Clinical significance of the determinatim of changes of serum cytokines after treatment in patient with endometriosis

Objective To explore the clinical significance of serum IL-2,IL-6,hs-CRP and TNF-α levels after treatment in patient with endometriosis.Methods The levels of serum IL-2,IL-6,hs-CRP and TNF-α(with RIA) were determined in 32 patients with endometriosis both before and after treatment as well as in 35 controls.Results Before the treatment,the serum IL-6,hs-CRP and TNF-α levels in patients were significatly higher than those in the controls(P0.01),while the serum IL-2 level was significatly lower(P0.01).After 3 mouths of treatment,all the levels were not significantly different from those in the controls(P0.05).Conclusion Development of endometriosis is closely related to the serum levels of IL-2,IL-6,hs-CRP and TNF-α.