Analyse des Profils zellfreier microRNAs im Follikelpunktat von Frauen mit und ohne Endometriose bei künstlicher Befruchtung

This study analyzed cell-free microRNA profiles in follicular fluid collected from 75 women undergoing IVF or ICSI, comparing those with endometriosis to those without using spike-in normalized, PCR-based TaqMan microRNA array profiling of 754 human microRNAs from pooled samples. The exploratory results found that miR-126, miR-142-3p, miR-145, miR-223, and miR-451 were higher in follicular fluid from endometriosis patients. A key limitation explicitly noted is that the array analysis was performed on pools, and the authors call for verification with further qPCR in non-pooled samples. This paper is centrally about endometriosis — it compares follicular-fluid cell-free microRNA expression in IVF/ICSI patients with and without endometriosis to identify potential endometriosis-associated biomarker candidates.

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