Gene Expression Dynamics in Endometriosis and Hashimoto Disease: Insights into Potential Overlaps

Ruojue Wang, Beibei Hu, Manlin Zhang
In: 2025 15th International Conference on Biomedical Engineering and Technology (ICBET) · 2025 · pp. 197–201 · doi:10.1109/icbet66094.2025.11470317 · W4407888515
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Abstract

Objective: Investigate the relationship between endometriosis and Hashimoto's thyroiditis and analyze their potential molecular mechanisms. Methods: Employed multiple analytical methods including Mendelian Randomization Analysis using GWAS data, mRNA expression analysis from GEO database, GeneFriends analysis, and gene regulatory network construction. Results: No direct causal relationship found. mRNA expression analysis revealed common upregulated and downregulated genes associated with cell structure/function and phosphorylation/deamination. NOTCH signaling pathway was significantly enriched. GeneFriends analysis identified TNFRSF21 and MBNL3 as highly expressed genes. Regulatory network analysis identified TFs and miRNAs potentially regulating these genes. Conclusion: No direct causal relationship, but significant overlap in mRNA expression, pathways, and immune regulation suggests shared molecular mechanisms. Future research can explore shared therapeutic targets.

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endometriosis

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