Gene Expression Dynamics in Endometriosis and Hashimoto Disease: Insights into Potential Overlaps

Ruojue Wang, Beibei Hu, Manlin Zhang
In: 2025 15th International Conference on Biomedical Engineering and Technology (ICBET) · 2025 · pp. 197–201 · doi:10.1109/icbet66094.2025.11470317 · W4407888515
article OA: closed CC0
View on OpenAlex View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-14 ⓘ

This study found no direct causal link between endometriosis and Hashimoto's thyroiditis, but identified shared mRNA expression patterns, enriched NOTCH signaling, and key regulatory genes suggesting common molecular mechanisms.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

Objective: Investigate the relationship between endometriosis and Hashimoto's thyroiditis and analyze their potential molecular mechanisms. Methods: Employed multiple analytical methods including Mendelian Randomization Analysis using GWAS data, mRNA expression analysis from GEO database, GeneFriends analysis, and gene regulatory network construction. Results: No direct causal relationship found. mRNA expression analysis revealed common upregulated and downregulated genes associated with cell structure/function and phosphorylation/deamination. NOTCH signaling pathway was significantly enriched. GeneFriends analysis identified TNFRSF21 and MBNL3 as highly expressed genes. Regulatory network analysis identified TFs and miRNAs potentially regulating these genes. Conclusion: No direct causal relationship, but significant overlap in mRNA expression, pathways, and immune regulation suggests shared molecular mechanisms. Future research can explore shared therapeutic targets.

My notes (saved in your browser only)

Condition tags

endometriosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (24)

Source provenance

openalex
last seen: 2026-06-10T17:14:06.276822+00:00
License: CC0 · commercial use OK