 and 1 mM of Ni had no significant effect on safflower seedlings’ protein content after 3 days of germination (Fig. 5 ). Toxicity of Ni on the protein content of safflower was first observed at 3.0 and 5.0 mM Ni concentrations, in which the amount of proteins decreased by approximately 25% compared to the control. The most dramatic decline was observed at 10- and 15-mM Ni, with more than a 50% decrease in protein content per seedling. Proteins are vital for the regulation of many physiological processes in all life forms such as enzymatic activities, therefore an interruption in the protein metabolism is inevitably harmful for organisms. In Helianthus annuus L. and Triticum aestivum L., Ni has been shown to inhibit the activity of protease (Ashraf et al. 2011 ; Negi et al. 2014 ), an essential enzyme to hydrolyze seed proteins to amino acids in order to synthesize new essential ones. In coherence with our results, Kevresan et al. ( 2001 )’s findings about Ni toxicity on Pisum sativum L. demonstrate that Ni alters the protein metabolism and decreases the amount of protein in young pea plants. Ni treatment of 0.1 and 1 ppm increased the protein content in Scenedesmus obliquus , but 2, 3, and 3.5 ppm of Ni decreased it compared to the control group (Osman et al. 2003). 3.4. Effect of Ni on pigment content of seeds Our results demonstrate that chlorophyll a is the most affected pigment by Ni at lower concentrations (0.75, 1.0, and 3.0 mM). Statistical analysis depicted a significant decrease in the amount of all photosynthetic pigments at 3.0 mM Ni treatment, in which chlorophyll a, b, and carotenoid contents decreased by 88, 83 and 85% compared to control, respectively (Fig. 6 ). At higher concentrations than 3.0 mM no pigments were detected in the seedlings of safflower. Photosynthetic pigments are indispensable for a plant to capture the light energy for photosynthesis. Our results indicate that when the carotenoid amount drops dramatically, other pigment contents are also prone to decrease more. This may be related to the fact that carotenoids are known to protect chlorophylls from various stress effects or synthesis of pigments is interrupted by Ni exposure in the event of germination (Aqeel et al. 2022 ; Yusuf et al. 2011). Similar results to ours were reported by different researchers; Ni reduced the chlorophyll content in the seedlings of Alisma plantago-aquatica L. Sium latifolium L., Raphanus sativus L., T. aestivum and Vigna radiata L. (Yadav et al. 2009; Lapirov et al. 2016; Parlak 2020; Parveen et al. 2023 ). 3.5 Effect of Ni on the MDA level of seedlings Heavy metals, including Ni cause reactive oxygen species (ROS) production in plants, which results in oxidative stress, such as lipid peroxidation that is harmful to membrane stability. MDA is the final product of membrane damage and is used to express it numerically. Therefore, MDA facilitates as a stress marker in plants (Gao et al. 2022 ). The amount of MDA significantly increased due to Ni exposure in safflower in our study (Fig. 7 ). These findings are consistent with the literature. Helaoui et al. ( 2020 ) determined that MDA levels in Medicago sativa L. increased in parallel to Ni levels. In a study conducted with safflower under 0, 25, 50, 75, and 100 mg L − 1 of cadmium treatments, MDA levels increased respectively, with 100 mg L − 1 being 52.14% more than the control group (Tunçtürk et al. 2023 ). 50 and 100 µM Ni application also caused H 2 O 2 and MDA levels to rise in Gossypium hirsutum L., which was attributed to the damage in the membrane to oxidative stress due to Ni (Khaliq et al. 2016). In Solanum lycopersicum L., besides H 2 O 2 , O 2 •− is also one of the ROS that accumulates with Ni exposure and MDA and ROS increasements are related; because when melatonin is added to alleviate the effects of Ni, ROS amount decreases with melatonin, so does MDA (Altaf et al. 2021 ). Contrary to these results, Gao et al. ( 2022 )’s research demonstrates that H 2 O 2 and MDA levels decreased in the leaves of three desert plants grown in locally obtained heavy metal-polluted soil. They also measured high antioxidant enzyme levels in these metal-exposed plants and ascribed the low amount of MDA and H 2 O 2 to antioxidant activity. Baran and Ekmekci (2022), reported that 0.75 mM Ni almost doubled the amount of H 2 O 2 in safflower. Since ROS are responsible for membrane damage, this result is in parallel to our research’s findings about MDA levels. 3.4. Effects of Ni on plant anatomy The values of root, stem, and leaf sections taken from the control and Ni treatment of the safflower plant are presented in Fig. 8 . Results have shown that there was no significant difference in some cell types in roots (cortex, endodermis length, tracheid), stems (epidermis, cortex, phloem, pith), and leaves (epidermis width, spongy, and palisade parenchyma width) between the control and Ni treatment. However, significant differences were observed in other cells. Trachea diameters increased in both root and stem. These increases were 1.4 times in the root and 1.3 times in the stem. Although the tracheid diameter did not alter in the root, it increased 1.2 times in the stem. This is consistent with the results of Gao et al. ( 2022 ), who, in their study on the effects of heavy metals on Atriplex sp. and Chenopodium glaucum L., stated that heavy metal stress reduced the density of vessels in the xylem of plant stems. They also speculated that plants increase their vessel diameter when exposed to heavy metals, which might be a stress response. Gomes et al. ( 2011 ) stated that heavy metals have the potential to alter the ratio of root hormones, which in turn may alter tissue morphogenesis and the number of cells in these tissues. Additionally, the reduction in the metaxylem area and the high number of tracheary parts change the hydraulic capacity. Larger diameter vessels are more effective but less safe due to the higher possibility of blisters. On the contrary, Reis et al. ( 2017 ) stated that soybean plants under Ni treatment showed negative impacts on root phloem and xylem diameter. In the present study, it has also been determined that the lengths of epidermis, spongy parenchyma, and palisade parenchyma in leaves were decreased by 1.4 times compared to controls. Also, the cross-sections of root, stem, and leaf are shown in Fig. 9 . Ni-induced deformation (star-like) was observed in the membranes of the cortex in stems (Fig. 9 -d). Batool et al. ( 2015 ) have also reported that Ni may cause deformation in parenchyma cells. The cell wall's flexibility may be reduced as a result of metal binding, which can ultimately cause deformation. Also, heavy metals can decrease cell turgidity due to decreased vacuole size, thereby causing deformation of cell walls (Mousa et al. 2015). Similarly, it is clearly seen that the leaf epidermis shape was altered by Ni treatment (Fig. 9 -f). In parallel with our results, Kalefetoğlu-Macar et al. (2022), in their study with Allium cepa L., also found Ni treatment caused epidermal and cortex cell damage in the transmission tissue in their study and stated that Ni-induced injuries related to growth retardation, genotoxicity, oxidative stress, and meristematic cell damage of Ni concentration. 4. Conclusion The findings of this research revealed that Ni exposure significantly inhibits safflower seed germination and photosynthetic pigment and protein content in seeds. Our results also revealed that the effect of NiCl 2 on the germination of safflower seeds was not caused by Cl but was caused by Ni. Exposure to Ni increases the amount of MDA in safflower. Also, excess Ni affected the root endodermis, phloem, and trachea; stem trachea and tracheid; and leaf epidermis and spongy parenchyma tissues of safflower. Because safflower accumulates more Ni in the underground part of the plant, root tissue was more affected by Ni toxicity. Declarations CRediT authorship contribution statement Uğurcan Baran and Ahmet Aksoy conceptualized the study; Sude Tanık and Mert Can Vardar conducted the laboratory trials with the assistance of Güray Ülger; Sude Tanık and Güray Ülger performed data analysis; Uğurcan Baran and Sude Tanık wrote the original draft; Ahmet Aksoy reviewed the manuscript and supervised all over the work. Declaration of Interest Statement The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. Acknowledgments This study was supported by The Scientific and Technological Research Council of Türkiye (TÜBİTAK, Project No: KBAG-222Z011). Ethical Approval and Consent for Participate Not applicable Consent for Publish Not applicable Availability of data and materials All data generated or analysed in the study are included in this manuscript. 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Inland Water Biol 10:308-314 https://doi.org/10.1134/S1995082917030099 Lichtenthaler HK (1987) Chlorophylls and carotenoids: pigments of photosynthetic biomembranes. Meth Enzymol 148: 350-382 https://doi.org/ 10.1016/0076-6879(87)48036-1 Ma Y, Sawhney VK, Steeves TA (1993) Staining of paraffin-embedded plant material in safranin and fast green without prior removal of the paraffin. Canad J Bot 71 (7):996-999 https://doi.org/10.1139/b93-114 Molas J (1997) Changes in morphological and anatomical structure of cabbage ( Brassica oleracea L.) outer leaves and in ultrastructure of their chloroplasts caused by an in vitro excess of nickel. Photosynthetica 34(4):513-522 https://doi.org/10.1023/A:1006805327340 Moosavi S, Gharineh MH, Tavakkol Afshari R, Ebrahimi A (2012) Effects of some heavy metals on seed germination characteristics of canola ( Barassica napus ), wheat ( Triticum aestivum ) and safflower ( Carthamus tinctorious ) to evaluate phytoremediation potential of these crops. 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Plant Sci 163:753-758 https://doi.org/10.1016/S0168-9452(02)00210-8 Parveen A, Sonkar S, Sarangi P, Singh A, Sahoo U, Gupta R, Prus P, Imbrea F, Smuleac L, Pașcalău R (2023) Harnessing the eco-friendly potential of Asparagus racemosus leaf extract fabricated Ni/Ni(OH) 2 nanoparticles for sustainable seed germination and seedling growth of Vigna radiata . Agronomy 13:2073 https://doi.org/10.3390/agronomy13082073 Prasad MNV (2005) Nickelophilous plants and their significance in phytotechnologies. Braz J Plant Physiol 17:113-128 https://doi.org/10.1590/S1677-04202005000100010 Pourghasemian N, Landberg T, Ehsanzadeh P, Greger M (2019) Different response to Cd stress in domesticated and wild safflower ( Carthamus spp.). Ecotox Environ Safe 171:321-328 https://doi.org/10.1016/j.ecoenv.2018.12.052 Reis A, Barcelos J, Osório Christian Santos E, Aparecido Manzani Lisboa L, Santini J, Santos M, Furlani Junior E, Campos M, Figueiredo P, Lavres Junior J, Gratão P (2017) A glimpse into the physiological, biochemical and nutritional status of soybean plants under Ni-stress conditions. Environ Exp Bot 144:76-87 https://doi.org/10.1016/j.envexpbot.2017.10.006. Ribeiro A, de Oliveira V, Junior U, Silva B, Batista B, Lobato A (2020) 24-Epibrassinolide mitigates nickel toxicity in young Eucalyptus urophylla S.T. Blake plants: nutritional, physiological, biochemical, anatomical and morphological responses. Ann For Sci 77:1-19 https://doi.org/10.1007/s13595-019-0909-9 Saraiva M, Maia C, Silva B, Batista B, Lobato A (2021) 24-Epibrassinolide induces protection against nickel excess in soybean plants: anatomical evidences. Braz J Bot 44:197-205 https://doi.org/10.1007/s40415-021-00701-3 Singh S, Parihar P, Singh R, Singh VP, Prasad SM (2016) Heavy metal tolerance in plants: Role of transcriptomics, proteomics, metabolomics, and ionomics. Front Plant Sci 6:1143 https://doi.org/10.3389/fpls.2015.01143 Thakur S, Sharma SS (2016) Characterization of seed germination, seedling growth, and associated metabolic responses of Brassica juncea L. cultivars to elevated nickel concentrations. Protoplasma 253(2):571-80 https://doi.org/10.1007/s00709-015-0835-0 Tunçtürk M, Rezaee Danesh Y, Tunçtürk R, Oral E, Najafi S, Nohutçu L, Jalal A, da Silva Oliveira CE, Filho MCMT (2023) Safflower ( Carthamus tinctorius L.) Response to cadmium stress: morpho-physiological traits and mineral concentrations. Life 13:135 https://doi.org/ 10.3390/life13010135 Uruç Parlak K, (2016) Effect of nickel on growth and biochemical characteristics of wheat ( Triticum aestivum L.) seedlings. Wagen J Life Sc 76:1-5 https://doi.org/10.1016/j.njas.2012.07.001 Yadav Shiv, Shukla R, Sharma Y (2009) Nickel toxicity on seed germination and growth in radish ( Raphanus sativus ) and its recovery using copper and boron. J Environ Biol 30:461-466 Yusuf Mohammad, Fariduddin Q, Hayat, S, Ahmad A (2011) Nickel: An overview of uptake, essentiality and toxicity in plants. Bull Environ Contam Toxicol 86:1-17 https://doi.org/10.1007/s00128-010-0171-1 Supplementary Files Graphicalabstract.png Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-4106206","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":288117949,"identity":"3b34c866-e525-42aa-9130-9248355cd489","order_by":0,"name":"Uğurcan Baran","email":"","orcid":"","institution":"Akdeniz University: Akdeniz Universitesi","correspondingAuthor":false,"prefix":"","firstName":"Uğurcan","middleName":"","lastName":"Baran","suffix":""},{"id":288117950,"identity":"95b2237f-5087-4fc1-a4fc-99f625f8031f","order_by":1,"name":"Sude Tanık","email":"","orcid":"","institution":"Akdeniz University: Akdeniz Universitesi","correspondingAuthor":false,"prefix":"","firstName":"Sude","middleName":"","lastName":"Tanık","suffix":""},{"id":288117951,"identity":"92dd1aba-42d7-4336-a5e7-6ac160d7624e","order_by":2,"name":"Mert Can Vardar","email":"","orcid":"","institution":"Akdeniz University: Akdeniz Universitesi","correspondingAuthor":false,"prefix":"","firstName":"Mert","middleName":"Can","lastName":"Vardar","suffix":""},{"id":288117952,"identity":"d0e9b5eb-d635-419b-9ecc-3aaf7e949b37","order_by":3,"name":"Güray Ülger","email":"","orcid":"","institution":"Akdeniz University: Akdeniz Universitesi","correspondingAuthor":false,"prefix":"","firstName":"Güray","middleName":"","lastName":"Ülger","suffix":""},{"id":288117953,"identity":"da33ad94-1012-4bf8-8e28-e3edc2a54d5d","order_by":4,"name":"Ahmet Aksoy","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAA60lEQVRIiWNgGAWjYDACHhBRwWDAcIABhBgYG4jTcgZFCzMRWhjbIFoYiNLC33P84WPeeXbGfMd7Dx78wWAju+EA/7EP+LRInO0xNubdlmwmeeZcwgEJhjTjDQeYmWfgteY8D5s07zZmG4MbOQYHDBgOJ4K04NUhf579mTTvnHobg/tvDA4kMPwnrMXgbIOZNG/DYTODGzwGBw4wHCCsxfDMGWPDOceOG0ueyTE42GCQbDzzMLMxXi1yZ9IfPnhTU23Yd/yM8ccfFXayfccbH+PVAgJMPAh3AjGhmAQBxh9EKBoFo2AUjIIRDABdBk1cN3snagAAAABJRU5ErkJggg==","orcid":"https://orcid.org/0000-0002-9696-7122","institution":"Akdeniz University: Akdeniz Universitesi","correspondingAuthor":true,"prefix":"","firstName":"Ahmet","middleName":"","lastName":"Aksoy","suffix":""}],"badges":[],"createdAt":"2024-03-15 08:38:22","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-4106206/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-4106206/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":54410695,"identity":"644d83be-bbc8-4c03-ab17-33688c882ab2","added_by":"auto","created_at":"2024-04-10 05:17:39","extension":"png","order_by":1,"title":"Figure 1","display":"","copyAsset":false,"role":"figure","size":251458,"visible":true,"origin":"","legend":"\u003cp\u003eEffect of 0.75 mM Ni on biomass (a) and plant length (b) in safflower. For this and other graphs, the asterisk bracket (*) indicates the significant differences (p \u0026lt; 0.05) between the control and Ni treatment\u003c/p\u003e","description":"","filename":"Fig1.png","url":"https://assets-eu.researchsquare.com/files/rs-4106206/v1/91957605d294c9f6476f4b1f.png"},{"id":54410691,"identity":"de7d96f1-6d4f-4983-a7fa-1bdebb9b23f0","added_by":"auto","created_at":"2024-04-10 05:17:39","extension":"png","order_by":2,"title":"Figure 2","display":"","copyAsset":false,"role":"figure","size":123300,"visible":true,"origin":"","legend":"\u003cp\u003eEffect of 0.75 mM Ni on leaf number in safflower\u003c/p\u003e","description":"","filename":"Fig2.png","url":"https://assets-eu.researchsquare.com/files/rs-4106206/v1/0290fbe647abd54beb2e7ec1.png"},{"id":54410693,"identity":"255680c4-7b82-4dfb-b1b4-8faeba5f6502","added_by":"auto","created_at":"2024-04-10 05:17:39","extension":"png","order_by":3,"title":"Figure 3","display":"","copyAsset":false,"role":"figure","size":202575,"visible":true,"origin":"","legend":"\u003cp\u003eEffect of 0.75 mM Ni on stoma guard cell in safflower\u003c/p\u003e","description":"","filename":"Fig3.png","url":"https://assets-eu.researchsquare.com/files/rs-4106206/v1/b9f98785ea4164d8781345f0.png"},{"id":54411040,"identity":"9a2fcf7e-6594-45e8-90e3-9b4c128564f4","added_by":"auto","created_at":"2024-04-10 05:25:39","extension":"png","order_by":4,"title":"Figure 4","display":"","copyAsset":false,"role":"figure","size":324155,"visible":true,"origin":"","legend":"\u003cp\u003eEffect of increasing NiCl\u003csub\u003e2\u003c/sub\u003e (a), NaCl, and KCl (b) levels on seed germination in safflower\u003c/p\u003e","description":"","filename":"Fig4.png","url":"https://assets-eu.researchsquare.com/files/rs-4106206/v1/b2f89180a1ea76d368a05c02.png"},{"id":54410692,"identity":"1e0c2d2b-2cf7-409d-9ede-0d1a1ecc5f6d","added_by":"auto","created_at":"2024-04-10 05:17:39","extension":"png","order_by":5,"title":"Figure 5","display":"","copyAsset":false,"role":"figure","size":431498,"visible":true,"origin":"","legend":"\u003cp\u003eEffect of increasing Ni levels on protein content of safflower seeds\u003c/p\u003e","description":"","filename":"Fig5.png","url":"https://assets-eu.researchsquare.com/files/rs-4106206/v1/235583882f8cdaa91f398b4a.png"},{"id":54411039,"identity":"22baae57-5236-4750-9143-72a6cebbe65f","added_by":"auto","created_at":"2024-04-10 05:25:39","extension":"png","order_by":6,"title":"Figure 6","display":"","copyAsset":false,"role":"figure","size":134520,"visible":true,"origin":"","legend":"\u003cp\u003eEffect of increasing Ni levels on photosynthetic pigment content of safflower seeds\u003c/p\u003e","description":"","filename":"Fig6.png","url":"https://assets-eu.researchsquare.com/files/rs-4106206/v1/13d3bb32e42408e51cb2b3ff.png"},{"id":54410696,"identity":"0979f8a4-ac1a-4dc0-9c40-03ff6d034d64","added_by":"auto","created_at":"2024-04-10 05:17:39","extension":"png","order_by":7,"title":"Figure 7","display":"","copyAsset":false,"role":"figure","size":101734,"visible":true,"origin":"","legend":"\u003cp\u003eEffect of 0.75 mM Ni on MDA levels of safflower seedlings\u003c/p\u003e","description":"","filename":"Fig7..png","url":"https://assets-eu.researchsquare.com/files/rs-4106206/v1/bfa12366c539b75fbb47069b.png"},{"id":54410699,"identity":"c0f2bcf3-49d1-4f65-a154-c9b5dc2839e4","added_by":"auto","created_at":"2024-04-10 05:17:39","extension":"png","order_by":8,"title":"Figure 8","display":"","copyAsset":false,"role":"figure","size":477264,"visible":true,"origin":"","legend":"\u003cp\u003eEffect of 0.75 mM Ni on the root (a), stem (b), and leaf (c) anatomy in safflower\u003c/p\u003e","description":"","filename":"Fig8.png","url":"https://assets-eu.researchsquare.com/files/rs-4106206/v1/d9ff310839ad2fd2683a6ffa.png"},{"id":54410701,"identity":"8757637f-2cff-4796-a72a-ecee67cc4b3a","added_by":"auto","created_at":"2024-04-10 05:17:40","extension":"jpg","order_by":9,"title":"Figure 9","display":"","copyAsset":false,"role":"figure","size":13444042,"visible":true,"origin":"","legend":"\u003cp\u003eControl (a-root, c-stem, and e-leaf) and 0.75 mM Ni treatment (b-root, d-stem, and f-leaf) cross-sections of safflower (C-cambium, Co-cortex, E-epidermis, En-endodermis, Le-lower epidermis, Me-mesophyll, Pa-palisade parenchyma, Pe-periderm, Ph-phloem, Pi-pith, Sp-spongy parenchyma, Th-Tracheid, Tr-trake, Ue-upper epidermis, Vb-vascular bundle, X-xylem)\u003c/p\u003e","description":"","filename":"Fig9.jpg","url":"https://assets-eu.researchsquare.com/files/rs-4106206/v1/71be93eb0b7fe60a9bd8246d.jpg"},{"id":60806196,"identity":"aa0a900b-f17b-4f0d-8add-df5ffaa451c0","added_by":"auto","created_at":"2024-07-22 09:59:33","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":15459833,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-4106206/v1/a7678f0c-a23e-4755-99fe-74a97fe8e742.pdf"},{"id":54410700,"identity":"c399ff2a-d159-42d7-b30a-65156a96face","added_by":"auto","created_at":"2024-04-10 05:17:39","extension":"png","order_by":15,"title":"","display":"","copyAsset":false,"role":"supplement","size":373725,"visible":true,"origin":"","legend":"","description":"","filename":"Graphicalabstract.png","url":"https://assets-eu.researchsquare.com/files/rs-4106206/v1/ab597046420f5f19a8f2f131.png"}],"financialInterests":"","formattedTitle":"Nickel toxicity to safflower seed germination and seedling morpho-anatomy","fulltext":[{"header":"1. Introduction","content":"\u003cp\u003eIncreased human activity, rapid industrialization, and contemporary farming practices have contributed to heavy metal contamination, which is hazardous to the biota. Significant tracts of land face the risk of being contaminated with various metals due to industrial waste, the prevalent usage of pesticides and fertilizers, and the release of heavy metals from metalliferous mines. Ni is one of these heavy metals in soil that is rapidly rising to the top of the list of global environmental problems (Singh et al. \u003cspan citationid=\"CR36\" class=\"CitationRef\"\u003e2016\u003c/span\u003e; Prasad \u003cspan citationid=\"CR31\" class=\"CitationRef\"\u003e2005\u003c/span\u003e).\u003c/p\u003e \u003cp\u003eGermination is the first response of defense against unfavorable environmental conditions. Ni is known to inhibit seed germination in different plant species (Moosavi et al. 2016). Especially the early stages of seed germination have been shown to be gradually affected by Ni in high concentrations. Ni prevents the uptake of water during the imbibition phase, thereby stopping the onset of seed germination. Ni harms protein synthesis, the recovery of K and Mg, and the reactivation of oxygen in seeds during germination (Ashraf et al. \u003cspan citationid=\"CR6\" class=\"CitationRef\"\u003e2011\u003c/span\u003e). Moreover, it is reported that during the process of germination, some key glycolytic and proteolytic enzymes for initiating seed germination, such as α-amylase and protease, are negatively affected by Ni. Thus, Ni can prevent sugars from being converted from starch, which is essential to provide energy to the growing plumule and radicle (Ashraf et al. \u003cspan citationid=\"CR6\" class=\"CitationRef\"\u003e2011\u003c/span\u003e). Ni has the ability to penetrate the seed coat, a crucial component of the first line of defense against abiotic stressors, alters numerous physiological processes involved in germination, and determines their impact on imbibition and radicle elongation (Moreira et al. 2020). Some plants have the capacity to adsorb Ni ions in their seed coats, which prevents Ni from reaching the embryo and protects the seeds while germinating. According to some studies, certain seeds can germinate in the presence of high concentrations of Ni, but seedling growth may be impaired (Moreira et al. 2020).\u003c/p\u003e \u003cp\u003eIn addition to its toxic effects on germination, Ni also causes changes in plant physiology, morphology, and anatomy. Vital plant biomolecules, such as enzymes, membranes, and proteins can be directly damaged by Ni. Furthermore, Ni can also disrupt many physiological processes, as it easily wins the competition against other essential metals, such as Mg and Fe. Because Ni reduces the photosynthetic efficiency, morphologic parameters like biomass are directly affected by its toxicity.\u003c/p\u003e \u003cp\u003eThe uptake of Ni is known to trigger anatomical changes in various plant organs. It has been shown that heavy metals can alter several cell types, such as parenchymatous tissue in the cortex, pith, sclerenchyma, and xylem vessels in the roots. Thus, root diameter shrinkage may occur (Batool et al. \u003cspan citationid=\"CR8\" class=\"CitationRef\"\u003e2015\u003c/span\u003e). Consequently, the movement of water can be interrupted from underground to aerial parts. Ni stress also modifies stem and root anatomy. It is reported that metals have negative impacts on the size of mesophyll parenchyma, vascular bundles, epidermal cells, and the diameter of xylem vessels. In addition, stomatal deformation, and alterations of their density in the adaxial and abaxial sides of leaves have also been reported under Ni stress (Molas, 1998; Batool et al. \u003cspan citationid=\"CR8\" class=\"CitationRef\"\u003e2015\u003c/span\u003e; Ribeiro et al. \u003cspan citationid=\"CR34\" class=\"CitationRef\"\u003e2020\u003c/span\u003e). Ultimately, these anatomical stress responses directly affect crucial physiological processes such as transpiration, photosynthesis, and gas exchange.\u003c/p\u003e \u003cp\u003eSafflower (\u003cem\u003eCarthamus tinctorius\u003c/em\u003e L.) is a plant that belongs to the Asteraceae family. With its ability to tolerate conditions such as drought, salt, and metal stress, safflower is a notable oilseed crop used in bioenergy production and phytoremediation (Al Chami et al. \u003cspan citationid=\"CR2\" class=\"CitationRef\"\u003e2015\u003c/span\u003e; Pourghasemian et al. \u003cspan citationid=\"CR32\" class=\"CitationRef\"\u003e2019\u003c/span\u003e; \u0026Ccedil;ulha-Erdal et al. 2021; Baran and Ekmekci, 2022). According to the data of the Seed Registration and Certification Central Directorate (TTSM, 2021), there are 15 safflower cultivars registered in T\u0026uuml;rkiye, and the cultivar Olas, which stands out with its high oil content and yield, was registered in 2015 and (Arslan and Culpan, \u003cspan citationid=\"CR5\" class=\"CitationRef\"\u003e2020\u003c/span\u003e). The anatomic responses of safflower to heavy metal stress, particularly Ni, are still poorly understood. Identification of alterations in the morpho-anatomical structure of safflower seedlings and the change in some seed germination parameters in Ni-exposed safflower seeds to widely understand this plant\u0026rsquo;s tolerance and toxicity responses to Ni was the goal of this study.\u003c/p\u003e"},{"header":"2. Material and methods","content":"\u003cdiv id=\"Sec3\" class=\"Section2\"\u003e \u003ch2\u003e2.1. Plant material\u003c/h2\u003e \u003cp\u003eSeeds of safflower (\u003cem\u003eC. tinctorius\u003c/em\u003e) cultivar Olas were procured from Trakya Agricultural Research Institute, Edirne.\u003c/p\u003e \u003c/div\u003e \u003cdiv id=\"Sec4\" class=\"Section2\"\u003e \u003ch2\u003e2.2. Germination experiments and seedling growth\u003c/h2\u003e \u003cp\u003eUniform safflower seeds were selected, and surfaces were sterilized with %5 sodium hypochlorite for 5 min, then washed with distilled water 10 times. After the sterilization step, safflower seeds were germinated under dark conditions at 23\u0026plusmn;2\u0026deg;C for 4 days. In the germination experiments, treatment series were set up using 0, 0.75, 1.0, 3.0, 5.0, 10.0, and 15.0 mM concentrations of Ni (NiCl\u003csub\u003e2\u003c/sub\u003e.6H\u003csub\u003e2\u003c/sub\u003eO) solution, while in the control series, only distilled water was used. Moreover, to ensure that the negative impacts of NiCl\u003csub\u003e2\u003c/sub\u003e were solely on Ni, the effect of 50 mM NaCl and KCl on germination rate was also tested. To calculate the germination rate, petri dishes were checked daily for 3 days. Radicle lengths were recorded every day. Seeds were considered germinated when a root had emerged over 5 mm.\u003c/p\u003e \u003cp\u003eFor morpho-anatomic and physiologic tests, following the method in our previous study (Baran and Ekmek\u0026ccedil;i, \u003cspan citationid=\"CR7\" class=\"CitationRef\"\u003e2022\u003c/span\u003e), safflower seedlings were transferred to a hydroponic culture containing Hoagland\u0026rsquo;s nutrient solution after germination and were grown for 10 days in a control condition. On the 10th day of the growth, Ni stress was treated by applying Hoagland's nutrient solution containing 0.75 mM Ni for the next 7 days. All experiments were carried out in a growth cabinet (N\u0026uuml;ve, TK-600) at 23\u0026deg;C, 16/8 hours light/dark photoperiod, 180\u0026ndash;200 \u0026micro;mol.m\u003csup\u003e\u0026minus;\u0026thinsp;1\u003c/sup\u003es\u003csup\u003e\u0026minus;\u0026thinsp;1\u003c/sup\u003e light intensity and 40\u0026ndash;50% humidity. Experiments were terminated, and plants were harvested on the 21st day.\u003c/p\u003e \u003c/div\u003e \u003cdiv id=\"Sec5\" class=\"Section2\"\u003e \u003ch2\u003e2.3. Determination of total protein of seeds\u003c/h2\u003e \u003cp\u003eFor the determination of total protein, 0.02 mg of 72-hour-old germinating seeds were homogenized using 750 \u0026micro;l of 100 mM potassium phosphate buffer (pH 7.5) with 1 mM EDTA and 1% PVP-40. Homogenized samples were centrifuged with N\u0026uuml;ve NF 800R at 14.000 rpm for 20 min at 4\u0026deg;C. Bradford (\u003cspan citationid=\"CR10\" class=\"CitationRef\"\u003e1976\u003c/span\u003e)\u0026rsquo;s method was followed to determine the protein content from supernatants at 595 nm using a Soif UV/Vis 5100 Optical Instruments spectrophotometer. Bovine serum albumin was used to prepare a standard curve and protein content was calculated as g seed\u003csup\u003e\u0026minus;\u0026thinsp;1\u003c/sup\u003e.\u003c/p\u003e \u003c/div\u003e \u003cdiv id=\"Sec6\" class=\"Section2\"\u003e \u003ch2\u003e2.4. Determination of pigment content of seeds\u003c/h2\u003e \u003cp\u003eChlorophyll a, b, and carotenoid contents in 72-hour-old cotyledons of safflower were determined according to Lichtenthaler (\u003cspan citationid=\"CR22\" class=\"CitationRef\"\u003e1987\u003c/span\u003e). In 1 ml 100% acetone, 0.03 g of cotyledons were grounded for extraction, and then the extracts were centrifuged at 3500 rpm for 5 min. The absorbance of the samples was recorded at 470 nm for carotenoids, 644.8 nm for chlorophyll b, and 661.6 nm for chlorophyll a.\u003c/p\u003e \u003c/div\u003e \u003cdiv id=\"Sec7\" class=\"Section2\"\u003e \u003ch2\u003e2.5 Determination of malondialdehyde (MDA) amount of seedlings\u003c/h2\u003e \u003cp\u003eThe amount of MDA, the last product of membrane damage, was determined using Esterbauer and Cheeseman (X)\u0026rsquo;s method. 0.1 g of leaf (fresh weight; FW) samples taken from plants were homogenized with 0.1% trichloroacetic acid (TCA) at 4\u0026deg;C. The homogenate was centrifuged at 10000 rpm for 15 minutes. Then, 0.5 ml supernatant was added to a glass tube with 1 ml TCA-TBA-HCl (15% trichloroacetic acid, 0.375% thiobarbituric acid, 0.25 N HCl) solution and 0.5 ml tris/HCl buffer (from a 0.1 M solution with 7.6 pH). The solution was heated for 45 minutes in a 97\u0026deg;C water bath. After this step, the solution was centrifuged at 10000 rpm for 5 minutes. Absorbance values at 532 and 600 nm wavelengths were recorded. The MDA amount in leaf tissues was calculated as g FW\u003csup\u003e\u0026minus;\u0026thinsp;1\u003c/sup\u003e.\u003c/p\u003e \u003c/div\u003e \u003cdiv id=\"Sec8\" class=\"Section2\"\u003e \u003ch2\u003e2.6. Morphologic and anatomic measurements of seedlings\u003c/h2\u003e \u003cp\u003eThe fresh and dry weight (DW) of roots and shoots of safflower were determined as g and dg plant\u003csup\u003e\u0026minus;\u0026thinsp;1\u003c/sup\u003e, while their lengths were determined as cm plant\u003csup\u003e\u0026minus;\u0026thinsp;1\u003c/sup\u003e. For DW measurement, plant parts were oven-dried at 80\u0026deg;C until a constant weight was obtained.\u003c/p\u003e \u003cp\u003eFor the anatomical studies, Johansen (\u003cspan citationid=\"CR17\" class=\"CitationRef\"\u003e1940\u003c/span\u003e) and Ma et al. (\u003cspan citationid=\"CR23\" class=\"CitationRef\"\u003e1993\u003c/span\u003e) were followed in the sectioning and staining methods with modifications. 3 mm pieces were taken from the root, stem, and leaf of safflowers. The plant sections were fixed in 70% ethanol for 48 hours, after that they proceeded through a series of xylol and ethyl alcohol at 70, 90, and 96%. Then the plant parts were embedded in paraffin and sectioned by a sliding microtome at thicknesses of 10\u0026ndash;15 \u0026micro;m. To remove the paraffin from the sections, the samples were placed in an oven set at 65\u0026deg;C. After that, the samples were exposed to the xylol and ethyl alcohol series, soaked in saffron all night long, following stained for 20 seconds using fast green. Measurements and photographs were taken with the help of a camera-equipped light microscope (Leica DM750). In this study, cortex width and length, endodermis width and length, phloem width and length, trachea diameter, and tracheid diameter in the root; epidermis width and length, cortex width and length, trachea diameter, tracheid diameter, phloem width and length, and pith diameter in the stem; epidermis width and length, spongy parenchyma width and length, palisade parenchyma width and length were observed in the leaf of safflower plants grown under control and Ni conditions.\u003c/p\u003e \u003c/div\u003e \u003cdiv id=\"Sec9\" class=\"Section2\"\u003e \u003ch2\u003e2.7. Experimental design and data analysis\u003c/h2\u003e \u003cp\u003eThis study used a completely randomized experimental design. Anatomical measurements were performed with 6 plant replicates and 5 cell repeats in each plant. Thus, a total of 30 measurements were taken for each anatomic parameter. For germination experiments, a setup with a total of 100 seeds, 25 seeds in each Petri dish, and experimental replication was performed 3 times. The other experiments in this study were performed with min 3 repeats. Statistical significances were assessed with an independent samples T-test for anatomical data and seedling parameters; One-Way ANOVA was performed for germination experiments using SPSS 20.0 software (IBM SPSS Statistics), and a P-value\u0026thinsp;\u0026lt;\u0026thinsp;0.05 was defined as significant.\u003c/p\u003e \u003c/div\u003e"},{"header":"3. Results and Discussion","content":"\u003cdiv id=\"Sec11\" class=\"Section2\"\u003e \u003ch2\u003e3.1. Effects of Ni on plant growth\u003c/h2\u003e \u003cp\u003eToxic doses of Ni harm crop growth and production. According to our results, plant growth was inhibited after Ni application in safflower. The root and shoot fresh weight of safflower were decreased by 66 and 65%, respectively, at 0.75 mM Ni treatment compared to their controls. These decreases were found to be around 51.6 and 19.9% in dry weight measurements (Fig.\u0026nbsp;\u003cspan refid=\"Fig1\" class=\"InternalRef\"\u003e1\u003c/span\u003e-a). Although some of Ni are transported to the upper part of the plant, Ni mainly accumulates in the roots of safflower (Baran and Ekmek\u0026ccedil;i, \u003cspan citationid=\"CR7\" class=\"CitationRef\"\u003e2022\u003c/span\u003e). Therefore, the dry weight of the roots was expected to be more affected by Ni than the dry weight of the shoots, and these results are in concordance with our previous study (Baran and Ekmek\u0026ccedil;i, \u003cspan citationid=\"CR7\" class=\"CitationRef\"\u003e2022\u003c/span\u003e). Tun\u0026ccedil;t\u0026uuml;rk et al. (\u003cspan citationid=\"CR38\" class=\"CitationRef\"\u003e2023\u003c/span\u003e) also had similar results in safflower plants under metal toxicity. In their study in which they applied 0-100 mg/L Cd to the safflower plant, they reported that the Cd stress decreased plant height, root length and weight, stem weight, leaf weight, and leaf number. In the present study, at the 0.75 mM Ni concentration, the shoot length of safflower decreased by 40%, while there was no significant difference in roots compared to the control (Fig.\u0026nbsp;\u003cspan refid=\"Fig1\" class=\"InternalRef\"\u003e1\u003c/span\u003e-b).\u003c/p\u003e \u003cp\u003e \u003c/p\u003e \u003cp\u003eNaveed et al. (\u003cspan citationid=\"CR27\" class=\"CitationRef\"\u003e2023\u003c/span\u003e)\u0026rsquo;s results show a decrease in the length of shoots and no significant change in the length of roots at the highest Ni treatment (75 mM) compared to the controls in \u003cem\u003eAlbizia lebbeck\u003c/em\u003e (L.). Since Ni affects plant growth in many ways, leaf growth also slows down. It has been shown that under Ni treatment, the length of the stomatal guard cells of the leaves increases significantly in contrast to the width (Fig.\u0026nbsp;\u003cspan refid=\"Fig3\" class=\"InternalRef\"\u003e3\u003c/span\u003e). In our study, the number of leaves reduced from 2.8 to 1.7 per plant at 0.75 mM Ni treatment (Fig.\u0026nbsp;\u003cspan refid=\"Fig2\" class=\"InternalRef\"\u003e2\u003c/span\u003e). Similar to this, Naveed et al. (\u003cspan citationid=\"CR27\" class=\"CitationRef\"\u003e2023\u003c/span\u003e) also reported that the number of leaves significantly reduced (67%) under Ni stress.\u003c/p\u003e \u003cp\u003e \u003c/p\u003e \u003cp\u003eAlso, the stomatal index was determined as 20.53 and 22.82 in the control group and 0.75 mM Ni treatment, respectively. Contrary to our findings, many researchers reported that plants under Ni stress have fewer stomatal density per area (Ahmad et al. 2011; Saraiva et al. \u003cspan citationid=\"CR35\" class=\"CitationRef\"\u003e2021\u003c/span\u003e; Naveed et al. \u003cspan citationid=\"CR27\" class=\"CitationRef\"\u003e2023\u003c/span\u003e).\u003c/p\u003e \u003cp\u003e \u003c/p\u003e \u003c/div\u003e \u003cdiv id=\"Sec12\" class=\"Section2\"\u003e \u003ch2\u003e3.2. Effects of Ni on seed germination\u003c/h2\u003e \u003cp\u003eVarious glycolytic and proteolytic enzymes are produced in the germinating seed. Toxic Ni concentrations interfere with enzymes and osmatic regulation, and thus, the germination rate decreases (Ashraf et al. \u003cspan citationid=\"CR6\" class=\"CitationRef\"\u003e2011\u003c/span\u003e). These enzymes are indispensable for metabolic activities like starch hydrolysis for energy production to initiate the germination process. In the present study, the germination rate of safflower seeds was decreased with increasing Ni levels (0\u0026ndash;50 mM). 4 days after the beginning of the experiment, the germination rate was determined as 84, 84, 75, 51, 46, 23 and 11% at 0, 0.75, 1.0, 3.0, 5.0, 10.0, and 15.0 mM Ni levels, respectively (Fig.\u0026nbsp;\u003cspan refid=\"Fig4\" class=\"InternalRef\"\u003e4\u003c/span\u003e-a). It was observed that there was a strict decline in germination rates starting with the treatment of 3.0 mM Ni. In the 10.0 mM Ni treatment, this decrease was quite drastic, and there was only 11% germination at the highest concentration of 15.0 mM. Moreover, to ensure that the observed effect was not due to Cl, an experiment was also conducted with NaCl and KCl at 50.0 mM, almost 3 times higher than the highest concentration in the germination experiments. According to these results, no difference from the control group was observed, and it was revealed that this level of Cl did not affect the germination of safflower seeds (Fig.\u0026nbsp;\u003cspan refid=\"Fig4\" class=\"InternalRef\"\u003e4\u003c/span\u003e-b).\u003c/p\u003e \u003cp\u003e \u003c/p\u003e \u003cp\u003eSimilar to our results, many researchers reported that Ni concentrations reduce the germination rate in different plant species (Houshmandfar and Moraghebi, \u003cspan citationid=\"CR16\" class=\"CitationRef\"\u003e2011\u003c/span\u003e; Thakur et al. 2016). Treatment of 0.75 mM Ni, which was toxic to plant biomass production and anatomy, did not decrease the germination rate of the safflower plant. Consequently, our findings indicate that the germination process is more tolerant to Ni toxicity in safflower plants than plant growth and development.\u003c/p\u003e \u003cp\u003eOur results show that 0.75 and 1.0 mM of Ni had no significant toxic influence on safflower\u0026rsquo;s radicle length. Coherent with germination rates, significant toxicity on radicle growth at day 3 was recorded at 3.0 mM of Ni exposure. Ni toxicity on the radicles can also be observed as darkened tips, especially at higher than 5.0 mM Ni treatments (Table\u0026nbsp;\u003cspan refid=\"Tab1\" class=\"InternalRef\"\u003e1\u003c/span\u003e).\u003c/p\u003e \u003cp\u003e\u003cstrong\u003eTable 1.\u0026nbsp;\u003c/strong\u003eEffect of increasing Ni concentrations (0-15 mM) on radicle length in germinating safflowers\u003c/p\u003e\n\u003cp\u003e\u003cimg 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\" height=\"337\" width=\"637\"\u003e\u003c/p\u003e\n \u003c/div\u003e \u003cdiv id=\"Sec13\" class=\"Section2\"\u003e \u003ch2\u003e3.3. Effect of Ni on the total protein amount of seeds\u003c/h2\u003e \u003cp\u003e According to our results, 0.75 and 1 mM of Ni had no significant effect on safflower seedlings\u0026rsquo; protein content after 3 days of germination (Fig.\u0026nbsp;\u003cspan refid=\"Fig5\" class=\"InternalRef\"\u003e5\u003c/span\u003e). Toxicity of Ni on the protein content of safflower was first observed at 3.0 and 5.0 mM Ni concentrations, in which the amount of proteins decreased by approximately 25% compared to the control. The most dramatic decline was observed at 10- and 15-mM Ni, with more than a 50% decrease in protein content per seedling.\u003c/p\u003e \u003cp\u003eProteins are vital for the regulation of many physiological processes in all life forms such as enzymatic activities, therefore an interruption in the protein metabolism is inevitably harmful for organisms. In \u003cem\u003eHelianthus annuus\u003c/em\u003e L. and \u003cem\u003eTriticum aestivum\u003c/em\u003e L., Ni has been shown to inhibit the activity of protease (Ashraf et al. \u003cspan citationid=\"CR6\" class=\"CitationRef\"\u003e2011\u003c/span\u003e; Negi et al. \u003cspan citationid=\"CR28\" class=\"CitationRef\"\u003e2014\u003c/span\u003e), an essential enzyme to hydrolyze seed proteins to amino acids in order to synthesize new essential ones. In coherence with our results, Kevresan et al. (\u003cspan citationid=\"CR19\" class=\"CitationRef\"\u003e2001\u003c/span\u003e)\u0026rsquo;s findings about Ni toxicity on \u003cem\u003ePisum sativum\u003c/em\u003e L. demonstrate that Ni alters the protein metabolism and decreases the amount of protein in young pea plants. Ni treatment of 0.1 and 1 ppm increased the protein content in \u003cem\u003eScenedesmus obliquus\u003c/em\u003e, but 2, 3, and 3.5 ppm of Ni decreased it compared to the control group (Osman et al. 2003).\u003c/p\u003e \u003c/div\u003e \u003cdiv id=\"Sec14\" class=\"Section2\"\u003e \u003ch2\u003e3.4. Effect of Ni on pigment content of seeds\u003c/h2\u003e \u003cp\u003eOur results demonstrate that chlorophyll a is the most affected pigment by Ni at lower concentrations (0.75, 1.0, and 3.0 mM). Statistical analysis depicted a significant decrease in the amount of all photosynthetic pigments at 3.0 mM Ni treatment, in which chlorophyll a, b, and carotenoid contents decreased by 88, 83 and 85% compared to control, respectively (Fig.\u0026nbsp;\u003cspan refid=\"Fig6\" class=\"InternalRef\"\u003e6\u003c/span\u003e). At higher concentrations than 3.0 mM no pigments were detected in the seedlings of safflower.\u003c/p\u003e \u003cp\u003e \u003c/p\u003e \u003cp\u003ePhotosynthetic pigments are indispensable for a plant to capture the light energy for photosynthesis. Our results indicate that when the carotenoid amount drops dramatically, other pigment contents are also prone to decrease more. This may be related to the fact that carotenoids are known to protect chlorophylls from various stress effects or synthesis of pigments is interrupted by Ni exposure in the event of germination (Aqeel et al. \u003cspan citationid=\"CR4\" class=\"CitationRef\"\u003e2022\u003c/span\u003e; Yusuf et al. 2011). Similar results to ours were reported by different researchers; Ni reduced the chlorophyll content in the seedlings of \u003cem\u003eAlisma plantago-aquatica\u003c/em\u003e L. \u003cem\u003eSium latifolium\u003c/em\u003e L., \u003cem\u003eRaphanus sativus\u003c/em\u003e L., \u003cem\u003eT. aestivum\u003c/em\u003e and \u003cem\u003eVigna radiata\u003c/em\u003e L. (Yadav et al. 2009; Lapirov et al. 2016; Parlak 2020; Parveen et al. \u003cspan citationid=\"CR30\" class=\"CitationRef\"\u003e2023\u003c/span\u003e).\u003c/p\u003e \u003c/div\u003e \u003cdiv id=\"Sec15\" class=\"Section2\"\u003e \u003ch2\u003e3.5 Effect of Ni on the MDA level of seedlings\u003c/h2\u003e \u003cp\u003eHeavy metals, including Ni cause reactive oxygen species (ROS) production in plants, which results in oxidative stress, such as lipid peroxidation that is harmful to membrane stability. MDA is the final product of membrane damage and is used to express it numerically. Therefore, MDA facilitates as a stress marker in plants (Gao et al. \u003cspan citationid=\"CR13\" class=\"CitationRef\"\u003e2022\u003c/span\u003e). The amount of MDA significantly increased due to Ni exposure in safflower in our study (Fig.\u0026nbsp;\u003cspan refid=\"Fig7\" class=\"InternalRef\"\u003e7\u003c/span\u003e). These findings are consistent with the literature. Helaoui et al. (\u003cspan citationid=\"CR15\" class=\"CitationRef\"\u003e2020\u003c/span\u003e) determined that MDA levels in \u003cem\u003eMedicago sativa\u003c/em\u003e L. increased in parallel to Ni levels. In a study conducted with safflower under 0, 25, 50, 75, and 100 mg L\u003csup\u003e\u0026minus;\u0026thinsp;1\u003c/sup\u003e of cadmium treatments, MDA levels increased respectively, with 100 mg L\u003csup\u003e\u0026minus;\u0026thinsp;1\u003c/sup\u003e being 52.14% more than the control group (Tun\u0026ccedil;t\u0026uuml;rk et al. \u003cspan citationid=\"CR38\" class=\"CitationRef\"\u003e2023\u003c/span\u003e). 50 and 100 \u0026micro;M Ni application also caused H\u003csub\u003e2\u003c/sub\u003eO\u003csub\u003e2\u003c/sub\u003e and MDA levels to rise in \u003cem\u003eGossypium hirsutum\u003c/em\u003e L., which was attributed to the damage in the membrane to oxidative stress due to Ni (Khaliq et al. 2016). In \u003cem\u003eSolanum lycopersicum\u003c/em\u003e L., besides H\u003csub\u003e2\u003c/sub\u003eO\u003csub\u003e2\u003c/sub\u003e, O\u003csub\u003e2\u003c/sub\u003e\u003csup\u003e\u0026bull;\u0026minus;\u003c/sup\u003e is also one of the ROS that accumulates with Ni exposure and MDA and ROS increasements are related; because when melatonin is added to alleviate the effects of Ni, ROS amount decreases with melatonin, so does MDA (Altaf et al. \u003cspan citationid=\"CR3\" class=\"CitationRef\"\u003e2021\u003c/span\u003e). Contrary to these results, Gao et al. (\u003cspan citationid=\"CR13\" class=\"CitationRef\"\u003e2022\u003c/span\u003e)\u0026rsquo;s research demonstrates that H\u003csub\u003e2\u003c/sub\u003eO\u003csub\u003e2\u003c/sub\u003e and MDA levels decreased in the leaves of three desert plants grown in locally obtained heavy metal-polluted soil. They also measured high antioxidant enzyme levels in these metal-exposed plants and ascribed the low amount of MDA and H\u003csub\u003e2\u003c/sub\u003eO\u003csub\u003e2\u003c/sub\u003e to antioxidant activity. Baran and Ekmekci (2022), reported that 0.75 mM Ni almost doubled the amount of H\u003csub\u003e2\u003c/sub\u003eO\u003csub\u003e2\u003c/sub\u003e in safflower. Since ROS are responsible for membrane damage, this result is in parallel to our research\u0026rsquo;s findings about MDA levels.\u003c/p\u003e \u003cp\u003e \u003c/p\u003e \u003c/div\u003e \u003cdiv id=\"Sec16\" class=\"Section2\"\u003e \u003ch2\u003e3.4. Effects of Ni on plant anatomy\u003c/h2\u003e \u003cp\u003eThe values of root, stem, and leaf sections taken from the control and Ni treatment of the safflower plant are presented in Fig.\u0026nbsp;\u003cspan refid=\"Fig8\" class=\"InternalRef\"\u003e8\u003c/span\u003e. Results have shown that there was no significant difference in some cell types in roots (cortex, endodermis length, tracheid), stems (epidermis, cortex, phloem, pith), and leaves (epidermis width, spongy, and palisade parenchyma width) between the control and Ni treatment. However, significant differences were observed in other cells. Trachea diameters increased in both root and stem. These increases were 1.4 times in the root and 1.3 times in the stem. Although the tracheid diameter did not alter in the root, it increased 1.2 times in the stem. This is consistent with the results of Gao et al. (\u003cspan citationid=\"CR13\" class=\"CitationRef\"\u003e2022\u003c/span\u003e), who, in their study on the effects of heavy metals on \u003cem\u003eAtriplex\u003c/em\u003e sp. and \u003cem\u003eChenopodium glaucum\u003c/em\u003e L., stated that heavy metal stress reduced the density of vessels in the xylem of plant stems. They also speculated that plants increase their vessel diameter when exposed to heavy metals, which might be a stress response. Gomes et al. (\u003cspan citationid=\"CR14\" class=\"CitationRef\"\u003e2011\u003c/span\u003e) stated that heavy metals have the potential to alter the ratio of root hormones, which in turn may alter tissue morphogenesis and the number of cells in these tissues. Additionally, the reduction in the metaxylem area and the high number of tracheary parts change the hydraulic capacity. Larger diameter vessels are more effective but less safe due to the higher possibility of blisters. On the contrary, Reis et al. (\u003cspan citationid=\"CR33\" class=\"CitationRef\"\u003e2017\u003c/span\u003e) stated that soybean plants under Ni treatment showed negative impacts on root phloem and xylem diameter. In the present study, it has also been determined that the lengths of epidermis, spongy parenchyma, and palisade parenchyma in leaves were decreased by 1.4 times compared to controls.\u003c/p\u003e \u003cp\u003e \u003c/p\u003e \u003cp\u003eAlso, the cross-sections of root, stem, and leaf are shown in Fig.\u0026nbsp;\u003cspan refid=\"Fig9\" class=\"InternalRef\"\u003e9\u003c/span\u003e. Ni-induced deformation (star-like) was observed in the membranes of the cortex in stems (Fig.\u0026nbsp;\u003cspan refid=\"Fig9\" class=\"InternalRef\"\u003e9\u003c/span\u003e-d). Batool et al. (\u003cspan citationid=\"CR8\" class=\"CitationRef\"\u003e2015\u003c/span\u003e) have also reported that Ni may cause deformation in parenchyma cells. The cell wall's flexibility may be reduced as a result of metal binding, which can ultimately cause deformation. Also, heavy metals can decrease cell turgidity due to decreased vacuole size, thereby causing deformation of cell walls (Mousa et al. 2015). Similarly, it is clearly seen that the leaf epidermis shape was altered by Ni treatment (Fig.\u0026nbsp;\u003cspan refid=\"Fig9\" class=\"InternalRef\"\u003e9\u003c/span\u003e-f). In parallel with our results, Kalefetoğlu-Macar et al. (2022), in their study with \u003cem\u003eAllium cepa\u003c/em\u003e L., also found Ni treatment caused epidermal and cortex cell damage in the transmission tissue in their study and stated that Ni-induced injuries related to growth retardation, genotoxicity, oxidative stress, and meristematic cell damage of Ni concentration.\u003c/p\u003e \u003cp\u003e \u003c/p\u003e \u003c/div\u003e"},{"header":"4. Conclusion","content":"\u003cp\u003eThe findings of this research revealed that Ni exposure significantly inhibits safflower seed germination and photosynthetic pigment and protein content in seeds. Our results also revealed that the effect of NiCl\u003csub\u003e2\u003c/sub\u003e on the germination of safflower seeds was not caused by Cl but was caused by Ni. Exposure to Ni increases the amount of MDA in safflower. Also, excess Ni affected the root endodermis, phloem, and trachea; stem trachea and tracheid; and leaf epidermis and spongy parenchyma tissues of safflower. Because safflower accumulates more Ni in the underground part of the plant, root tissue was more affected by Ni toxicity.\u003c/p\u003e "},{"header":"Declarations","content":"\u003cp\u003e\u003cstrong\u003eCRediT authorship contribution statement\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eUğurcan Baran and Ahmet Aksoy conceptualized the study; Sude Tanık and Mert Can Vardar conducted the laboratory trials with the assistance of Güray Ülger; Sude Tanık and Güray Ülger performed data analysis; Uğurcan Baran and Sude Tanık wrote the original draft; Ahmet Aksoy reviewed the manuscript and supervised all over the work.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eDeclaration of Interest Statement\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAcknowledgments\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThis study was supported by The Scientific and Technological Research Council of Türkiye (TÜBİTAK, Project No: KBAG-222Z011).\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eEthical Approval and Consent for Participate\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eNot applicable\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConsent for Publish\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eNot applicable\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAvailability of data and materials\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eAll data generated or analysed in the study are included in this manuscript.\u003c/p\u003e"},{"header":"References","content":"\u003col\u003e\n\u003cli\u003eAhmad MSA, Ashraf M (2012) Essential roles and hazardous effects of nickel in plants. 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Bull Environ Contam Toxicol 86:1-17 https://doi.org/10.1007/s00128-010-0171-1 \u003c/li\u003e\n\u003c/ol\u003e"}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":true,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":false,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"Carthamus tinctorius L., Crop, Heavy metal, Ni, Stress","lastPublishedDoi":"10.21203/rs.3.rs-4106206/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-4106206/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"The safflowers (Carthamus tinctorius L. cv Olas) grown hydroponically under nickel (Ni) conditions have been studied in this work. The effects of 0, 0.75, 1.0, 3.0, 5.0, 10.0-, and 15.0-mM Ni on seed germination rate, protein, and pigment content of germinating seeds were investigated. Also, the toxicity of 0.75 mM Ni on plant growth, malondialdehyde (MDA) amount, and anatomy of 21-day-old safflower seedlings’ roots, stems, and leaves were determined. While Ni (especially higher than 3.0 mM) adversely affected the germination rate, radicle length, protein, and pigment content of safflower seeds, it also negatively affected the biomass production, plant length, leaf number, MDA amount, as well as some cell size/structure of roots (endodermis, phloem, trachea), stems (trachea and tracheid), and leaves (epidermis and sponge parenchyma) of safflower seedlings. Our results revealed that seedling growth was more sensitive to Ni exposure than germination. Although severe toxic effects were observed in 0.75 mM Ni treatment for plant growth parameters, seed germination only started to be highly affected at concentrations higher than 3.0 mM Ni.","manuscriptTitle":"Nickel toxicity to safflower seed germination and seedling morpho-anatomy","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2024-04-10 05:17:34","doi":"10.21203/rs.3.rs-4106206/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"6b727ad0-e4c7-4174-be3f-c0621c9f3dee","owner":[],"postedDate":"April 10th, 2024","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[],"tags":[],"updatedAt":"2024-07-22T09:51:12+00:00","versionOfRecord":[],"versionCreatedAt":"2024-04-10 05:17:34","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-4106206","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-4106206","identity":"rs-4106206","version":["v1"]},"buildId":"8U1c8b4HqxoKbykW_rLl7","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}