The effectiveness of psychological and psychosocial interventions in reducing pain interference in women with endometriosis: A systematic review.

This systematic review focuses on the effectiveness of psychological and psychosocial interventions in reducing pain interference in women with endometriosis. Pain is one of the most burdensome and persistent symptoms of endometriosis, often leading to significant psychological distress and functional impairment. While pharmacological and surgical options remain standard, their limitations—such as recurrence, side effects, and low acceptability—underscore the need for evidence-based, non-pharmacological approaches. This review will synthesize findings from randomized controlled trials evaluating interventions such as psychoeducation, cognitive-behavioral therapy, mindfulness-based programs, biofeedback and other psychosocial treatments. Our aim is to map and critically assess the current evidence, focusing on how these interventions affect pain-related outcomes such as pain interference or health-related quality of life. Given the heterogeneity of endometriosis in symptom expression and psychosocial burden, this review will also consider differences in intervention formats and populations to identify promising approaches for personalized care. By providing a structured overview of existing evidence, this work aims to support clinicians and researchers in improving the psychological management of endometriosis-related pain.