Dynamic Endobronchial Findings in a Patient with Endobronchial Endometriosis before and after Progestin Therapy: A Case Report

Ryo Torii, Yamasaki K, Tatsuya Shingu, Moe Kidogawa, Ryosuke Hata, K Saito, Shunsuke Fukuyo, Takanobu Jotatsu, Yatera K
In: Respiratory Endoscopy · 2026 · vol. 4(2) , pp. 126–130 · doi:10.58585/respend.2025-0050 · W7171328748
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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-07-30 ⓘ

This case report details a patient with endobronchial endometriosis whose endobronchial lesions and hemoptysis resolved after progestin therapy.

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⚙ AI-generated deep summary by qwen3.7-flash, 2026-08-16 · read from full text ⓘ

This case report describes a 23-year-old female presenting with recurrent hemoptysis and menstrual-synchronized ground-glass opacities on chest CT. Bronchoscopic evaluation identified reddish swollen epithelium and subepithelial lesions, leading to a suspected diagnosis of endobronchial endometriosis based on the temporal link between symptoms and menstruation. Treatment with progestin therapy resulted in the complete resolution of both the hemoptysis and the observed endobronchial abnormalities, marking the first reported instance of such dynamic improvement in this condition. This paper is centrally about endometriosis — specifically the rare manifestation of endobronchial endometriosis affecting the respiratory tract.

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Abstract

Endobronchial endometriosis represents an uncommon form of pulmonary endometriosis. A 23-year-old female was hospitalized due to recurrent hemoptysis. Chest computed tomography revealed ground-glass opacities that appeared synchronized with her menstrual cycle. Bronchoscopic examination revealed reddish swollen epithelium, prominent subepithelial blood vessels, and multiple red subepithelial lesions in the bronchial epithelium. Given the temporal association of hemoptysis with menstruation, ground-glass opacities in the lung field, and endobronchial abnormalities, along with a history of induced abortion and heavy menstrual bleeding, endobronchial endometriosis was suspected. Treatment with progestin completely resolved her hemoptysis and the abnormal endobronchial findings, and she was subsequently diagnosed with endobronchial endometriosis. To our knowledge, this is the first reported case demonstrating improvement in endobronchial lesions before and after progestin treatment in a patient with endobronchial endometriosis.
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Keywords

catamenial hemoptysis, progestin, endobronchial endometriosis, pulmonary endometriosis, case report 2026 Volume 4 Issue 2 Pages 126-130 Details

Abstract

Endobronchial endometriosis represents an uncommon form of pulmonary endometriosis. A 23-year-old female was hospitalized due to recurrent hemoptysis. Chest computed tomography revealed ground-glass opacities that appeared synchronized with her menstrual cycle. Bronchoscopic examination revealed reddish swollen epithelium, prominent subepithelial blood vessels, and multiple red subepithelial lesions in the bronchial epithelium. Given the temporal association of hemoptysis with menstruation, ground-glass opacities in the lung field, and endobronchial abnormalities, along with a history of induced abortion and heavy menstrual bleeding, endobronchial endometriosis was suspected. Treatment with progestin completely resolved her hemoptysis and the abnormal endobronchial findings, and she was subsequently diagnosed with endobronchial endometriosis. To our knowledge, this is the first reported case demonstrating improvement in endobronchial lesions before and after progestin treatment in a patient with endobronchial endometriosis. © 2026 The Japan Society for Respiratory Endoscopy This article is licensed under a Creative Commons [Attribution 4.0 International] license. https://creativecommons.org/licenses/by/4.0/ Favorites & Alerts Recently viewed articles

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