Levels of CA_(125) and anti-transferrin antibody in serum and peritoneal fluid of patients with endometriosis-associated infertility

Objective:To explore the levels of CA125 and anti-transferrin antibody in serum and peritoneal fluid of patients with endometriosis-associated infertility.Methods:Ninety one patients with infertility were selected and divided into endometriosis group(31 patients with endometriosis),inflammation group(30 patients with pelvic inflammation),and control group(30 patients with pelvic cavity).ELISA was used to detect the levels of CA125 and anti-transferrin antibody in serum and peritoneal fluid of patients in the three groups.Results:The levels of CA125 in serum and peritoneal fluid of endometriosis group were statistically significantly higher than those in control group and inflammation group(P0.01);the levels of CA125 in serum and peritoneal fluid of patients with severe endometriosis increased significantly(P0.01);while in patients with mild endometriosis,the level of CA125 in peritoneal fluid increased(P0.05).The levels of anti-transferrin antibody in serum and peritoneal fluid of endometriosis group were statistically significantly higher than those in control group and inflammation group(P0.01);the levels of anti-transferrin antibody in serum and peritoneal fluid of patients with mild and severe endometriosis were statistically significantly higher than those in control group and inflammation group(P0.01).Conclusion:The mechanism of endometriosis-associated infertility may be correlated with autoimmune response;detecting the levels of CA125 and anti-transferrin antibody in serum and peritoneal fluid is helpful to screening and auxiliary diagnosis of endometriosis-associated infertility.