Genetic Determinants of Endometriosis and Uterine Myoma Combinatin
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Abstract
Benign proliferative diseases of the uterus, which include uterine myoma and endometriosis occupy a leading place in the structure of gynecological diseases. The objective of the research was a bioinformatic study of the involvement of candidate genes in the formation of a combination of endometriosis with uterine myoma in women. As a result of the study, 5 molecular-genetic markers were genotyped in 109 patients with a combination of endometriosis with uterine myoma and 981 women of the control group. It has been established that the combinations of molecular genetic markers rs466639 with rs713586 and rs10441737 (OR = 2.45) and rs466639 with rs3756261, rs713586 and rs10980926 (OR = 1.36) are risk factors for the development of a combination of endometriosis and uterine myoma among women of the Central region of Russia.
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