Designing Asymmetrically Modified Nanochannel Sensors Using Virtual EIS

We devised an approach to capture the physics of localized charge modulation and its effect on ionic transport across asymmetrically charged nanopores by combining computational and experimental strategies. A virtual EIS tool has been developed to compute the impedance across nanopores. Nanoporous anodic alumina membrane (NAA) is employed for thrombin detection with thrombin binding aptamer to experimentally validate the computed impedance results. Using the approach proposed in this work, a novel biosensor is designed and a way to enhance the sensitivity of the sensor is established.