Dose-related Adaptive Reconstruction of DMN in isoflurane Administration: a Study in the Rat

Abstract The anesthetic states are accompanied by functional alterations. However, the dose-related adaptive alterations in the higher-order network under anesthesia, e. g. default mode network (DMN), are poorly revealed. Herein, we implanted electrodes in brain regions of the rat DMN to acquire local field potentials to investigate the perturbations produced by anesthesia. Relative power spectral density, static functional connectivity (FC), fuzzy entropy of dynamic FC, and topological features were computed from the data. The results showed that adaptive reconstruction were induced by isoflurane, exhibiting reduced static and stable long-range FC, altered topological features. These reconstruction patterns were in a dose-related fashion and delta-band dominated. These results might impart insights into the neural network mechanisms underlying anesthesia and suggest the potential of monitoring the depth of anesthesia based on the parameters of DMN.