Relationship between endometriosis and RANTES genetic polymorphism

Objective:To investigate the association of RANTES genetic polymorphism with endometriosis.Methods: PCR-PFLP technique and Sequencing method was used to detect C/G single nucleotide polymorphisms of-28 locus in RANTES gene of 46 women with endometriosis(endometriosis group) and 35 women without endometriosis(control group).Results: In endometriosis group,the distribution frequencies of C/C genotype and C/G genotype of-28 locus in RANTES gene were 84.78% and 15.22%,respectively;in control group,the distribution frequencies of C/C genotype and C/G genotype of-28 locus in RANTES gene were 85.71% and 4.29%,respectively,there was no significant difference between the two groups(P0.05).The distribution frequencies of C allele and G allele of-28 locus in RANTES gene were 92.39% and 7.61% in endometriosis group,92.86% and 7.14% in control group,respectively,there was no significant difference between the two groups(P0.05).Conclusions: C/G polymorphism of-28 locus in RANTES gene may be independent of hereditary susceptibility of endometriosis.