KR Endometritis Tanısı ve Tedavisi

Sümeyye Mermi, Mustafa Öztürk
In: Tüp Bebek Okulu Klinik ve Embriyoloji Eğitim Kitabı · 2026 · pp. 379–390 · doi:10.37609/akya.3886.c5070 · W7164041192
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⚙ AI-generated summary by claude@2026-07+body, 2026-07-09 ⓘ

This paper reviews the diagnosis and treatment of chronic endometritis, referencing studies on its impact on reproduction and infertility.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-12 · read from full text ⓘ

The paper is a review-style compilation focused on chronic endometritis, summarizing proposed effects on reproduction and synthesizing evidence on diagnosis and treatment, including associations with infertility and repeated implantation failure using methods such as histology, hysteroscopy, molecular microbiology, and analyses of immunoglobulin subclasses, cytokine/growth factor transcription, and other endometrial factors. Key findings across cited studies include that chronic endometritis is detected with multiple approaches (each with limitations) and is linked in some reports to impaired reproductive outcomes, while diagnostic and therapeutic results vary across studies and populations. The paper’s major caveat is that it relies on heterogeneous underlying evidence and, for specific interventions, meta-analytic conclusions can depend on study designs and definitions of chronic endometritis. Relevance to endometriosis: at least one cited component study explicitly examines chronic endometritis prevalence and risk factors in patients with adenomyosis and infertility, placing chronic endometritis in a comorbidity context relevant to adenomyosis.

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KR Endometritis Tanısı ve Tedavisi Özet Referanslar Kimura F, Takebayashi A, Ishida M, Nakamura A, Kita- zawa J, Morimune A, et al. Review: Chronic endometritis and its effect on reproduction. Journal of Obstetrics and Gynaecology Research. 2019 May 6;45(5):951–60. Kitaya K, Tada Y, Hayashi T, Taguchi S, Funabiki M, Nakamura Y. Comprehensive Endometrial Immunoglobulin Subclass Analysis in Infertile Women Suffering from Repeated Implantation Failure with or without Chronic Endometritis. American Journal of Reproduc- tive Immunology. 2014 Oct 5;72(4):386–91. Di Pietro C, Cicinelli E, Guglielmino MR, Ragusa M, Farina M, Palumbo MA, et al. Altered Transcriptional Regulation of Cytokines, Growth Factors, and Apop- totic Proteins in the Endometrium of Infertile Women with Chronic Endometritis. American Journal of Reproductive Immunology. 2013 May 28;69(5):509–17. Yoshii N, Hamatani T, Inagaki N, Hosaka T, Inoue O, Yamada M, et al. Successful implantation after redu- cing matrix metalloproteinase activity in the uterine cavity. Reproductive Biology and Endocrinology. 2013 Dec 11;11(1):37. Veiga EC de A, Soares Junior JM, Samama M, Ikeda F, Francisco LS, Sartor A, et al. Chronic endometritis and assisted reproduction: a systematic review and me- ta-analysis. Revista da Associação Médica Brasileira. Michels TC. Chronic endometritis. Am Family Physician. 1995 Jul;52(1):217–22. Greenwood SM, Moran JJ. Chronic endometritis: morphologic and clinical observations. Obstetrics and gynecology. 1981 Aug;58(2):176–84. Katherine T Chen. Endometritis unrelated to preg- nancy. [Online] https://www.uptodate.com/contents/ endometritisunrelatedtopregnancysearch=CHRO- NIC20ENDOMETRITIS&source=search_result&- selectedTitle=1~150&usage_type=default&display_ rank=1#references Cimadomo D, de los Santos MJ, Griesinger G, Lainas G, Le Clef N, McLernon DJ, et al. ESHRE good practi- ce recommendations on recurrent implantation failure. Human Reproduction Open. 2023 Jun 1;2023(3). Espinós JJ, Fabregues F, Fontes J, García-Velasco JA, Llácer J, Requena A, et al. Impact of chronic endomet- ritis in infertility: a SWOT analysis. Reproduction Bio- medicine Online. 2021 May;42(5):939–51. Cicinelli E, Matteo M, Trojano G, Mitola PC, Tinelli R, Vitagliano A, et al. Chronic endometritis in patients with unexplained infertility: Prevalence and effects of antibiotic treatment on spontaneous conception. Ame- rican Journal of Reproductive Immunology. 2018 Jan 14;79(1). Li J, Wei J, Chen S, Wang X, Chen J, Zeng D, et al. Prevalence and risk factors for chronic endometritis in patients with adenomyosis and infertility: a retros- pective cohort study. BMC Womens Health. 2024 Jul 16;24(1):403. Cimadomo D, Craciunas L, Vermeulen N, Vomstein K, Toth B. Definition, diagnostic and therapeutic options in recurrent implantation failure: an international sur do A, Saccone G, Cicinelli E, et al. Effects of chronic endometritis therapy on in vitro fertilization outcome in women with repeated implantation failure: a sys- tematic review and meta-analysis. Fertil Steril. 2018 Jul;110(1):103-112.e1. Ticconi C, Inversetti A, Marraffa S, Campagnolo L, Arthur J, Zambella E, et al. Chronic endometritis and recurrent reproductive failure: a systematic review and meta-analysis. Frontiers in Immunology. 2024 Aug 16;15. Moreno I, Cicinelli E, Garcia-Grau I, Gonzalez-Mon- fort M, Bau D, Vilella F, et al. The diagnosis of chronic endometritis in infertile asymptomatic women: a com- parative study of histology, microbial cultures, hyste- roscopy, and molecular microbiology. American Jour- nal of Obstetrics & Gynecology. 2018 Jun;218(6):602. e1-602.e16. Liu H, Song J, Zhang F, Li J, Kong W, Lv S, et al. A New Hysteroscopic Scoring System for Diagnosing Chronic Endometritis. Journal of Minimally Invasive Gyneco- logy. 2020 Jul;27(5):1127–32. Kitaya K, Nagai Y, Arai W, Sakuraba Y, Ishikawa T. Characterization of Microbiota in Endometrial Fluid and Vaginal Secretions in Infertile Women with Re- peated Implantation Failure. Mediators Inflammation. 2019 May 21;2019:1–10. Kitaya K, Yasuo T, Yamaguchi T. Bridging the Diagnos- tic Gap between Histopathologic and Hysteroscopic Chronic Endometritis with Deep Learning Models. Medicina (B Aires). 2024 Jun 12;60(6):972. Küçük T, Safali M. “Chromohysteroscopy” for evalua- vey of clinicians and embryologists. Human Reproduc- tion. 2021 Jan 25;36(2):305–17. Akopians A, Pisarska M, Wang E. The Role of Inflamtion of endometrium in recurrent in vitro fertilization failure. Journal of Assisted Reproduction and Genetics. 2008 Mar 29;25(2–3):79–82. Ozturk M, Ulubay M, Alanbay I, Keskin U, Karasahin E, Yenen MC. Using narrow-band imaging with conventional hysteroscopy increases the detection of ch- ronic endometritis in abnormal uterine bleeding and postmenopausal bleeding. Journal of Obstetrics and Gynaecology Research. 2016 Jan;42(1):67–71. Cheng X, Huang Z, Xiao Z, Bai Y. Does antibiotic the- rapy for chronic endometritis improve clinical outco- mes of patients with recurrent implantation failure in subsequent IVF cycles? A systematic review and me- ta-analysis. Journal of Assisted Reproduction and Gene- tics. 2022 Aug 13;39(8):1797–813. Yasuo T, Kitaya K. Challenges in Clinical Diagnosis and Management of Chronic Endometritis. Diagnosti- cs. 2022 Nov 5;12(11):2711. Workowski KA, Bachmann LH, Chan PA, Johnston CM, Muzny CA, Park I, et al. Sexually Transmitted Infections Treatment Guidelines, 2021. MMWR Recom- mendations Report. 2021 Jul 23;70(4):1–187. Kitaya K, Matsubayashi H, Takaya Y, Nishiyama R, Ya- maguchi K, Takeuchi T, et al. Live birth rate following oral antibiotic treatment for chronic endometritis in infertile women with repeated implantation failure. American Journal of Reproductive Immunology. 2017 Nov 13;78(5). Di Gennaro F, Guido G, Frallonardo L, Pennazzi L, Bevilacqua M, Locantore P, et al. Chronic Endometritis and Antimicrobial Resistance: Towards a Multid- rug-Resistant Endometritis? An Expert Opinion. Mic- roorganisms. 2025 Jan 17;13(1):197. Cicinelli E, Matteo M, Tinelli R, Lepera A, Alfonso R, Indraccolo U, et al. Prevalence of chronic endometritis in repeated unexplained implantation failure and the IVF success rate after antibiotic therapy. Human Repro- duction. 2015 Feb 1;30(2):323–30. Vitagliano A, Laganà AS, De Ziegler D, Cicinelli R, Santarsiero CM, Buzzaccarini G, et al. Chronic Endometritis in Infertile Women: Impact of Untreated Dise- ase, Plasma Cell Count and Antibiotic Therapy on IVF Outcome—A Systematic Review and Meta-Analysis. Diagnostics. 2022 Sep 18;12(9):2250. Di Gennaro F, Guido G, Frallonardo L, Pennazzi L, Bevilacqua M, Locantore P, et al. Chronic Endometritis and Antimicrobial Resistance: Towards a Multid- rug-Resistant Endometritis? An Expert Opinion. Microorganisms. 2025 Jan 17;13(1):197.

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