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This experimental study used a rat model of endometriosis with five groups (healthy control, endometriosis, endometriosis plus swimming exercise, endometriosis plus vitamin E, and endometriosis plus both) to test whether swimming training for 8 weeks and/or vitamin E intake (200 mg/kg) altered ovarian tissue oxidative stress markers. The key findings were that superoxide dismutase activity and catalase activity increased in the exercise and/or vitamin E groups compared with the endometriosis group, and malondialdehyde levels decreased in all intervention groups versus the endometriosis group. The main limitation explicitly implied by the design is that the conclusions are based on an animal model assessing biochemical markers in ovarian tissue rather than direct clinical outcomes. This paper is centrally about endometriosis — it evaluates how swimming exercise and vitamin E change oxidative stress biomarkers in endometriosis-model rats.
Abstract
Introduction: Endometriosis is an estrogen-dependent inflammatory disease. Studies show that in women with endometriosis, the activity of macrophages in the peritoneal cavity increases, resulting in inflammatory reactions and stabilization of endometriosis. This study was performed with aim to investigate the effect of a period of swimming exercise and vitamin E intake on catalase and superoxide dismutase activity, and malondialdehyde levels in ovarian tissue of endometriosis model rats. Methods: In this experimental study, 25 rats were randomly divided into 5 groups; healthy-control, endometriosis, endometriosis+exercise, endometriosis+vitaminE, endometriosis+vitaminE+exercise. To induce endometriosis, ovarian tissue was removed along with part of the fallopian tube tissue and the tissue pieces were grafted to the area of the right pelvic wall. Vitamin E intake was 200 mg / kg. Swimming training was eight weeks and 30 minutes each day. Data were analyzed by SPSS software (version 23) and one-way ANOVA and Tukey's post hoc tests. P < 0.05 was considered statistically significant. Results: The groups of endometriosis+exercise, endometriosis+vitamin E and endometriosis+exercise+vitamin E showed a significant increase in Superoxide dismutase activity compared to the endometriosis group (P<0.0001) and endometriosis+exercise+vitamin E group compared to the endometriosis+exercise (P=0.0013) and endometriosis+vitamin E groups (P=0.0257). Also, a significant increase in Catalase activity was observed in endometriosis+exercise (P=0.0036), endometriosis+vitamin E (P=0.0006) and endometriosis+exercise+vitamin (P<0.0001) groups compared to the endometriosis group. However, the concentration of Malondialdehyde showed a significant decrease in endometriosis+exercise, endometriosis+vitamin E and endometriosis+exercise+vitamin E compared to the endometriosis group (P<0.0001). Conclusion: The desired changes in the catalase and superoxide dismutase activity and malondialdehydelevels in the endometriosis process can improve the relative oxidative status of the disease in the animal model; performing the swimming exercises as well as the simultaneous use of vitamin E will help to improve oxidation indices in the animal model.
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Majallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān (Nov 2020)
Effect of a period of swimming exercise and vitamin E intake on catalase and superoxide dismutase activity, and malondialdehyde levels in ovarian tissue of endometriosis model rats
Abstract
Introduction: Endometriosis is an estrogen-dependent inflammatory disease. Studies show that in women with endometriosis, the activity of macrophages in the peritoneal cavity increases, resulting in inflammatory reactions and stabilization of endometriosis. This study was performed with aim to investigate the effect of a period of swimming exercise and vitamin E intake on catalase and superoxide dismutase activity, and malondialdehyde levels in ovarian tissue of endometriosis model rats. Methods: In this experimental study, 25 rats were randomly divided into 5 groups; healthy-control, endometriosis, endometriosis+exercise, endometriosis+vitaminE, endometriosis+vitaminE+exercise. To induce endometriosis, ovarian tissue was removed along with part of the fallopian tube tissue and the tissue pieces were grafted to the area of the right pelvic wall. Vitamin E intake was 200 mg / kg. Swimming training was eight weeks and 30 minutes each day. Data were analyzed by SPSS software (version 23) and one-way ANOVA and Tukey's post hoc tests. P < 0.05 was considered statistically significant. Results: The groups of endometriosis+exercise, endometriosis+vitamin E and endometriosis+exercise+vitamin E showed a significant increase in Superoxide dismutase activity compared to the endometriosis group (P<0.0001) and endometriosis+exercise+vitamin E group compared to the endometriosis+exercise (P=0.0013) and endometriosis+vitamin E groups (P=0.0257). Also, a significant increase in Catalase activity was observed in endometriosis+exercise (P=0.0036), endometriosis+vitamin E (P=0.0006) and endometriosis+exercise+vitamin (P<0.0001) groups compared to the endometriosis group. However, the concentration of Malondialdehyde showed a significant decrease in endometriosis+exercise, endometriosis+vitamin E and endometriosis+exercise+vitamin E compared to the endometriosis group (P<0.0001). Conclusion: The desired changes in the catalase and superoxide dismutase activity and malondialdehydelevels in the endometriosis process can improve the relative oxidative status of the disease in the animal model; performing the swimming exercises as well as the simultaneous use of vitamin E will help to improve oxidation indices in the animal model.
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