Current Evidence on Thiamin (Vitamin B1) Status in Healthy European Adults: A Systematic Review of Biomarkers and Deficiency Prevalence

Current Evidence on Thiamin (Vitamin B1) Status in Healthy European Adults: A Systematic Review of Biomarkers and Deficiency Prevalence | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Systematic Review Current Evidence on Thiamin (Vitamin B1) Status in Healthy European Adults: A Systematic Review of Biomarkers and Deficiency Prevalence Vid VIČIČ, Sergej PIRKMAJER, Andreja KUKEC This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-8997297/v1 This work is licensed under a CC BY 4.0 License Status: Under Revision Version 1 posted 13 You are reading this latest preprint version Abstract Objective: This systematic review evaluates the thiamin status of the European adult population, identifying critical gaps and priorities for future research. Methods: The review was conducted according to a pre-registered protocol (PROSPERO: CRD420251101630) and PRISMA guidelines. A systematic search of PubMed and Scopus was carried out to identify observational studies reporting relevant thiamin status biomarkers (erythrocyte transketolase activity coefficient (ETKAC), whole blood thiamin diphosphate (WB ThDP), total thiamin in whole blood, or erythrocyte thiamin diphosphate - RBC ThDP) in apparently healthy, community-dwelling adults (≥18 years) from European countries. Results: A total of 19 cross-sectional studies from 11 countries, published between 1976 and 2024, met the inclusion criteria, providing data on 1687 individuals. The prevalence of thiamin deficiency (ETKAC >1.25, WB ThDP <70 nmol/L, total thiamin <75 nmol/L, RBC ThDP <280 ng/g Hb) ranged from 0 % to 41.2 %. When pregnant and post-partum women were excluded, the prevalence of thiamin deficiency ranged from 0 % to 10 %. Discussion: The prevalence of thiamin deficiency in Europe has not been reliably established owing to the lack of representative, population-based studies. Representative studies using harmonized thiamin biomarkers are urgently needed to establish the prevalence and public health significance of thiamin deficiency in Europe. Particular attention should be given to prevention of thiamin deficiency in high-risk groups, such as pregnant and lactating women, individuals following low-carbohydrate high-fat (LCHF) diets, and people with alcohol use disorder. Conclusions: It is commonly assumed that thiamin deficiency is not a problem in Europe, but the main finding of this systematic review is that there is virtually no representative data to support this assumption. Thiamin Micronutrient deficiency Wernicke encephalopathy beriberi Europe Vitamin B1 ThDP ETKAC Figures Figure 1 Figure 2 Figure 3 1. BACKGROUND Thiamin (vitamin B1) is a water-soluble vitamin essential for carbohydrate and amino acid metabolism, energy production and neuronal function [ 1 ]. Thiamin is ingested mainly in phosphorylated forms and free thiamin is produced by intestinal phosphatases [ 2 , 3 ]. Once dephosphorylated, free thiamin is absorbed in the small intestine primarily via thiamin transporters THTR1 (SLC19A2) and THTR2 (SLC19A3) [ 4 , 5 ]. THTR1 and THTR2 also mediate thiamin transport in the kidney and other tissues [ 6 , 7 ]. In addition to these classical thiamin transporters, several other carriers are likely involved in thiamin handling [ 8 ]. For instance, reduced folate carrier 1 (RFC1 aka SLC19A1) may contribute to thiamin absorption by transporting thiamin monophosphate [ 9 ]. Inside the cell, thiamin is phosphorylated to thiamin diphosphate (ThDP) (older name: thiamin pyrophosphate -TPP), its major physiological form, by thiamin pyrophosphokinase [ 10 – 12 ]. In the cytoplasm, ThDP participates in the pentose phosphate pathway as a cofactor of transketolase (Fig. 1 ), which catalyses the conversion of pentose sugars to intermediates of glycolysis, thus enabling production of NADPH even when ribose-5-phosphate is not needed for nucleotide synthesis [ 2 , 13 – 15 ]. Mitochondrial carrier SLC25A19 transports ThDP to the mitochondrial matrix [ 16 ], where it serves as a cofactor in oxidative decarboxylation of α-keto acids, including pyruvate [ 16 , 17 ], α-ketoglutarate [ 16 , 18 ], and α-keto acids of branched-chain amino acids [ 19 , 20 ] (Fig. 1 ). Besides the role of ThDP as a cofactor, thiamin and its phosphorylated derivatives affect membrane function and seem to play a role in regulation of neuronal excitability [ 21 , 22 ]. Thiamin deficiency is still widespread in low- and middle-income countries that rely heavily on processed staple foods, such as polished rice. Although thiamin is naturally present in a wide range of foods, its content is significantly diminished by bran removal (milling, polishing), refining, processing, and cooking [ 23 ]. The best sources of thiamin are pork, wholegrain cereals and legumes [ 24 ]. Although it is often assumed that thiamin deficiency is rare in the general population in Europe and is limited to high-risk groups such as malnourished or people with alcohol use disorder (AUD) [ 25 ], this assumption is hardly supported by evidence. There are few general population-based studies [ 26 , 27 ] that have investigated thiamin status in European countries, highlighting a critical gap in public health research. While some micronutrients like vitamin D have been extensively studied in high income populations, thiamin status remains under-investigated in epidemiological research [ 28 ]. Thiamin must be supplied regularly, as body stores are minimal. Diet almost devoid of thiamin produces first sign of deficiency in just 10 days [ 29 ]. Clinical thiamin deficiency may present with a spectrum of neurological, psychiatric, and cardiovascular signs and symptoms [ 30 ]. Subclinical deficiencies can also impair cognitive and physical functions [ 23 ]. Early signs of thiamin deficiency are often unrecognized [ 31 ], none of the signs and symptoms are pathognomonic, and can be mistaken for psychosomatic disorders [ 32 ]. Dietary thiamin deficiency may ultimately lead to beriberi (dry, wet, or infantile) and Wernicke-Korsakoff syndrome. In adults, dry beriberi presents with peripheral sensory and motor neuropathy [ 33 ], while wet beriberi presents with increased cardiac output, cardiomegaly, heart failure, and peripheral oedema [ 34 , 35 ]. Cardiac dysfunction, which can be severe, is a major feature of infantile beriberi which appears in infants during first months of life [ 36 ], while the nervous system dysfunction may predominate in older children [ 37 ]. Thiamin deficiency, especially in alcohol use disorder, may manifest also as Wernicke’s encephalopathy and Korsakoff syndrome [ 25 ]. Wernicke’s encephalopathy is characterized by mental changes, abnormal eye movements, and/or ataxia [ 38 – 40 ]. If untreated, Wernicke’s encephalopathy may progress to Korsakoff’s syndrome, an irreversible condition which manifests with amnesia and confabulation [ 40 ]. In one study the researchers examined material from 6,964 autopsies. 52 cases of Wernicke's encephalopathy were found, of which 12 (23%) were found in people without alcohol dependence. Only 4 cases (7.7%) were diagnosed based on clinical symptoms in living patients. None of the people without alcohol dependence were given thiamin therapy [ 41 ]. Long-term alcohol consumption can lead to thiamin deficiency by reducing dietary intake of thiamin, inhibiting absorption in the gastrointestinal tract and disrupting its cellular utilization [ 42 ]. Thiamin deficiency also occurs in malnourished patients, patients after bariatric surgery [ 30 ], people living with obesity [ 43 ], patients on total parenteral nutrition [ 30 , 44 ] and patients with diabetes [ 45 ]. Thiamin deficiency may also occur in the context of refeeding syndrome, since the transition from starvation to feeding greatly increases the demand for thiamin, which serves as a cofactor for glucose-dependent metabolic pathways (Fig. 1 ) [ 46 ]. Lastly, ultra-processed foods, snacks and soft drinks contribute significantly to energy intake while being low in thiamin [ 47 ]. The population reference intake for thiamin is the same for all population groups: 0.1 mg/MJ (0.4 mg/1000 kcal) as it is dependent on energy intake [ 48 ].The ultra-processed food share in energy intake in Europe ranges from 14–44%, the highest being in United Kingdom [ 49 ]. All risk factors contributing to thiamin deficiency are presented in Fig. 2 . This systematic review evaluates thiamin status of the European adult population, identifying critical gaps and priorities for future research. 2. MATERIALS AND METHODS The study was conducted according to a previously registered protocol in the international prospective register of systematic reviews PROSPERO ID - CRD420251101630 [ 58 ]. The systematic review was conducted according to PRISMA guidelines [ 59 ]. 2.1 STUDY POPULATION, EXPOSURE AND OUTCOME The study population included apparently healthy, community-dwelling adults aged ≥ 18 years from European countries meeting the inclusion criteria. Thiamin status is usually assessed through two approaches: 1. Direct measurement of thiamin or its phosphorylated metabolites (thiamin diphosphate (ThDP) in whole blood (WB) or erythrocytes (RBC) or total thiamin in whole blood (WB)). Thiamin deficiency is generally associated with low total thiamin or ThDP concentrations in whole blood and erythrocytes [ 48 ] . 2. Functional assessment via the erythrocyte transketolase activity coefficient (ETKAC), an indirect marker of thiamin-dependent enzymatic saturation (ETKAC = ETK activity with added ThDP (U/g Hb) / baseline ETK activity (U/g Hb)). ETKAC is a sensitive marker for thiamin function and status [ 48 ]. There is also a possibility of measurement of excreted thiamin in 24h urine, which has good correlation with thiamin intake [ 48 , 60 ], but is not a biomarker of thiamin status, especially when thiamin intake is low [ 61 ]. The primary exposure was thiamin status, assessed using the biomarkers defined in Table 1 . The outcomes included: 1. absolute measurements of biomarkers and 2. the prevalence of thiamin deficiency defined by the cut-off values listed in Table 1 . 2.2 THE INCLUSION AND EXCLUSION CRITERIA The inclusion criteria were (1) apparently healthy, community-dwelling adults aged ≥ 18 years, including pregnant and lactating women, (2) observational studies (cohort, case-control, or cross-sectional) and baseline data from interventional studies collected prior to any intervention, (3) studies reporting selected thiamin biomarkers listed in Table 1 , (4) studies including healthy European adults, (5) no restrictions on language, (6) no restrictions on publication date, and (7) a minimum sample size of 10 participants. The exclusion criteria were (1) case reports, narrative reviews, and conference abstracts, (2) studies reporting biomarkers that do not reflect thiamin status, as specified in Table 2 , (3) individuals taking thiamin food supplements, (4) participants with alcohol use disorder (AUD), obesity (BMI > 30 kg/m²), type 1 or type 2 diabetes mellitus, chronic kidney disease, liver dysfunction, malabsorption syndromes (e.g., celiac disease, Crohn’s disease), or other conditions known to affect thiamin status, (5) studies involving institutionalized populations or specific clinical subgroups such as individuals post-bariatric surgery or with Wernicke–Korsakoff syndrome, and (6) studies focusing on special populations such as seamen, or aboriginal groups. Table 1 Thiamin biomarkers included in the systematic review. BIOMARKER BIOL. SAMPLE USE CUTOFF FOR DEFICIENCY ThDP - thiamin diphosphate in whole blood ( older name: thiamin pyrophosphate -TPP) Whole blood Biologically active vitamer and indicator of thiamin status [ 30 ]. Deficiency < 70 nmol/L [ 62 ]. ThDP - thiamin diphosphate in erythrocytes (older name: thiamin pyrophosphate -TPP) Washed erythrocytes Deficiency < 280 ng/g Hb RBC ThDP [ 63 ]. Total thiamin in whole blood (free thiamin plus its esters) Whole blood Includes inactive thiamin forms. Less reliable biomarker of thiamin status than ThDP - thiamin diphosphate in whole blood or erythrocytes [ 23 ]. < 75nmol/L [ 62 ]. ETKAC - Erythrocyte transketolase activity coefficient Washed erythrocytes Functional test of biological activity. Sensitive marker of thiamin function and status [ 48 ]. ETKAC = ETK activity with added ThDP (U/g Hb) / baseline ETK activity (U/g Hb)[ 61 ]. Deficiency: ETKAC > 1.25 (α > 25%) Insufficiency: ETKAC 1.15–1.25 (α 15–25%). Adequate (sufficiency): ETKAC < 1.15 (α < 15%) [ 23 , 48 , 61 ]. Table 2 Thiamin biomarkers not included in the systematic review. BIOMARKER BIOL. SAMPLE USE REASON FOR EXCLUSION Plasma thiamin Plasma Reflects recent intake Not an indicator of thiamin status [ 23 , 48 ]. ThMP- thiamin monophosphate, older: TMP Plasma Reflects recent intake 24-h urinary thiamin 24h urine 1 mg of thiamin intake predicts 268.2 µg of thiamin excreted in urine [ 60 ] Biomarker of thiamin intake, not status. Not reliable when thiamin intakes are low. Requires at least 24h urine collection [ 48 , 60 , 61 ]. Basal ETK - Basal erythrocyte transketolase activity Washed erythrocytes Complementary biomarker [ 64 ]. Useful in specific populations. Aids in interpretation of thiamin status in context of variable apoenzyme concentrations. Cutoff for deficiency is not clearly defined; <0.50 U/gHb or < 0.59 U/gHb are used as cutoffs for deficiency [ 64 ]. This allows differentiation between whether the low activity is due to thiamin deficiency or reduced synthesis of the enzyme itself. 2.3 SEARCH AND SCREENING STRATEGY The review team comprises two experts in public health and nutrition. The literature search was conducted in PubMed and Scopus and supplemented by snowballing (screening reference lists and citations of included studies). Search Process : We defined the search criteria. The PubMed and SCOPUS search combined terms for European populations with thiamin-related keywords (e.g., thiamin, vitamin B1, ThDP, ETK, ETKAC, ThDP etc.). The search was limited to human studies. Full search syntax is available in supplemental data. The titles and abstracts were searched manually and selected as described in Study Flow Diagram. (Fig. 3 ). The data from selected studies was manually extracted into excel spreadsheet. The data was then rechecked by second researcher. Study risk of bias assessment Newcastle-Ottawa Scale adapted for cross-sectional studies was used [ 65 ]. Grading is available in supplemental data. DATA SYNTHESIS AND ANALYSIS Only one study included at least a regionally representative population sample [ 27 ] and many countries were not represented. The meta-analysis was not feasible. 3. RESULTS A total of 19 cross-sectional studies from 11 countries published between 1976 and 2024 met the inclusion criteria and provided data on the thiamin status of 1687 healthy European adults. The results are stratified by the biomarkers erythrocyte transketolase activity coefficient (ETKAC) in Table 3 , whole blood thiamin diphosphate (WB ThDP; nmol/L) in Table 4 , total thiamin in whole blood (nmol/L) in Table 5 and erythrocyte thiamin diphosphate (RBC ThDP; ng/g Hb) in Table 6 . While most studies included community-dwelling adults, several investigated specific subgroups, including pregnant and postpartum women, university students, individuals following LCHF diet (low carbohydrate high fat diet), and convenience samples of healthcare workers. Study populations were recruited from 11 countries: Spain, United Kingdom, Austria, Poland, Germany, Hungary, France, Belgium, Italy, Norway and the Netherlands. There was a single (Spanish) study with a representative sample of the healthy adult population [ 27 ]. 3.1 SUMMARY OF BIOMARKER FINDINGS The prevalence of thiamin deficiency (ETKAC > 1.25, WB ThDP < 70 nmol/L, total thiamin < 75 nmol/L, RBC ThDP < 280 ng/g Hb), ranged from 0% to 41.2%. If pregnant and postpartum women were excluded, the prevalence of thiamin deficiency ranged from 0% to 10%. Table 3 Studies reporting erythrocyte transketolase activity coefficients (ETKAC). Author, year Population Location No. of subjects Age (mean ± SD or range yrs) ETKAC (mean ± SD) Thiamin deficiency (%) ETKAC > 1.25 Thiamin insufficiency (%) ETKAC > 1.15 Ortega et al. 2004 [ 66 ] Healthy women in third trimester pregnancy Cuenca, Spain 51 (♀51) 29.9 ± 3.8 1.06 ± 0.22 13.7% 31.3% Sánchez et al. 1999 [ 67 ] Healthy post-partum women Coast of Catalonia province, Spain 131 (♀131) 26 ± 5 1.25 ± 0.17 41.2% 62.6% Malara et al. 2013 [ 68 ] Healthy volunteers with low or high physical activity Warsaw, Poland 80 (♀40) 19.7 ± 0.71 1.053 ± 0.054 0% Mataix et al. 2003 [ 27 ] Representative sample of healthy population Andalusia, Spain 372 (♀191) 25–60 1.01 ± 0.17 6.4% 13.6% (ETKAC > 1.16) Hötzel and Bitsch 1976 [ 69 ] Healthy students Bonn, West Germany 130 (♀84) adult 1.126 ± 0.121 10.00% 20% Jones et al. 2023 [ 64 ] Selected samples from nationally representative study NDNS RP United Kingdom 134 (♀134) 44.0 ± 11.8 1.09 ± 0.05 0% 13% Fabian et al. 2008 [ 70 ] Healthy, with no fermented food consumption in last 7 days Vienna, Austria 33 (♀33) 24.4 ± 2.8 1.085 ± 0.024 N/A Studies using healthy volunteers for controls or reference values establishment are marked with (#) and presented in grey. Herve et al. 1995 [ 71 ] Healthy volunteers (#) Clichy, France 52 (♀28) 21–65 1.12 ± 0.1 N/A N/A Elmadfa et al. 2001 [ 53 ] Healthy volunteers (#) Vienna, Austria 12 (♀6) 25–30 1.12 ± 0.1 N/A Jermendy 2006 [ 72 ] Healthy control (#) Budapest, Hungary. 60 (♀28) 54.1 ± 2.5 1.08 ± 0.02 N/A Boni et al. 1980 [ 73 ] Healthy medical and laboratory personnel (#) Leuven, Belgium 12 (♀NR) adult 1.135 (range 1.08–1.185) 0% N/A SD, standard deviation; ETKAC, erythrocyte transketolase activity coefficients. Table 4 Studies reporting whole blood thiamin diphosphate - WB ThDP (nmol/L). Author, year Population Location No. of subjects Age (mean ± SD or range yrs) WB ThDP (nmol/L) (mean ± SD) Thiamin deficiency (%), WB ThDP < 70 nmol/L Studies using healthy volunteers for controls or reference values establishment are marked with (#) and presented in grey. Mancinelli et al. 2003 [ 74 ] Random selection of healthy employees undergoing routine medical examinations (#) Rome, Italy 103 (♀58) 42.9 ± 10.2 222.2 ± 56.3 N/A Verstraete and Stove 2021 [ 75 ] Healthy volunteers (#) Ghent, Belgium 50 (♀NR) adult 145 ± 22.1 0% Körner et al. 2009 [ 76 ] Healthy volunteers (#) North Rhine-Westphalia, Germany 30 (♀16) 40.5 (18–65) 194.7 ± 27.5 0% Herve et al. 1995 [ 71 ] Healthy volunteers (#) Clichy, France 52 (♀28) 21–65 176 ± 28 N/A Lynch et al. 1997 [ 77 ] Healthy laboratory staff (#) Belfast, United Kingdom 45 (♀16) 38 (20–60) median (range) 174.2 ± 34.05 N/A Tallaksen et al. 1991 [ 78 ] Healthy volunteers (#) Oslo, Norway 30 (♀15) 43 (32–54) median (range) 143 ± 35 N/A SD, standard deviation; WB ThDP, whole blood thiamin diphosphate. Table 5 Studies reporting total whole blood thiamin (nmol/L). Author, year Population Location No. of subjects Age (mean ± SD or range yrs) Total WB thiamin (nmol/L) (mean ± SD) Thiamin deficiency (%) Total WB thiamin < 75 nmol/L Studies using healthy volunteers for controls or reference values establishment are marked with (#) and presented in grey. Schrijver et al. 1982 [ 79 ] Healthy volunteers (#) Utrecht, Netherlands 98 (♀nd) adult 115 (range 70–185) 1–2% Herve et al. 1995 [ 71 ] Healthy volunteers (#) Clichy, France 52 (♀28) 21–65 186 ± 30 N/A SD, standard deviation; WB, whole blood. Table 6: Studies reporting erythrocyte thiamin diphosphate - RBC ThDP (ng/g Hb). 4. DISCUSSION To the best of our knowledge, and according to the available literature, this systematic review represents the first comprehensive summary of thiamin status in healthy European adults. On a global level the prevalence of thiamin deficiency was reviewed by Johnson et al. [ 80 ] and Whitfield et al. [ 23 ] and systematic review of thiamin deficiency cases in paediatric population in high-income countries was done by Rakotoambinina et al. [ 81 ]. The prevalence of thiamin deficiency and insufficiency in Europe remains largely unknown. The available data, limited to 19 studies from only eleven countries, highlights the need for additional research. One study using a representative sample from the Andalusian region in Spain reported a deficiency prevalence of 6.4% (ETKAC > 1.25) and insufficiency 13.6% (ETKAC > 1.16 (authors used slightly different cutoff)) [ 27 ]. Another study done in the United Kingdom used selected samples from nationally representative study found prevalence of thiamin insufficiency (ETKAC > 1.15) in 13%. This suggests that the extent of the issue may be significantly higher than previously assumed [ 64 ]. Inadequate thiamin intake was recently estimated in a modelling analysis, which compared age and sex specific nutrient requirements with available dietary intake data. Based on these estimates 29.7% of the global population (2.2 billion people) have inadequate thiamin intake. For European countries the prevalence of estimated inadequate intake ranged from 8.4% (Belgium) to 56.2% (Italy). The model did not account for intake from food fortification or food supplements [ 82 ]. As dietary intake data are typically self-reported, they are subject to bias and must be interpreted with caution [ 83 ]. Additionally methodological differences and errors in data collection can produce significant errors. For example, in Cambodia, a country with one of the highest prevalences of thiamin deficiency [ 80 ] their estimated prevalence of inadequate thiamin intake was only 24% [ 82 ]. 4.1 SPECIAL SUBPOPULATIONS The risk of thiamin deficiency is higher in populations with increased relative thiamin requirements, such as pregnant and post-partum women (European Food Safety Authority, 2016; Oudman et al., 2019). A Spanish study in women in the third trimester of pregnancy reported thiamin deficiency in 13.7% of participants (ETKAC > 1.25) (Ortega et al., 2004), while another Spanish study in post-partum women found a prevalence of 41.2% (ETKAC > 1.25). Only 14.8% of infants born to thiamin deficient mothers had adequate thiamin status (ETKAC < 1.15) [ 67 ]. Moreover, breast milk of thiamin-deficient mothers contains reduced thiamin levels, leading to deficiency in the offspring [ 66 , 84 ]. Conditions such as hyperemesis gravidarum reduce dietary intake. Additionally i/v glucose administration during labor increases thiamin needs [ 54 ]. Cases of Wernicke encephalopathy with long-term consequences following hyperemesis gravidarum have also been reported [ 52 ]. Thiamin deficiency has been documented in families exhibiting a high incidence of Sudden Infant Death Syndrome (SIDS) [ 25 , 85 ]. A systematic review by Rakotoambinina et al. [ 81 ] summarized pediatric thiamin deficiency in high-income countries and identified predisposing factors including genetic causes, diabetes, obesity, excessive consumption of sugar-sweetened beverages, eating disorders, gastrointestinal disorders/surgeries, critical illness, cancer, and artificial nutrition. In the European union, this risk is mitigated by mandatory fortification of processed cereal-based baby foods with thiamin at 25 µg/100 kJ (100 µg/100 kcal) [ 86 ] and the composition of infant formulas in EU, including thiamin content is tightly regulated [ 87 ]. General fortification of cereals in most European countries is not mandatory [ 23 ]. This raises concerns regarding population-level adequacy, particularly given the high proportion of thiamin-devoid ultra-processed foods in the diet. Across Europe, ultra-processed foods account for 14–44% of total energy intake, with the highest share reported in the United Kingdom [ 49 ]. Despite this high prevalence of thiamin deficiency (ETKAC > 1.25) was found in Norwich (UK) adolescents. 13.5% had thiamin deficiency and 26.8% had thiamin insufficiency (ETKAC > 1.15) [ 88 ]. Korean study found association of higher ultra-processed food intake with lower thiamin intake [ 47 ]. However, a Brazilian study has shown that the consumption of ultra-processed foods is associated with a lower risk of inadequate thiamin intake due to fortification of ultra processed food [ 89 ]. Alcohol dependence significantly contributes to thiamin deficiency; 30–80% alcohol dependent individuals are thiamin deficient [ 42 ]. The prevalence of alcohol dependence among adults aged 18–64 years in the EU was estimated at 3.4%, with significant variation between sexes and countries. The lowest prevalence was observed in Spain (0.7%) and the highest prevalence was observed in Latvian men (21.2%) [ 90 ]. Restrictive diets also increase risk for deficiency. Thiamin deficiency (α-ETK > 1.25) was found in 8% of volunteers following unsupplemented LCHF (Low-carbohydrate high-fat) and in 2% of healthy unsupplemented Glasgow (UK) adults following general diet and [ 26 ]. High prevalence of thiamin deficiency was reported in people living with obesity; in those preparing for bariatric surgery the pooled prevalence was 7% (95% CI: 4–12%). Many studies included patients already on weight loss diet [ 51 ]. Two studies not included in the systematic review were conducted in the northern regions of the Russian Federation, where thiamin deficiency (ETKAC > 1.25) was highly prevalent [ 91 , 92 ]. Reported prevalence of deficiency for Cargopol, Arkangelsk provice was was 57.7% in males and 68.8% in females (ETKAC > 1.25) [ 92 ]. 4.2 LIMITATIONS AND STRENGTHS The main limitation of this review is inclusion of studies that were not using representative samples of population. Study populations included in this review are very heterogeneous and include pregnant women [ 66 ], post-partum women [ 67 ], convenience samples comprising of staff, that are usually healthier better nourished, and socioeconomically advantaged [ 63 , 73 , 77 ], university students [ 69 ], and employees undergoing routine medical examinations [ 74 ]. The remaining studies utilized cohorts of healthy volunteers serving as control groups or for reference value establishment [ 53 , 70 – 72 , 68 , 79 , 75 , 76 , 78 ]. However, the main strength of this review is the strict definition of appropriate thiamin status biomarkers. Many studies continue to be published, cited, and included in systematic reviews using inappropriate biomarkers, such as plasma thiamin or plasma thiamin monophosphate (ThMP). Studies that did not specify or cite the method used were excluded from this review. The cutoffs for thiamin deficiency, insufficiency, and adequacy are not universally standardized. Johnson et al. [ 80 ] reviewed proposed cutoffs. For this review, we applied the cutoffs defined in Table 1 , which are also reported in brackets whenever deficiency or insufficiency is reported. The synthesis of results was further complicated by the use of different biomarkers and a lack of standardized diagnostic cut-offs, which impedes direct comparability across studies [ 64 , 80 , 93 ]. 4.3 PRACTICAL CONSIDERATIONS In contrast to vitamin D, for which adequate intake from unfortified foods is practically unachievable and population sufficiency can only be ensured through fortification [ 94 ], sufficient thiamin intake in high-income adult populations can easily be achieved through a varied diet. Thiamin deficiency could be considered a sign of alcohol abuse [ 42 ], restrictive diets [ 26 , 95 ] or generally very poor diet. In thiamin deficient populations, deficiency of other micronutrients should be expected [ 67 , 95 ]. Therefore public health interventions should promote balanced diet that includes cereals, especially fortified breakfast cereals, seeds, legumes and meat, particularly lean pork [ 48 ]. Considering the increased needs during pregnancy and lactation, severe consequences of thiamin deficiency [ 25 , 85 ] and safety of thiamin, routine supplementation by prenatal micronutrient food supplements containing thiamin is reasonable. Even at dosages of several hundred milligrams, there are no reports of adverse effects of oral thiamin supplementation [ 96 ]. This also ensures sufficient thiamin content in breast milk [ 66 , 84 ]. Infants and children should be provided with varied diet, and fortified cereals should be used. Thiamin supplementation in clinical settings is covered in ESPEN micronutrient guidelines [ 30 ] and thiamin use in persons with alcohol use disorder (AUD) was described by Shakory [ 97 ]. 4.3 FUTURE RESEARCH Representative, population-based studies using harmonized biomarkers are urgently needed to establish the prevalence and risk factors for thiamin deficiency in Europe. Further targeted investigations are warranted among subpopulations with potentially increased requirements or reduced intake, including pregnant and lactating women and other groups with increased physiological requirements, individuals adhering to restrictive or low-carbohydrate diets, people living with obesity, persons with alcohol use disorder (AUD) and persons of lower socioeconomic status. 5. CONCLUSIONS Until general population-level data become available, it is scientifically unjustified to conclude that thiamin deficiency is not a public health concern in Europe. Abbreviations α-KGDH: α-ketoglutarate dehydrogenase complex AUD: Alcohol use disorder BCKDH: Branched-chain α-keto acid dehydrogenase complex BMI: Body mass index EFSA: European Food Safety Authority ESPEN: European Society for Clinical Nutrition and Metabolism ETK: Erythrocyte transketolase ETKAC: Erythrocyte transketolase activity coefficient EU: European Union Hb: Hemoglobin HPLC: High-performance liquid chromatography IB-CoA: Isobutyryl-CoA Ile: Isoleucine IQR: Interquartile range i/v: Intravenous IV-CoA: Isovaleryl-CoA KIC: α-ketoisocaproate KIV: α-ketoisovalerate KMV: α-keto β-methylvalerate LCHF: Low-carbohydrate high-fat Leu: Leucine MB-CoA: Methylbutyryl-CoA NADPH: Nicotinamide adenine dinucleotide phosphate PDH: Pyruvate dehydrogenase complex PRISMA: Preferred Reporting Items for Systematic Reviews and Meta-Analyses PROSPERO: International Prospective Register of Systematic Reviews RBC: Erythrocyte (Red blood cell) RFC1: Reduced folate carrier 1 SD: Standard deviation SIDS: Sudden infant death syndrome SLC19A1: Solute carrier family 19 member 1 SLC19A2: Solute carrier family 19 member 2 SLC19A3: Solute carrier family 19 member 3 SLC25A19: Solute carrier family 25 member 19 TCA: Tricarboxylic acid cycle ThDP: Thiamin diphosphate ThMP: Thiamin monophosphate THTR1: Thiamin transporter 1 THTR2: Thiamin transporter 2 TKT: Transketolase TPP: Thiamin pyrophosphate Val: Valine WB: Whole blood WHO: World Health Organization Declarations Author Contributions: Conceptualisation: V.V.; writing: V.V., S.P.; data synthesis: V.V., A.K., supervision: A.K. All authors have read and agreed to the published version of the manuscript. Funding: This work was supported by the Slovenian Research and Innovation Agency (ARIS), projects: 1. MULTIPART (J7-60123); 2. SLORApro (P3-0429); 3. Molekularni mehanizmi razvoja in delovanja skeletne mišice (P3-0043) and 4. NeuroMyo (J7-60125). Data availability: Search strategy and bias assessment is available in supplemental data and on PROSPERO: https://www.crd.york.ac.uk/PROSPEROFILES/dd0680a43ba5a2be5fad83d708c13cd8.pdf. Conflict of interest: There are no conflicts of interest to declare. Ethics approval: Not applicable. References Manzetti S, Zhang J, van der Spoel D (2014) Thiamin function, metabolism, uptake, and transport. Biochemistry 53:821–835. https://doi.org/10.1021/bi401618y Brown G (2014) Defects of thiamine transport and metabolism. J Inherit Metab Dis 37:577–585. https://doi.org/10.1007/s10545-014-9712-9 Said HM, Nexo E (2018) Gastrointestinal Handling of Water-Soluble Vitamins. Compr Physiol 8:1291–1311. https://doi.org/10.1002/cphy.c170054 Rajgopal A, Edmondnson A, Goldman ID, Zhao R (2001) SLC19A3 encodes a second thiamine transporter ThTr2. Biochim Biophys Acta 1537:175–178. https://doi.org/10.1016/s0925-4439(01)00073-4 Reidling JC, Lambrecht N, Kassir M, Said HM (2010) Impaired intestinal vitamin B1 (thiamin) uptake in thiamin transporter-2-deficient mice. Gastroenterology 138:1802–1809. https://doi.org/10.1053/j.gastro.2009.10.042 Boulware MJ, Subramanian VS, Said HM, Marchant JS (2003) Polarized expression of members of the solute carrier SLC19A gene family of water-soluble multivitamin transporters: implications for physiological function. Biochem J 376:43–48. https://doi.org/10.1042/BJ20031220 Kono S, Miyajima H, Yoshida K, et al (2009) Mutations in a thiamine-transporter gene and Wernicke’s-like encephalopathy. N Engl J Med 360:1792–1794. https://doi.org/10.1056/NEJMc0809100 Overton E, Emelyanova A, Bunik VI (2025) Thiamine, gastrointestinal beriberi and acetylcholine signaling. Front Nutr 12:1541054. https://doi.org/10.3389/fnut.2025.1541054 Zhao R, Gao F, Goldman ID (2002) Reduced folate carrier transports thiamine monophosphate: an alternative route for thiamine delivery into mammalian cells. Am J Physiol Cell Physiol 282:C1512-1517. https://doi.org/10.1152/ajpcell.00547.2001 Zhao R, Gao F, Goldman ID (2001) Molecular cloning of human thiamin pyrophosphokinase. Biochim Biophys Acta 1517:320–322. https://doi.org/10.1016/s0167-4781(00)00264-5 Mayr JA, Freisinger P, Schlachter K, et al (2011) Thiamine pyrophosphokinase deficiency in encephalopathic children with defects in the pyruvate oxidation pathway. Am J Hum Genet 89:806–812. https://doi.org/10.1016/j.ajhg.2011.11.007 Nosaka K, Onozuka M, Nishino H, et al (1999) Molecular cloning and expression of a mouse thiamin pyrophosphokinase cDNA. J Biol Chem 274:34129–34133. https://doi.org/10.1074/jbc.274.48.34129 Boyle L, Wamelink MMC, Salomons GS, et al (2016) Mutations in TKT Are the Cause of a Syndrome Including Short Stature, Developmental Delay, and Congenital Heart Defects. Am J Hum Genet 98:1235–1242. https://doi.org/10.1016/j.ajhg.2016.03.030 Kochetov GA, Solovjeva ON (2014) Structure and functioning mechanism of transketolase. Biochim Biophys Acta 1844:1608–1618. https://doi.org/10.1016/j.bbapap.2014.06.003 McCool BA, Plonk SG, Martin PR, Singleton CK (1993) Cloning of human transketolase cDNAs and comparison of the nucleotide sequence of the coding region in Wernicke-Korsakoff and non-Wernicke-Korsakoff individuals. J Biol Chem 268:1397–1404 Lindhurst MJ, Fiermonte G, Song S, et al (2006) Knockout of Slc25a19 causes mitochondrial thiamine pyrophosphate depletion, embryonic lethality, CNS malformations, and anemia. Proc Natl Acad Sci U S A 103:15927–15932. https://doi.org/10.1073/pnas.0607661103 Naito E, Ito M, Takeda E, et al (1994) Molecular analysis of abnormal pyruvate dehydrogenase in a patient with thiamine-responsive congenital lactic acidemia. Pediatr Res 36:340–346. https://doi.org/10.1203/00006450-199409000-00013 Yap ZY, Strucinska K, Matsuzaki S, et al (2021) A biallelic pathogenic variant in the OGDH gene results in a neurological disorder with features of a mitochondrial disease. J Inherit Metab Dis 44:388–400. https://doi.org/10.1002/jimd.12248 Yang N, Han L, Gu X, et al (2012) Analysis of gene mutations in Chinese patients with maple syrup urine disease. Mol Genet Metab 106:412–418. https://doi.org/10.1016/j.ymgme.2012.05.023 Chuang JL, Wynn RM, Moss CC, et al (2004) Structural and biochemical basis for novel mutations in homozygous Israeli maple syrup urine disease patients: a proposed mechanism for the thiamin-responsive phenotype. J Biol Chem 279:17792–17800. https://doi.org/10.1074/jbc.M313879200 Nghiêm HO, Bettendorff L, Changeux JP (2000) Specific phosphorylation of Torpedo 43K rapsyn by endogenous kinase(s) with thiamine triphosphate as the phosphate donor. FASEB J Off Publ Fed Am Soc Exp Biol 14:543–554. https://doi.org/10.1096/fasebj.14.3.543 Sasa M, Takemoto I, Nishino K, Itokawa Y (1976) The role of thiamine on excitable membrane of crayfish giant axon. J Nutr Sci Vitaminol (Tokyo) 22 SUPPL:21–24. https://doi.org/10.3177/jnsv.22.supplement_21 Whitfield KC, Bourassa MW, Adamolekun B, et al (2018) Thiamine deficiency disorders: diagnosis, prevalence, and a roadmap for global control programs. Ann N Y Acad Sci 1430:3–43. https://doi.org/10.1111/nyas.13919 European Food Safety Authority (2025) Food composition data. https://www.efsa.europa.eu/en/data-report/food-composition-data. Accessed 15 Sept 2025 World Health Organization. Thiamine deficiency and its prevention and control in major emergencies. WHO Reference Number: WHO/NHD/99.13. Geneva: World Health Organization; 1999. Available from: https://www.who.int/publications/i/item/WHO-NHD-99.13 Churuangsuk C, Catchpole A, Talwar D, et al (2024) Low thiamine status in adults following low-carbohydrate / ketogenic diets: a cross-sectional comparative study of micronutrient intake and status. Eur J Nutr 63:2667–2679. https://doi.org/10.1007/s00394-024-03459-y Mataix J, Aranda P, Sánchez C, et al (2003) Assessment of thiamin (vitamin B1) and riboflavin (vitamin B2) status in an adult Mediterranean population. Br J Nutr 90:661–666. https://doi.org/10.1079/BJN2003926 Brown KH, Hess SY, Moore SE, et al (2025) Neglected micronutrients—considering a broader set of vitamins and minerals in public health nutrition programs worldwide: a narrative review. Am J Clin Nutr 122:680–694. https://doi.org/10.1016/j.ajcnut.2025.06.030 Anderson M, Mickelsen O, Keys A (1946) Diets and food items for the experimental production of thiamin deficiency in man. J Am Diet Assoc 22:1–7 Berger MM, Shenkin A, Schweinlin A, et al (2022) ESPEN micronutrient guideline. Clin Nutr Edinb Scotl 41:1357–1424. https://doi.org/10.1016/j.clnu.2022.02.015 Karakonstantis S, Galani D, Korela D, et al (2020) Missing the early signs of thiamine deficiency. A case associated with a liquid-only diet. Nutr Neurosci 23:384–386. https://doi.org/10.1080/1028415X.2018.1507964 Lonsdale D (2018) Thiamin. Adv Food Nutr Res 83:1–56. https://doi.org/10.1016/bs.afnr.2017.11.001 Mauermann ML, Staff NP (2026) Peripheral Neuropathy: A Review. JAMA 335:255–266. https://doi.org/10.1001/jama.2025.19400 Pereira AG, Cunha LN de P, Paiva SAR, et al (2025) An Overview of Beriberi. Med Princ Pract Int J Kuwait Univ Health Sci Cent 1–7. https://doi.org/10.1159/000547719 Inoue A, Itabashi K, Iwai T, et al (2021) Imaging findings of vitamin deficiencies: are they forgotten diseases? BJR Open 3:20210011. https://doi.org/10.1259/bjro.20210011 Coats D, Shelton-Dodge K, Ou K, et al (2012) Thiamine Deficiency in Cambodian Infants with and without Beriberi. J Pediatr 161:843–847. https://doi.org/10.1016/j.jpeds.2012.05.006 Smith TJ, Johnson CR, Koshy R, et al (2021) Thiamine deficiency disorders: a clinical perspective. Ann N Y Acad Sci 1498:9–28. https://doi.org/10.1111/nyas.14536 Li S, Xing C (2025) Wernicke encephalopathy: a mini review of the clinical spectrum, atypical manifestations, and diagnostic challenges. Front Neurol 16:1566366. https://doi.org/10.3389/fneur.2025.1566366 Brust JCM (2008) A 74-year-old man with memory loss and neuropathy who enjoys alcoholic beverages. JAMA 299:1046–1054. https://doi.org/10.1001/jama.299.5.jrr80000 Harper CG, Giles M, Finlay-Jones R (1986) Clinical signs in the Wernicke-Korsakoff complex: a retrospective analysis of 131 cases diagnosed at necropsy. J Neurol Neurosurg Psychiatry 49:341–345. https://doi.org/10.1136/jnnp.49.4.341 Lindboe CF, Løberg EM (1989) Wernicke’s encephalopathy in non-alcoholics. An autopsy study. J Neurol Sci 90:125–129. https://doi.org/10.1016/0022-510x(89)90095-6 Mancinelli R, Ceccanti M (2009) Biomarkers in alcohol misuse: their role in the prevention and detection of thiamine deficiency. Alcohol Alcohol Oxf Oxfs 44:177–182. https://doi.org/10.1093/alcalc/agn117 Kerns JC, Arundel C, Chawla LS (2015) Thiamin Deficiency in People with Obesity12. Adv Nutr 6:147–153. https://doi.org/10.3945/an.114.007526 Salvatori G, Mondì V, Piersigilli F, et al (2016) Thiamine Deficiency in a Developed Country: Acute Lactic Acidosis in Two Neonates Due to Unsupplemented Parenteral Nutrition. JPEN J Parenter Enteral Nutr 40:886–889. https://doi.org/10.1177/0148607114568316 Ziegler D, Reiners K, Strom A, Obeid R (2023) Association between diabetes and thiamine status - A systematic review and meta-analysis. Metabolism 144:155565. https://doi.org/10.1016/j.metabol.2023.155565 da Silva JSV, Seres DS, Sabino K, et al (2020) ASPEN Consensus Recommendations for Refeeding Syndrome. Nutr Clin Pract 35:178–195. https://doi.org/10.1002/ncp.10474 Shim J-S, Shim SY, Cha H-J, et al (2022) Association between Ultra-processed Food Consumption and Dietary Intake and Diet Quality in Korean Adults. J Acad Nutr Diet 122:583–594. https://doi.org/10.1016/j.jand.2021.07.012 European Food Safety Authority (2016) Dietary reference values for thiamin. EFSA J 14:4653. https://doi.org/10.2903/j.efsa.2016.4653 Mertens E, Colizzi C, Peñalvo JL (2022) Ultra-processed food consumption in adults across Europe. Eur J Nutr 61:1521–1539. https://doi.org/10.1007/s00394-021-02733-7 O’Brien M, Quirke R, Gowan R, McNicholas F (2025) Prevalence of thiamine deficiency in anorexia nervosa: a systematic review and narrative synthesis. Eur Child Adolesc Psychiatry 34:1281–1293. https://doi.org/10.1007/s00787-024-02576-7 Karimi Behnagh A, Eghbali M, Abdolmaleki F, et al (2024) Pre- and Post-surgical Prevalence of Thiamine Deficiency in Patients Undergoing Bariatric Surgery: a Systematic Review and Meta-analysis. Obes Surg 34:653–665. https://doi.org/10.1007/s11695-023-06896-6 Oudman E, Wijnia JW, Oey M, et al (2019) Wernicke’s encephalopathy in hyperemesis gravidarum: A systematic review. Eur J Obstet Gynecol Reprod Biol 236:84–93. https://doi.org/10.1016/j.ejogrb.2019.03.006 Elmadfa I, Majchrzak D, Rust P, Genser D (2001) The thiamine status of adult humans depends on carbohydrate intake. Int J Vitam Nutr Res Int Z Vitam- Ernahrungsforschung J Int Vitaminol Nutr 71:217–221. https://doi.org/10.1024/0300-9831.71.4.217 Clark AF (2024) Use of Thiamine Supplementation in Pregnant Women Diagnosed With Hyperemesis Gravidarum and Wernicke Encephalopathy. Nurs Womens Health 28:222–226. https://doi.org/10.1016/j.nwh.2024.02.003 Saka Y, Naruse T, Kato A, et al (2018) Thiamine status in end-stage chronic kidney disease patients: a single-center study. Int Urol Nephrol 50:1913–1918. https://doi.org/10.1007/s11255-018-1974-y Lautenschläger T, Neinhuis C, Monizi M, et al (2017) Edible insects of Northern Angola. Afr Invertebr 58:55–82. https://doi.org/10.3897/afrinvertebr.58.21083 Nishimune T, Watanabe Y, Okazaki H, Akai H (2000) Thiamin is decomposed due to Anaphe spp. entomophagy in seasonal ataxia patients in Nigeria. J Nutr 130:1625–1628. https://doi.org/10.1093/jn/130.6.1625 Vid Vičič, Andreja Kukec (2025) Systematic review of thiamine (vitamin B1) status in healthy European adults ID - CRD420251101630 ER -. In: https://www.crd.york.ac.uk/PROSPERO/view/CRD420251101630 Page MJ, McKenzie JE, Bossuyt PM, et al (2021) The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. Syst Rev 10:89. https://doi.org/10.1186/s13643-021-01626-4 Tasevska N, Runswick SA, McTaggart A, Bingham SA (2008) Twenty-four-hour urinary thiamine as a biomarker for the assessment of thiamine intake. Eur J Clin Nutr 62:1139–1147. https://doi.org/10.1038/sj.ejcn.1602829 Jones KS, Parkington DA, Cox LJ, Koulman A (2021) Erythrocyte transketolase activity coefficient (ETKAC) assay protocol for the assessment of thiamine status. Ann N Y Acad Sci 1498:77–84. https://doi.org/10.1111/nyas.14547 Lu J, Frank EL (2008) Rapid HPLC Measurement of Thiamine and Its Phosphate Esters in Whole Blood. Clin Chem 54:901–906. https://doi.org/10.1373/clinchem.2007.099077 Talwar D, Davidson H, Cooney J, St JO’Reilly D (2000) Vitamin B(1) status assessed by direct measurement of thiamin pyrophosphate in erythrocytes or whole blood by HPLC: comparison with erythrocyte transketolase activation assay. Clin Chem 46:704–710 Jones KS, Parkington DA, Bourassa MW, et al (2023) Protocol and application of basal erythrocyte transketolase activity to improve assessment of thiamine status. Ann N Y Acad Sci 1521:104–111. https://doi.org/10.1111/nyas.14962 Herzog R, Álvarez-Pasquin MJ, Díaz C, et al (2013) Are healthcare workers’ intentions to vaccinate related to their knowledge, beliefs and attitudes? a systematic review. BMC Public Health 13:154. https://doi.org/10.1186/1471-2458-13-154 Ortega RM, Martínez RM, Andrés P, et al (2004) Thiamin status during the third trimester of pregnancy and its influence on thiamin concentrations in transition and mature breast milk. Br J Nutr 92:129–135. https://doi.org/10.1079/BJN20041153 Sánchez DJ, Murphy MM, Bosch-Sabater J, Fernández-Ballart J (1999) Enzymic evaluation of thiamin, riboflavin and pyridoxine status of parturient mothers and their newborn infants in a Mediterranean area of Spain. Eur J Clin Nutr 53:27–38. https://doi.org/10.1038/sj.ejcn.1600674 Malara M, Hübner-Wozniak E, Lewandowska I (2013) Assessment of intake and nutritional status of vitamin B1, B2, and B6 in men and women with different physical activity levels. Biol Sport 30:117–123. https://doi.org/10.5604/20831862.1044430 Hötzel D, Bitsch R (1976) Thiamine status of human subjects, estimated by biochemical methods. J Nutr Sci Vitaminol (Tokyo) 22:41–45. https://doi.org/10.3177/jnsv.22.Supplement_41 Fabian E, Majchrzak D, Dieminger B, et al (2008) Influence of probiotic and conventional yoghurt on the status of vitamins B1, B2 and B6 in young healthy women. Ann Nutr Metab 52:29–36. https://doi.org/10.1159/000114408 Herve C, Beyne P, Lettéron P, Delacoux E (1995) Comparison of erythrocyte transketolase activity with thiamine and thiamine phosphate ester levels in chronic alcoholic patients. Clin Chim Acta Int J Clin Chem 234:91–100. https://doi.org/10.1016/0009-8981(94)05980-7 Jermendy G (2006) Evaluating thiamine deficiency in patients with diabetes. Diab Vasc Dis Res 3:120–121. https://doi.org/10.3132/dvdr.2006.014 Boni L, Kieckens L, Hendrikx A (1980) An Evaluation of a Modified Erythrocyte Transketolase Assay for Assessing Thiamine Nutritional Adequacy. J Nutr Sci Vitaminol (Tokyo) 26:507–514. https://doi.org/10.3177/jnsv.26.507 Mancinelli R, Ceccanti M, Guiducci MS, et al (2003) Simultaneous liquid chromatographic assessment of thiamine, thiamine monophosphate and thiamine diphosphate in human erythrocytes: a study on alcoholics. J Chromatogr B 789:355–363. https://doi.org/10.1016/S1570-0232(03)00139-9 Verstraete J, Stove C (2021) Volumetric absorptive microsampling (VAMS) as a reliable tool to assess thiamine status in dried blood microsamples: a comparative study. Am J Clin Nutr 114:1200–1207. https://doi.org/10.1093/ajcn/nqab146 Körner RW, Vierzig A, Roth B, Müller C (2009) Determination of thiamin diphosphate in whole blood samples by high-performance liquid chromatography--a method suitable for pediatric diagnostics. J Chromatogr B Analyt Technol Biomed Life Sci 877:1882–1886. https://doi.org/10.1016/j.jchromb.2009.05.013 Lynch PLM, Trimble ER, Young IS (1997) High-performance liquid chromatographic determination of thiamine diphosphate in erythrocytes using internal standard methodology. J Chromatogr B Biomed Sci App 701:120–123. https://doi.org/10.1016/S0378-4347(97)00353-8 Tallaksen CME, Bøhmer T, Bell H, Karlsen J (1991) Concomitant determination of thiamin and its phosphate esters in human blood and serum by high-performance liquid chromatography. J Chromatogr B Biomed Sci App 564:127–136. https://doi.org/10.1016/0378-4347(91)80075-N Schrijver J, Speek AJ, Klosse JA, et al (1982) A Reliable Semiautomated Method for the Determination of Total Thiamine in Whole Blood by the Thiochrome Method with High-Performance Liquid Chromatography. Ann Clin Biochem 19:52–56. https://doi.org/10.1177/000456328201900111 Johnson CR, Fischer PR, Thacher TD, et al (2019) Thiamin deficiency in low- and middle-income countries: Disorders, prevalences, previous interventions and current recommendations. Nutr Health 25:127–151. https://doi.org/10.1177/0260106019830847 Rakotoambinina B, Hiffler L, Gomes F (2021) Pediatric thiamine deficiency disorders in high-income countries between 2000 and 2020: a clinical reappraisal. Ann N Y Acad Sci 1498:57–76. https://doi.org/10.1111/nyas.14669 Passarelli S, Free CM, Shepon A, et al (2024) Global estimation of dietary micronutrient inadequacies: a modelling analysis. Lancet Glob Health 12:e1590–e1599. https://doi.org/10.1016/S2214-109X(24)00276-6 Hebert JR, Clemow L, Pbert L, et al (1995) Social desirability bias in dietary self-report may compromise the validity of dietary intake measures. Int J Epidemiol 24:389–398. https://doi.org/10.1093/ije/24.2.389 Gallant J, Chan K, Green TJ, et al (2021) Low-dose thiamine supplementation of lactating Cambodian mothers improves human milk thiamine concentrations: a randomized controlled trial. Am J Clin Nutr 114:90–100. https://doi.org/10.1093/ajcn/nqab052 Lonsdale D (2015) Sudden infant death syndrome and abnormal metabolism of thiamin. Med Hypotheses 85:922–926. https://doi.org/10.1016/j.mehy.2015.09.009 European Commission. Commission Directive 2006/125/EC of 5 December 2006 on processed cereal‑based foods and baby foods for infants and young children (Text with EEA relevance). OJ L 339, 6.12.2006, pp. 16–35. Brussels: European Union. European Commission. Commission Delegated Regulation (EU) 2016/127 of 25 September 2015 supplementing Regulation (EU) No 609/2013 of the European Parliament and of the Council as regards the specific compositional and information requirements for infant formula and follow‑on formula and as regards requirements on information relating to infant and young child feeding (Text with EEA relevance). OJ L 25, 2.2.2016, pp. 1–29. Brussels: European Union. Bailey AL, Finglas PM, Wright AJA, Southon S (1994) Thiamin intake, erythrocyte transketolase (EC 2.2.1.1) activity and total erythrocyte thiamin in adolescents. Br J Nutr 72:111–125. https://doi.org/10.1079/BJN19940014 Falcão RCTM de A, Lyra C de O, Morais CMM de, et al (2019) Processed and ultra-processed foods are associated with high prevalence of inadequate selenium intake and low prevalence of vitamin B1 and zinc inadequacy in adolescents from public schools in an urban area of northeastern Brazil. PloS One 14:e0224984. https://doi.org/10.1371/journal.pone.0224984 Rehm J, Anderson P, Barry J, et al (2015) Prevalence of and potential influencing factors for alcohol dependence in Europe. Eur Addict Res 21:6–18. https://doi.org/10.1159/000365284 Bichkaeva FA, Tkachev AV, Boiko ER, et al (2003) Vitamin B1 Levels in Residents of the European North. Hum Physiol 29:119–121. https://doi.org/10.1023/A:1022073123466 Bojko ER (2001) Thiamine Status in Inhabitants of the Russian European North. Int J Circumpolar Health 60:466–468. https://doi.org/10.1080/25761900.2022.12220617 Whitfield KC, Smith TJ, Rohner F, et al (2021) Thiamine fortification strategies in low- and middle-income settings: a review. Ann N Y Acad Sci 1498:29–45. https://doi.org/10.1111/nyas.14565 Vičič V, Mikuš RP, Kugler S, et al (2023) Vitamin D fortification of eggs alone and in combination with milk in women aged 44-65 years: Fortification model and economic evaluation. Zdr Varst 62:30–38. https://doi.org/10.2478/sjph-2023-0005 Churuangsuk C, Griffiths D, Lean MEJ, Combet E (2019) Impacts of carbohydrate-restricted diets on micronutrient intakes and status: A systematic review. Obes Rev Off J Int Assoc Study Obes 20:1132–1147. https://doi.org/10.1111/obr.12857 European Commission, Scientific Committee on Food. Opinion of the Scientific Committee on Food on the Tolerable Upper Intake Level of Vitamin B1 (expressed on 11 July 2001). SCF/CS/NUT/UPPLEV/46 Final, 16 July 2001. Brussels: European Commission. Available at: https://food.ec.europa.eu/system/files/2020-12/sci-com_scf_out93_en.pdf Shakory S (2020) Thiamine in the management of alcohol use disorders. Can Fam Physician 66:165–166 Additional Declarations No competing interests reported. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-8997297","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Systematic Review","associatedPublications":[],"authors":[{"id":620442628,"identity":"e08bb141-b5f8-4514-be49-bb44d44dcdf3","order_by":0,"name":"Vid VIČIČ","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAA5ElEQVRIie3PMQrCMBSA4RcC7fIga0UPkRO0V0kRnDs5RwRdPIDeQm8QydBFvIAO7aJrxw4OJhHqYqNuIvkpJU3ztQlAKPSLUeBgLoRYQmOezQCEnfmAoCJrR+g70r1NhCP2I/54SbcUi3TENtdaksV5ZEhF2sJDdFRQ5GNMTiI35OI2Zmb6yWCOnKy5Qj4UZUUWGjNtiO8sTzLYz6Ql9i+k9RBm99BYklDSEfBtjNGoUI09y2FCpDg+iPaRiOldJW5pxpZlLZupziBe5XV76yc21Y2Eu6NQL9d5ir8WoVAo9N/dAWb4QinbwoRNAAAAAElFTkSuQmCC","orcid":"","institution":"University of Ljubljana, Faculty of Health Sciences","correspondingAuthor":true,"prefix":"","firstName":"Vid","middleName":"","lastName":"VIČIČ","suffix":""},{"id":620442634,"identity":"c6d753a8-3075-44a3-a106-7d1ece9f9432","order_by":1,"name":"Sergej PIRKMAJER","email":"","orcid":"","institution":"University of Ljubljana, Faculty of Medicine","correspondingAuthor":false,"prefix":"","firstName":"Sergej","middleName":"","lastName":"PIRKMAJER","suffix":""},{"id":620442637,"identity":"0ca1bbaf-b831-4498-b005-6ade9fe2a2d6","order_by":2,"name":"Andreja KUKEC","email":"","orcid":"","institution":"University of Ljubljana, Faculty of Medicine","correspondingAuthor":false,"prefix":"","firstName":"Andreja","middleName":"","lastName":"KUKEC","suffix":""}],"badges":[],"createdAt":"2026-02-28 18:08:42","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-8997297/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-8997297/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":106743954,"identity":"0f632515-7921-4a6f-b3bd-efd884f31cf8","added_by":"auto","created_at":"2026-04-13 04:44:57","extension":"png","order_by":1,"title":"Figure 1","display":"","copyAsset":false,"role":"figure","size":125933,"visible":true,"origin":"","legend":"\u003cp\u003eRole of ThDP in energy metabolism. Abbreviations: α-KGDH: α-ketoglutarate dehydrogenase complex, BCKDH: branched-chain α-keto acid dehydrogenase complex, KIC: α-ketoisocaproate, KIV: α-ketoisovalerate, KMV: α-keto β-methylvalerate, IB-CoA: isobutyryl-CoA, Ile: isoleucine; Leu: Leucine, MB-CoA: methylbutyryl-CoA, IV-CoA: isovaleryl-CoA, PDH: pyruvate dehydrogenase complex, TCA: tricarboxylic acid, TKT: transketolase, Val: Valine.\u003c/p\u003e","description":"","filename":"1.png","url":"https://assets-eu.researchsquare.com/files/rs-8997297/v1/89a564b7b9f35fe5389cbb6c.png"},{"id":106960825,"identity":"3570e798-1eed-41a2-ac3f-a78dea513ac4","added_by":"auto","created_at":"2026-04-15 09:23:17","extension":"png","order_by":2,"title":"Figure 2","display":"","copyAsset":false,"role":"figure","size":255712,"visible":true,"origin":"","legend":"\u003cp\u003e\u003cstrong\u003eRisk factors contributing to thiamin deficiency\u003c/strong\u003e: \u003cstrong\u003e1. Low thiamin intake.\u003c/strong\u003e The reason for low thiamin intake may be generally low food intake for example in people with anorexia nervosa [50], bariatric surgery [51] or vomiting [52]. More often the cause is diet dominated by foods low in thiamin (polished rice, soft drinks, ultra processed foods) [23]. \u003cstrong\u003e2.\u003c/strong\u003e \u003cstrong\u003eImpaired absorption and cellular utilization of thiamin.\u003c/strong\u003e Chronic alcohol consumption affects food intake, thiamin absorption, cellular utilization and increases thiamin needs. Additionally, alcoholic beverages provide substantial energy while contributing negligible amounts of thiamin. [42]. Bariatric surgery decreases thiamin intake and absorption [51]. \u003cstrong\u003e3. High carbohydrate and energy intake.\u003c/strong\u003e Thiamin requirements depend on carbohydrate and energy intake [48, 53]. Children, adolescents, pregnant women, lactating women, and people living with obesity have increased thiamin needs. Intravenous infusions of glucose given to thiamin deficient patients increase thiamin requirements and exacerbate deficiency [54]. \u003cstrong\u003e4.\u003c/strong\u003e \u003cstrong\u003eIncreased thiamin excretion.\u003c/strong\u003eUse of diuretics, chronic kidney disease and dialysis can increase thiamin excretion [55]. \u003cstrong\u003e5. High intake of thiaminase\u003c/strong\u003e from insufficiently cooked larvae of African silkworm Anaphe venata causes seasonal thiamin deficiency in Nigeria [56, 57]. In Europe, thiaminase contribution to thiamin deficiency is negligible. Source of images:\u003cstrong\u003e \u003c/strong\u003eCanva.\u003c/p\u003e","description":"","filename":"2.png","url":"https://assets-eu.researchsquare.com/files/rs-8997297/v1/1072a2901d3bdc117f86b621.png"},{"id":106960437,"identity":"adbc29f2-4de5-4153-b60a-e7fee3953e65","added_by":"auto","created_at":"2026-04-15 09:21:06","extension":"png","order_by":3,"title":"Figure 3","display":"","copyAsset":false,"role":"figure","size":72888,"visible":true,"origin":"","legend":"\u003cp\u003eStudy flow diagram. Made according to PRISMA guidelines [59].\u003c/p\u003e","description":"","filename":"3.png","url":"https://assets-eu.researchsquare.com/files/rs-8997297/v1/d539e2941e9d7a9c92430cf8.png"},{"id":106963315,"identity":"3c9ddf5d-a630-4b3b-9272-0f616766d947","added_by":"auto","created_at":"2026-04-15 09:43:34","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":1638201,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-8997297/v1/6fbb7c6a-cecf-4348-9e2f-5e697b021c75.pdf"},{"id":106743953,"identity":"6fa09e36-2845-416d-8bbb-5cec2867a1f3","added_by":"auto","created_at":"2026-04-13 04:44:57","extension":"docx","order_by":0,"title":"","display":"","copyAsset":false,"role":"supplement","size":35100,"visible":true,"origin":"","legend":"","description":"","filename":"24.2.2026SUPP.docx","url":"https://assets-eu.researchsquare.com/files/rs-8997297/v1/26cb41d8cadc7a89631f4d09.docx"},{"id":106743957,"identity":"7cbe22e2-ed01-41de-be7d-598294e3d585","added_by":"auto","created_at":"2026-04-13 04:44:57","extension":"docx","order_by":1,"title":"","display":"","copyAsset":false,"role":"supplement","size":276014,"visible":true,"origin":"","legend":"","description":"","filename":"PRISMA2020checklist.docx","url":"https://assets-eu.researchsquare.com/files/rs-8997297/v1/8ed6e4fb78a791299f7c600b.docx"}],"financialInterests":"No competing interests reported.","formattedTitle":"\u003cp\u003eCurrent Evidence on Thiamin (Vitamin B1) Status in Healthy European Adults: A Systematic Review of Biomarkers and Deficiency Prevalence\u003c/p\u003e","fulltext":[{"header":"1. BACKGROUND","content":"\u003cp\u003eThiamin (vitamin B1) is a water-soluble vitamin essential for carbohydrate and amino acid metabolism, energy production and neuronal function [\u003cspan citationid=\"CR1\" class=\"CitationRef\"\u003e1\u003c/span\u003e]. Thiamin is ingested mainly in phosphorylated forms and free thiamin is produced by intestinal phosphatases [\u003cspan citationid=\"CR2\" class=\"CitationRef\"\u003e2\u003c/span\u003e, \u003cspan citationid=\"CR3\" class=\"CitationRef\"\u003e3\u003c/span\u003e]. Once dephosphorylated, free thiamin is absorbed in the small intestine primarily via thiamin transporters THTR1 (SLC19A2) and THTR2 (SLC19A3) [\u003cspan citationid=\"CR4\" class=\"CitationRef\"\u003e4\u003c/span\u003e, \u003cspan citationid=\"CR5\" class=\"CitationRef\"\u003e5\u003c/span\u003e]. THTR1 and THTR2 also mediate thiamin transport in the kidney and other tissues [\u003cspan citationid=\"CR6\" class=\"CitationRef\"\u003e6\u003c/span\u003e, \u003cspan citationid=\"CR7\" class=\"CitationRef\"\u003e7\u003c/span\u003e]. In addition to these classical thiamin transporters, several other carriers are likely involved in thiamin handling [\u003cspan citationid=\"CR8\" class=\"CitationRef\"\u003e8\u003c/span\u003e]. For instance, reduced folate carrier 1 (RFC1 aka SLC19A1) may contribute to thiamin absorption by transporting thiamin monophosphate [\u003cspan citationid=\"CR9\" class=\"CitationRef\"\u003e9\u003c/span\u003e].\u003c/p\u003e \u003cp\u003eInside the cell, thiamin is phosphorylated to thiamin diphosphate (ThDP) (older name: thiamin pyrophosphate -TPP), its major physiological form, by thiamin pyrophosphokinase [\u003cspan additionalcitationids=\"CR11\" citationid=\"CR10\" class=\"CitationRef\"\u003e10\u003c/span\u003e\u0026ndash;\u003cspan citationid=\"CR12\" class=\"CitationRef\"\u003e12\u003c/span\u003e]. In the cytoplasm, ThDP participates in the pentose phosphate pathway as a cofactor of transketolase (Fig.\u0026nbsp;\u003cspan refid=\"Fig1\" class=\"InternalRef\"\u003e1\u003c/span\u003e), which catalyses the conversion of pentose sugars to intermediates of glycolysis, thus enabling production of NADPH even when ribose-5-phosphate is not needed for nucleotide synthesis [\u003cspan citationid=\"CR2\" class=\"CitationRef\"\u003e2\u003c/span\u003e, \u003cspan additionalcitationids=\"CR14\" citationid=\"CR13\" class=\"CitationRef\"\u003e13\u003c/span\u003e\u0026ndash;\u003cspan citationid=\"CR15\" class=\"CitationRef\"\u003e15\u003c/span\u003e]. Mitochondrial carrier SLC25A19 transports ThDP to the mitochondrial matrix [\u003cspan citationid=\"CR16\" class=\"CitationRef\"\u003e16\u003c/span\u003e], where it serves as a cofactor in oxidative decarboxylation of α-keto acids, including pyruvate [\u003cspan citationid=\"CR16\" class=\"CitationRef\"\u003e16\u003c/span\u003e, \u003cspan citationid=\"CR17\" class=\"CitationRef\"\u003e17\u003c/span\u003e], α-ketoglutarate [\u003cspan citationid=\"CR16\" class=\"CitationRef\"\u003e16\u003c/span\u003e, \u003cspan citationid=\"CR18\" class=\"CitationRef\"\u003e18\u003c/span\u003e], and α-keto acids of branched-chain amino acids [\u003cspan citationid=\"CR19\" class=\"CitationRef\"\u003e19\u003c/span\u003e, \u003cspan citationid=\"CR20\" class=\"CitationRef\"\u003e20\u003c/span\u003e] (Fig.\u0026nbsp;\u003cspan refid=\"Fig1\" class=\"InternalRef\"\u003e1\u003c/span\u003e). Besides the role of ThDP as a cofactor, thiamin and its phosphorylated derivatives affect membrane function and seem to play a role in regulation of neuronal excitability [\u003cspan citationid=\"CR21\" class=\"CitationRef\"\u003e21\u003c/span\u003e, \u003cspan citationid=\"CR22\" class=\"CitationRef\"\u003e22\u003c/span\u003e].\u003c/p\u003e \u003cp\u003e \u003c/p\u003e \u003cp\u003eThiamin deficiency is still widespread in low- and middle-income countries that rely heavily on processed staple foods, such as polished rice. Although thiamin is naturally present in a wide range of foods, its content is significantly diminished by bran removal (milling, polishing), refining, processing, and cooking [\u003cspan citationid=\"CR23\" class=\"CitationRef\"\u003e23\u003c/span\u003e]. The best sources of thiamin are pork, wholegrain cereals and legumes [\u003cspan citationid=\"CR24\" class=\"CitationRef\"\u003e24\u003c/span\u003e].\u003c/p\u003e \u003cp\u003eAlthough it is often assumed that thiamin deficiency is rare in the general population in Europe and is limited to high-risk groups such as malnourished or people with alcohol use disorder (AUD) [\u003cspan citationid=\"CR25\" class=\"CitationRef\"\u003e25\u003c/span\u003e], this assumption is hardly supported by evidence. There are few general population-based studies [\u003cspan citationid=\"CR26\" class=\"CitationRef\"\u003e26\u003c/span\u003e, \u003cspan citationid=\"CR27\" class=\"CitationRef\"\u003e27\u003c/span\u003e] that have investigated thiamin status in European countries, highlighting a critical gap in public health research.\u003c/p\u003e \u003cp\u003eWhile some micronutrients like vitamin D have been extensively studied in high income populations, thiamin status remains under-investigated in epidemiological research [\u003cspan citationid=\"CR28\" class=\"CitationRef\"\u003e28\u003c/span\u003e].\u003c/p\u003e \u003cp\u003eThiamin must be supplied regularly, as body stores are minimal. Diet almost devoid of thiamin produces first sign of deficiency in just 10 days [\u003cspan citationid=\"CR29\" class=\"CitationRef\"\u003e29\u003c/span\u003e]. Clinical thiamin deficiency may present with a spectrum of neurological, psychiatric, and cardiovascular signs and symptoms [\u003cspan citationid=\"CR30\" class=\"CitationRef\"\u003e30\u003c/span\u003e]. Subclinical deficiencies can also impair cognitive and physical functions [\u003cspan citationid=\"CR23\" class=\"CitationRef\"\u003e23\u003c/span\u003e]. Early signs of thiamin deficiency are often unrecognized [\u003cspan citationid=\"CR31\" class=\"CitationRef\"\u003e31\u003c/span\u003e], none of the signs and symptoms are pathognomonic, and can be mistaken for psychosomatic disorders [\u003cspan citationid=\"CR32\" class=\"CitationRef\"\u003e32\u003c/span\u003e].\u003c/p\u003e \u003cp\u003eDietary thiamin deficiency may ultimately lead to beriberi (dry, wet, or infantile) and Wernicke-Korsakoff syndrome. In adults, dry beriberi presents with peripheral sensory and motor neuropathy [\u003cspan citationid=\"CR33\" class=\"CitationRef\"\u003e33\u003c/span\u003e], while wet beriberi presents with increased cardiac output, cardiomegaly, heart failure, and peripheral oedema [\u003cspan citationid=\"CR34\" class=\"CitationRef\"\u003e34\u003c/span\u003e, \u003cspan citationid=\"CR35\" class=\"CitationRef\"\u003e35\u003c/span\u003e]. Cardiac dysfunction, which can be severe, is a major feature of infantile beriberi which appears in infants during first months of life [\u003cspan citationid=\"CR36\" class=\"CitationRef\"\u003e36\u003c/span\u003e], while the nervous system dysfunction may predominate in older children [\u003cspan citationid=\"CR37\" class=\"CitationRef\"\u003e37\u003c/span\u003e]. Thiamin deficiency, especially in alcohol use disorder, may manifest also as Wernicke\u0026rsquo;s encephalopathy and Korsakoff syndrome [\u003cspan citationid=\"CR25\" class=\"CitationRef\"\u003e25\u003c/span\u003e]. Wernicke\u0026rsquo;s encephalopathy is characterized by mental changes, abnormal eye movements, and/or ataxia [\u003cspan additionalcitationids=\"CR39\" citationid=\"CR38\" class=\"CitationRef\"\u003e38\u003c/span\u003e\u0026ndash;\u003cspan citationid=\"CR40\" class=\"CitationRef\"\u003e40\u003c/span\u003e]. If untreated, Wernicke\u0026rsquo;s encephalopathy may progress to Korsakoff\u0026rsquo;s syndrome, an irreversible condition which manifests with amnesia and confabulation [\u003cspan citationid=\"CR40\" class=\"CitationRef\"\u003e40\u003c/span\u003e]. In one study the researchers examined material from 6,964 autopsies. 52 cases of Wernicke's encephalopathy were found, of which 12 (23%) were found in people without alcohol dependence. Only 4 cases (7.7%) were diagnosed based on clinical symptoms in living patients. None of the people without alcohol dependence were given thiamin therapy [\u003cspan citationid=\"CR41\" class=\"CitationRef\"\u003e41\u003c/span\u003e].\u003c/p\u003e \u003cp\u003eLong-term alcohol consumption can lead to thiamin deficiency by reducing dietary intake of thiamin, inhibiting absorption in the gastrointestinal tract and disrupting its cellular utilization [\u003cspan citationid=\"CR42\" class=\"CitationRef\"\u003e42\u003c/span\u003e]. Thiamin deficiency also occurs in malnourished patients, patients after bariatric surgery [\u003cspan citationid=\"CR30\" class=\"CitationRef\"\u003e30\u003c/span\u003e], people living with obesity [\u003cspan citationid=\"CR43\" class=\"CitationRef\"\u003e43\u003c/span\u003e], patients on total parenteral nutrition [\u003cspan citationid=\"CR30\" class=\"CitationRef\"\u003e30\u003c/span\u003e, \u003cspan citationid=\"CR44\" class=\"CitationRef\"\u003e44\u003c/span\u003e] and patients with diabetes [\u003cspan citationid=\"CR45\" class=\"CitationRef\"\u003e45\u003c/span\u003e]. Thiamin deficiency may also occur in the context of refeeding syndrome, since the transition from starvation to feeding greatly increases the demand for thiamin, which serves as a cofactor for glucose-dependent metabolic pathways (Fig.\u0026nbsp;\u003cspan refid=\"Fig1\" class=\"InternalRef\"\u003e1\u003c/span\u003e) [\u003cspan citationid=\"CR46\" class=\"CitationRef\"\u003e46\u003c/span\u003e]. Lastly, ultra-processed foods, snacks and soft drinks contribute significantly to energy intake while being low in thiamin [\u003cspan citationid=\"CR47\" class=\"CitationRef\"\u003e47\u003c/span\u003e]. The population reference intake for thiamin is the same for all population groups: 0.1 mg/MJ (0.4 mg/1000 kcal) as it is dependent on energy intake [\u003cspan citationid=\"CR48\" class=\"CitationRef\"\u003e48\u003c/span\u003e].The ultra-processed food share in energy intake in Europe ranges from 14\u0026ndash;44%, the highest being in United Kingdom [\u003cspan citationid=\"CR49\" class=\"CitationRef\"\u003e49\u003c/span\u003e]. All risk factors contributing to thiamin deficiency are presented in Fig.\u0026nbsp;\u003cspan refid=\"Fig2\" class=\"InternalRef\"\u003e2\u003c/span\u003e.\u003c/p\u003e \u003cp\u003eThis systematic review evaluates thiamin status of the European adult population, identifying critical gaps and priorities for future research.\u003c/p\u003e \u003cp\u003e \u003c/p\u003e"},{"header":"2. MATERIALS AND METHODS","content":"\u003cp\u003eThe study was conducted according to a previously registered protocol in the international prospective register of systematic reviews PROSPERO ID - CRD420251101630 [\u003cspan citationid=\"CR58\" class=\"CitationRef\"\u003e58\u003c/span\u003e]. The systematic review was conducted according to PRISMA guidelines [\u003cspan citationid=\"CR59\" class=\"CitationRef\"\u003e59\u003c/span\u003e].\u003c/p\u003e\n\u003cdiv id=\"Sec3\" class=\"Section2\"\u003e\n \u003ch2\u003e2.1 STUDY POPULATION, EXPOSURE AND OUTCOME\u003c/h2\u003e\n \u003cp\u003eThe study population included apparently healthy, community-dwelling adults aged\u0026thinsp;\u0026ge;\u0026thinsp;18 years from European countries meeting the inclusion criteria.\u003c/p\u003e\n \u003cp\u003eThiamin status is usually assessed through two approaches:\u003c/p\u003e\u003cspan\u003e\n \u003cp\u003e1. Direct measurement of thiamin or its phosphorylated metabolites (thiamin diphosphate (ThDP) in whole blood (WB) or erythrocytes (RBC) or total thiamin in whole blood (WB)). Thiamin deficiency is generally associated with low total thiamin or ThDP concentrations in whole blood and erythrocytes [\u003cspan citationid=\"CR48\" class=\"CitationRef\"\u003e48\u003c/span\u003e] .\u003c/p\u003e\n \u003c/span\u003e \u003cspan\u003e\n \u003cp\u003e2. Functional assessment via the erythrocyte transketolase activity coefficient (ETKAC), an indirect marker of thiamin-dependent enzymatic saturation (ETKAC\u0026thinsp;=\u0026thinsp;ETK activity with added ThDP (U/g Hb) / baseline ETK activity (U/g Hb)). ETKAC is a sensitive marker for thiamin function and status [\u003cspan citationid=\"CR48\" class=\"CitationRef\"\u003e48\u003c/span\u003e].\u003c/p\u003e\n \u003c/span\u003e\n \u003cp\u003eThere is also a possibility of measurement of excreted thiamin in 24h urine, which has good correlation with thiamin intake [\u003cspan citationid=\"CR48\" class=\"CitationRef\"\u003e48\u003c/span\u003e, \u003cspan citationid=\"CR60\" class=\"CitationRef\"\u003e60\u003c/span\u003e], but is not a biomarker of thiamin status, especially when thiamin intake is low [\u003cspan citationid=\"CR61\" class=\"CitationRef\"\u003e61\u003c/span\u003e].\u003c/p\u003e\n \u003cp\u003eThe primary exposure was thiamin status, assessed using the biomarkers defined in Table \u003cspan refid=\"Tab1\" class=\"InternalRef\"\u003e1\u003c/span\u003e. The outcomes included: 1. absolute measurements of biomarkers and 2. the prevalence of thiamin deficiency defined by the cut-off values listed in Table \u003cspan refid=\"Tab1\" class=\"InternalRef\"\u003e1\u003c/span\u003e.\u003c/p\u003e\n\u003c/div\u003e\n\u003cdiv id=\"Sec4\" class=\"Section2\"\u003e\n \u003ch2\u003e2.2 THE INCLUSION AND EXCLUSION CRITERIA\u003c/h2\u003e\n \u003cp\u003e\u003cstrong\u003eThe inclusion criteria were\u003c/strong\u003e\u003c/p\u003e\n \u003cp\u003e(1) apparently healthy, community-dwelling adults aged\u0026thinsp;\u0026ge;\u0026thinsp;18 years, including pregnant and lactating women, (2) observational studies (cohort, case-control, or cross-sectional) and baseline data from interventional studies collected prior to any intervention, (3) studies reporting selected thiamin biomarkers listed in Table \u003cspan refid=\"Tab1\" class=\"InternalRef\"\u003e1\u003c/span\u003e, (4) studies including healthy European adults, (5) no restrictions on language, (6) no restrictions on publication date, and (7) a minimum sample size of 10 participants.\u003c/p\u003e\n \u003cp\u003e\u003cstrong\u003eThe exclusion criteria were\u003c/strong\u003e\u003c/p\u003e\n \u003cp\u003e(1) case reports, narrative reviews, and conference abstracts, (2) studies reporting biomarkers that do not reflect thiamin status, as specified in Table\u0026nbsp;\u003cspan refid=\"Tab2\" class=\"InternalRef\"\u003e2\u003c/span\u003e, (3) individuals taking thiamin food supplements, (4) participants with alcohol use disorder (AUD), obesity (BMI\u0026thinsp;\u0026gt;\u0026thinsp;30 kg/m\u0026sup2;), type 1 or type 2 diabetes mellitus, chronic kidney disease, liver dysfunction, malabsorption syndromes (e.g., celiac disease, Crohn\u0026rsquo;s disease), or other conditions known to affect thiamin status, (5) studies involving institutionalized populations or specific clinical subgroups such as individuals post-bariatric surgery or with Wernicke\u0026ndash;Korsakoff syndrome, and (6) studies focusing on special populations such as seamen, or aboriginal groups.\u003c/p\u003e\n \u003cdiv class=\"gridtable\"\u003e\u0026nbsp;\u003ctable float=\"Yes\" id=\"Tab1\" border=\"1\"\u003e\n \u003ccaption language=\"En\"\u003e\n \u003cdiv class=\"CaptionNumber\"\u003eTable 1\u003c/div\u003e\n \u003cdiv class=\"CaptionContent\"\u003e\n \u003cp\u003eThiamin biomarkers included in the systematic review.\u003c/p\u003e\n \u003c/div\u003e\n \u003c/caption\u003e\n \u003ccolgroup cols=\"4\"\u003e\u003c/colgroup\u003e\n \u003cthead\u003e\n \u003ctr\u003e\n \u003cth align=\"left\" colname=\"c1\"\u003e\n \u003cp\u003eBIOMARKER\u003c/p\u003e\n \u003c/th\u003e\n \u003cth align=\"left\" colname=\"c2\"\u003e\n \u003cp\u003eBIOL. SAMPLE\u003c/p\u003e\n \u003c/th\u003e\n \u003cth align=\"left\" colname=\"c3\"\u003e\n \u003cp\u003eUSE\u003c/p\u003e\n \u003c/th\u003e\n \u003cth align=\"left\" colname=\"c4\"\u003e\n \u003cp\u003eCUTOFF FOR DEFICIENCY\u003c/p\u003e\n \u003c/th\u003e\n \u003c/tr\u003e\n \u003c/thead\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\" colname=\"c1\"\u003e\n \u003cp\u003e\u003cstrong\u003eThDP - thiamin diphosphate in whole blood (\u003c/strong\u003eolder name: thiamin pyrophosphate -TPP)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c2\"\u003e\n \u003cp\u003eWhole blood\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c3\" morerows=\"1\" rowspan=\"2\"\u003e\n \u003cp\u003eBiologically active vitamer and indicator of thiamin status [\u003cspan citationid=\"CR30\" class=\"CitationRef\"\u003e30\u003c/span\u003e].\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c4\"\u003e\n \u003cp\u003eDeficiency\u0026thinsp;\u0026lt;\u0026thinsp;70 nmol/L [\u003cspan citationid=\"CR62\" class=\"CitationRef\"\u003e62\u003c/span\u003e].\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\" colname=\"c1\"\u003e\n \u003cp\u003e\u003cstrong\u003eThDP - thiamin diphosphate in erythrocytes\u003c/strong\u003e (older name: thiamin pyrophosphate -TPP)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c2\"\u003e\n \u003cp\u003eWashed erythrocytes\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c4\"\u003e\n \u003cp\u003eDeficiency\u0026thinsp;\u0026lt;\u0026thinsp;280 ng/g Hb RBC ThDP [\u003cspan citationid=\"CR63\" class=\"CitationRef\"\u003e63\u003c/span\u003e].\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\" colname=\"c1\"\u003e\n \u003cp\u003e\u003cstrong\u003eTotal thiamin in whole blood (free thiamin plus its esters)\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c2\"\u003e\n \u003cp\u003eWhole blood\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c3\"\u003e\n \u003cp\u003eIncludes inactive thiamin forms. Less reliable biomarker of thiamin status than ThDP - thiamin diphosphate in whole blood or erythrocytes [\u003cspan citationid=\"CR23\" class=\"CitationRef\"\u003e23\u003c/span\u003e].\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c4\"\u003e\n \u003cp\u003e\u0026lt;\u0026thinsp;75nmol/L [\u003cspan citationid=\"CR62\" class=\"CitationRef\"\u003e62\u003c/span\u003e].\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\" colname=\"c1\"\u003e\n \u003cp\u003e\u003cstrong\u003eETKAC - Erythrocyte transketolase activity coefficient\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c2\"\u003e\n \u003cp\u003eWashed erythrocytes\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c3\"\u003e\n \u003cp\u003eFunctional test of biological activity. Sensitive marker of thiamin function and status [\u003cspan citationid=\"CR48\" class=\"CitationRef\"\u003e48\u003c/span\u003e].\u003c/p\u003e\n \u003cp\u003eETKAC\u0026thinsp;=\u0026thinsp;ETK activity with added ThDP (U/g Hb) / baseline ETK activity (U/g Hb)[\u003cspan citationid=\"CR61\" class=\"CitationRef\"\u003e61\u003c/span\u003e].\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c4\"\u003e\n \u003cp\u003eDeficiency: ETKAC\u0026thinsp;\u0026gt;\u0026thinsp;1.25 (\u0026alpha;\u0026thinsp;\u0026gt;\u0026thinsp;25%) Insufficiency: ETKAC 1.15\u0026ndash;1.25 (\u0026alpha; 15\u0026ndash;25%). Adequate (sufficiency): ETKAC\u0026thinsp;\u0026lt;\u0026thinsp;1.15 (\u0026alpha;\u0026thinsp;\u0026lt;\u0026thinsp;15%) [\u003cspan citationid=\"CR23\" class=\"CitationRef\"\u003e23\u003c/span\u003e, \u003cspan citationid=\"CR48\" class=\"CitationRef\"\u003e48\u003c/span\u003e, \u003cspan citationid=\"CR61\" class=\"CitationRef\"\u003e61\u003c/span\u003e].\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n \u003c/table\u003e\n \u003c/div\u003e\n \u003cdiv class=\"gridtable\"\u003e\n \u003cdiv align=\"left\" class=\"colspec\" colname=\"c4\" colnum=\"4\"\u003e\u003cbr\u003e\u003c/div\u003e\n \u003cdiv align=\"left\" class=\"colspec\" colname=\"c5\" colnum=\"5\"\u003e\u003cbr\u003e\u003c/div\u003e\u0026nbsp;\u003ctable float=\"Yes\" id=\"Tab2\" border=\"1\"\u003e\n \u003ccaption language=\"En\"\u003e\n \u003cdiv class=\"CaptionNumber\"\u003eTable 2\u003c/div\u003e\n \u003cdiv class=\"CaptionContent\"\u003e\n \u003cp\u003eThiamin biomarkers \u003cspan type=\"BoldUnderline\" class=\"BoldUnderline\" name=\"Emphasis\"\u003enot included\u003c/span\u003e in the systematic review.\u003c/p\u003e\n \u003c/div\u003e\n \u003c/caption\u003e\n \u003ccolgroup cols=\"5\"\u003e\u003c/colgroup\u003e\n \u003cthead\u003e\n \u003ctr\u003e\n \u003cth align=\"left\" colspan=\"2\" nameend=\"c2\" namest=\"c1\"\u003e\n \u003cp\u003eBIOMARKER\u003c/p\u003e\n \u003c/th\u003e\n \u003cth align=\"left\" colname=\"c3\"\u003e\n \u003cp\u003eBIOL. SAMPLE\u003c/p\u003e\n \u003c/th\u003e\n \u003cth align=\"left\" colname=\"c4\"\u003e\n \u003cp\u003eUSE\u003c/p\u003e\n \u003c/th\u003e\n \u003cth align=\"left\" colname=\"c5\"\u003e\n \u003cp\u003eREASON FOR EXCLUSION\u003c/p\u003e\n \u003c/th\u003e\n \u003c/tr\u003e\n \u003c/thead\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\" colname=\"c1\"\u003e\n \u003cp\u003ePlasma thiamin\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colspan=\"2\" nameend=\"c3\" namest=\"c2\"\u003e\n \u003cp\u003ePlasma\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c4\"\u003e\n \u003cp\u003eReflects recent intake\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c5\" morerows=\"1\" rowspan=\"2\"\u003e\n \u003cp\u003eNot an indicator of thiamin status [\u003cspan citationid=\"CR23\" class=\"CitationRef\"\u003e23\u003c/span\u003e, \u003cspan citationid=\"CR48\" class=\"CitationRef\"\u003e48\u003c/span\u003e].\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\" colname=\"c1\"\u003e\n \u003cp\u003eThMP- thiamin monophosphate, older: TMP\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colspan=\"2\" nameend=\"c3\" namest=\"c2\"\u003e\n \u003cp\u003ePlasma\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c4\"\u003e\n \u003cp\u003eReflects recent intake\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\" colname=\"c1\"\u003e\n \u003cp\u003e24-h urinary thiamin\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colspan=\"2\" nameend=\"c3\" namest=\"c2\"\u003e\n \u003cp\u003e24h urine\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c4\"\u003e\n \u003cp\u003e1 mg of thiamin intake predicts 268.2 \u0026micro;g of thiamin excreted in urine [\u003cspan citationid=\"CR60\" class=\"CitationRef\"\u003e60\u003c/span\u003e]\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c5\"\u003e\n \u003cp\u003eBiomarker of thiamin intake, not status. Not reliable when thiamin intakes are low. Requires at least 24h urine collection [\u003cspan citationid=\"CR48\" class=\"CitationRef\"\u003e48\u003c/span\u003e, \u003cspan citationid=\"CR60\" class=\"CitationRef\"\u003e60\u003c/span\u003e, \u003cspan citationid=\"CR61\" class=\"CitationRef\"\u003e61\u003c/span\u003e].\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\" colname=\"c1\"\u003e\n \u003cp\u003eBasal ETK - Basal erythrocyte transketolase activity\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colspan=\"2\" nameend=\"c3\" namest=\"c2\"\u003e\n \u003cp\u003eWashed erythrocytes\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c4\"\u003e\n \u003cp\u003eComplementary biomarker [\u003cspan citationid=\"CR64\" class=\"CitationRef\"\u003e64\u003c/span\u003e].\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c5\"\u003e\n \u003cp\u003eUseful in specific populations. Aids in interpretation of thiamin status in context of variable apoenzyme concentrations. Cutoff for deficiency is not clearly defined; \u0026lt;0.50 U/gHb or \u0026lt;\u0026thinsp;0.59 U/gHb are used as cutoffs for deficiency [\u003cspan citationid=\"CR64\" class=\"CitationRef\"\u003e64\u003c/span\u003e]. This allows differentiation between whether the low activity is due to thiamin deficiency or reduced synthesis of the enzyme itself.\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n \u003c/table\u003e\n \u003c/div\u003e\n \u003cp\u003e\u003cbr\u003e2.3 SEARCH AND SCREENING STRATEGY\u003c/p\u003e\n\u003c/div\u003e\n\u003cdiv id=\"Sec5\" class=\"Section2\"\u003e\n \u003cp\u003eThe review team comprises two experts in public health and nutrition. The literature search was conducted in PubMed and Scopus and supplemented by snowballing (screening reference lists and citations of included studies).\u003c/p\u003e\n \u003cp\u003e\u003cstrong\u003eSearch Process\u003c/strong\u003e:\u003c/p\u003e\n \u003cul\u003e\n \u003cli\u003e\n \u003cp\u003eWe defined the search criteria. The PubMed and SCOPUS search combined terms for European populations with thiamin-related keywords (e.g., thiamin, vitamin B1, ThDP, ETK, ETKAC, ThDP etc.). The search was limited to human studies. Full search syntax is available in supplemental data.\u003c/p\u003e\n \u003c/li\u003e\n \u003cli\u003e\n \u003cp\u003eThe titles and abstracts were searched manually and selected as described in Study Flow Diagram. (Fig. \u003cspan refid=\"Fig3\" class=\"InternalRef\"\u003e3\u003c/span\u003e).\u003c/p\u003e\n \u003c/li\u003e\n \u003cli\u003e\n \u003cp\u003eThe data from selected studies was manually extracted into excel spreadsheet.\u003c/p\u003e\n \u003c/li\u003e\n \u003cli\u003e\n \u003cp\u003eThe data was then rechecked by second researcher.\u003c/p\u003e\n \u003c/li\u003e\n \u003c/ul\u003e\n \u003cp\u003e\u003cstrong\u003eStudy risk of bias assessment\u003c/strong\u003e\u003c/p\u003e\n \u003cp\u003eNewcastle-Ottawa Scale adapted for cross-sectional studies was used [\u003cspan citationid=\"CR65\" class=\"CitationRef\"\u003e65\u003c/span\u003e]. Grading is available in supplemental data.\u003c/p\u003e\n\u003c/div\u003e\n\u003cdiv id=\"Sec6\" class=\"Section2\"\u003e\n \u003cp\u003eDATA SYNTHESIS AND ANALYSIS\u003c/p\u003e\n \u003cp\u003eOnly one study included at least a regionally representative population sample [\u003cspan citationid=\"CR27\" class=\"CitationRef\"\u003e27\u003c/span\u003e] and many countries were not represented. The meta-analysis was not feasible.\u003c/p\u003e\n\u003c/div\u003e"},{"header":"3. RESULTS","content":"\u003cp\u003eA total of 19 cross-sectional studies from 11 countries published between 1976 and 2024 met the inclusion criteria and provided data on the thiamin status of 1687 healthy European adults. The results are stratified by the biomarkers erythrocyte transketolase activity coefficient (ETKAC) in Table\u0026nbsp;\u003cspan refid=\"Tab3\" class=\"InternalRef\"\u003e3\u003c/span\u003e, whole blood thiamin diphosphate (WB ThDP; nmol/L) in Table\u0026nbsp;\u003cspan refid=\"Tab4\" class=\"InternalRef\"\u003e4\u003c/span\u003e, total thiamin in whole blood (nmol/L) in Table\u0026nbsp;\u003cspan refid=\"Tab5\" class=\"InternalRef\"\u003e5\u003c/span\u003e and erythrocyte thiamin diphosphate (RBC ThDP; ng/g Hb) in Table\u0026nbsp;\u003cspan refid=\"Tab6\" class=\"InternalRef\"\u003e6\u003c/span\u003e.\u003c/p\u003e\n\u003cp\u003eWhile most studies included community-dwelling adults, several investigated specific subgroups, including pregnant and postpartum women, university students, individuals following LCHF diet (low carbohydrate high fat diet), and convenience samples of healthcare workers. Study populations were recruited from 11 countries: Spain, United Kingdom, Austria, Poland, Germany, Hungary, France, Belgium, Italy, Norway and the Netherlands. There was a single (Spanish) study with a representative sample of the healthy adult population [\u003cspan citationid=\"CR27\" class=\"CitationRef\"\u003e27\u003c/span\u003e].\u003c/p\u003e\n\u003cdiv id=\"Sec8\" class=\"Section2\"\u003e\n \u003ch2\u003e3.1 SUMMARY OF BIOMARKER FINDINGS\u003c/h2\u003e\n \u003cp\u003eThe prevalence of thiamin deficiency (ETKAC\u0026thinsp;\u0026gt;\u0026thinsp;1.25, WB ThDP\u0026thinsp;\u0026lt;\u0026thinsp;70 nmol/L, total thiamin\u0026thinsp;\u0026lt;\u0026thinsp;75 nmol/L, RBC ThDP\u0026thinsp;\u0026lt;\u0026thinsp;280 ng/g Hb), ranged from 0% to 41.2%. If pregnant and postpartum women were excluded, the prevalence of thiamin deficiency ranged from 0% to 10%.\u003c/p\u003e\n \u003cdiv class=\"gridtable\"\u003e\u0026nbsp;\u003ctable float=\"Yes\" id=\"Tab3\" border=\"1\"\u003e\n \u003ccaption language=\"En\"\u003e\n \u003cdiv class=\"CaptionNumber\"\u003eTable 3\u003c/div\u003e\n \u003cdiv class=\"CaptionContent\"\u003e\n \u003cp\u003eStudies reporting erythrocyte transketolase activity coefficients (ETKAC).\u003c/p\u003e\n \u003c/div\u003e\n \u003c/caption\u003e\n \u003cthead\u003e\n \u003ctr\u003e\n \u003cth align=\"left\" colname=\"c1\"\u003e\n \u003cp\u003eAuthor, year\u003c/p\u003e\n \u003c/th\u003e\n \u003cth align=\"left\" colname=\"c2\"\u003e\n \u003cp\u003ePopulation\u003c/p\u003e\n \u003c/th\u003e\n \u003cth align=\"left\" colname=\"c3\"\u003e\n \u003cp\u003eLocation\u003c/p\u003e\n \u003c/th\u003e\n \u003cth align=\"left\" colname=\"c4\"\u003e\n \u003cp\u003eNo. of subjects\u003c/p\u003e\n \u003c/th\u003e\n \u003cth align=\"left\" colname=\"c5\"\u003e\n \u003cp\u003eAge (mean\u0026thinsp;\u0026plusmn;\u0026thinsp;SD or range yrs)\u003c/p\u003e\n \u003c/th\u003e\n \u003cth align=\"left\" colname=\"c6\"\u003e\n \u003cp\u003eETKAC (mean\u0026thinsp;\u0026plusmn;\u0026thinsp;SD)\u003c/p\u003e\n \u003c/th\u003e\n \u003cth align=\"left\" colname=\"c7\"\u003e\n \u003cp\u003eThiamin deficiency (%)\u003c/p\u003e\n \u003cp\u003eETKAC\u0026thinsp;\u0026gt;\u0026thinsp;1.25\u003c/p\u003e\n \u003c/th\u003e\n \u003cth align=\"left\" colname=\"c8\"\u003e\n \u003cp\u003eThiamin insufficiency (%)\u003c/p\u003e\n \u003cp\u003eETKAC\u0026thinsp;\u0026gt;\u0026thinsp;1.15\u003c/p\u003e\n \u003c/th\u003e\n \u003c/tr\u003e\n \u003c/thead\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\" colname=\"c1\"\u003e\n \u003cp\u003eOrtega et al. 2004 [\u003cspan citationid=\"CR66\" class=\"CitationRef\"\u003e66\u003c/span\u003e]\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c2\"\u003e\n \u003cp\u003eHealthy women in third trimester pregnancy\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c3\"\u003e\n \u003cp\u003eCuenca, Spain\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c4\"\u003e\n \u003cp\u003e51 (♀51)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c5\"\u003e\n \u003cp\u003e29.9\u0026thinsp;\u0026plusmn;\u0026thinsp;3.8\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c6\"\u003e\n \u003cp\u003e1.06\u0026thinsp;\u0026plusmn;\u0026thinsp;0.22\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c7\"\u003e\n \u003cp\u003e13.7%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c8\"\u003e\n \u003cp\u003e31.3%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\" colname=\"c1\"\u003e\n \u003cp\u003eS\u0026aacute;nchez et al. 1999 [\u003cspan citationid=\"CR67\" class=\"CitationRef\"\u003e67\u003c/span\u003e]\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c2\"\u003e\n \u003cp\u003eHealthy post-partum women\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c3\"\u003e\n \u003cp\u003eCoast of Catalonia province, Spain\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c4\"\u003e\n \u003cp\u003e131 (♀131)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c5\"\u003e\n \u003cp\u003e26\u0026thinsp;\u0026plusmn;\u0026thinsp;5\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c6\"\u003e\n \u003cp\u003e1.25\u0026thinsp;\u0026plusmn;\u0026thinsp;0.17\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c7\"\u003e\n \u003cp\u003e41.2%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c8\"\u003e\n \u003cp\u003e62.6%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\" colname=\"c1\"\u003e\n \u003cp\u003eMalara et al. 2013 [\u003cspan citationid=\"CR68\" class=\"CitationRef\"\u003e68\u003c/span\u003e]\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c2\"\u003e\n \u003cp\u003eHealthy volunteers with low or high physical activity\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c3\"\u003e\n \u003cp\u003eWarsaw, Poland\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c4\"\u003e\n \u003cp\u003e80 (♀40)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c5\"\u003e\n \u003cp\u003e19.7\u0026thinsp;\u0026plusmn;\u0026thinsp;0.71\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c6\"\u003e\n \u003cp\u003e1.053\u0026thinsp;\u0026plusmn;\u0026thinsp;0.054\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c7\"\u003e\n \u003cp\u003e0%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c8\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\" colname=\"c1\"\u003e\n \u003cp\u003eMataix et al. 2003\u003c/p\u003e\n \u003cp\u003e[\u003cspan citationid=\"CR27\" class=\"CitationRef\"\u003e27\u003c/span\u003e]\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c2\"\u003e\n \u003cp\u003eRepresentative sample of healthy population\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c3\"\u003e\n \u003cp\u003eAndalusia, Spain\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c4\"\u003e\n \u003cp\u003e372 (♀191)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c5\"\u003e\n \u003cp\u003e25\u0026ndash;60\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c6\"\u003e\n \u003cp\u003e1.01\u0026thinsp;\u0026plusmn;\u0026thinsp;0.17\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c7\"\u003e\n \u003cp\u003e6.4%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c8\"\u003e\n \u003cp\u003e13.6% (ETKAC\u0026thinsp;\u0026gt;\u0026thinsp;1.16)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\" colname=\"c1\"\u003e\n \u003cp\u003eH\u0026ouml;tzel and Bitsch 1976 [\u003cspan citationid=\"CR69\" class=\"CitationRef\"\u003e69\u003c/span\u003e]\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c2\"\u003e\n \u003cp\u003eHealthy students\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c3\"\u003e\n \u003cp\u003eBonn, West Germany\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c4\"\u003e\n \u003cp\u003e130 (♀84)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c5\"\u003e\n \u003cp\u003eadult\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c6\"\u003e\n \u003cp\u003e1.126\u0026thinsp;\u0026plusmn;\u0026thinsp;0.121\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c7\"\u003e\n \u003cp\u003e10.00%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c8\"\u003e\n \u003cp\u003e20%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\" colname=\"c1\"\u003e\n \u003cp\u003eJones et al. 2023 [\u003cspan citationid=\"CR64\" class=\"CitationRef\"\u003e64\u003c/span\u003e]\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c2\"\u003e\n \u003cp\u003eSelected samples from nationally representative study NDNS RP\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c3\"\u003e\n \u003cp\u003eUnited Kingdom\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c4\"\u003e\n \u003cp\u003e134 (♀134)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c5\"\u003e\n \u003cp\u003e44.0\u0026thinsp;\u0026plusmn;\u0026thinsp;11.8\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c6\"\u003e\n \u003cp\u003e1.09\u0026thinsp;\u0026plusmn;\u0026thinsp;0.05\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c7\"\u003e\n \u003cp\u003e0%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c8\"\u003e\n \u003cp\u003e13%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\" colname=\"c1\"\u003e\n \u003cp\u003eFabian et al. 2008\u003c/p\u003e\n \u003cp\u003e[\u003cspan citationid=\"CR70\" class=\"CitationRef\"\u003e70\u003c/span\u003e]\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c2\"\u003e\n \u003cp\u003eHealthy, with no fermented food consumption in last 7 days\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c3\"\u003e\n \u003cp\u003eVienna, Austria\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c4\"\u003e\n \u003cp\u003e33 (♀33)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c5\"\u003e\n \u003cp\u003e24.4\u0026thinsp;\u0026plusmn;\u0026thinsp;2.8\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c6\"\u003e\n \u003cp\u003e1.085\u0026thinsp;\u0026plusmn;\u0026thinsp;0.024\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c7\"\u003e\n \u003cp\u003eN/A\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c8\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\" colspan=\"8\" nameend=\"c8\" namest=\"c1\"\u003e\n \u003cp\u003eStudies using healthy volunteers for controls or reference values establishment are marked with (#) and presented in grey.\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\" colname=\"c1\"\u003e\n \u003cp\u003eHerve et al. 1995 [\u003cspan citationid=\"CR71\" class=\"CitationRef\"\u003e71\u003c/span\u003e]\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c2\"\u003e\n \u003cp\u003eHealthy volunteers (#)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c3\"\u003e\n \u003cp\u003eClichy, France\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c4\"\u003e\n \u003cp\u003e52 (♀28)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c5\"\u003e\n \u003cp\u003e21\u0026ndash;65\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c6\"\u003e\n \u003cp\u003e1.12\u0026thinsp;\u0026plusmn;\u0026thinsp;0.1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c7\"\u003e\n \u003cp\u003eN/A\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c8\"\u003e\n \u003cp\u003eN/A\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\" colname=\"c1\"\u003e\n \u003cp\u003eElmadfa et al. 2001\u003c/p\u003e\n \u003cp\u003e[\u003cspan citationid=\"CR53\" class=\"CitationRef\"\u003e53\u003c/span\u003e]\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c2\"\u003e\n \u003cp\u003eHealthy volunteers (#)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c3\"\u003e\n \u003cp\u003eVienna, Austria\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c4\"\u003e\n \u003cp\u003e12 (♀6)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c5\"\u003e\n \u003cp\u003e25\u0026ndash;30\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c6\"\u003e\n \u003cp\u003e1.12\u0026thinsp;\u0026plusmn;\u0026thinsp;0.1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c7\"\u003e\n \u003cp\u003eN/A\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c8\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\" colname=\"c1\"\u003e\n \u003cp\u003eJermendy 2006\u003c/p\u003e\n \u003cp\u003e[\u003cspan citationid=\"CR72\" class=\"CitationRef\"\u003e72\u003c/span\u003e]\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c2\"\u003e\n \u003cp\u003eHealthy control (#)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c3\"\u003e\n \u003cp\u003eBudapest, Hungary.\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c4\"\u003e\n \u003cp\u003e60 (♀28)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c5\"\u003e\n \u003cp\u003e54.1\u0026thinsp;\u0026plusmn;\u0026thinsp;2.5\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c6\"\u003e\n \u003cp\u003e1.08\u0026thinsp;\u0026plusmn;\u0026thinsp;0.02\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c7\"\u003e\n \u003cp\u003eN/A\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c8\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\" colname=\"c1\"\u003e\n \u003cp\u003eBoni et al. 1980\u003c/p\u003e\n \u003cp\u003e[\u003cspan citationid=\"CR73\" class=\"CitationRef\"\u003e73\u003c/span\u003e]\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c2\"\u003e\n \u003cp\u003eHealthy medical and laboratory personnel (#)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c3\"\u003e\n \u003cp\u003eLeuven, Belgium\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c4\"\u003e\n \u003cp\u003e12 (♀NR)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c5\"\u003e\n \u003cp\u003eadult\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c6\"\u003e\n \u003cp\u003e1.135 (range 1.08\u0026ndash;1.185)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c7\"\u003e\n \u003cp\u003e0%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c8\"\u003e\n \u003cp\u003eN/A\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\" colspan=\"8\" nameend=\"c8\" namest=\"c1\"\u003e\n \u003cp\u003eSD, standard deviation; ETKAC, erythrocyte transketolase activity coefficients.\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n \u003c/table\u003e\n \u003c/div\u003e\n \u003cdiv class=\"gridtable\"\u003e\n \u003cdiv align=\"left\" class=\"colspec\" colname=\"c6\" colnum=\"6\"\u003e\u003cbr\u003e\u003c/div\u003e\n \u003cdiv align=\"left\" class=\"colspec\" colname=\"c7\" colnum=\"7\"\u003e\u003cbr\u003e\u003c/div\u003e\u0026nbsp;\u003ctable float=\"Yes\" id=\"Tab4\" border=\"1\"\u003e\n \u003ccaption language=\"En\"\u003e\n \u003cdiv class=\"CaptionNumber\"\u003eTable 4\u003c/div\u003e\n \u003cdiv class=\"CaptionContent\"\u003e\n \u003cp\u003eStudies reporting whole blood thiamin diphosphate - WB ThDP (nmol/L).\u003c/p\u003e\n \u003c/div\u003e\n \u003c/caption\u003e\n \u003cthead\u003e\n \u003ctr\u003e\n \u003cth align=\"left\" colname=\"c1\"\u003e\n \u003cp\u003eAuthor, year\u003c/p\u003e\n \u003c/th\u003e\n \u003cth align=\"left\" colname=\"c2\"\u003e\n \u003cp\u003ePopulation\u003c/p\u003e\n \u003c/th\u003e\n \u003cth align=\"left\" colname=\"c3\"\u003e\n \u003cp\u003eLocation\u003c/p\u003e\n \u003c/th\u003e\n \u003cth align=\"left\" colname=\"c4\"\u003e\n \u003cp\u003eNo. of subjects\u003c/p\u003e\n \u003c/th\u003e\n \u003cth align=\"left\" colname=\"c5\"\u003e\n \u003cp\u003eAge (mean\u0026thinsp;\u0026plusmn;\u0026thinsp;SD or range yrs)\u003c/p\u003e\n \u003c/th\u003e\n \u003cth align=\"left\" colname=\"c6\"\u003e\n \u003cp\u003eWB ThDP (nmol/L) (mean\u0026thinsp;\u0026plusmn;\u0026thinsp;SD)\u003c/p\u003e\n \u003c/th\u003e\n \u003cth align=\"left\" colname=\"c7\"\u003e\n \u003cp\u003eThiamin deficiency (%), WB ThDP\u0026thinsp;\u0026lt;\u0026thinsp;70 nmol/L\u003c/p\u003e\n \u003c/th\u003e\n \u003c/tr\u003e\n \u003c/thead\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\" colspan=\"7\" nameend=\"c7\" namest=\"c1\"\u003e\n \u003cp\u003eStudies using healthy volunteers for controls or reference values establishment are marked with (#) and presented in grey.\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\" colname=\"c1\"\u003e\n \u003cp\u003eMancinelli et al. 2003 [\u003cspan citationid=\"CR74\" class=\"CitationRef\"\u003e74\u003c/span\u003e]\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c2\"\u003e\n \u003cp\u003eRandom selection of healthy employees undergoing routine medical examinations (#)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c3\"\u003e\n \u003cp\u003eRome, Italy\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c4\"\u003e\n \u003cp\u003e103 (♀58)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c5\"\u003e\n \u003cp\u003e42.9\u0026thinsp;\u0026plusmn;\u0026thinsp;10.2\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c6\"\u003e\n \u003cp\u003e222.2\u0026thinsp;\u0026plusmn;\u0026thinsp;56.3\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c7\"\u003e\n \u003cp\u003eN/A\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\" colname=\"c1\"\u003e\n \u003cp\u003eVerstraete and Stove 2021 [\u003cspan citationid=\"CR75\" class=\"CitationRef\"\u003e75\u003c/span\u003e]\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c2\"\u003e\n \u003cp\u003eHealthy volunteers (#)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c3\"\u003e\n \u003cp\u003eGhent, Belgium\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c4\"\u003e\n \u003cp\u003e50 (♀NR)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c5\"\u003e\n \u003cp\u003eadult\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c6\"\u003e\n \u003cp\u003e145\u0026thinsp;\u0026plusmn;\u0026thinsp;22.1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c7\"\u003e\n \u003cp\u003e0%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\" colname=\"c1\"\u003e\n \u003cp\u003eK\u0026ouml;rner et al. 2009 [\u003cspan citationid=\"CR76\" class=\"CitationRef\"\u003e76\u003c/span\u003e]\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c2\"\u003e\n \u003cp\u003eHealthy volunteers (#)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c3\"\u003e\n \u003cp\u003eNorth Rhine-Westphalia, Germany\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c4\"\u003e\n \u003cp\u003e30 (♀16)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c5\"\u003e\n \u003cp\u003e40.5 (18\u0026ndash;65)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c6\"\u003e\n \u003cp\u003e194.7\u0026thinsp;\u0026plusmn;\u0026thinsp;27.5\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c7\"\u003e\n \u003cp\u003e0%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\" colname=\"c1\"\u003e\n \u003cp\u003eHerve et al. 1995 [\u003cspan citationid=\"CR71\" class=\"CitationRef\"\u003e71\u003c/span\u003e]\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c2\"\u003e\n \u003cp\u003eHealthy volunteers (#)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c3\"\u003e\n \u003cp\u003eClichy, France\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c4\"\u003e\n \u003cp\u003e52 (♀28)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c5\"\u003e\n \u003cp\u003e21\u0026ndash;65\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c6\"\u003e\n \u003cp\u003e176\u0026thinsp;\u0026plusmn;\u0026thinsp;28\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c7\"\u003e\n \u003cp\u003eN/A\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\" colname=\"c1\"\u003e\n \u003cp\u003eLynch et al. 1997 [\u003cspan citationid=\"CR77\" class=\"CitationRef\"\u003e77\u003c/span\u003e]\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c2\"\u003e\n \u003cp\u003eHealthy laboratory staff (#)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c3\"\u003e\n \u003cp\u003eBelfast, United Kingdom\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c4\"\u003e\n \u003cp\u003e45 (♀16)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c5\"\u003e\n \u003cp\u003e38 (20\u0026ndash;60) median (range)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c6\"\u003e\n \u003cp\u003e174.2\u0026thinsp;\u0026plusmn;\u0026thinsp;34.05\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c7\"\u003e\n \u003cp\u003eN/A\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\" colname=\"c1\"\u003e\n \u003cp\u003eTallaksen et al. 1991 [\u003cspan citationid=\"CR78\" class=\"CitationRef\"\u003e78\u003c/span\u003e]\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c2\"\u003e\n \u003cp\u003eHealthy volunteers (#)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c3\"\u003e\n \u003cp\u003eOslo, Norway\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c4\"\u003e\n \u003cp\u003e30 (♀15)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c5\"\u003e\n \u003cp\u003e43 (32\u0026ndash;54) median (range)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c6\"\u003e\n \u003cp\u003e143\u0026thinsp;\u0026plusmn;\u0026thinsp;35\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c7\"\u003e\n \u003cp\u003eN/A\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\" colspan=\"7\" nameend=\"c7\" namest=\"c1\"\u003e\n \u003cp\u003eSD, standard deviation; WB ThDP, whole blood thiamin diphosphate.\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n \u003c/table\u003e\n \u003c/div\u003e\n \u003cdiv class=\"gridtable\"\u003e\n \u003cdiv align=\"left\" class=\"colspec\" colname=\"c7\" colnum=\"7\"\u003e\u003cbr\u003e\u003c/div\u003e\u0026nbsp;\u003ctable float=\"Yes\" id=\"Tab5\" border=\"1\"\u003e\n \u003ccaption language=\"En\"\u003e\n \u003cdiv class=\"CaptionNumber\"\u003eTable 5\u003c/div\u003e\n \u003cdiv class=\"CaptionContent\"\u003e\n \u003cp\u003eStudies reporting total whole blood thiamin (nmol/L).\u003c/p\u003e\n \u003c/div\u003e\n \u003c/caption\u003e\n \u003cthead\u003e\n \u003ctr\u003e\n \u003cth align=\"left\" colname=\"c1\"\u003e\n \u003cp\u003eAuthor, year\u003c/p\u003e\n \u003c/th\u003e\n \u003cth align=\"left\" colname=\"c2\"\u003e\n \u003cp\u003ePopulation\u003c/p\u003e\n \u003c/th\u003e\n \u003cth align=\"left\" colname=\"c3\"\u003e\n \u003cp\u003eLocation\u003c/p\u003e\n \u003c/th\u003e\n \u003cth align=\"left\" colname=\"c4\"\u003e\n \u003cp\u003eNo. of subjects\u003c/p\u003e\n \u003c/th\u003e\n \u003cth align=\"left\" colname=\"c5\"\u003e\n \u003cp\u003eAge (mean\u0026thinsp;\u0026plusmn;\u0026thinsp;SD or range yrs)\u003c/p\u003e\n \u003c/th\u003e\n \u003cth align=\"left\" colname=\"c6\"\u003e\n \u003cp\u003eTotal WB thiamin (nmol/L) (mean\u0026thinsp;\u0026plusmn;\u0026thinsp;SD)\u003c/p\u003e\n \u003c/th\u003e\n \u003cth align=\"left\" colname=\"c7\"\u003e\n \u003cp\u003eThiamin deficiency (%)\u003c/p\u003e\n \u003cp\u003eTotal WB thiamin\u0026thinsp;\u0026lt;\u0026thinsp;75 nmol/L\u003c/p\u003e\n \u003c/th\u003e\n \u003c/tr\u003e\n \u003c/thead\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\" colspan=\"7\" nameend=\"c7\" namest=\"c1\"\u003e\n \u003cp\u003eStudies using healthy volunteers for controls or reference values establishment are marked with (#) and presented in grey.\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\" colname=\"c1\"\u003e\n \u003cp\u003eSchrijver et al. 1982 [\u003cspan citationid=\"CR79\" class=\"CitationRef\"\u003e79\u003c/span\u003e]\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c2\"\u003e\n \u003cp\u003eHealthy volunteers (#)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c3\"\u003e\n \u003cp\u003eUtrecht, Netherlands\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c4\"\u003e\n \u003cp\u003e98 (♀nd)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c5\"\u003e\n \u003cp\u003eadult\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c6\"\u003e\n \u003cp\u003e115 (range 70\u0026ndash;185)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c7\"\u003e\n \u003cp\u003e1\u0026ndash;2%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\" colname=\"c1\"\u003e\n \u003cp\u003eHerve et al. 1995 [\u003cspan citationid=\"CR71\" class=\"CitationRef\"\u003e71\u003c/span\u003e]\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c2\"\u003e\n \u003cp\u003eHealthy volunteers (#)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c3\"\u003e\n \u003cp\u003eClichy, France\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c4\"\u003e\n \u003cp\u003e52 (♀28)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c5\"\u003e\n \u003cp\u003e21\u0026ndash;65\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c6\"\u003e\n \u003cp\u003e186\u0026thinsp;\u0026plusmn;\u0026thinsp;30\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colname=\"c7\"\u003e\n \u003cp\u003eN/A\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n \u003ctfoot\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"7\"\u003eSD, standard deviation; WB, whole blood.\u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tfoot\u003e\n \u003c/table\u003e\n \u003c/div\u003e\n \u003cdiv class=\"gridtable\"\u003e\n \u003cdiv align=\"left\" class=\"colspec\" colname=\"c9\" colnum=\"9\"\u003e\u003cbr\u003e\u003c/div\u003e\n \u003cdiv align=\"left\" class=\"colspec\" colname=\"c10\" colnum=\"10\"\u003e\u003cbr\u003e\u003c/div\u003e\u0026nbsp;Table 6: Studies reporting erythrocyte thiamin diphosphate - RBC ThDP (ng/g Hb).\u0026nbsp;\n \u003c/div\u003e\n \u003cp\u003e\u003cimg 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\"\u003e\u003c/p\u003e\n\u003c/div\u003e"},{"header":"4. DISCUSSION","content":"\u003cp\u003eTo the best of our knowledge, and according to the available literature, this systematic review represents the first comprehensive summary of thiamin status in healthy European adults. On a global level the prevalence of thiamin deficiency was reviewed by Johnson et al. [\u003cspan citationid=\"CR80\" class=\"CitationRef\"\u003e80\u003c/span\u003e] and Whitfield et al. [\u003cspan citationid=\"CR23\" class=\"CitationRef\"\u003e23\u003c/span\u003e] and systematic review of thiamin deficiency cases in paediatric population in high-income countries was done by Rakotoambinina et al. [\u003cspan citationid=\"CR81\" class=\"CitationRef\"\u003e81\u003c/span\u003e].\u003c/p\u003e\n\u003cp\u003eThe prevalence of thiamin deficiency and insufficiency in Europe remains largely unknown. The available data, limited to 19 studies from only eleven countries, highlights the need for additional research. One study using a representative sample from the Andalusian region in Spain reported a deficiency prevalence of 6.4% (ETKAC\u0026thinsp;\u0026gt;\u0026thinsp;1.25) and insufficiency 13.6% (ETKAC\u0026thinsp;\u0026gt;\u0026thinsp;1.16 (authors used slightly different cutoff)) [\u003cspan citationid=\"CR27\" class=\"CitationRef\"\u003e27\u003c/span\u003e]. Another study done in the United Kingdom used selected samples from nationally representative study found prevalence of thiamin insufficiency (ETKAC\u0026thinsp;\u0026gt;\u0026thinsp;1.15) in 13%. This suggests that the extent of the issue may be significantly higher than previously assumed [\u003cspan citationid=\"CR64\" class=\"CitationRef\"\u003e64\u003c/span\u003e].\u003c/p\u003e\n\u003cp\u003eInadequate thiamin intake was recently estimated in a modelling analysis, which compared age and sex specific nutrient requirements with available dietary intake data. Based on these estimates 29.7% of the global population (2.2\u0026nbsp;billion people) have inadequate thiamin intake. For European countries the prevalence of estimated inadequate intake ranged from 8.4% (Belgium) to 56.2% (Italy). The model did not account for intake from food fortification or food supplements [\u003cspan citationid=\"CR82\" class=\"CitationRef\"\u003e82\u003c/span\u003e]. As dietary intake data are typically self-reported, they are subject to bias and must be interpreted with caution [\u003cspan citationid=\"CR83\" class=\"CitationRef\"\u003e83\u003c/span\u003e]. Additionally methodological differences and errors in data collection can produce significant errors. For example, in Cambodia, a country with one of the highest prevalences of thiamin deficiency [\u003cspan citationid=\"CR80\" class=\"CitationRef\"\u003e80\u003c/span\u003e] their estimated prevalence of inadequate thiamin intake was only 24% [\u003cspan citationid=\"CR82\" class=\"CitationRef\"\u003e82\u003c/span\u003e].\u003c/p\u003e\n\u003cdiv id=\"Sec10\" class=\"Section2\"\u003e\n \u003ch2\u003e4.1 SPECIAL SUBPOPULATIONS\u003c/h2\u003e\n \u003cp\u003eThe risk of thiamin deficiency is higher in populations with increased relative thiamin requirements, such as pregnant and post-partum women (European Food Safety Authority, 2016; Oudman et al., 2019). A Spanish study in women in the third trimester of pregnancy reported thiamin deficiency in 13.7% of participants (ETKAC\u0026thinsp;\u0026gt;\u0026thinsp;1.25) (Ortega et al., 2004), while another Spanish study in post-partum women found a prevalence of 41.2% (ETKAC\u0026thinsp;\u0026gt;\u0026thinsp;1.25). Only 14.8% of infants born to thiamin deficient mothers had adequate thiamin status (ETKAC\u0026thinsp;\u0026lt;\u0026thinsp;1.15) [\u003cspan citationid=\"CR67\" class=\"CitationRef\"\u003e67\u003c/span\u003e]. Moreover, breast milk of thiamin-deficient mothers contains reduced thiamin levels, leading to deficiency in the offspring [\u003cspan citationid=\"CR66\" class=\"CitationRef\"\u003e66\u003c/span\u003e, \u003cspan citationid=\"CR84\" class=\"CitationRef\"\u003e84\u003c/span\u003e]. Conditions such as hyperemesis gravidarum reduce dietary intake. Additionally i/v glucose administration during labor increases thiamin needs [\u003cspan citationid=\"CR54\" class=\"CitationRef\"\u003e54\u003c/span\u003e]. Cases of Wernicke encephalopathy with long-term consequences following hyperemesis gravidarum have also been reported [\u003cspan citationid=\"CR52\" class=\"CitationRef\"\u003e52\u003c/span\u003e]. Thiamin deficiency has been documented in families exhibiting a high incidence of Sudden Infant Death Syndrome (SIDS) [\u003cspan citationid=\"CR25\" class=\"CitationRef\"\u003e25\u003c/span\u003e, \u003cspan citationid=\"CR85\" class=\"CitationRef\"\u003e85\u003c/span\u003e].\u003c/p\u003e\n \u003cp\u003eA systematic review by Rakotoambinina et al. [\u003cspan citationid=\"CR81\" class=\"CitationRef\"\u003e81\u003c/span\u003e] summarized pediatric thiamin deficiency in high-income countries and identified predisposing factors including genetic causes, diabetes, obesity, excessive consumption of sugar-sweetened beverages, eating disorders, gastrointestinal disorders/surgeries, critical illness, cancer, and artificial nutrition. In the European union, this risk is mitigated by mandatory fortification of processed cereal-based baby foods with thiamin at 25 \u0026micro;g/100 kJ (100 \u0026micro;g/100 kcal) [\u003cspan citationid=\"CR86\" class=\"CitationRef\"\u003e86\u003c/span\u003e] and the composition of infant formulas in EU, including thiamin content is tightly regulated [\u003cspan citationid=\"CR87\" class=\"CitationRef\"\u003e87\u003c/span\u003e].\u003c/p\u003e\n \u003cp\u003eGeneral fortification of cereals in most European countries is not mandatory [\u003cspan citationid=\"CR23\" class=\"CitationRef\"\u003e23\u003c/span\u003e]. This raises concerns regarding population-level adequacy, particularly given the high proportion of thiamin-devoid ultra-processed foods in the diet. Across Europe, ultra-processed foods account for 14\u0026ndash;44% of total energy intake, with the highest share reported in the United Kingdom [\u003cspan citationid=\"CR49\" class=\"CitationRef\"\u003e49\u003c/span\u003e]. Despite this high prevalence of thiamin deficiency (ETKAC\u0026thinsp;\u0026gt;\u0026thinsp;1.25) was found in Norwich (UK) adolescents. 13.5% had thiamin deficiency and 26.8% had thiamin insufficiency (ETKAC\u0026thinsp;\u0026gt;\u0026thinsp;1.15) [\u003cspan citationid=\"CR88\" class=\"CitationRef\"\u003e88\u003c/span\u003e]. Korean study found association of higher ultra-processed food intake with lower thiamin intake [\u003cspan citationid=\"CR47\" class=\"CitationRef\"\u003e47\u003c/span\u003e]. However, a Brazilian study has shown that the consumption of ultra-processed foods is associated with a lower risk of inadequate thiamin intake due to fortification of ultra processed food [\u003cspan citationid=\"CR89\" class=\"CitationRef\"\u003e89\u003c/span\u003e].\u003c/p\u003e\n \u003cp\u003eAlcohol dependence significantly contributes to thiamin deficiency; 30\u0026ndash;80% alcohol dependent individuals are thiamin deficient [\u003cspan citationid=\"CR42\" class=\"CitationRef\"\u003e42\u003c/span\u003e]. The prevalence of alcohol dependence among adults aged 18\u0026ndash;64 years in the EU was estimated at 3.4%, with significant variation between sexes and countries. The lowest prevalence was observed in Spain (0.7%) and the highest prevalence was observed in Latvian men (21.2%) [\u003cspan citationid=\"CR90\" class=\"CitationRef\"\u003e90\u003c/span\u003e].\u003c/p\u003e\n \u003cp\u003eRestrictive diets also increase risk for deficiency. Thiamin deficiency (\u0026alpha;-ETK\u0026thinsp;\u0026gt;\u0026thinsp;1.25) was found in 8% of volunteers following unsupplemented LCHF (Low-carbohydrate high-fat) and in 2% of healthy unsupplemented Glasgow (UK) adults following general diet and [\u003cspan citationid=\"CR26\" class=\"CitationRef\"\u003e26\u003c/span\u003e].\u003c/p\u003e\n \u003cp\u003eHigh prevalence of thiamin deficiency was reported in people living with obesity; in those preparing for bariatric surgery the pooled prevalence was 7% (95% CI: 4\u0026ndash;12%). Many studies included patients already on weight loss diet [\u003cspan citationid=\"CR51\" class=\"CitationRef\"\u003e51\u003c/span\u003e]. Two studies not included in the systematic review were conducted in the northern regions of the Russian Federation, where thiamin deficiency (ETKAC\u0026thinsp;\u0026gt;\u0026thinsp;1.25) was highly prevalent [\u003cspan citationid=\"CR91\" class=\"CitationRef\"\u003e91\u003c/span\u003e, \u003cspan citationid=\"CR92\" class=\"CitationRef\"\u003e92\u003c/span\u003e]. Reported prevalence of deficiency for Cargopol, Arkangelsk provice was was 57.7% in males and 68.8% in females (ETKAC\u0026thinsp;\u0026gt;\u0026thinsp;1.25) [\u003cspan citationid=\"CR92\" class=\"CitationRef\"\u003e92\u003c/span\u003e].\u003c/p\u003e\n\u003c/div\u003e\n\u003cdiv id=\"Sec11\" class=\"Section2\"\u003e\n \u003ch2\u003e4.2 LIMITATIONS AND STRENGTHS\u003c/h2\u003e\n \u003cp\u003eThe main limitation of this review is inclusion of studies that were not using representative samples of population. Study populations included in this review are very heterogeneous and include pregnant women [\u003cspan citationid=\"CR66\" class=\"CitationRef\"\u003e66\u003c/span\u003e], post-partum women [\u003cspan citationid=\"CR67\" class=\"CitationRef\"\u003e67\u003c/span\u003e], convenience samples comprising of staff, that are usually healthier better nourished, and socioeconomically advantaged [\u003cspan citationid=\"CR63\" class=\"CitationRef\"\u003e63\u003c/span\u003e, \u003cspan citationid=\"CR73\" class=\"CitationRef\"\u003e73\u003c/span\u003e, \u003cspan citationid=\"CR77\" class=\"CitationRef\"\u003e77\u003c/span\u003e], university students [\u003cspan citationid=\"CR69\" class=\"CitationRef\"\u003e69\u003c/span\u003e], and employees undergoing routine medical examinations [\u003cspan citationid=\"CR74\" class=\"CitationRef\"\u003e74\u003c/span\u003e]. The remaining studies utilized cohorts of healthy volunteers serving as control groups or for reference value establishment [\u003cspan citationid=\"CR53\" class=\"CitationRef\"\u003e53\u003c/span\u003e, \u003cspan additionalcitationids=\"CR71\" citationid=\"CR70\" class=\"CitationRef\"\u003e70\u003c/span\u003e\u0026ndash;\u003cspan citationid=\"CR72\" class=\"CitationRef\"\u003e72\u003c/span\u003e, \u003cspan citationid=\"CR68\" class=\"CitationRef\"\u003e68\u003c/span\u003e, \u003cspan citationid=\"CR79\" class=\"CitationRef\"\u003e79\u003c/span\u003e, \u003cspan citationid=\"CR75\" class=\"CitationRef\"\u003e75\u003c/span\u003e, \u003cspan citationid=\"CR76\" class=\"CitationRef\"\u003e76\u003c/span\u003e, \u003cspan citationid=\"CR78\" class=\"CitationRef\"\u003e78\u003c/span\u003e]. However, the main strength of this review is the strict definition of appropriate thiamin status biomarkers. Many studies continue to be published, cited, and included in systematic reviews using inappropriate biomarkers, such as plasma thiamin or plasma thiamin monophosphate (ThMP). Studies that did not specify or cite the method used were excluded from this review. The cutoffs for thiamin deficiency, insufficiency, and adequacy are not universally standardized. Johnson et al. [\u003cspan citationid=\"CR80\" class=\"CitationRef\"\u003e80\u003c/span\u003e] reviewed proposed cutoffs. For this review, we applied the cutoffs defined in Table\u0026nbsp;\u003cspan refid=\"Tab1\" class=\"InternalRef\"\u003e1\u003c/span\u003e, which are also reported in brackets whenever deficiency or insufficiency is reported.\u003c/p\u003e\n \u003cp\u003eThe synthesis of results was further complicated by the use of different biomarkers and a lack of standardized diagnostic cut-offs, which impedes direct comparability across studies [\u003cspan citationid=\"CR64\" class=\"CitationRef\"\u003e64\u003c/span\u003e, \u003cspan citationid=\"CR80\" class=\"CitationRef\"\u003e80\u003c/span\u003e, \u003cspan citationid=\"CR93\" class=\"CitationRef\"\u003e93\u003c/span\u003e].\u003c/p\u003e\n\u003c/div\u003e\n\u003cdiv id=\"Sec12\" class=\"Section2\"\u003e\n \u003ch2\u003e4.3 PRACTICAL CONSIDERATIONS\u003c/h2\u003e\n \u003cp\u003eIn contrast to vitamin D, for which adequate intake from unfortified foods is practically unachievable and population sufficiency can only be ensured through fortification [\u003cspan citationid=\"CR94\" class=\"CitationRef\"\u003e94\u003c/span\u003e], sufficient thiamin intake in high-income adult populations can easily be achieved through a varied diet. Thiamin deficiency could be considered a sign of alcohol abuse [\u003cspan citationid=\"CR42\" class=\"CitationRef\"\u003e42\u003c/span\u003e], restrictive diets [\u003cspan citationid=\"CR26\" class=\"CitationRef\"\u003e26\u003c/span\u003e, \u003cspan citationid=\"CR95\" class=\"CitationRef\"\u003e95\u003c/span\u003e] or generally very poor diet. In thiamin deficient populations, deficiency of other micronutrients should be expected [\u003cspan citationid=\"CR67\" class=\"CitationRef\"\u003e67\u003c/span\u003e, \u003cspan citationid=\"CR95\" class=\"CitationRef\"\u003e95\u003c/span\u003e]. Therefore public health interventions should promote balanced diet that includes cereals, especially fortified breakfast cereals, seeds, legumes and meat, particularly lean pork [\u003cspan citationid=\"CR48\" class=\"CitationRef\"\u003e48\u003c/span\u003e]. Considering the increased needs during pregnancy and lactation, severe consequences of thiamin deficiency [\u003cspan citationid=\"CR25\" class=\"CitationRef\"\u003e25\u003c/span\u003e, \u003cspan citationid=\"CR85\" class=\"CitationRef\"\u003e85\u003c/span\u003e] and safety of thiamin, routine supplementation by prenatal micronutrient food supplements containing thiamin is reasonable. Even at dosages of several hundred milligrams, there are no reports of adverse effects of oral thiamin supplementation [\u003cspan citationid=\"CR96\" class=\"CitationRef\"\u003e96\u003c/span\u003e]. This also ensures sufficient thiamin content in breast milk [\u003cspan citationid=\"CR66\" class=\"CitationRef\"\u003e66\u003c/span\u003e, \u003cspan citationid=\"CR84\" class=\"CitationRef\"\u003e84\u003c/span\u003e]. Infants and children should be provided with varied diet, and fortified cereals should be used. Thiamin supplementation in clinical settings is covered in ESPEN micronutrient guidelines [\u003cspan citationid=\"CR30\" class=\"CitationRef\"\u003e30\u003c/span\u003e] and thiamin use in persons with alcohol use disorder (AUD) was described by Shakory [\u003cspan citationid=\"CR97\" class=\"CitationRef\"\u003e97\u003c/span\u003e].\u003c/p\u003e\n\u003c/div\u003e\n\u003cdiv id=\"Sec13\" class=\"Section2\"\u003e\n \u003ch2\u003e4.3 FUTURE RESEARCH\u003c/h2\u003e\n \u003cp\u003eRepresentative, population-based studies using harmonized biomarkers are urgently needed to establish the prevalence and risk factors for thiamin deficiency in Europe. Further targeted investigations are warranted among subpopulations with potentially increased requirements or reduced intake, including pregnant and lactating women and other groups with increased physiological requirements, individuals adhering to restrictive or low-carbohydrate diets, people living with obesity, persons with alcohol use disorder (AUD) and persons of lower socioeconomic status.\u003c/p\u003e\n\u003c/div\u003e"},{"header":"5. CONCLUSIONS","content":"\u003cp\u003eUntil general population-level data become available, it is scientifically unjustified to conclude that thiamin deficiency is not a public health concern in Europe.\u003c/p\u003e"},{"header":"Abbreviations","content":"\u003cp\u003eα-KGDH: α-ketoglutarate dehydrogenase complex\u003c/p\u003e\n\u003cp\u003eAUD: Alcohol use disorder\u003c/p\u003e\n\u003cp\u003eBCKDH: Branched-chain α-keto acid dehydrogenase complex\u003c/p\u003e\n\u003cp\u003eBMI: Body mass index\u003c/p\u003e\n\u003cp\u003eEFSA: European Food Safety Authority\u003c/p\u003e\n\u003cp\u003eESPEN: European Society for Clinical Nutrition and Metabolism\u003c/p\u003e\n\u003cp\u003eETK: Erythrocyte transketolase\u003c/p\u003e\n\u003cp\u003eETKAC: Erythrocyte transketolase activity coefficient\u003c/p\u003e\n\u003cp\u003eEU: European Union\u003c/p\u003e\n\u003cp\u003eHb: Hemoglobin\u003c/p\u003e\n\u003cp\u003eHPLC: High-performance liquid chromatography\u003c/p\u003e\n\u003cp\u003eIB-CoA: Isobutyryl-CoA\u003c/p\u003e\n\u003cp\u003eIle: Isoleucine\u003c/p\u003e\n\u003cp\u003eIQR: Interquartile range\u003c/p\u003e\n\u003cp\u003ei/v: Intravenous\u003c/p\u003e\n\u003cp\u003eIV-CoA: Isovaleryl-CoA\u003c/p\u003e\n\u003cp\u003eKIC: α-ketoisocaproate\u003c/p\u003e\n\u003cp\u003eKIV: α-ketoisovalerate\u003c/p\u003e\n\u003cp\u003eKMV: α-keto β-methylvalerate\u003c/p\u003e\n\u003cp\u003eLCHF: Low-carbohydrate high-fat\u003c/p\u003e\n\u003cp\u003eLeu: Leucine\u003c/p\u003e\n\u003cp\u003eMB-CoA: Methylbutyryl-CoA\u003c/p\u003e\n\u003cp\u003eNADPH: Nicotinamide adenine dinucleotide phosphate\u003c/p\u003e\n\u003cp\u003ePDH: Pyruvate dehydrogenase complex\u003c/p\u003e\n\u003cp\u003ePRISMA: Preferred Reporting Items for Systematic Reviews and Meta-Analyses\u003c/p\u003e\n\u003cp\u003ePROSPERO: International Prospective Register of Systematic Reviews\u003c/p\u003e\n\u003cp\u003eRBC: Erythrocyte (Red blood cell)\u003c/p\u003e\n\u003cp\u003eRFC1: Reduced folate carrier 1\u003c/p\u003e\n\u003cp\u003eSD: Standard deviation\u003c/p\u003e\n\u003cp\u003eSIDS: Sudden infant death syndrome\u003c/p\u003e\n\u003cp\u003eSLC19A1: Solute carrier family 19 member 1\u003c/p\u003e\n\u003cp\u003eSLC19A2: Solute carrier family 19 member 2\u003c/p\u003e\n\u003cp\u003eSLC19A3: Solute carrier family 19 member 3\u003c/p\u003e\n\u003cp\u003eSLC25A19: Solute carrier family 25 member 19\u003c/p\u003e\n\u003cp\u003eTCA: Tricarboxylic acid cycle\u003c/p\u003e\n\u003cp\u003eThDP: Thiamin diphosphate\u003c/p\u003e\n\u003cp\u003eThMP: Thiamin monophosphate\u003c/p\u003e\n\u003cp\u003eTHTR1: Thiamin transporter 1\u003c/p\u003e\n\u003cp\u003eTHTR2: Thiamin transporter 2\u003c/p\u003e\n\u003cp\u003eTKT: Transketolase\u003c/p\u003e\n\u003cp\u003eTPP: Thiamin pyrophosphate\u003c/p\u003e\n\u003cp\u003eVal: Valine\u003c/p\u003e\n\u003cp\u003eWB: Whole blood\u003c/p\u003e\n\u003cp\u003eWHO: World Health Organization\u003c/p\u003e"},{"header":"Declarations","content":"\u003cp\u003e\u003cstrong\u003eAuthor Contributions: \u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eConceptualisation: V.V.; writing: V.V., S.P.; data synthesis: V.V., A.K., supervision: A.K. All authors have read and agreed to the published version of the manuscript.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eFunding: \u003c/strong\u003eThis work was supported by the Slovenian Research and Innovation Agency (ARIS), projects: 1. MULTIPART (J7-60123); 2. SLORApro (P3-0429); 3. Molekularni mehanizmi razvoja in delovanja skeletne mi\u0026scaron;ice (P3-0043) and 4. NeuroMyo (J7-60125).\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eData availability:\u003c/strong\u003e Search strategy and bias assessment is available in supplemental data and on PROSPERO: https://www.crd.york.ac.uk/PROSPEROFILES/dd0680a43ba5a2be5fad83d708c13cd8.pdf.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConflict of interest: \u003c/strong\u003eThere are no conflicts of interest to declare.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eEthics approval: \u003c/strong\u003eNot applicable.\u003c/p\u003e\n"},{"header":"References","content":"\u003col\u003e\n \u003cli\u003eManzetti S, Zhang J, van der Spoel D (2014) Thiamin function, metabolism, uptake, and transport. Biochemistry 53:821\u0026ndash;835. https://doi.org/10.1021/bi401618y\u003c/li\u003e\n \u003cli\u003eBrown G (2014) Defects of thiamine transport and metabolism. J Inherit Metab Dis 37:577\u0026ndash;585. https://doi.org/10.1007/s10545-014-9712-9\u003c/li\u003e\n \u003cli\u003eSaid HM, Nexo E (2018) Gastrointestinal Handling of Water-Soluble Vitamins. Compr Physiol 8:1291\u0026ndash;1311. https://doi.org/10.1002/cphy.c170054\u003c/li\u003e\n \u003cli\u003eRajgopal A, Edmondnson A, Goldman ID, Zhao R (2001) SLC19A3 encodes a second thiamine transporter ThTr2. Biochim Biophys Acta 1537:175\u0026ndash;178. https://doi.org/10.1016/s0925-4439(01)00073-4\u003c/li\u003e\n \u003cli\u003eReidling JC, Lambrecht N, Kassir M, Said HM (2010) Impaired intestinal vitamin B1 (thiamin) uptake in thiamin transporter-2-deficient mice. Gastroenterology 138:1802\u0026ndash;1809. https://doi.org/10.1053/j.gastro.2009.10.042\u003c/li\u003e\n \u003cli\u003eBoulware MJ, Subramanian VS, Said HM, Marchant JS (2003) Polarized expression of members of the solute carrier SLC19A gene family of water-soluble multivitamin transporters: implications for physiological function. Biochem J 376:43\u0026ndash;48. https://doi.org/10.1042/BJ20031220\u003c/li\u003e\n \u003cli\u003eKono S, Miyajima H, Yoshida K, et al (2009) Mutations in a thiamine-transporter gene and Wernicke\u0026rsquo;s-like encephalopathy. N Engl J Med 360:1792\u0026ndash;1794. https://doi.org/10.1056/NEJMc0809100\u003c/li\u003e\n \u003cli\u003eOverton E, Emelyanova A, Bunik VI (2025) Thiamine, gastrointestinal beriberi and acetylcholine signaling. Front Nutr 12:1541054. https://doi.org/10.3389/fnut.2025.1541054\u003c/li\u003e\n \u003cli\u003eZhao R, Gao F, Goldman ID (2002) Reduced folate carrier transports thiamine monophosphate: an alternative route for thiamine delivery into mammalian cells. Am J Physiol Cell Physiol 282:C1512-1517. https://doi.org/10.1152/ajpcell.00547.2001\u003c/li\u003e\n \u003cli\u003eZhao R, Gao F, Goldman ID (2001) Molecular cloning of human thiamin pyrophosphokinase. Biochim Biophys Acta 1517:320\u0026ndash;322. https://doi.org/10.1016/s0167-4781(00)00264-5\u003c/li\u003e\n \u003cli\u003eMayr JA, Freisinger P, Schlachter K, et al (2011) Thiamine pyrophosphokinase deficiency in encephalopathic children with defects in the pyruvate oxidation pathway. Am J Hum Genet 89:806\u0026ndash;812. https://doi.org/10.1016/j.ajhg.2011.11.007\u003c/li\u003e\n \u003cli\u003eNosaka K, Onozuka M, Nishino H, et al (1999) Molecular cloning and expression of a mouse thiamin pyrophosphokinase cDNA. J Biol Chem 274:34129\u0026ndash;34133. https://doi.org/10.1074/jbc.274.48.34129\u003c/li\u003e\n \u003cli\u003eBoyle L, Wamelink MMC, Salomons GS, et al (2016) Mutations in TKT Are the Cause of a Syndrome Including Short Stature, Developmental Delay, and Congenital Heart Defects. Am J Hum Genet 98:1235\u0026ndash;1242. https://doi.org/10.1016/j.ajhg.2016.03.030\u003c/li\u003e\n \u003cli\u003eKochetov GA, Solovjeva ON (2014) Structure and functioning mechanism of transketolase. Biochim Biophys Acta 1844:1608\u0026ndash;1618. https://doi.org/10.1016/j.bbapap.2014.06.003\u003c/li\u003e\n \u003cli\u003eMcCool BA, Plonk SG, Martin PR, Singleton CK (1993) Cloning of human transketolase cDNAs and comparison of the nucleotide sequence of the coding region in Wernicke-Korsakoff and non-Wernicke-Korsakoff individuals. J Biol Chem 268:1397\u0026ndash;1404\u003c/li\u003e\n \u003cli\u003eLindhurst MJ, Fiermonte G, Song S, et al (2006) Knockout of Slc25a19 causes mitochondrial thiamine pyrophosphate depletion, embryonic lethality, CNS malformations, and anemia. Proc Natl Acad Sci U S A 103:15927\u0026ndash;15932. https://doi.org/10.1073/pnas.0607661103\u003c/li\u003e\n \u003cli\u003eNaito E, Ito M, Takeda E, et al (1994) Molecular analysis of abnormal pyruvate dehydrogenase in a patient with thiamine-responsive congenital lactic acidemia. Pediatr Res 36:340\u0026ndash;346. https://doi.org/10.1203/00006450-199409000-00013\u003c/li\u003e\n \u003cli\u003eYap ZY, Strucinska K, Matsuzaki S, et al (2021) A biallelic pathogenic variant in the OGDH gene results in a neurological disorder with features of a mitochondrial disease. J Inherit Metab Dis 44:388\u0026ndash;400. https://doi.org/10.1002/jimd.12248\u003c/li\u003e\n \u003cli\u003eYang N, Han L, Gu X, et al (2012) Analysis of gene mutations in Chinese patients with maple syrup urine disease. Mol Genet Metab 106:412\u0026ndash;418. https://doi.org/10.1016/j.ymgme.2012.05.023\u003c/li\u003e\n \u003cli\u003eChuang JL, Wynn RM, Moss CC, et al (2004) Structural and biochemical basis for novel mutations in homozygous Israeli maple syrup urine disease patients: a proposed mechanism for the thiamin-responsive phenotype. J Biol Chem 279:17792\u0026ndash;17800. https://doi.org/10.1074/jbc.M313879200\u003c/li\u003e\n \u003cli\u003eNghi\u0026ecirc;m HO, Bettendorff L, Changeux JP (2000) Specific phosphorylation of Torpedo 43K rapsyn by endogenous kinase(s) with thiamine triphosphate as the phosphate donor. FASEB J Off Publ Fed Am Soc Exp Biol 14:543\u0026ndash;554. https://doi.org/10.1096/fasebj.14.3.543\u003c/li\u003e\n \u003cli\u003eSasa M, Takemoto I, Nishino K, Itokawa Y (1976) The role of thiamine on excitable membrane of crayfish giant axon. J Nutr Sci Vitaminol (Tokyo) 22 SUPPL:21\u0026ndash;24. https://doi.org/10.3177/jnsv.22.supplement_21\u003c/li\u003e\n \u003cli\u003eWhitfield KC, Bourassa MW, Adamolekun B, et al (2018) Thiamine deficiency disorders: diagnosis, prevalence, and a roadmap for global control programs. Ann N Y Acad Sci 1430:3\u0026ndash;43. https://doi.org/10.1111/nyas.13919\u003c/li\u003e\n \u003cli\u003eEuropean Food Safety Authority (2025) Food composition data. https://www.efsa.europa.eu/en/data-report/food-composition-data. Accessed 15 Sept 2025\u003c/li\u003e\n \u003cli\u003eWorld Health Organization. Thiamine deficiency and its prevention and control in major emergencies. WHO Reference Number: WHO/NHD/99.13. Geneva: World Health Organization; 1999. Available from: https://www.who.int/publications/i/item/WHO-NHD-99.13\u003c/li\u003e\n \u003cli\u003eChuruangsuk C, Catchpole A, Talwar D, et al (2024) Low thiamine status in adults following low-carbohydrate / ketogenic diets: a cross-sectional comparative study of micronutrient intake and status. Eur J Nutr 63:2667\u0026ndash;2679. https://doi.org/10.1007/s00394-024-03459-y\u003c/li\u003e\n \u003cli\u003eMataix J, Aranda P, S\u0026aacute;nchez C, et al (2003) Assessment of thiamin (vitamin B1) and riboflavin (vitamin B2) status in an adult Mediterranean population. Br J Nutr 90:661\u0026ndash;666. https://doi.org/10.1079/BJN2003926\u003c/li\u003e\n \u003cli\u003eBrown KH, Hess SY, Moore SE, et al (2025) Neglected micronutrients\u0026mdash;considering a broader set of vitamins and minerals in public health nutrition programs worldwide: a narrative review. Am J Clin Nutr 122:680\u0026ndash;694. https://doi.org/10.1016/j.ajcnut.2025.06.030\u003c/li\u003e\n \u003cli\u003eAnderson M, Mickelsen O, Keys A (1946) Diets and food items for the experimental production of thiamin deficiency in man. J Am Diet Assoc 22:1\u0026ndash;7\u003c/li\u003e\n \u003cli\u003eBerger MM, Shenkin A, Schweinlin A, et al (2022) ESPEN micronutrient guideline. Clin Nutr Edinb Scotl 41:1357\u0026ndash;1424. https://doi.org/10.1016/j.clnu.2022.02.015\u003c/li\u003e\n \u003cli\u003eKarakonstantis S, Galani D, Korela D, et al (2020) Missing the early signs of thiamine deficiency. A case associated with a liquid-only diet. Nutr Neurosci 23:384\u0026ndash;386. https://doi.org/10.1080/1028415X.2018.1507964\u003c/li\u003e\n \u003cli\u003eLonsdale D (2018) Thiamin. Adv Food Nutr Res 83:1\u0026ndash;56. https://doi.org/10.1016/bs.afnr.2017.11.001\u003c/li\u003e\n \u003cli\u003eMauermann ML, Staff NP (2026) Peripheral Neuropathy: A Review. JAMA 335:255\u0026ndash;266. https://doi.org/10.1001/jama.2025.19400\u003c/li\u003e\n \u003cli\u003ePereira AG, Cunha LN de P, Paiva SAR, et al (2025) An Overview of Beriberi. Med Princ Pract Int J Kuwait Univ Health Sci Cent 1\u0026ndash;7. https://doi.org/10.1159/000547719\u003c/li\u003e\n \u003cli\u003eInoue A, Itabashi K, Iwai T, et al (2021) Imaging findings of vitamin deficiencies: are they forgotten diseases? BJR Open 3:20210011. https://doi.org/10.1259/bjro.20210011\u003c/li\u003e\n \u003cli\u003eCoats D, Shelton-Dodge K, Ou K, et al (2012) Thiamine Deficiency in Cambodian Infants with and without Beriberi. J Pediatr 161:843\u0026ndash;847. https://doi.org/10.1016/j.jpeds.2012.05.006\u003c/li\u003e\n \u003cli\u003eSmith TJ, Johnson CR, Koshy R, et al (2021) Thiamine deficiency disorders: a clinical perspective. Ann N Y Acad Sci 1498:9\u0026ndash;28. https://doi.org/10.1111/nyas.14536\u003c/li\u003e\n \u003cli\u003eLi S, Xing C (2025) Wernicke encephalopathy: a mini review of the clinical spectrum, atypical manifestations, and diagnostic challenges. Front Neurol 16:1566366. https://doi.org/10.3389/fneur.2025.1566366\u003c/li\u003e\n \u003cli\u003eBrust JCM (2008) A 74-year-old man with memory loss and neuropathy who enjoys alcoholic beverages. JAMA 299:1046\u0026ndash;1054. https://doi.org/10.1001/jama.299.5.jrr80000\u003c/li\u003e\n \u003cli\u003eHarper CG, Giles M, Finlay-Jones R (1986) Clinical signs in the Wernicke-Korsakoff complex: a retrospective analysis of 131 cases diagnosed at necropsy. J Neurol Neurosurg Psychiatry 49:341\u0026ndash;345. https://doi.org/10.1136/jnnp.49.4.341\u003c/li\u003e\n \u003cli\u003eLindboe CF, L\u0026oslash;berg EM (1989) Wernicke\u0026rsquo;s encephalopathy in non-alcoholics. An autopsy study. J Neurol Sci 90:125\u0026ndash;129. https://doi.org/10.1016/0022-510x(89)90095-6\u003c/li\u003e\n \u003cli\u003eMancinelli R, Ceccanti M (2009) Biomarkers in alcohol misuse: their role in the prevention and detection of thiamine deficiency. Alcohol Alcohol Oxf Oxfs 44:177\u0026ndash;182. https://doi.org/10.1093/alcalc/agn117\u003c/li\u003e\n \u003cli\u003eKerns JC, Arundel C, Chawla LS (2015) Thiamin Deficiency in People with Obesity12. Adv Nutr 6:147\u0026ndash;153. https://doi.org/10.3945/an.114.007526\u003c/li\u003e\n \u003cli\u003eSalvatori G, Mond\u0026igrave; V, Piersigilli F, et al (2016) Thiamine Deficiency in a Developed Country: Acute Lactic Acidosis in Two Neonates Due to Unsupplemented Parenteral Nutrition. JPEN J Parenter Enteral Nutr 40:886\u0026ndash;889. https://doi.org/10.1177/0148607114568316\u003c/li\u003e\n \u003cli\u003eZiegler D, Reiners K, Strom A, Obeid R (2023) Association between diabetes and thiamine status - A systematic review and meta-analysis. Metabolism 144:155565. https://doi.org/10.1016/j.metabol.2023.155565\u003c/li\u003e\n \u003cli\u003eda Silva JSV, Seres DS, Sabino K, et al (2020) ASPEN Consensus Recommendations for Refeeding Syndrome. Nutr Clin Pract 35:178\u0026ndash;195. https://doi.org/10.1002/ncp.10474\u003c/li\u003e\n \u003cli\u003eShim J-S, Shim SY, Cha H-J, et al (2022) Association between Ultra-processed Food Consumption and Dietary Intake and Diet Quality in Korean Adults. J Acad Nutr Diet 122:583\u0026ndash;594. https://doi.org/10.1016/j.jand.2021.07.012\u003c/li\u003e\n \u003cli\u003eEuropean Food Safety Authority (2016) Dietary reference values for thiamin. EFSA J 14:4653. https://doi.org/10.2903/j.efsa.2016.4653\u003c/li\u003e\n \u003cli\u003eMertens E, Colizzi C, Pe\u0026ntilde;alvo JL (2022) Ultra-processed food consumption in adults across Europe. Eur J Nutr 61:1521\u0026ndash;1539. https://doi.org/10.1007/s00394-021-02733-7\u003c/li\u003e\n \u003cli\u003eO\u0026rsquo;Brien M, Quirke R, Gowan R, McNicholas F (2025) Prevalence of thiamine deficiency in anorexia nervosa: a systematic review and narrative synthesis. Eur Child Adolesc Psychiatry 34:1281\u0026ndash;1293. https://doi.org/10.1007/s00787-024-02576-7\u003c/li\u003e\n \u003cli\u003eKarimi Behnagh A, Eghbali M, Abdolmaleki F, et al (2024) Pre- and Post-surgical Prevalence of Thiamine Deficiency in Patients Undergoing Bariatric Surgery: a Systematic Review and Meta-analysis. Obes Surg 34:653\u0026ndash;665. https://doi.org/10.1007/s11695-023-06896-6\u003c/li\u003e\n \u003cli\u003eOudman E, Wijnia JW, Oey M, et al (2019) Wernicke\u0026rsquo;s encephalopathy in hyperemesis gravidarum: A systematic review. Eur J Obstet Gynecol Reprod Biol 236:84\u0026ndash;93. https://doi.org/10.1016/j.ejogrb.2019.03.006\u003c/li\u003e\n \u003cli\u003eElmadfa I, Majchrzak D, Rust P, Genser D (2001) The thiamine status of adult humans depends on carbohydrate intake. Int J Vitam Nutr Res Int Z Vitam- Ernahrungsforschung J Int Vitaminol Nutr 71:217\u0026ndash;221. https://doi.org/10.1024/0300-9831.71.4.217\u003c/li\u003e\n \u003cli\u003eClark AF (2024) Use of Thiamine Supplementation in Pregnant Women Diagnosed With Hyperemesis Gravidarum and Wernicke Encephalopathy. Nurs Womens Health 28:222\u0026ndash;226. https://doi.org/10.1016/j.nwh.2024.02.003\u003c/li\u003e\n \u003cli\u003eSaka Y, Naruse T, Kato A, et al (2018) Thiamine status in end-stage chronic kidney disease patients: a single-center study. Int Urol Nephrol 50:1913\u0026ndash;1918. https://doi.org/10.1007/s11255-018-1974-y\u003c/li\u003e\n \u003cli\u003eLautenschl\u0026auml;ger T, Neinhuis C, Monizi M, et al (2017) Edible insects of Northern Angola. Afr Invertebr 58:55\u0026ndash;82. https://doi.org/10.3897/afrinvertebr.58.21083\u003c/li\u003e\n \u003cli\u003eNishimune T, Watanabe Y, Okazaki H, Akai H (2000) Thiamin is decomposed due to Anaphe spp. entomophagy in seasonal ataxia patients in Nigeria. J Nutr 130:1625\u0026ndash;1628. https://doi.org/10.1093/jn/130.6.1625\u003c/li\u003e\n \u003cli\u003eVid Vičič, Andreja Kukec (2025) Systematic review of thiamine (vitamin B1) status in healthy European adults ID - CRD420251101630 ER -. In: https://www.crd.york.ac.uk/PROSPERO/view/CRD420251101630\u003c/li\u003e\n \u003cli\u003ePage MJ, McKenzie JE, Bossuyt PM, et al (2021) The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. Syst Rev 10:89. https://doi.org/10.1186/s13643-021-01626-4\u003c/li\u003e\n \u003cli\u003eTasevska N, Runswick SA, McTaggart A, Bingham SA (2008) Twenty-four-hour urinary thiamine as a biomarker for the assessment of thiamine intake. Eur J Clin Nutr 62:1139\u0026ndash;1147. https://doi.org/10.1038/sj.ejcn.1602829\u003c/li\u003e\n \u003cli\u003eJones KS, Parkington DA, Cox LJ, Koulman A (2021) Erythrocyte transketolase activity coefficient (ETKAC) assay protocol for the assessment of thiamine status. Ann N Y Acad Sci 1498:77\u0026ndash;84. https://doi.org/10.1111/nyas.14547\u003c/li\u003e\n \u003cli\u003eLu J, Frank EL (2008) Rapid HPLC Measurement of Thiamine and Its Phosphate Esters in Whole Blood. Clin Chem 54:901\u0026ndash;906. https://doi.org/10.1373/clinchem.2007.099077\u003c/li\u003e\n \u003cli\u003eTalwar D, Davidson H, Cooney J, St JO\u0026rsquo;Reilly D (2000) Vitamin B(1) status assessed by direct measurement of thiamin pyrophosphate in erythrocytes or whole blood by HPLC: comparison with erythrocyte transketolase activation assay. Clin Chem 46:704\u0026ndash;710\u003c/li\u003e\n \u003cli\u003eJones KS, Parkington DA, Bourassa MW, et al (2023) Protocol and application of basal erythrocyte transketolase activity to improve assessment of thiamine status. Ann N Y Acad Sci 1521:104\u0026ndash;111. https://doi.org/10.1111/nyas.14962\u003c/li\u003e\n \u003cli\u003eHerzog R, \u0026Aacute;lvarez-Pasquin MJ, D\u0026iacute;az C, et al (2013) Are healthcare workers\u0026rsquo; intentions to vaccinate related to their knowledge, beliefs and attitudes? a systematic review. BMC Public Health 13:154. https://doi.org/10.1186/1471-2458-13-154\u003c/li\u003e\n \u003cli\u003eOrtega RM, Mart\u0026iacute;nez RM, Andr\u0026eacute;s P, et al (2004) Thiamin status during the third trimester of pregnancy and its influence on thiamin concentrations in transition and mature breast milk. Br J Nutr 92:129\u0026ndash;135. https://doi.org/10.1079/BJN20041153\u003c/li\u003e\n \u003cli\u003eS\u0026aacute;nchez DJ, Murphy MM, Bosch-Sabater J, Fern\u0026aacute;ndez-Ballart J (1999) Enzymic evaluation of thiamin, riboflavin and pyridoxine status of parturient mothers and their newborn infants in a Mediterranean area of Spain. Eur J Clin Nutr 53:27\u0026ndash;38. https://doi.org/10.1038/sj.ejcn.1600674\u003c/li\u003e\n \u003cli\u003eMalara M, H\u0026uuml;bner-Wozniak E, Lewandowska I (2013) Assessment of intake and nutritional status of vitamin B1, B2, and B6 in men and women with different physical activity levels. Biol Sport 30:117\u0026ndash;123. https://doi.org/10.5604/20831862.1044430\u003c/li\u003e\n \u003cli\u003eH\u0026ouml;tzel D, Bitsch R (1976) Thiamine status of human subjects, estimated by biochemical methods. J Nutr Sci Vitaminol (Tokyo) 22:41\u0026ndash;45. https://doi.org/10.3177/jnsv.22.Supplement_41\u003c/li\u003e\n \u003cli\u003eFabian E, Majchrzak D, Dieminger B, et al (2008) Influence of probiotic and conventional yoghurt on the status of vitamins B1, B2 and B6 in young healthy women. Ann Nutr Metab 52:29\u0026ndash;36. https://doi.org/10.1159/000114408\u003c/li\u003e\n \u003cli\u003eHerve C, Beyne P, Lett\u0026eacute;ron P, Delacoux E (1995) Comparison of erythrocyte transketolase activity with thiamine and thiamine phosphate ester levels in chronic alcoholic patients. Clin Chim Acta Int J Clin Chem 234:91\u0026ndash;100. https://doi.org/10.1016/0009-8981(94)05980-7\u003c/li\u003e\n \u003cli\u003eJermendy G (2006) Evaluating thiamine deficiency in patients with diabetes. Diab Vasc Dis Res 3:120\u0026ndash;121. https://doi.org/10.3132/dvdr.2006.014\u003c/li\u003e\n \u003cli\u003eBoni L, Kieckens L, Hendrikx A (1980) An Evaluation of a Modified Erythrocyte Transketolase Assay for Assessing Thiamine Nutritional Adequacy. J Nutr Sci Vitaminol (Tokyo) 26:507\u0026ndash;514. https://doi.org/10.3177/jnsv.26.507\u003c/li\u003e\n \u003cli\u003eMancinelli R, Ceccanti M, Guiducci MS, et al (2003) Simultaneous liquid chromatographic assessment of thiamine, thiamine monophosphate and thiamine diphosphate in human erythrocytes: a study on alcoholics. J Chromatogr B 789:355\u0026ndash;363. https://doi.org/10.1016/S1570-0232(03)00139-9\u003c/li\u003e\n \u003cli\u003eVerstraete J, Stove C (2021) Volumetric absorptive microsampling (VAMS) as a reliable tool to assess thiamine status in dried blood microsamples: a comparative study. Am J Clin Nutr 114:1200\u0026ndash;1207. https://doi.org/10.1093/ajcn/nqab146\u003c/li\u003e\n \u003cli\u003eK\u0026ouml;rner RW, Vierzig A, Roth B, M\u0026uuml;ller C (2009) Determination of thiamin diphosphate in whole blood samples by high-performance liquid chromatography--a method suitable for pediatric diagnostics. J Chromatogr B Analyt Technol Biomed Life Sci 877:1882\u0026ndash;1886. https://doi.org/10.1016/j.jchromb.2009.05.013\u003c/li\u003e\n \u003cli\u003eLynch PLM, Trimble ER, Young IS (1997) High-performance liquid chromatographic determination of thiamine diphosphate in erythrocytes using internal standard methodology. J Chromatogr B Biomed Sci App 701:120\u0026ndash;123. https://doi.org/10.1016/S0378-4347(97)00353-8\u003c/li\u003e\n \u003cli\u003eTallaksen CME, B\u0026oslash;hmer T, Bell H, Karlsen J (1991) Concomitant determination of thiamin and its phosphate esters in human blood and serum by high-performance liquid chromatography. J Chromatogr B Biomed Sci App 564:127\u0026ndash;136. https://doi.org/10.1016/0378-4347(91)80075-N\u003c/li\u003e\n \u003cli\u003eSchrijver J, Speek AJ, Klosse JA, et al (1982) A Reliable Semiautomated Method for the Determination of Total Thiamine in Whole Blood by the Thiochrome Method with High-Performance Liquid Chromatography. Ann Clin Biochem 19:52\u0026ndash;56. https://doi.org/10.1177/000456328201900111\u003c/li\u003e\n \u003cli\u003eJohnson CR, Fischer PR, Thacher TD, et al (2019) Thiamin deficiency in low- and middle-income countries: Disorders, prevalences, previous interventions and current recommendations. Nutr Health 25:127\u0026ndash;151. https://doi.org/10.1177/0260106019830847\u003c/li\u003e\n \u003cli\u003eRakotoambinina B, Hiffler L, Gomes F (2021) Pediatric thiamine deficiency disorders in high-income countries between 2000 and 2020: a clinical reappraisal. Ann N Y Acad Sci 1498:57\u0026ndash;76. https://doi.org/10.1111/nyas.14669\u003c/li\u003e\n \u003cli\u003ePassarelli S, Free CM, Shepon A, et al (2024) Global estimation of dietary micronutrient inadequacies: a modelling analysis. Lancet Glob Health 12:e1590\u0026ndash;e1599. https://doi.org/10.1016/S2214-109X(24)00276-6\u003c/li\u003e\n \u003cli\u003eHebert JR, Clemow L, Pbert L, et al (1995) Social desirability bias in dietary self-report may compromise the validity of dietary intake measures. Int J Epidemiol 24:389\u0026ndash;398. https://doi.org/10.1093/ije/24.2.389\u003c/li\u003e\n \u003cli\u003eGallant J, Chan K, Green TJ, et al (2021) Low-dose thiamine supplementation of lactating Cambodian mothers improves human milk thiamine concentrations: a randomized controlled trial. Am J Clin Nutr 114:90\u0026ndash;100. https://doi.org/10.1093/ajcn/nqab052\u003c/li\u003e\n \u003cli\u003eLonsdale D (2015) Sudden infant death syndrome and abnormal metabolism of thiamin. Med Hypotheses 85:922\u0026ndash;926. https://doi.org/10.1016/j.mehy.2015.09.009\u003c/li\u003e\n \u003cli\u003eEuropean Commission. Commission Directive 2006/125/EC of 5 December 2006 on processed cereal‑based foods and baby foods for infants and young children (Text with EEA relevance). OJ L 339, 6.12.2006, pp. 16\u0026ndash;35. Brussels: European Union.\u003c/li\u003e\n \u003cli\u003eEuropean Commission. Commission Delegated Regulation (EU) 2016/127 of 25 September 2015 supplementing Regulation (EU) No 609/2013 of the European Parliament and of the Council as regards the specific compositional and information requirements for infant formula and follow‑on formula and as regards requirements on information relating to infant and young child feeding (Text with EEA relevance). OJ L 25, 2.2.2016, pp. 1\u0026ndash;29. Brussels: European Union.\u003c/li\u003e\n \u003cli\u003eBailey AL, Finglas PM, Wright AJA, Southon S (1994) Thiamin intake, erythrocyte transketolase (EC 2.2.1.1) activity and total erythrocyte thiamin in adolescents. Br J Nutr 72:111\u0026ndash;125. https://doi.org/10.1079/BJN19940014\u003c/li\u003e\n \u003cli\u003eFalc\u0026atilde;o RCTM de A, Lyra C de O, Morais CMM de, et al (2019) Processed and ultra-processed foods are associated with high prevalence of inadequate selenium intake and low prevalence of vitamin B1 and zinc inadequacy in adolescents from public schools in an urban area of northeastern Brazil. PloS One 14:e0224984. https://doi.org/10.1371/journal.pone.0224984\u003c/li\u003e\n \u003cli\u003eRehm J, Anderson P, Barry J, et al (2015) Prevalence of and potential influencing factors for alcohol dependence in Europe. Eur Addict Res 21:6\u0026ndash;18. https://doi.org/10.1159/000365284\u003c/li\u003e\n \u003cli\u003eBichkaeva FA, Tkachev AV, Boiko ER, et al (2003) Vitamin B1 Levels in Residents of the European North. Hum Physiol 29:119\u0026ndash;121. https://doi.org/10.1023/A:1022073123466\u003c/li\u003e\n \u003cli\u003eBojko ER (2001) Thiamine Status in Inhabitants of the Russian European North. Int J Circumpolar Health 60:466\u0026ndash;468. https://doi.org/10.1080/25761900.2022.12220617\u003c/li\u003e\n \u003cli\u003eWhitfield KC, Smith TJ, Rohner F, et al (2021) Thiamine fortification strategies in low- and middle-income settings: a review. Ann N Y Acad Sci 1498:29\u0026ndash;45. https://doi.org/10.1111/nyas.14565\u003c/li\u003e\n \u003cli\u003eVičič V, Miku\u0026scaron; RP, Kugler S, et al (2023) Vitamin D fortification of eggs alone and in combination with milk in women aged 44-65 years: Fortification model and economic evaluation. Zdr Varst 62:30\u0026ndash;38. https://doi.org/10.2478/sjph-2023-0005\u003c/li\u003e\n \u003cli\u003eChuruangsuk C, Griffiths D, Lean MEJ, Combet E (2019) Impacts of carbohydrate-restricted diets on micronutrient intakes and status: A systematic review. Obes Rev Off J Int Assoc Study Obes 20:1132\u0026ndash;1147. https://doi.org/10.1111/obr.12857\u003c/li\u003e\n \u003cli\u003eEuropean Commission, Scientific Committee on Food. Opinion of the Scientific Committee on Food on the Tolerable Upper Intake Level of Vitamin B1 (expressed on 11 July 2001). SCF/CS/NUT/UPPLEV/46 Final, 16 July 2001. Brussels: European Commission. Available at: https://food.ec.europa.eu/system/files/2020-12/sci-com_scf_out93_en.pdf\u003c/li\u003e\n \u003cli\u003eShakory S (2020) Thiamine in the management of alcohol use disorders. Can Fam Physician 66:165\u0026ndash;166\u003cstrong\u003e\u003cbr clear=\"all\"\u003e\u003c/strong\u003e\u003c/li\u003e\n\u003c/ol\u003e"}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":true,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":true,"hideJournal":false,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":false,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"journal-of-health-population-and-nutrition","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"johp","sideBox":"Learn more about [Journal of Health, Population and Nutrition](http://jhpn.biomedcentral.com/)","snPcode":"41043","submissionUrl":"https://submission.nature.com/new-submission/41043/3","title":"Journal of Health, Population and Nutrition","twitterHandle":"@BioMedCentral","acdcEnabled":true,"dfaEnabled":true,"editorialSystem":"em","reportingPortfolio":"BMC/SO AJ","inReviewEnabled":true,"inReviewRevisionsEnabled":true},"keywords":"Thiamin, Micronutrient deficiency, Wernicke encephalopathy, beriberi, Europe, Vitamin B1, ThDP, ETKAC","lastPublishedDoi":"10.21203/rs.3.rs-8997297/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-8997297/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003eObjective: This systematic review evaluates the thiamin status of the European adult population, identifying critical gaps and priorities for future research.\u003c/p\u003e\n\u003cp\u003eMethods: The review was conducted according to a pre-registered protocol (PROSPERO: CRD420251101630) and PRISMA guidelines. A systematic search of PubMed and Scopus was carried out to identify observational studies reporting relevant thiamin status biomarkers (erythrocyte transketolase activity coefficient (ETKAC), whole blood thiamin diphosphate (WB ThDP), total thiamin in whole blood, or erythrocyte thiamin diphosphate - RBC ThDP) in apparently healthy, community-dwelling adults (≥18 years) from European countries.\u003c/p\u003e\n\u003cp\u003eResults: A total of 19 cross-sectional studies from 11 countries, published between 1976 and 2024, met the inclusion criteria, providing data on 1687 individuals. The prevalence of thiamin deficiency (ETKAC \u0026gt;1.25, WB ThDP \u0026lt;70 nmol/L, total thiamin \u0026lt;75 nmol/L, RBC ThDP \u0026lt;280 ng/g Hb) ranged from 0 % to 41.2 %. When pregnant and post-partum women were excluded, the prevalence of thiamin deficiency ranged from 0 % to 10 %.\u003c/p\u003e\n\u003cp\u003eDiscussion: The prevalence of thiamin deficiency in Europe has not been reliably established owing to the lack of representative, population-based studies. Representative studies using harmonized thiamin biomarkers are urgently needed to establish the prevalence and public health significance of thiamin deficiency in Europe. Particular attention should be given to prevention of thiamin deficiency in high-risk groups, such as pregnant and lactating women, individuals following low-carbohydrate high-fat (LCHF) diets, and people with alcohol use disorder.\u003c/p\u003e\n\u003cp\u003eConclusions: It is commonly assumed that thiamin deficiency is not a problem in Europe, but the main finding of this systematic review is that there is virtually no representative data to support this assumption.\u003c/p\u003e","manuscriptTitle":"Current Evidence on Thiamin (Vitamin B1) Status in Healthy European Adults: A Systematic Review of Biomarkers and Deficiency Prevalence","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2026-04-13 04:44:53","doi":"10.21203/rs.3.rs-8997297/v1","editorialEvents":[{"type":"communityComments","content":0},{"type":"decision","content":"Revision requested","date":"2026-05-11T15:00:08+00:00","index":"","fulltext":""},{"type":"editorInvitedReview","content":"","date":"2026-05-08T14:21:54+00:00","index":"hide","fulltext":""},{"type":"reviewerAgreed","content":"271948823163155641616471306770154622295","date":"2026-05-01T15:07:24+00:00","index":"hide","fulltext":""},{"type":"reviewerAgreed","content":"40398298059775959068398644380250792048","date":"2026-04-30T10:06:21+00:00","index":"hide","fulltext":""},{"type":"editorInvitedReview","content":"","date":"2026-04-29T13:35:08+00:00","index":"hide","fulltext":""},{"type":"editorInvitedReview","content":"","date":"2026-04-24T21:58:11+00:00","index":"hide","fulltext":""},{"type":"reviewerAgreed","content":"238440121753638194759412456966414937830","date":"2026-04-22T09:39:25+00:00","index":"hide","fulltext":""},{"type":"reviewerAgreed","content":"148177043015570823669401708030509687082","date":"2026-04-15T11:59:19+00:00","index":"hide","fulltext":""},{"type":"reviewerAgreed","content":"223002490617893509028308394301967616210","date":"2026-04-15T11:51:23+00:00","index":"hide","fulltext":""},{"type":"reviewersInvited","content":"","date":"2026-04-13T10:57:29+00:00","index":"","fulltext":""},{"type":"editorAssigned","content":"","date":"2026-03-03T11:53:54+00:00","index":"","fulltext":""},{"type":"checksComplete","content":"","date":"2026-03-03T11:52:56+00:00","index":"","fulltext":""},{"type":"submitted","content":"Journal of Health, Population and Nutrition","date":"2026-02-28T17:52:10+00:00","index":"","fulltext":""}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"journal-of-health-population-and-nutrition","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"johp","sideBox":"Learn more about [Journal of Health, Population and Nutrition](http://jhpn.biomedcentral.com/)","snPcode":"41043","submissionUrl":"https://submission.nature.com/new-submission/41043/3","title":"Journal of Health, Population and Nutrition","twitterHandle":"@BioMedCentral","acdcEnabled":true,"dfaEnabled":true,"editorialSystem":"em","reportingPortfolio":"BMC/SO AJ","inReviewEnabled":true,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"ca456b78-494b-4ded-b60a-2a91611511d7","owner":[],"postedDate":"April 13th, 2026","published":true,"recentEditorialEvents":[{"type":"decision","content":"Revision requested","date":"2026-05-11T15:00:08+00:00","index":"","fulltext":""},{"type":"editorInvitedReview","content":"","date":"2026-05-08T14:21:54+00:00","index":77,"fulltext":""},{"type":"reviewerAgreed","content":"271948823163155641616471306770154622295","date":"2026-05-01T15:07:24+00:00","index":74,"fulltext":""},{"type":"reviewerAgreed","content":"40398298059775959068398644380250792048","date":"2026-04-30T10:06:21+00:00","index":73,"fulltext":""},{"type":"editorInvitedReview","content":"","date":"2026-04-29T13:35:08+00:00","index":72,"fulltext":""}],"rejectedJournal":[],"revision":"","amendment":"","status":"in-revision","subjectAreas":[],"tags":[],"updatedAt":"2026-05-11T15:12:17+00:00","versionOfRecord":[],"versionCreatedAt":"2026-04-13 04:44:53","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-8997297","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-8997297","identity":"rs-8997297","version":["v1"]},"buildId":"XKTyCvWXoU3ODBz1xrDgd","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}