Global burden of brain and other central nervous system cancer in older adults aged over 65: a population-based study

Global burden of brain and other central nervous system cancer in older adults aged over 65: a population-based study | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Article Global burden of brain and other central nervous system cancer in older adults aged over 65: a population-based study Shuoyang Xu, Guoming Hu This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-5642854/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Background Brain and central nervous system cancer remains a major healthy concern among the elder worldwide. This study is performed to assess the global burden of CNS cancer among adults aged ≥ 65 years across 204 countries and territories from 1990 to 2021 and to predict future trends in the next 25 years. Methods We analyzed the incidence, mortality and disability adjusted life years (DALYs) based on data from the Global Burden of Disease Study 2021. In addition, we obtained and analyzed the age-standardized incidence rate (ASIR), age‐standardized death rate (ASDR), and age‐standardized DALYs rate during 1990–2021. Then we assessed the impact of geographical variations and the Socio‐demographic Index (SDI) on disease burden of CNS cancer. Furthermore, we calculated EAPC and AAPC to reveal temporal trends of CNS cancer incidence and mortality among adults aged ≥ 65 years. Results Globally, CNS cancer incident cases among adults aged ≥ 65 years increased from 40344 in 1990 to 130100 in 2021. The ASIR rose from 3.7 to 4.3 per 100,000 (EAPC:0.44, 95% CI: 0.4–0.49). Low-middle SDI regions showed the largest ASIR increase (EAPC:1.04, 95% CI: 0.99–1.09), while High SDI regions had the lowest (EAPC:0.43, 95% CI: 0.36–0.5). The global ASDR rose from 3 per 100,000 in 1990 to 3.1 per 100,000 in 2021, and the age-standardized DALYs rate decreased from 119.9 to 107.9 per 100,000 between 1990 and 2021. Geographically, the incidence and mortality rates of CNS cancer among adults aged ≥ 65 years increased in most countries and territories. Conclusion The global burden of CNS cancer among the elder has risen sharply from 1990 to 2021, with divisions and disparities observed across different regions. Specific medical interventions and policies to consolidate early detection and better healthcare service in impoverished regions are essential for reducing the global impact of CNS cancer. Health sciences/Oncology/Cancer Health sciences/Neurology/Neurological disorders Global burden of disease Brain and central nervous system cancers Age-period‐cohort Disability‐adjusted life years Incidence Full Text Additional Declarations No competing interests reported. Supplementary Files eTable5.xlsx Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-5642854","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Article","associatedPublications":[],"authors":[{"id":406589642,"identity":"8636be4d-833f-4f77-b9c0-1920d6c904c1","order_by":0,"name":"Shuoyang Xu","email":"","orcid":"","institution":"Shaoxing People’s Hospital, Zhejiang University School of Medicine","correspondingAuthor":false,"prefix":"","firstName":"Shuoyang","middleName":"","lastName":"Xu","suffix":""},{"id":406589643,"identity":"72cdc0e9-b4a1-4020-9ec2-9b43cb77a5f5","order_by":1,"name":"Guoming Hu","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAABA0lEQVRIiWNgGAWjYDCCA0CcAMQGIM4HBjYGGJs4LYwziNYCU8bMg2DjBny3j1/d8HBHrb25RI7hY5s/fIkN7M3bJBhq7uDUInkup+xG4pnjzJYzcoyNc3jYEht4jpVJMBx7hlOLwRmetBuJbcfYDG7kmEnnSAC1SOSYSTA2HCaohQeoxfy3hQFQi/wbQlrYjwG11EiAbGFmSADZwoNfi+QZHjaglgMGBmeeFUv2HGAzbuNJK7ZIOIZbC98Z9mc3f7bV2RscT9744cefY7L97Ic33vhQg1sLAwMPKBaACgQSQLxjkMhMwKOBgYH9AZCoY2DgPwDi1eBVOwpGwSgYBSMTAABUf1lg7cEfDwAAAABJRU5ErkJggg==","orcid":"","institution":"Shaoxing People’s Hospital, Zhejiang University School of Medicine","correspondingAuthor":true,"prefix":"","firstName":"Guoming","middleName":"","lastName":"Hu","suffix":""}],"badges":[],"createdAt":"2024-12-14 10:08:21","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-5642854/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-5642854/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":79153687,"identity":"eb8e1cfa-8fda-4489-a4c2-cdaf6da8a4e7","added_by":"auto","created_at":"2025-03-25 05:32:39","extension":"pdf","order_by":1,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":1928878,"visible":true,"origin":"","legend":"","description":"","filename":"GBD.pdf","url":"https://assets-eu.researchsquare.com/files/rs-5642854/v1_covered_4382ad83-8a69-43f3-a170-6a46a4b5fd6d.pdf"},{"id":74907249,"identity":"c78850f6-3860-457c-9d58-e65b1f355417","added_by":"auto","created_at":"2025-01-28 08:24:59","extension":"xlsx","order_by":1,"title":"","display":"","copyAsset":false,"role":"supplement","size":51721276,"visible":true,"origin":"","legend":"","description":"","filename":"eTable5.xlsx","url":"https://assets-eu.researchsquare.com/files/rs-5642854/v1/723bc0f34bb28d8ad0493b64.xlsx"}],"financialInterests":"No competing interests reported.","formattedTitle":"Global burden of brain and other central nervous system cancer in older adults aged over 65: a population-based study","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"Global burden of disease, Brain and central nervous system cancers, Age-period‐cohort, Disability‐adjusted life years, Incidence","lastPublishedDoi":"10.21203/rs.3.rs-5642854/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-5642854/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003ch2\u003eBackground\u003c/h2\u003e \u003cp\u003eBrain and central nervous system cancer remains a major healthy concern among the elder worldwide. This study is performed to assess the global burden of CNS cancer among adults aged\u0026thinsp;\u0026ge;\u0026thinsp;65 years across 204 countries and territories from 1990 to 2021 and to predict future trends in the next 25 years.\u003c/p\u003e\u003ch2\u003eMethods\u003c/h2\u003e \u003cp\u003eWe analyzed the incidence, mortality and disability adjusted life years (DALYs) based on data from the Global Burden of Disease Study 2021. In addition, we obtained and analyzed the age-standardized incidence rate (ASIR), age‐standardized death rate (ASDR), and age‐standardized DALYs rate during 1990\u0026ndash;2021. Then we assessed the impact of geographical variations and the Socio‐demographic Index (SDI) on disease burden of CNS cancer. Furthermore, we calculated EAPC and AAPC to reveal temporal trends of CNS cancer incidence and mortality among adults aged\u0026thinsp;\u0026ge;\u0026thinsp;65 years.\u003c/p\u003e\u003ch2\u003eResults\u003c/h2\u003e \u003cp\u003eGlobally, CNS cancer incident cases among adults aged\u0026thinsp;\u0026ge;\u0026thinsp;65 years increased from 40344 in 1990 to 130100 in 2021. The ASIR rose from 3.7 to 4.3 per 100,000 (EAPC:0.44, 95% CI: 0.4\u0026ndash;0.49). Low-middle SDI regions showed the largest ASIR increase (EAPC:1.04, 95% CI: 0.99\u0026ndash;1.09), while High SDI regions had the lowest (EAPC:0.43, 95% CI: 0.36\u0026ndash;0.5). The global ASDR rose from 3 per 100,000 in 1990 to 3.1 per 100,000 in 2021, and the age-standardized DALYs rate decreased from 119.9 to 107.9 per 100,000 between 1990 and 2021. Geographically, the incidence and mortality rates of CNS cancer among adults aged\u0026thinsp;\u0026ge;\u0026thinsp;65 years increased in most countries and territories.\u003c/p\u003e\u003ch2\u003eConclusion\u003c/h2\u003e \u003cp\u003eThe global burden of CNS cancer among the elder has risen sharply from 1990 to 2021, with divisions and disparities observed across different regions. Specific medical interventions and policies to consolidate early detection and better healthcare service in impoverished regions are essential for reducing the global impact of CNS cancer.\u003c/p\u003e","manuscriptTitle":"Global burden of brain and other central nervous system cancer in older adults aged over 65: a population-based study","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2025-01-28 08:24:42","doi":"10.21203/rs.3.rs-5642854/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"d22cfda2-fde1-4d14-af7f-7b525511e0c8","owner":[],"postedDate":"January 28th, 2025","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[{"id":43358900,"name":"Health sciences/Oncology/Cancer"},{"id":43358901,"name":"Health sciences/Neurology/Neurological disorders"}],"tags":[],"updatedAt":"2025-03-25T05:08:29+00:00","versionOfRecord":[],"versionCreatedAt":"2025-01-28 08:24:42","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-5642854","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-5642854","identity":"rs-5642854","version":["v1"]},"buildId":"XKTyCvWXoU3ODBz1xrDgd","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}