The clinical observation of GnRHa and addback therapy for 153 cases of severe endometriosis after laparoscopic surgery

Objective To investigate the clinical effect of Gonadotropin-releasing hormone agonist(GnRHa) combined with addback therapy after laparoscopic surgery on 153 cases with severe endometriosis patients. Methods 153 cases with severe endometriosis patients who underwent laparoscopic surgery from 2011 to 2013 were retrospectively analyzed in the Second Affiliated Hospital of Zhengzhou University. According to GnRHa or addback therapy three groups were divided:GnRHa group,GnRHa and addback therapy group, control group. The curative effects of different treatment group, adverse reactions, recurrence rates, and fertility were analyzed. The follow-up time was 6-24 months with an average time of 17.15 months. Results 51 patients suffered from obvious menopausal symptoms and received addback therapy(Progynova,0.5 ~ 1 mg / d). The VAS score and Kupperman score in GnRHa group,GnRHa and addback therapy group were significantly superior to the control group(P 0.05). And no statistical significance was found in the interval to relapse, recurrence and postoperative pregnancy rate(P 0.05). The VAS scores in the GnRHa group and addback therapy group were 2.14±2.02 and 1.73±2.17, respectively(P 0.05). The main side effect of GnRHa group is hot flashes, diaphores, insomnia, sexual dysfunction, etc. The incidences were higher in the GnRHa group than that in the addback therapy group. But the addback therapy can significantly relieve the symptoms of low estrogen introduced by the application of GnRHa(P 0.05). Conclusions Laparoscopic combined with GnRHa treatment can significantly improve clinical curative effect of endometriosis. Addback therapy could abate the side reaction of GnRHa and do not affect the clinical curative effect. The clinical curative effect in the GnRHa and addbacktherapy group were superior to the GnRHa group.