The clinical significance of natural autoimmunity in patients with adhesive process and external genital endometriosis

N. R. Karakashian, E. I. Manukhina, M. A. Gevorgyan, И. Б. Манухин
In: Medical Council · 2016 · pp. 100–101 · doi:10.21518/2079-701x-2016-2-100-101 · W2613580580
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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-08 ⓘ

This study evaluated natural autoimmunity in 71 patients with adhesive process and external genital endometriosis, finding that correcting immunological disorders improves reproductive function recovery after surgery and antigonadotropic therapy.

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The paper discusses the clinical significance of “natural autoimmunity” in patients who have an adhesive process and external genital endometriosis, aiming to relate baseline autoimmune reactivity to these conditions. At a high level, it presents a clinical analysis focused on how natural autoimmunity may be manifested in this patient group. The main caveat is that the provided text includes only bibliographic details and the abstract/title metadata, without methodological specifics, results, or explicitly stated limitations. Relevance to endometriosis: the study’s core focus is explicitly on patients with external genital endometriosis together with adhesive pelvic processes.

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Abstract

The article presents the results of a study of 71 patients with adhesive process diagnosed with external genital endometriosis (EGE) confirmed by laparoscopy. In accordance with the specific serum immunoreactivity evaluation, all patients were divided into 3 groups: Group A (normal response type), Group B (hyper-response type) and group C (hypo-response type). The duration of infertility was on average 6,1 ± 1,3 years. After surgery patients underwent antigonadotropic therapy with 3.75 mg buserelin (a course of 4--6 injections). Against a background of the baseline therapy, all patients in groups B and C underwent correction of immunological disorders. Conclusion: Management of immunological disorders in patients with adhesive process associated with EGE enhances the effectiveness of recovery of the reproductive function
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Клиническое значение естественного аутоиммунитета у пациенток со спаечным процессом и наружным генитальным эндометриозом https://doi.org/10.21518/2079-701X-2016-2-100-101 Аннотация Об авторах Н. Р. КаракашянРоссия Е. И. Манухина Россия М. А. Геворкян Россия И. Б. Манухин Россия Список литературы 1. Краснопольская К.В., Штыров С.В., Мачанските О.В., Чеченова Ф.К. Исходы реконструктивно-пластических операций при трубно-перито-неальной форме бесплодия. Проблемы репродукции. 2001, 3: 12-5. 2. Кулаков В.И., Корнеева И.Е. Современные подходы к диагностике и лечению женского бесплодия. Акуш и гинекол. 2002. 2: 56-59. 3. Сухих ГТ., Назаренко Т.А. Бесплодный брак. Современные подходы к диагностике и лечению. М., 2010. 96-113. 4. Адамян Л.В., Гаспарян С.А. Генитальный эндометриоз. Современный взгляд на проблему. 2004. С. 228. 5. Адамян Л.В., Кулаков В. И., Андреева Е.Н. Эндометриозы. 2006. С 18 6. Баскаков В.П., Цвелев Ю.В., Кира Е.Ф. Эндометриоидная болезнь. 2002. С. 452. 7. Trinder J, CahiLL DJ. Endometriosis and infertility: the debate continues. Hum Fertil (Camb), 2002. 8. Adamyan L.V., Gasparyan S.A. Genital endometriosis. A modern view of the problem. 2004. P. 228. 9. Adamyan L.V., Kulakov V.I., Andreeva E.N. Endometriosis. 2006. P. 18. 10. Baskakov V.P., Tsvelev Y.V., Kira E.F. Endometriosis. 2002. P. 452. 11. Krasnopolskaya K.V., Shtyrov S.V., Machanskite O.V., Chechenova F.K. The outcomes of reconstructive and plastic surgery of tubal-peritoneal infertility. Problemy Reproduktsii. 2001, 3: 12-5. 12. Kulakov V.I., Korneeva I.E. Current approaches to diagnosis and treatment of femal infertility. Akush. i Gin. 2002. 2: 56-59. 13. Sukhikh G.T., Nazarenko T.A. Sterile marriage. Current approaches to diagnosis and treatment. М.: 2010. 96-113. Рецензия Для цитирования: Каракашян НР, Манухина ЕИ, Геворкян МА, Манухин ИБ. Клиническое значение естественного аутоиммунитета у пациенток со спаечным процессом и наружным генитальным эндометриозом. Медицинский Совет. 2016;(2):100-101. https://doi.org/10.21518/2079-701X-2016-2-100-101 For citation: Karakashian NR, Manukhina EI, Gevorgyan MA, Manukhin IB. The clinical significance of natural autoimmunity in patients with adhesive process and external genital endometriosis. Meditsinskiy sovet = Medical Council. 2016;(2):100-101. (In Russ.) https://doi.org/10.21518/2079-701X-2016-2-100-101 JATS XML

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endometriosisinfertility

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