Case Report: The role of Panchagavya and Panchakarma treatment in the management of radiotherapy and chemotherapy side effects in infiltrative ductal carcinoma

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Chemo- and radiotherapy are commonly used after the surgical intervention for radical cure. The occurrence of various side-effects of these chemo-radiation therapies creates much discomfort to the patient. Therefore, the compliance rate of the patient towards their adoption becomes poor, or the patient is highly affected by their associated side effects in unavoidable circumstances. It is imperative to study the effect of safe, alternative options such as Panchakarma and Panchagavya treatment, which are widely used in clinical practice as an adjuvant therapy in various types of carcinoma. This report presents the case of a 31-year-old female patient diagnosed with right infiltrative ductal carcinoma of the breast, and who was advised to undergo chemo-radiation therapy after surgical intervention. However, as soon as she finished the first chemo cycle, she suffered from palpitations, loss of appetite, nausea, vomiting, severe restlessness, and hot flushes. She was rushed to the Kamdhenu Panchgavya Ayurvedic Clinic of Govigyan Anusandhan Kendra. Specific Panchagvya treatment, along with Mrudu Shodhana based on Ayurvedic principles, was prescribed to her (Kamdhenu Gomutra Ark, Laghusutshekhar Ras, Panchagavya Ghrita, Panchatikta Kshir Vasti, Anuvasana Vasti with Panchgavya Ghrita) throughout her total rounds of chemo- and radiotherapy. After starting the above-said Ayurvedic treatment, the patient experienced significant relief in all symptoms. Her full six sittings of chemo- and radiotherapy were smoothly completed without causing any untoward effect. The selected combination of Ayurveda medicines gave relief in all symptoms induced by chemo- and radiotherapy therapy due to their Vatanulomak, Pittghna, Dahahara, Balya and Rasayana properties. The present case study shows that the Panchakarma and Panchagavya treatments are effective in subside the side effects induced by chemo- and radiotherapy and improving the compliance rate of the patients towards these conventional therapies." } { "@context": "http://schema.org", "@type": "BreadcrumbList", "itemListElement": [ { "@type": "ListItem", "position": "1", "item": { "@id": "https://f1000research.com/", "name": "Home" } }, { "@type": "ListItem", "position": "2", "item": { "@id": "https://f1000research.com/browse/articles", "name": "Browse" } }, { "@type": "ListItem", "position": "3", "item": { "@id": "https://f1000research.com/articles/12-1383/v2", "name": "Case Report: The role of Panchagavya and Panchakarma treatment in..." } } ] } Home Browse Case Report: The role of Panchagavya and Panchakarma treatment in... ALL Metrics - Views Downloads Get PDF Get XML Cite How to cite this article Sawarkar P, Sawarkar G and Bhojraj N. Case Report: The role of Panchagavya and Panchakarma treatment in the management of radiotherapy and chemotherapy side effects in infiltrative ductal carcinoma [version 2; peer review: 1 approved, 2 approved with reservations] . F1000Research 2024, 12 :1383 ( https://doi.org/10.12688/f1000research.139233.2 ) NOTE: If applicable, it is important to ensure the information in square brackets after the title is included in all citations of this article. Close Copy Citation Details Export Export Citation Sciwheel EndNote Ref. Manager Bibtex ProCite Sente EXPORT Select a format first Track Share ▬ ✚ Case Report Revised Case Report: The role of Panchagavya and Panchakarma treatment in the management of radiotherapy and chemotherapy side effects in infiltrative ductal carcinoma [version 2; peer review: 1 approved, 2 approved with reservations] Punam Sawarkar https://orcid.org/0000-0001-7980-7832 1 , Gaurav Sawarkar https://orcid.org/0000-0002-5605-795X 1 , Nandini Bhojraj 2 Punam Sawarkar https://orcid.org/0000-0001-7980-7832 1 , Gaurav Sawarkar https://orcid.org/0000-0002-5605-795X 1 , Nandini Bhojraj 2 PUBLISHED 08 Apr 2024 Author details Author details 1 Mahatma Gandhi Ayurved College Hospital and Research Centre, Datta Meghe Institute of Higher Education and Research, Wardha, Maharashtra, 442001, India 2 Consultant, Go Anusandhana Kendra, Deolapar, Maharashtra, 441401, India Punam Sawarkar Roles: Data Curation, Formal Analysis, Writing – Original Draft Preparation Gaurav Sawarkar Roles: Visualization, Writing – Original Draft Preparation, Writing – Review & Editing Nandini Bhojraj Roles: Conceptualization, Project Administration, Supervision, Writing – Original Draft Preparation OPEN PEER REVIEW DETAILS REVIEWER STATUS This article is included in the Datta Meghe Institute of Higher Education and Research collection. Abstract The incidence rate of infiltrative ductal carcinoma of the breast is increasing worldwide. Chemo- and radiotherapy are commonly used after the surgical intervention for radical cure. The occurrence of various side-effects of these chemo-radiation therapies creates much discomfort to the patient. Therefore, the compliance rate of the patient towards their adoption becomes poor, or the patient is highly affected by their associated side effects in unavoidable circumstances. It is imperative to study the effect of safe, alternative options such as Panchakarma and Panchagavya treatment, which are widely used in clinical practice as an adjuvant therapy in various types of carcinoma. This report presents the case of a 31-year-old female patient diagnosed with right infiltrative ductal carcinoma of the breast, and who was advised to undergo chemo-radiation therapy after surgical intervention. However, as soon as she finished the first chemo cycle, she suffered from palpitations, loss of appetite, nausea, vomiting, severe restlessness, and hot flushes. She was rushed to the Kamdhenu Panchgavya Ayurvedic Clinic of Govigyan Anusandhan Kendra. Specific Panchagvya treatment, along with Mrudu Shodhana based on Ayurvedic principles, was prescribed to her ( Kamdhenu Gomutra Ark, Laghusutshekhar Ras , Panchagavya Ghrita, Panchatikta Kshir Vasti, Anuvasana Vasti with Panchgavya Ghrita ) throughout her total rounds of chemo- and radiotherapy. After starting the above-said Ayurvedic treatment, the patient experienced significant relief in all symptoms. Her full six sittings of chemo- and radiotherapy were smoothly completed without causing any untoward effect. The selected combination of Ayurveda medicines gave relief in all symptoms induced by chemo- and radiotherapy therapy due to their Vatanulomak, Pittghna, Dahahara, Balya and Rasayana properties. The present case study shows that the Panchakarma and Panchagavya treatments are effective in subside the side effects induced by chemo- and radiotherapy and improving the compliance rate of the patients towards these conventional therapies. READ ALL READ LESS Keywords Breast Carcinoma, Chemotherapy, Panchagavya, Panchakarma, Radiotherapy Corresponding Author(s) Punam Sawarkar ( [email protected] ) Close Corresponding author: Punam Sawarkar Competing interests: No competing interests were disclosed. Grant information: The author(s) declared that no grants were involved in supporting this work. Copyright: © 2024 Sawarkar P et al . This is an open access article distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. How to cite: Sawarkar P, Sawarkar G and Bhojraj N. Case Report: The role of Panchagavya and Panchakarma treatment in the management of radiotherapy and chemotherapy side effects in infiltrative ductal carcinoma [version 2; peer review: 1 approved, 2 approved with reservations] . F1000Research 2024, 12 :1383 ( https://doi.org/10.12688/f1000research.139233.2 ) First published: 20 Oct 2023, 12 :1383 ( https://doi.org/10.12688/f1000research.139233.1 ) Latest published: 08 Apr 2024, 12 :1383 ( https://doi.org/10.12688/f1000research.139233.2 ) Revised Amendments from Version 1 Concepts are more emphasized in the discussion section based on reviewer comments and comparisons to prior published papers. A scale for quality of life is employed. WHOQOL-SRPB: scoring and coding for the WHOQOL SRPB field-test instrument: Users Manual, 2012 version, WHO Reference Number: WHO/MSD/MER/Rev.2012.05. Concepts are more emphasized in the discussion section based on reviewer comments and comparisons to prior published papers. A scale for quality of life is employed. WHOQOL-SRPB: scoring and coding for the WHOQOL SRPB field-test instrument: Users Manual, 2012 version, WHO Reference Number: WHO/MSD/MER/Rev.2012.05. See the authors' detailed response to the review by Amit Nakanekar and Payal Rathod READ REVIEWER RESPONSES Introduction Infiltrating ductal carcinoma (IDC), also called invasive ductal carcinoma, is a carcinoma involving the milk duct. It is the most typical breast carcinoma (80 % of total incidences of breast carcinoma). 1 Its spread takes place through the lymph nodes to other body tissues. 2 The number of patients of this type of carcinoma of breast are increasing day by day, both globally and in India. 3 Though the carcinoma of breast is considered as better compared to other cancers from a treatment and prognosis perspective, the recurrence of especially infiltrative ductal carcinoma is a common entity. 4 Therefore, its radical cure treatment in the form of chemo- and radiotherapy is highly appreciated, preceded by surgical intervention. However, there are multiple side-effects of these chemo-radiation therapies such as body aches, nausea, vomiting, and a severe burning sensation, which is quite troublesome for the patient as these symptoms adversely affect the quality of life of the patient. 5 As a result, many patients decline to undergo further courses and may be deprived of their total expected therapeutic outcome. 6 In these circumstances, the pathogenesis of the primary disease may worsen or may even lead to the death of the patient due to further metastatic changes. Moreover, modern science is limited in preventing such complications; it is difficult to target cancer stem cells (CSCs), drug resistance properties of cancer stem cells make them immune to anticancer drugs, a lack of cancer epigenetic profiling and specificity of existing epi-drugs, problems associated with cancer diagnosis make it difficult to treat, a lack of effective biomarkers for cancer diagnosis and prognosis, and there are limitations of conventional chemotherapeutic agents. 7 Therefore, it is the need of the hour to search for some safe alternative options in Ayurveda to manage these complications effectively. Panchagavya treatment and Mrudu Shodhana, sourced from Ayurveda medicine, seem to be a ray of hope for such patients which is demonstrated through this case report. Case report Patient information The 31-year-old married female patient, housewife, with a diagnosis of right infiltrative ductal carcinoma of the breast, who had a mastectomy three weeks before her first chemotherapy session, approached Go-Anusandhana Chikitsasalaya , Nagpur, in February 2014. According to her history, she was experiencing issues such as palpitations, loss of appetite, nausea, and vomiting. These symptoms began after the first chemo session, and after the third session she additionally experienced hot flushes, constipation, burning micturition, and sensations of burning in the anal region. Thus, she was unable to consume any food. A detailed history of the patient is presented in Table 1 . Upon examination at her first visit to the outpatient department, the general condition of the patient was fair, no icterus/swelling was found, mild pallor, palpable axillary lymphadenopathy, and blood pressure was 90/70 mm of Hg. Prakriti of patient was Vatapradhan Pittaj Prakriti. Ashatavidha Parikshana results are mentioned in Table 2 . Table 1. Patient past-present-drug and family history. Past medical history Jaundice before six years No other major medical/surgical illness Personal history Diet: vegetarian Sleep: disturbed Occupation: housewife Menstrual history: Menarche at the age of 13 years Regular (30 days cycle) for four days, painless with moderate bleeding Obstetric history: G1P1A0 (normal delivery but a mentally disabled male child) Drug History Chemotherapy Family history Father: no specific history Mother: K/C/O HTN Siblings: normal Paternal uncle: K/C/O carcinoma of stomach Table 2. Ashatavidha Parikshana. S.N. Head Observation S.N. Head Observation 1 Nadi (pulse) 64/min ( Vata-Pittaja ) 5 Shabda (speech) Spashta (clear) 2 Mala (stool) Constipated (after third chemo) 6 Sparsha (touch) Ushna 3 Mutra (urine) Burning micturition 7 Druka (vision) Good 4 Jivha (tongue) Sama 8 Akruti ( posture) Madhyam She was given Ayurvedic medication as adjuvant therapy for infiltrative ductal cancer and to address these side effects of chemotherapy. The patient self-reported that the intensity of the above symptoms was controlled with the prescribed medicines: Kamdhenu Gomutra Ark (distilled cow urine) 10 ml twice a day with the dilution of 100 ml water on an empty stomach; Laghusutashekhar Rasa (comprising of Swarna gairika – purified red ochre, iron oxide; Shunthi – ginger rhizome, Zingiber officinalis; Nagavalli – betel leaf juice extract, piper betel) 125 mg tablets twice a day with clarified butter and candy sugar; Panchagavya Ghrita 10 ml twice a day with each meal when hungry; Panchatikta Kshir Vasti 50 ml before the day of chemotherapy and alternating three enemas sittings after three days of chemotherapy; Matra Vasti with Panchagavya Ghrita 60 ml once a week after food for six months. However, eight weeks after completing her third chemo round, she visited the out-patient department again, suffering from additional symptoms such as severe hot flushes (all over the body), constipation, burning micturition, and burning sensation in the anal region, and quality of life was also severely affected. Therefore, specific Panchakarma (Mrudu Shodhana ) of 60 ml Matra Basti with Panchagavya Ghrut was prescribed, which was continued throughout her chemo- and radiotherapy. After adding this, encouraging results were found in all signs and symptoms, and all sittings of chemo-radiotherapy were completed smoothly without any undue effect. Timeline and diagnostic assessment The patient first reported to the outpatient department with a pre-existing diagnosis of breast infiltrative ductal carcinoma. The oncologist did not determine the patient’s prognosis due to the unknown metastases in the body. Pathological investigations of the patient carried out for the diagnosis are described in Table 3 . Table 3. Method of diagnosis and investigation. S.N. Method of diagnosis/investigations Timeline Impression/remark 1 Self-recognition 16/02/2014 The feeling of a lump in the right breast 2 Chest PA view 17/02/2014 NAD 3 USG (abdomen & pelvis) 17/02/2014 Bulky uterus with small cystic lesions in left ovary 4 Skeletal scintigraphy 18/02/2014 Scan negative for skeletal metastasis 5 Bilateral mammography 17/02/2014 Irregular speculated high-density 3.5*2.5 cm lump in the upper right breast ACR-BI-RADS Category 6 Biopsy (histopathology) 21/02/2014 + ve for malignancy Muscle bundles with a small focus of tumor showing infiltrating duct carcinoma 7 FNAC (Rt axillary lymph node) 21/02/2014 Scattered polymorphs in hemorrhagic background 8 Surgical intervention 27/02/2014 Mastectomy 9 First chemo 20/03/2014 Side-effects started After the initial chemo treatments, the patient reported to the outpatient department with palpitation, lack of appetite, nausea, and vomiting. Kamdhenu Gomutra Ark, Laghusutshekhar, and Panchagavya Ghrit were prescribed for primary treatment. After 4 weeks between chemo rounds, the patient felt better. After 8 weeks, the third chemo session, the patient reported additional symptoms such as hot flushes, constipation, burning micturition, and anal burning. Panchatikta Kshir Vasti was administered before chemo, three enemas three days after chemo, and Matra Vasti with Panchagavya Ghrita once a week after eating. After six months, the patient claimed improvement from palpitation, loss of appetite, nausea, vomiting, hot flushes, constipation, burning micturition, and anal burning. Therapeutic intervention In this therapeutic intervention, palliative treatment and purification were given: prescribed medicines: Kamdhenu Gomutra Ark (distilled cow urine) 10 ml twice a day with the dilution of 100 ml water on an empty stomach; Laghusutashekhar Rasa 3 125 mg tablets twice a day with clarified butter and candy sugar ; Panchagavya Ghrita (Ghrit prepared from cow milk, curd, clarified butter, urine, and dung) 10 ml twice a day with each meal when hungry; Panchatikta Kshir Vasti (enema of cow milk treated with Azadirachta indica (stem bark), Tinospora cordifolia (stem), Adhatoda vasica (root), Solanum xanthocarpum (root) and Trichosanthes dioica (aerial parts)) 50 ml before the day of chemotherapy and alternating three enemas after three days of chemotherapy; Matra Vasti with Panchagavya Ghrita (medicated clarified butter enema with Panchagavya ) 60 ml once a week after food for six months. Palliative treatment increases the quality of life of patients, and their families who are dealing with the hardships of a life-threatening disease, and the purification method helps to detoxify the body for better improvement in quality of life. Details of the types of therapeutic intervention and administration of therapeutic intervention applied in this case are depicted in Table 4 . Table 4. Details of therapeutic intervention applied. S.N. Medicine Dose Frequency Time of administration After drink Duration 1 Kamdhenu Gomutra Ark (Distilled cow urine) 10 ml Twice a day With empty stomach With the dilution of 100ml water For six months 2 Laghusutashekhar Rasa 3tabs Twice a day 10 a.m. - 2.p.m. Goghrita+ candy sugar 3 Panchagavya Ghrita (Ghrit prepared from cow milk, curd, clarified butter, urine, and dung) 10 ml Twice a day At the time of hunger with each meal 4 Panchatikta Kshir Vasti [Enema of Cow milk treated with Azadirachta indica (stem bark), Tinospora cordifolia (stem), Adhatoda vasica (root), Solanum xanthocarpum (root) and Trichosanthes dioica (aerial parts)] 50 ml (Godugdha 25 ml +Pancha tikta Ghrita 25 ml) - Before the day of chemo & alternate three enemas after three days of chemo - Six months 5 Matra Vasti with Panchagavya Ghrita [Medicated clarified butter enema with Panchagavya] 60 ml - Once a week after the food - Six months Follow-up and therapeutic outcome After prescribing the above treatment plan compromising of Mrudu Shodhana (Ksheervasti +Anuvasana Vasti ) with Panchagavya Chikitsa for 6 months, the patient felt significant relief in all side effects of the chemo- and radiotherapy and the conventional therapies were completed smoothly and successfully. Moreover, to date, there is no recurrence of the disease or any complication in the form of metastasis. The symptoms like palpitations, lack of appetite, nausea, vomiting, hot flushes, constipation, burning micturition, and burning sensation in the anal region reduced remarkably. Therapeutic outcomes observed in this patient are mentioned in Table 5 . A scale for quality of life is employed. WHOQOL-SRPB: scoring and coding for the WHOQOL SRPB field-test instrument: Users Manual, 2012 version, WHO Reference Number: WHO/MSD/MER/Rev.2012.05. Table 5. Therapeutic outcome. S.N. Clinical findings Before Treatment After one month After two months After three months After four months After five months After six months 1 Palpitation 4 2 1 0 0 0 0 2 Loss of appetite 3 1 1 1 0 0 0 3 Nausea 4 1 1 1 0 0 0 4 Vomiting 4 0 0 0 0 0 0 5 Hot flushes (All over body) - - - 4 1 0 0 6 Constipation - - - 4 0 0 0 7 Burning micturition - - - 4 0 0 0 8 Burning sensation in anal region - - - 3 0 0 0 Discussion Kamdhenu Gomutra Arka (distilled cow urine) is one of the most effective medicines among Panchagavya formulations. 8 Due to its highly concentrated nature as a result of the specific method of preparation and original properties of Gomutra; it is highly effective in decreasing Kapha properties and increasing digestive fire, which increases the patient’s appetite. 9 According to the modern perspective, potassium in Gomutra Arka is responsible for its effect on appetite 9 dried nature decreases the excess liquid qualities of Pitta which results in relief of nausea. The sodium in Gomutra Arka relieves hyperacidity. Mainly, Gomutra corrects the Kledak Kapha vitiation, which is the leading cause of Chhardi, i.e., vomiting. Due to its Kapha- decreasing properties, it is useful in Kapha- predominant conditions in Granthi and Arbuda (Cyst & tumour). It is highly effective in various carcinomatous conditions due to the anti-cancer properties of Gomutra. 10 Gomutra is diuretic in nature; it eliminates the excess Kleda (toxic materials induced by chemotherapeutic agents) and also decreases the burning sensation during urination. 11 It also decreases hematological toxicities induced by chemo and radiation therapies. 12 , 13 Gomutra plays a crucial role in immune modulation by enhancing the activity of macrophages, lymphocytes (both T and B cells), humoral cellular immunity, and cytokines (interleukin 1 and 2), and works as an adjuvant therapy with the conventional modalities. 14 It also protects the cell from getting damaged by free radicals, which can cause tumor cell growth or recurrence. 14 Laghusutashekhar Rasa is the combination of herbs and minerals that consists of Gairik responsible for the Pitta pacification effect due to its cooling properties, which subsides the symptoms of Pitta vitiation such as hot flushes, burning micturition and burning sensation in anal region. It absorbs the excess liquid properties of vitiated Pitta, which occurs due to heating properties of the chemotherapeutic agent. Therefore, it decreases the sensation of nausea and reduces the frequency of vomiting 15 and is highly recommended for acid peptic disease and lack of appetite. It also pacifies Vata due to its sweet, oily properties. 16 As it contains–cow ghee, which increases digestive fire, it results in increased appetite. 17 Panchagavya Ghrita (Ghee prepared from cow milk, curd, clarified butter, urine, and dung) is the medicated ghee that pacifies the Pitta and Kapha. 18 In this case, it was used in the pacification of toxins and Matra Vasti (medicated enema). Pacifier ghee intake, with Panchagavya Ghrita, acts as a carrier that can facilitate the drug or its pharmacological properties to get into the cells, enhancing the effects of pacifier medicine. 19 It processes free radicals as a result of the anti-oxidant effects due to vitamins A, C, and E, and fatty acids present in it. It is especially recommended for liver disorders. 20 It acts as the best immuno-modulator through its anti-oxidant properties. 20 It also has anti-cancer properties and helps to remove the hematogenous toxins induced by chemotherapeutic agents. 21 – 22 The neuroprotective action of Panchagvaya Ghrita is demonstrated by Sawarkar G et al. (2018), resulting in the relief in hot flushes. 23 Matra Vasti (medicated enema) with Panchgavya Ghrita (enema of cow milk treated with Azadirachta indica (stem bark), Tinospora cordifolia (stem), Adhatoda vasica (root), Solanum xanthocarpum (root) and Trichosanthes dioica (aerial parts)) acts as a mild type of purification and can be adopted to induce harmony between the vitiated Dosha and Dhatu , which can normalize the Vata without causing any deterioration in the status of the person. 24 While Shodhan Vasti (putative enema) is contraindicated in cancer treatment due to the complexity of the disease, Shaman Vasti (pacificatory enema) can be used with cancer patients as it is a mild type of enema. Moreover, side effects induced by chemo- and radiotherapy mainly affect the Rasavaha (channel of nutrition) , Annavaha (food carrying channels), and Pursihvaha Strotas (body waste product channel) by primarily causing vitiation of Vata and Pitta. Therefore, Panchagavya Ghrita, which is mainly a Pitta pacifier, also brings the Vatanulomama (downward Vata movement) due to the oily quality of Ghrita. As a result, it corrects the Saman Vayu (digestive air) and Pachak Pitta (digestive fire). It reverts the normalcy of Annavaha Strotas by improving appetite. 25 Panchtikta Kshir Vasti (medicated clarified butter enema with Panchagavya ) is recommended for Pitta predominant and degenerative conditions due to its Pitta pacification properties , Kledahara (factor responsible for minimizing moisture) , Balya (creating power), and Rasayan (rejuvenation) properties. 26 In clinical practice, it has significant results in Amlapittta Daha (hyperacidity), bone or bone marrow-based diseases. 27 The Kaphaghna (Kapha pacifing) and Sukshma (micro functioning) properties of Panchtikta (Guduchi, Patol, Kantakari, Nimba, and Vasa) reduce the inflammation in gastric mucosa induced by chemotherapeutic agents due to their anti-inflammatory and antioxidant properties. 28 At the same time, clarified butter and cow milk in this enema preparation induce a soothing effect due to their Pitta Shamaka nature. 17 Strengths and limitations The combination of all Ayurveda medicines and Panchagavya therapies induces the Anulomana (air movement in downward direction) of Apana Vayu , which stimulates the Samana Vayu (digestive air) and corrects the vitiation of Kledka Kapha (moisture minimizing) and Pachaka Pitta (digestive fire). 24 Therefore, symptoms related to Amlapitta (acidity) and Sarvanaga Daha (burning sensation in body) completely subsided. Due to Kledahara (moisture minimizing) and Agnidipaka (increasing appetite) properties, it removes the vitiation of circulatory tissues in the body, resulting in the relief of heart palpitations. As a result, symptoms induced by chemo- and radiotherapy therapy will ease due to the correct combination of Panchakarma and Panchagavya formulations with their Vatanulomak (downward direction of air), Pittghna (anti-bilious), Dahahara (minimizing burning sensation), Balya (powerful/nutritive), and Rasayana (immuno-modulators, anti-oxidant, bio-enhancing) properties. Because this is only a single case study, the patient should be treated according to suitable medical guidelines and under the supervision of specialists in the respective domains in the future. Panchagavya therapy believe it can help modify the immune system, which is critical in combating cancer cells. The components of Panchagavya are thought to increase immunity and support general wellness. Panchagavya therapy is also supposed to help in detoxification of the body. Detoxifying the body may help the body’s natural systems for clearing toxins, which may be useful in cancer prevention and treatment. Panchagavya’s components, particularly milk, ghee, and curd, include critical nutrients that may promote general health and well-being throughout cancer therapy. 29 Some research indicates that Panchagavya components have anti-inflammatory capabilities. Chronic inflammation is connected to cancer development, and lowering inflammation may aid in cancer preventive methods. 30 Panchagavya contains a lot of antioxidants, including ghee. Antioxidants aid in neutralizing free radicals in the body, which can contribute to cell damage and even cancer formation. 21 Conclusion The present case study shows that the Ayurvedic intervention based on Panchagavya and Panchakarma is effective in subsiding the side effects induced by the chemo- and radiotherapy through their threefold effects of Shamana, Bruhana, and Mrudu Shodhana. It is also helpful to increase the compliance rate of the patients towards conventional therapies like chemo-radiotherapy. Further multi-centric clinical trials with large sample sizes are encouraged to establish the significant and comprehensive role of Panchagavya Chikitsa with Panchakarma in Ayurveda. It will become a milestone for Ayurveda in oncology for its acceptance at a global level. Patient perspective The patient is satisfied with the treatment protocol and desired outcomes. Ethical statement Written informed consent was received from the patient for publishing this case study and the patient consented to the disclosure of her clinical details. The ethical clearance for the publication of this case study was taken from the local ethical committee at Mahatma Gandhi Ayurveda College, Hospital and Research Centre, Salod (H), Wardha with IRB No. MGAC/IEC/April/2023/102. All procedures and treatments advised and performed in this study were conducted by ethical standards mentioned in the 1964 Declaration of Helsinki, as revised in 2013. Glossary • Agnidipaka: increasing appetite • Amlapittta Daha: hyper acidity • Annavaha Strotas : gastro-intestinal channels • Anulomana- correct direction • Anuvasana Vasti with Panchgavya Ghrita: medicated clarified butter enema with Panchagavya • Apan Vayu: air entity below umbilicus • Ashatavidha Parikshana: eight-fold examination • Astha-Majjagata Dushti Vikara: disease that occurred due to vitiation of toxins at bone and bone marrow • Balya: nutritive • Bruhana: nutritive treatment • Chhardi: vomiting • Chikitsa: treatment • Dahahara: dispelling one’s burning sensation • Dhatu: body tissue • Dhatukshayajanaya Vata Vyadhi: diseases of air entity due to its depletion • Dosha: bio humour • Drava Guna of Pitta :liquid nature of fire/hot entity in body • Go–Ghrita: cow clarified butter • Gomutra: cow urine • Granthi and Arbuda: cyst • Guda Daha: burning sensation at the anus • Guduch: Tinospora cordifolia • Kamdhenu Gomutra Ark: distilled cow urine • Kantakari: Solanum xanthocarpum • Kapha : phlegm • Kaphaghna : anti-phlegm • Kledahara: hydrous conetent absorber • Kledak Kapha Dushti: vitiation of phlegm • Laghusutshekhar Ras: herbs-minerals Ayurveda drug combination • Matra Vasti: oil retention enema • Mootra Daha: burning micturition • Mrudu Shodhana: mild detoxification • Nimba: Azadirachta indica • Niruha Vasti: decoction enema • Pachak Pitta: fire/hot entity in abdomen • Panchagavya: a combination of cow milk, curd, clarified butter, urine, and dung • Panchagavya Ghrita: Ghrit prepared from cow milk, curd, clarified butter, urine, and dung • Panchakarma: putative therapy • Panchatikta Kshir Vasti: enema of cow milk treated with Azadirachta indica (stem bark), Tinospora cordifolia (stem), Adhatoda vasica (root), Solanum xanthocarpum (root), and Trichosanthes dioica (aerial parts) • Patol: Trichosanthes dioica • Pitta Dosha: fire entity or humor in the body • Pitta Prakopaka: Pitta dosha flare-up • Pitta Shamaka: pacification of Pitta dosha • Pittghna: anti-bilious • Pursihvaha Strotas : eliminitory channels • Ras Dushti : vitiation of circulatory tissues in the body • Rasavaha Strotas : the channels of the body which convey the first tissue formed from the nutritive juices • Rasayana : immuno-modulators, anti-oxidant, bio-enhancing • Ruksha Guna : dry property • Saman Vayu: air entity at the abdomen • Sarvanaga Daha: burning sensation in all over body • Sarvang Daha : hot flushes • Shamana: pacification treatment • Shamana Snehapana: palliative oleation • Shodhana: purification • Snigdha Guna: unctuous property • Strotas :circulatory channels • Sukshma: micro • Tikshana Shodhana :extreme putative therapy • Ushna Guna: thermal properties • Vamana: therpeutic emesis • Vasa: Adhatoda vasica • Vatanulomak: the drugs responsible for the change in direction of Vata Dosha i.e. Vata means to blow or to move like the wind. 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PubMed Abstract | Publisher Full Text | Free Full Text Comments on this article Comments (0) Version 2 VERSION 2 PUBLISHED 20 Oct 2023 ADD YOUR COMMENT Comment Author details Author details 1 Mahatma Gandhi Ayurved College Hospital and Research Centre, Datta Meghe Institute of Higher Education and Research, Wardha, Maharashtra, 442001, India 2 Consultant, Go Anusandhana Kendra, Deolapar, Maharashtra, 441401, India Punam Sawarkar Roles: Data Curation, Formal Analysis, Writing – Original Draft Preparation Gaurav Sawarkar Roles: Visualization, Writing – Original Draft Preparation, Writing – Review & Editing Nandini Bhojraj Roles: Conceptualization, Project Administration, Supervision, Writing – Original Draft Preparation Competing interests No competing interests were disclosed. Grant information The author(s) declared that no grants were involved in supporting this work. Article Versions (2) version 2 Revised Published: 08 Apr 2024, 12:1383 https://doi.org/10.12688/f1000research.139233.2 version 1 Published: 20 Oct 2023, 12:1383 https://doi.org/10.12688/f1000research.139233.1 Copyright © 2024 Sawarkar P et al . This is an open access article distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Download Export To Sciwheel Bibtex EndNote ProCite Ref. Manager (RIS) Sente metrics Views Downloads F1000Research - - PubMed Central info_outline Data from PMC are received and updated monthly. - - Citations open_in_new 0 open_in_new 0 open_in_new SEE MORE DETAILS CITE how to cite this article Sawarkar P, Sawarkar G and Bhojraj N. Case Report: The role of Panchagavya and Panchakarma treatment in the management of radiotherapy and chemotherapy side effects in infiltrative ductal carcinoma [version 2; peer review: 1 approved, 2 approved with reservations] . F1000Research 2024, 12 :1383 ( https://doi.org/10.12688/f1000research.139233.2 ) NOTE: If applicable, it is important to ensure the information in square brackets after the title is included in all citations of this article. COPY CITATION DETAILS track receive updates on this article Track an article to receive email alerts on any updates to this article. TRACK THIS ARTICLE Share Open Peer Review Current Reviewer Status: ? Key to Reviewer Statuses VIEW HIDE Approved The paper is scientifically sound in its current form and only minor, if any, improvements are suggested Approved with reservations A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit. Not approved Fundamental flaws in the paper seriously undermine the findings and conclusions Version 2 VERSION 2 PUBLISHED 08 Apr 2024 Revised Views 0 Cite How to cite this report: Selvi BT. Reviewer Report For: Case Report: The role of Panchagavya and Panchakarma treatment in the management of radiotherapy and chemotherapy side effects in infiltrative ductal carcinoma [version 2; peer review: 1 approved, 2 approved with reservations] . F1000Research 2024, 12 :1383 ( https://doi.org/10.5256/f1000research.164456.r330371 ) The direct URL for this report is: https://f1000research.com/articles/12-1383/v2#referee-response-330371 NOTE: it is important to ensure the information in square brackets after the title is included in this citation. Close Copy Citation Details Reviewer Report 07 Nov 2024 B Thamarai Selvi , Sri Ramakrishna College of Arts and Science for Women, Coimbatore, Tamil Nadu, India Approved VIEWS 0 https://doi.org/10.5256/f1000research.164456.r330371 The Panchagavya and Panchakarma therapies outlined here offer a valuable complementary approach in the holistic management of cancer treatment side effects. These therapies help mitigate common symptoms like nausea, vomiting, appetite loss, and fatigue associated with chemotherapy ... Continue reading READ ALL The Panchagavya and Panchakarma therapies outlined here offer a valuable complementary approach in the holistic management of cancer treatment side effects. These therapies help mitigate common symptoms like nausea, vomiting, appetite loss, and fatigue associated with chemotherapy and radiotherapy, while also enhancing the immune system and promoting detoxification. he reported positive outcomes in the case study suggest that these Ayurvedic therapies can help improve patient quality of life and treatment compliance during cancer therapy. However, further research with larger sample sizes is essential to validate these findings on a wider scale. Is the background of the case’s history and progression described in sufficient detail? Yes Are enough details provided of any physical examination and diagnostic tests, treatment given and outcomes? Yes Is sufficient discussion included of the importance of the findings and their relevance to future understanding of disease processes, diagnosis or treatment? Yes Is the case presented with sufficient detail to be useful for other practitioners? Partly Competing Interests: No competing interests were disclosed. Reviewer Expertise: Strengths and Limitations: Strengths: Multi-Pronged Action: The combination of various therapies works on multiple aspects of the body, including immunity, digestion, and detoxification. Holistic Approach: Ayurvedic treatments like Panchagavya therapies can serve as complementary treatments that support the body during conventional cancer therapies. Immune Boosting: By enhancing immunity and detoxifying the body, Panchagavya therapies may help improve the patient's overall resilience to treatment and recovery. Limitations: Lack of Large-Scale Evidence: This case study is limited to a single patient, and while the results are promising, larger and more comprehensive studies are necessary to establish the efficacy of these treatments in a broader population. Medical Supervision Required: These therapies should be used under the supervision of trained Ayurvedic practitioners, especially in conjunction with conventional cancer treatments, to avoid any potential adverse effects. Herbal Medicines and ecofriendly dying I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard. Close READ LESS CITE CITE HOW TO CITE THIS REPORT Selvi BT. Reviewer Report For: Case Report: The role of Panchagavya and Panchakarma treatment in the management of radiotherapy and chemotherapy side effects in infiltrative ductal carcinoma [version 2; peer review: 1 approved, 2 approved with reservations] . F1000Research 2024, 12 :1383 ( https://doi.org/10.5256/f1000research.164456.r330371 ) The direct URL for this report is: https://f1000research.com/articles/12-1383/v2#referee-response-330371 NOTE: it is important to ensure the information in square brackets after the title is included in all citations of this article. COPY CITATION DETAILS Report a concern Respond or Comment COMMENT ON THIS REPORT Views 0 Cite How to cite this report: Joglekar AA and Joshi S. Reviewer Report For: Case Report: The role of Panchagavya and Panchakarma treatment in the management of radiotherapy and chemotherapy side effects in infiltrative ductal carcinoma [version 2; peer review: 1 approved, 2 approved with reservations] . F1000Research 2024, 12 :1383 ( https://doi.org/10.5256/f1000research.164456.r330370 ) The direct URL for this report is: https://f1000research.com/articles/12-1383/v2#referee-response-330370 NOTE: it is important to ensure the information in square brackets after the title is included in this citation. Close Copy Citation Details Reviewer Report 11 Oct 2024 Aishwarya Ashish Joglekar , Samhita Siddhant, All India Institute of Ayurveda, New Delhi, India Sumedh Joshi , Dravyaguna, All India Institute of Ayurveda, New Delhi, India Approved with Reservations VIEWS 0 https://doi.org/10.5256/f1000research.164456.r330370 The authors have successfully provided insights in the treatment of ductal carcinoma of breast. The scientific treatment is done with classical medications and simple therapeutic protocol. Few aspects mentioned below can be incorporated for further understanding of ... Continue reading READ ALL The authors have successfully provided insights in the treatment of ductal carcinoma of breast. The scientific treatment is done with classical medications and simple therapeutic protocol. Few aspects mentioned below can be incorporated for further understanding of the subject 1) Incidence and Prevalence of ductal carcinoma in India and/or globally can be expressed in numbers 2) Terms like modern science or modern perspective can be avoided and replaced with terms like western biomedicine and conventional medicine 3) Introduction can be give brief information regarding the Panchagavya treatment 4) English equivalent for all the sanskrit terms including basti etc should be provided 5) Pacifier Ghee intake ?? Clarify the statement 6) The name of GMP company from which the study drugs were used can be mentioned. Authentication certificate can be provided 7) Term Panchagavya Belief - Not clear 8) Recent research work done in this field can be mentioned (where in the use of same of drugs for the treatment of ductal carcinoma , ayurvedic treatment of ductal carcinoma can be mentioned) Is the background of the case’s history and progression described in sufficient detail? Partly Are enough details provided of any physical examination and diagnostic tests, treatment given and outcomes? Partly Is sufficient discussion included of the importance of the findings and their relevance to future understanding of disease processes, diagnosis or treatment? Yes Is the case presented with sufficient detail to be useful for other practitioners? Yes Competing Interests: No competing interests were disclosed. Reviewer Expertise: Ayurveda , Ayurveda Basic principles , endocrinology We confirm that we have read this submission and believe that we have an appropriate level of expertise to confirm that it is of an acceptable scientific standard, however we have significant reservations, as outlined above. Close READ LESS CITE CITE HOW TO CITE THIS REPORT Joglekar AA and Joshi S. Reviewer Report For: Case Report: The role of Panchagavya and Panchakarma treatment in the management of radiotherapy and chemotherapy side effects in infiltrative ductal carcinoma [version 2; peer review: 1 approved, 2 approved with reservations] . F1000Research 2024, 12 :1383 ( https://doi.org/10.5256/f1000research.164456.r330370 ) The direct URL for this report is: https://f1000research.com/articles/12-1383/v2#referee-response-330370 NOTE: it is important to ensure the information in square brackets after the title is included in all citations of this article. COPY CITATION DETAILS Report a concern Respond or Comment COMMENT ON THIS REPORT Version 1 VERSION 1 PUBLISHED 20 Oct 2023 Views 0 Cite How to cite this report: Nakanekar A and Rathod P. Reviewer Report For: Case Report: The role of Panchagavya and Panchakarma treatment in the management of radiotherapy and chemotherapy side effects in infiltrative ductal carcinoma [version 2; peer review: 1 approved, 2 approved with reservations] . F1000Research 2024, 12 :1383 ( https://doi.org/10.5256/f1000research.152493.r220496 ) The direct URL for this report is: https://f1000research.com/articles/12-1383/v1#referee-response-220496 NOTE: it is important to ensure the information in square brackets after the title is included in this citation. Close Copy Citation Details Reviewer Report 19 Dec 2023 Amit Nakanekar , Government Ayurved College, Maharashtra, India Payal Rathod , Kayachikitsa, Government Ayurved College Nagpur, Nagpur, Maharashtra, India Approved with Reservations VIEWS 0 https://doi.org/10.5256/f1000research.152493.r220496 This Case report nicely describes the importance of Pangavya and Panchkarma treatment in infiltrative ductal carcinoma. I congratulate the authors for successfully treating this challenging case. The authors have nicely explained the case in detail. I suggest authors avoid ... Continue reading READ ALL This Case report nicely describes the importance of Pangavya and Panchkarma treatment in infiltrative ductal carcinoma. I congratulate the authors for successfully treating this challenging case. The authors have nicely explained the case in detail. I suggest authors avoid the use of complicated Ayurvedic terminologies to increase the visibility and citation value of the article. Authors need to emphasise the concepts rather than medicines in the discussion section. Authors can compare their current study with previously published articles. Please mention the quality of life scales used for this case report. Provide all the reports as a supplementary material Is the background of the case’s history and progression described in sufficient detail? Yes Are enough details provided of any physical examination and diagnostic tests, treatment given and outcomes? Yes Is sufficient discussion included of the importance of the findings and their relevance to future understanding of disease processes, diagnosis or treatment? Partly Is the case presented with sufficient detail to be useful for other practitioners? Yes Competing Interests: No competing interests were disclosed. Reviewer Expertise: Ayurveda, Herbal Medicine, We confirm that we have read this submission and believe that we have an appropriate level of expertise to confirm that it is of an acceptable scientific standard, however we have significant reservations, as outlined above. Close READ LESS CITE CITE HOW TO CITE THIS REPORT Nakanekar A and Rathod P. Reviewer Report For: Case Report: The role of Panchagavya and Panchakarma treatment in the management of radiotherapy and chemotherapy side effects in infiltrative ductal carcinoma [version 2; peer review: 1 approved, 2 approved with reservations] . F1000Research 2024, 12 :1383 ( https://doi.org/10.5256/f1000research.152493.r220496 ) The direct URL for this report is: https://f1000research.com/articles/12-1383/v1#referee-response-220496 NOTE: it is important to ensure the information in square brackets after the title is included in all citations of this article. COPY CITATION DETAILS Report a concern Author Response 19 Jun 2024 Punam Sawarkar , $usrAffiliation 19 Jun 2024 Author Response Concepts are more emphasized in the discussion section based on reviewer comments and comparisons to prior published papers. A scale for quality of life is employed. WHOQOL-SRPB: scoring and coding ... Continue reading Concepts are more emphasized in the discussion section based on reviewer comments and comparisons to prior published papers. A scale for quality of life is employed. WHOQOL-SRPB: scoring and coding for the WHOQOL SRPB field-test instrument: Users Manual, 2012 version, WHO Reference Number: WHO/MSD/MER/Rev.2012.05. All the supporting reports are submitted as a supplementary material Concepts are more emphasized in the discussion section based on reviewer comments and comparisons to prior published papers. A scale for quality of life is employed. WHOQOL-SRPB: scoring and coding for the WHOQOL SRPB field-test instrument: Users Manual, 2012 version, WHO Reference Number: WHO/MSD/MER/Rev.2012.05. All the supporting reports are submitted as a supplementary material Competing Interests: Nil Close Report a concern Respond or Comment COMMENTS ON THIS REPORT Author Response 19 Jun 2024 Punam Sawarkar , $usrAffiliation 19 Jun 2024 Author Response Concepts are more emphasized in the discussion section based on reviewer comments and comparisons to prior published papers. A scale for quality of life is employed. WHOQOL-SRPB: scoring and coding ... Continue reading Concepts are more emphasized in the discussion section based on reviewer comments and comparisons to prior published papers. A scale for quality of life is employed. WHOQOL-SRPB: scoring and coding for the WHOQOL SRPB field-test instrument: Users Manual, 2012 version, WHO Reference Number: WHO/MSD/MER/Rev.2012.05. All the supporting reports are submitted as a supplementary material Concepts are more emphasized in the discussion section based on reviewer comments and comparisons to prior published papers. A scale for quality of life is employed. WHOQOL-SRPB: scoring and coding for the WHOQOL SRPB field-test instrument: Users Manual, 2012 version, WHO Reference Number: WHO/MSD/MER/Rev.2012.05. All the supporting reports are submitted as a supplementary material Competing Interests: Nil Close Report a concern COMMENT ON THIS REPORT Comments on this article Comments (0) Version 2 VERSION 2 PUBLISHED 20 Oct 2023 ADD YOUR COMMENT Comment keyboard_arrow_left keyboard_arrow_right Open Peer Review Reviewer Status info_outline Alongside their report, reviewers assign a status to the article: Approved The paper is scientifically sound in its current form and only minor, if any, improvements are suggested Approved with reservations A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit. Not approved Fundamental flaws in the paper seriously undermine the findings and conclusions Reviewer Reports Invited Reviewers 1 2 3 Version 2 (revision) 08 Apr 24 read read Version 1 20 Oct 23 read Amit Nakanekar , Government Ayurved College, Maharashtra, India Payal Rathod , Government Ayurved College Nagpur, Nagpur, India Aishwarya Ashish Joglekar , All India Institute of Ayurveda, New Delhi, India Sumedh Joshi , All India Institute of Ayurveda, New Delhi, India B Thamarai Selvi , Sri Ramakrishna College of Arts and Science for Women, Coimbatore, India Comments on this article All Comments (0) Add a comment Sign up for content alerts Sign Up You are now signed up to receive this alert Browse by related subjects keyboard_arrow_left Back to all reports Reviewer Report 0 Views copyright © 2024 Selvi B. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 07 Nov 2024 | for Version 2 B Thamarai Selvi , Sri Ramakrishna College of Arts and Science for Women, Coimbatore, Tamil Nadu, India 0 Views copyright © 2024 Selvi B. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. format_quote Cite this report speaker_notes Responses (0) Approved info_outline Alongside their report, reviewers assign a status to the article: Approved The paper is scientifically sound in its current form and only minor, if any, improvements are suggested Approved with reservations A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit. Not approved Fundamental flaws in the paper seriously undermine the findings and conclusions The Panchagavya and Panchakarma therapies outlined here offer a valuable complementary approach in the holistic management of cancer treatment side effects. These therapies help mitigate common symptoms like nausea, vomiting, appetite loss, and fatigue associated with chemotherapy and radiotherapy, while also enhancing the immune system and promoting detoxification. he reported positive outcomes in the case study suggest that these Ayurvedic therapies can help improve patient quality of life and treatment compliance during cancer therapy. However, further research with larger sample sizes is essential to validate these findings on a wider scale. Is the background of the case’s history and progression described in sufficient detail? Yes Are enough details provided of any physical examination and diagnostic tests, treatment given and outcomes? Yes Is sufficient discussion included of the importance of the findings and their relevance to future understanding of disease processes, diagnosis or treatment? Yes Is the case presented with sufficient detail to be useful for other practitioners? Partly Competing Interests No competing interests were disclosed. Reviewer Expertise Strengths and Limitations: Strengths: Multi-Pronged Action: The combination of various therapies works on multiple aspects of the body, including immunity, digestion, and detoxification. Holistic Approach: Ayurvedic treatments like Panchagavya therapies can serve as complementary treatments that support the body during conventional cancer therapies. Immune Boosting: By enhancing immunity and detoxifying the body, Panchagavya therapies may help improve the patient's overall resilience to treatment and recovery. Limitations: Lack of Large-Scale Evidence: This case study is limited to a single patient, and while the results are promising, larger and more comprehensive studies are necessary to establish the efficacy of these treatments in a broader population. Medical Supervision Required: These therapies should be used under the supervision of trained Ayurvedic practitioners, especially in conjunction with conventional cancer treatments, to avoid any potential adverse effects. Herbal Medicines and ecofriendly dying I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard. reply Respond to this report Responses (0) Selvi BT. Peer Review Report For: Case Report: The role of Panchagavya and Panchakarma treatment in the management of radiotherapy and chemotherapy side effects in infiltrative ductal carcinoma [version 2; peer review: 1 approved, 2 approved with reservations] . F1000Research 2024, 12 :1383 ( https://doi.org/10.5256/f1000research.164456.r330371) NOTE: it is important to ensure the information in square brackets after the title is included in this citation. The direct URL for this report is: https://f1000research.com/articles/12-1383/v2#referee-response-330371 keyboard_arrow_left Back to all reports Reviewer Report 0 Views copyright © 2024 Joglekar A et al. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 11 Oct 2024 | for Version 2 Aishwarya Ashish Joglekar , Samhita Siddhant, All India Institute of Ayurveda, New Delhi, India Sumedh Joshi , Dravyaguna, All India Institute of Ayurveda, New Delhi, India 0 Views copyright © 2024 Joglekar A et al. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. format_quote Cite this report speaker_notes Responses (0) Approved With Reservations info_outline Alongside their report, reviewers assign a status to the article: Approved The paper is scientifically sound in its current form and only minor, if any, improvements are suggested Approved with reservations A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit. Not approved Fundamental flaws in the paper seriously undermine the findings and conclusions The authors have successfully provided insights in the treatment of ductal carcinoma of breast. The scientific treatment is done with classical medications and simple therapeutic protocol. Few aspects mentioned below can be incorporated for further understanding of the subject 1) Incidence and Prevalence of ductal carcinoma in India and/or globally can be expressed in numbers 2) Terms like modern science or modern perspective can be avoided and replaced with terms like western biomedicine and conventional medicine 3) Introduction can be give brief information regarding the Panchagavya treatment 4) English equivalent for all the sanskrit terms including basti etc should be provided 5) Pacifier Ghee intake ?? Clarify the statement 6) The name of GMP company from which the study drugs were used can be mentioned. Authentication certificate can be provided 7) Term Panchagavya Belief - Not clear 8) Recent research work done in this field can be mentioned (where in the use of same of drugs for the treatment of ductal carcinoma , ayurvedic treatment of ductal carcinoma can be mentioned) Is the background of the case’s history and progression described in sufficient detail? Partly Are enough details provided of any physical examination and diagnostic tests, treatment given and outcomes? Partly Is sufficient discussion included of the importance of the findings and their relevance to future understanding of disease processes, diagnosis or treatment? Yes Is the case presented with sufficient detail to be useful for other practitioners? Yes Competing Interests No competing interests were disclosed. Reviewer Expertise Ayurveda , Ayurveda Basic principles , endocrinology We confirm that we have read this submission and believe that we have an appropriate level of expertise to confirm that it is of an acceptable scientific standard, however we have significant reservations, as outlined above. reply Respond to this report Responses (0) Joglekar AA and Joshi S. Peer Review Report For: Case Report: The role of Panchagavya and Panchakarma treatment in the management of radiotherapy and chemotherapy side effects in infiltrative ductal carcinoma [version 2; peer review: 1 approved, 2 approved with reservations] . F1000Research 2024, 12 :1383 ( https://doi.org/10.5256/f1000research.164456.r330370) NOTE: it is important to ensure the information in square brackets after the title is included in this citation. The direct URL for this report is: https://f1000research.com/articles/12-1383/v2#referee-response-330370 keyboard_arrow_left Back to all reports Reviewer Report 0 Views copyright © 2023 Nakanekar A et al. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 19 Dec 2023 | for Version 1 Amit Nakanekar , Government Ayurved College, Maharashtra, India Payal Rathod , Kayachikitsa, Government Ayurved College Nagpur, Nagpur, Maharashtra, India 0 Views copyright © 2023 Nakanekar A et al. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. format_quote Cite this report speaker_notes Responses (1) Approved With Reservations info_outline Alongside their report, reviewers assign a status to the article: Approved The paper is scientifically sound in its current form and only minor, if any, improvements are suggested Approved with reservations A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit. Not approved Fundamental flaws in the paper seriously undermine the findings and conclusions This Case report nicely describes the importance of Pangavya and Panchkarma treatment in infiltrative ductal carcinoma. I congratulate the authors for successfully treating this challenging case. The authors have nicely explained the case in detail. I suggest authors avoid the use of complicated Ayurvedic terminologies to increase the visibility and citation value of the article. Authors need to emphasise the concepts rather than medicines in the discussion section. Authors can compare their current study with previously published articles. Please mention the quality of life scales used for this case report. Provide all the reports as a supplementary material Is the background of the case’s history and progression described in sufficient detail? Yes Are enough details provided of any physical examination and diagnostic tests, treatment given and outcomes? Yes Is sufficient discussion included of the importance of the findings and their relevance to future understanding of disease processes, diagnosis or treatment? Partly Is the case presented with sufficient detail to be useful for other practitioners? Yes Competing Interests No competing interests were disclosed. Reviewer Expertise Ayurveda, Herbal Medicine, We confirm that we have read this submission and believe that we have an appropriate level of expertise to confirm that it is of an acceptable scientific standard, however we have significant reservations, as outlined above. reply Respond to this report Responses (1) Author Response 19 Jun 2024 Punam Sawarkar, Concepts are more emphasized in the discussion section based on reviewer comments and comparisons to prior published papers. A scale for quality of life is employed. WHOQOL-SRPB: scoring and coding for the WHOQOL SRPB field-test instrument: Users Manual, 2012 version, WHO Reference Number: WHO/MSD/MER/Rev.2012.05. All the supporting reports are submitted as a supplementary material View more View less Competing Interests Nil reply Respond Report a concern Nakanekar A and Rathod P. Peer Review Report For: Case Report: The role of Panchagavya and Panchakarma treatment in the management of radiotherapy and chemotherapy side effects in infiltrative ductal carcinoma [version 2; peer review: 1 approved, 2 approved with reservations] . F1000Research 2024, 12 :1383 ( https://doi.org/10.5256/f1000research.152493.r220496) NOTE: it is important to ensure the information in square brackets after the title is included in this citation. The direct URL for this report is: https://f1000research.com/articles/12-1383/v1#referee-response-220496 Alongside their report, reviewers assign a status to the article: Approved - the paper is scientifically sound in its current form and only minor, if any, improvements are suggested Approved with reservations - A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit. 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