The Value of GDF-15 and Conventional Markers in Combination for Clinical Diagnosis of Lung Cancer

The Value of GDF-15 and Conventional Markers in Combination for Clinical Diagnosis of Lung Cancer | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Article The Value of GDF-15 and Conventional Markers in Combination for Clinical Diagnosis of Lung Cancer Jingru Ni, Yongkang Wu, Limin Niu, Heng Liu, Qinghai Lin, Xiaohe Hao, and 1 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-5281123/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Lung cancer is a leading cause of morbidity and mortality worldwide, and effective biomarkers for its screening and monitoring are still lacking. This study aims to assess the diagnostic value of Growth Differentiation Factor 15 (GDF15) in lung cancer and its subtypes, compared to conventional biomarkers, to evaluate its potential as a predictive biomarker for lung cancer screening and monitoring. GDF15 levels were measured and analyzed in different subtypes of lung cancer and non-tumor controls. The correlation between GDF15 and the expression of eight conventional biomarkers was assessed by analyzing serum GDF15 levels in the markersnormal groups and the markershigh groups. The superiority of GDF15 in screening and monitoring of lung cancer was confirmed using ROC curve analysis of GDF15, alongside conventional biomarkers. Serum GDF15 levels were significantly higher in all subtypes of lung cancer compared with non-tumor controls, showing significant correlations with the levels of conventional biomarkers. ROC curve analysis demonstrated that GDF15 has superior sensitivity and specificity over conventional biomarkers, highlighting its potential as a promising diagnostic biomarker for lung cancer. GDF15 shows strong potential as a diagnostic tool for lung cancer, outperforming conventional markers. It presents a promising new biomarker for lung cancer monitoring and diagnosis. Biological sciences/Cancer/Cancer screening Biological sciences/Cancer/Lung cancer Biological sciences/Cancer/Tumour biomarkers GDF15 Lung Cancer Diagnosis Full Text Additional Declarations No competing interests reported. Supplementary Files Table1.docx Table2.docx Table3.docx Table4.docx TableS1.xlsx TableS1.xlsx Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-5281123","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Article","associatedPublications":[],"authors":[{"id":377216044,"identity":"97084c75-6f2c-4fa7-9318-cfed16cf642c","order_by":0,"name":"Jingru Ni","email":"","orcid":"","institution":"Shandong Cancer Hospital and Institute, Shandong First Medical University, Shandong Academy of Medical Sciences","correspondingAuthor":false,"prefix":"","firstName":"Jingru","middleName":"","lastName":"Ni","suffix":""},{"id":377216045,"identity":"139f6f08-c693-4289-a3a0-6b05ab239600","order_by":1,"name":"Yongkang 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