Malignant Brenner tumor of ovary: A case report and review of literature

Background: Brenner tumours of ovary are rare representing 1-5% of epithelial ovarian tumours. They are further categorized as benign, proliferative (borderline), or malignant. Diagnosis of Malignant Brenner requires surgical excision and histopathological examination as tumor does not possess pathognomonic imaging features. Further, histological diagnosis of malignant Brenner tumor is challenging due to overlapping morphologic and histopathological features with benign and proliferative Brenner tumours, and transitional cell carcinoma. Case details: A 49 years old female presented with history of vague abdominal pain for 2 months. A computerized tomography scan revealed a mixed cystic and solid anterior mass with thickened septations and peripheral nodularity. She underwent Total abdominal hysterectomy and bilateral salphingo-oophorectomy. Histopathological examination and immunohistochemistry was suggestive of malignant Brenner tumor of ovary. 2 years later she presented with nodal recurrence of disease for which she was started on Gemcitabine and Cisplatin combination chemotherapy. Conclusion: Malignant Brenner tumor has poor prognosis. The treatment approach is not well established in view of its rarity, while surgical excision of the tumour remains the constant. The real benefit of the adjuvant chemotherapy remains unclear. Treatment options for disease recurrence included gemcitabine, tamoxifen, doxorubicin, and eribulin, though disease recurred after all of these regimens