Expression and significance of MMP-2 and bFGF in endometriosis and adenomyosis

Aim To investigate the role of matrix metalloproteinase-2(MMP-2) and basic fibroblast growth factor(bFGF) in the pathogenesis of endometriosis(EMs). Methods Expression of MMP2 and bFGF in a total of 100 specimens, that is 70 cases of endometriotic tissues and 30 cases of the normal endometrial tissues (control group) were evaluated by immunohistochemicall staining (SABC methid) with polyclonal antibodies against MMP-2 and bFGF. Results The expression rate of MMP-2 in endometriotic tissues was higher than that in the normal endometrium (P0.01). Expression rate of bFGF in ectopic endometrial cells was also higher than that in normal endometrial cells (P0.01). Conclusion MMp2 is overexpressed in endometriotic tissues, which related to the in vasiveness of ectopic endometrial tissues. There were close relationships between bFGF and endometriototic angiogenesis. MMP-2 and bFGF play an important role in the progression of endometriosis.